LOCUS       NM_001676               4406 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ATPase H+/K+ transporting non-gastric alpha2 subunit
            (ATP12A), transcript variant 2, mRNA.
ACCESSION   NM_001676
VERSION     NM_001676.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4406)
  AUTHORS   Scudieri,P., Musante,I., Caci,E., Venturini,A., Morelli,P.,
            Walter,C., Tosi,D., Palleschi,A., Martin-Vasallo,P.,
            Sermet-Gaudelus,I., Planelles,G., Crambert,G. and Galietta,L.J.
  TITLE     Increased expression of ATP12A proton pump in cystic fibrosis
            airways
  JOURNAL   JCI Insight 3 (20), 123616 (2018)
   PUBMED   30333310
  REMARK    GeneRIF: Study in fresh bronchial samples and in cultured
            epithelial cells found that ATP12A expressed almost exclusively at
            the apical side of non-ciliated cells of airway epithelium and in
            submucosal glands, with much higher expression in cystic fibrosis
            samples. ATP12A upregulation is associated with depletion of K+ in
            airway surface liquid, an effect that may have an important role in
            the barrier function of airway epithelium.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4406)
  AUTHORS   Lennox,A.T., Coburn,S.L., Leech,J.A., Heidrich,E.M., Kleyman,T.R.,
            Wenzel,S.E., Pilewski,J.M., Corcoran,T.E. and Myerburg,M.M.
  TITLE     ATP12A promotes mucus dysfunction during Type 2 airway inflammation
  JOURNAL   Sci Rep 8 (1), 2109 (2018)
   PUBMED   29391451
  REMARK    GeneRIF: ATP12A knockdown or inhibition prevented the IL-13
            dependent increase in airway surface liquid (ASL) viscosity but did
            not alter the ASL pH
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4406)
  AUTHORS   Shah,V.S., Meyerholz,D.K., Tang,X.X., Reznikov,L., Abou Alaiwa,M.,
            Ernst,S.E., Karp,P.H., Wohlford-Lenane,C.L., Heilmann,K.P.,
            Leidinger,M.R., Allen,P.D., Zabner,J., McCray,P.B. Jr.,
            Ostedgaard,L.S., Stoltz,D.A., Randak,C.O. and Welsh,M.J.
  TITLE     Airway acidification initiates host defense abnormalities in cystic
            fibrosis mice
  JOURNAL   Science 351 (6272), 503-507 (2016)
   PUBMED   26823428
  REMARK    GeneRIF: expressing human ATP12A in cystic fibrosis mouse airways
            acidified airway surface liquid, impaired defenses, and increased
            airway bacteria.
REFERENCE   4  (bases 1 to 4406)
  AUTHORS   Knez,J., Salvi,E., Tikhonoff,V., Stolarz-Skrzypek,K., Ryabikov,A.,
            Thijs,L., Braga,D., Kloch-Badelek,M., Malyutina,S., Casiglia,E.,
            Czarnecka,D., Kawecka-Jaszcz,K., Cusi,D., Nawrot,T., Staessen,J.A.
            and Kuznetsova,T.
  TITLE     Left ventricular diastolic function associated with common genetic
            variation in ATP12A in a general population
  JOURNAL   BMC Med Genet 15, 121 (2014)
   PUBMED   25366262
  REMARK    GeneRIF: Genetic association studies show that carriers of ATP12A
            rs10507337 C allele or CCTTC haplotype had better pattern of
            myocardial relaxation as compared to non-carriers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4406)
  AUTHORS   Jakab,M., Hofer,S., Ravasio,A., Huber,F., Schmidt,S., Hitzl,W.,
            Geibel,J.P., Furst,J. and Ritter,M.
  TITLE     The putative role of the non-gastric H/K-ATPase ATP12A (ATP1AL1) as
            anti-apoptotic ion transporter: effect of the H/K ATPase inhibitor
            SCH28080 on butyrate-stimulated myelomonocytic HL-60 cells
  JOURNAL   Cell Physiol Biochem 34 (5), 1507-1526 (2014)
   PUBMED   25322912
REFERENCE   6  (bases 1 to 4406)
  AUTHORS   Grishin,A.V., Sverdlov,V.E., Kostina,M.B. and Modyanov,N.N.
  TITLE     Cloning and characterization of the entire cDNA encoded by
            ATP1AL1--a member of the human Na,K/H,K-ATPase gene family
  JOURNAL   FEBS Lett 349 (1), 144-150 (1994)
   PUBMED   8045293
REFERENCE   7  (bases 1 to 4406)
  AUTHORS   Modyanov,N.N., Petrukhin,K.E., Sverdlov,V.E., Grishin,A.V.,
            Orlova,M.Y., Kostina,M.B., Makarevich,O.I., Broude,N.E.,
            Monastyrskaya,G.S. and Sverdlov,E.D.
  TITLE     The family of human Na,K-ATPase genes. ATP1AL1 gene is
            transcriptionally competent and probably encodes the related ion
            transport ATPase
  JOURNAL   FEBS Lett 278 (1), 91-94 (1991)
   PUBMED   1847115
REFERENCE   8  (bases 1 to 4406)
  AUTHORS   Yang-Feng,T.L., Schneider,J.W., Lindgren,V., Shull,M.M., Benz,E.J.
            Jr., Lingrel,J.B. and Francke,U.
  TITLE     Chromosomal localization of human Na+, K+-ATPase alpha- and
            beta-subunit genes
  JOURNAL   Genomics 2 (2), 128-138 (1988)
   PUBMED   2842249
REFERENCE   9  (bases 1 to 4406)
  AUTHORS   Sverdlov,E.D., Monastyrskaya,G.S., Broude,N.E., Ushkaryov,Yu.A.,
            Allikmets,R.L., Melkov,A.M., Smirnov,Yu.V., Malyshev,I.V.,
            Dulobova,I.E., Petrukhin,K.E. et al.
  TITLE     The family of human Na+,K+-ATPase genes. No less than five genes
            and/or pseudogenes related to the alpha-subunit
  JOURNAL   FEBS Lett 217 (2), 275-278 (1987)
   PUBMED   3036582
REFERENCE   10 (bases 1 to 4406)
  AUTHORS   Shull,M.M. and Lingrel,J.B.
  TITLE     Multiple genes encode the human Na+,K+-ATPase catalytic subunit
  JOURNAL   Proc Natl Acad Sci U S A 84 (12), 4039-4043 (1987)
   PUBMED   3035563
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157364.15, DB216724.1,
            U02076.1, AK303498.1 and CA450333.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001676.6.
            
            Summary: The protein encoded by this gene belongs to the family of
            P-type cation transport ATPases. This gene encodes a catalytic
            subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the
            hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions
            across the plasma membrane. It is also responsible for potassium
            absorption in various tissues. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2010].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 5' end of an exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is shorter
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U02076.1, AK292968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381946.5/ ENSP00000371372.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL157364.15        49528-49530
            4-169               DB216724.1         1-166
            170-1922            U02076.1           1-1753
            1923-1966           AK303498.1         672-715
            1967-3563           U02076.1           1798-3394
            3564-3719           CA450333.1         17-172              c
            3720-4406           AL157364.15        80906-81592
FEATURES             Location/Qualifiers
     source          1..4406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.12"
     gene            1..4406
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /note="ATPase H+/K+ transporting non-gastric alpha2
                     subunit"
                     /db_xref="GeneID:479"
                     /db_xref="HGNC:HGNC:13816"
                     /db_xref="MIM:182360"
     exon            1..345
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..3456
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /EC_number="7.2.2.19"
                     /EC_number="7.2.2.13"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ATPase, Na+/K+ transporting, alpha polypeptide-like 1;
                     ATPase, H+/K+ transporting, nongastric, alpha polypeptide;
                     potassium-transporting ATPase alpha chain 2; HK alpha 2;
                     sodium pump; non-gastric Na(+)/K(+) ATPase subunit alpha"
                     /codon_start=1
                     /product="potassium-transporting ATPase alpha chain 2
                     isoform 2"
                     /protein_id="NP_001667.4"
                     /db_xref="CCDS:CCDS31948.1"
                     /db_xref="GeneID:479"
                     /db_xref="HGNC:HGNC:13816"
                     /db_xref="MIM:182360"
                     /translation="MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKK
                     NHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTP
                     EIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGI
                     FAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADI
                     RVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINT
                     GDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLD
                     SIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDK
                     TGTLTQNRMTVAHLWFDNQIFVADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKP
                     GQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIH
                     EMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMELGGLGER
                     VLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSA
                     GIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTG
                     MELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPAL
                     KKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYSLTKN
                     IAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKNK
                     DRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYVNDLK
                     DSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWV
                     GITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPG
                     SWWDKNMYY"
     exon            346..504
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            505..564
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            565..768
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            769..882
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1017
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1135
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1404
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1603
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1713
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1848
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2041
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2217
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2354
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2505
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2674
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2829
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2953
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3099
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3233
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3335
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3427
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..4406
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4383..4388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /note="hexamer: ACTAAA"
     polyA_site      4406
                     /gene="ATP12A"
                     /gene_synonym="ATP1AL1; H-K-ATPase; HK"
                     /note="major polyA site"
ORIGIN      
        1 ctcaatcctg gactctcccg acccctagct gtcggtcccc ctccctgcgc gcgcgccggc
       61 gggtttccta ccctccgagg cgtccgctgg cctgcgccct ggcggggacg tgggcggggc
      121 gggcggcatt taaggctggt gccacctccc cggtgcagcg gctggcgatc ggccgcggag
      181 gtgcgtgcag ggcccgcgcc gccgccggta tctccaccgc caacacctca gccactgcca
      241 ctgccacagc cacacgaggc cccccaccgt gcgctccgcc gctgcggtcc cggatccgcg
      301 ctccacgccc gcagcccgcg gcgccaccag cccagcatgc accagaaaac cccagaaatt
      361 tactccgtgg agctcagcgg aactaaggac atcgtgaaaa cagacaaggg ggatggcaag
      421 gagaagtata ggggtctgaa gaacaactgc ctggaactca aaaagaaaaa tcacaaagag
      481 gagtttcaga aagaactcca tctggatgac cacaaactca gcaataggga attggaagag
      541 aaatatggca cagacatcat tatgggtctc tccagcacca gagctgccga gctcctggcc
      601 cgggatgggc ccaactccct cacccctccc aagcagacgc ctgagatcgt caagttcctc
      661 aagcagatgg tgggggggtt ctctatcctc ctgtgggtgg gcgcctttct ctgttggatt
      721 gcatatggga ttcagtactc cagcgacaag tctgcatccc tgaacaacgt gtacttgggc
      781 tgtgtgcttg gtctggtggt cattttaacg gggatctttg cttattacca agaggcaaaa
      841 agcaccaaca tcatgtccag cttcaataag atgatccctc agcaagctct cgtcatccga
      901 gattccgaga agaagaccat cccttcagag cagctggtgg tgggggacat tgtggaggtc
      961 aaaggaggag accagatccc tgcagacatc agggtgctgt cttctcaggg gtgtcgggtg
     1021 gataactcat ctctcacggg ggagtctgag ccccagcccc gctcctctga gtttacccat
     1081 gaaaaccccc tggaaacaaa gaacatctgc ttctattcca caacgtgtct ggaaggcact
     1141 gtcaccggca tggttatcaa cacgggtgac cgcaccatca ttggccatat tgcctcattg
     1201 gcctcaggag ttggaaatga gaagacgccc attgccattg agatcgagca ctttgttcac
     1261 attgtggcag gagtggctgt ctccatcggc atccttttct tcatcatcgc tgtgtccctg
     1321 aagtatcaag tcctggactc catcatcttc ctcattggca tcattgtggc caatgtgccc
     1381 gagggcctcc tggccactgt cactgtgacc ctgtcgctga cagcaaaacg gatggccaag
     1441 aagaactgcc tggtgaagaa cctggaggct gtggagaccc tcggctccac ctccatcatc
     1501 tgctcggaca agactgggac actgacccag aacaggatga cagtggccca tctgtggttc
     1561 gacaatcaga tctttgtggc tgacaccagt gaggaccatt caaaccaagt ctttgaccaa
     1621 agctctagga cttgggcctc cttatccaag ataataacat tgtgtaaccg agcagagttc
     1681 aagccaggac aggaaaatgt ccccatcatg aagaaagctg tgattggaga tgcctcagaa
     1741 actgctcttt taaaattctc agaggtcatt ttgggtgatg tgatggaaat tagaaaaaga
     1801 aaccgcaaag tagctgaaat cccttttaac tctactaata aatttcagct ctccatccac
     1861 gagatggatg acccccacgg caagcgcttc ctcatggtga tgaagggggc ccctgagcgc
     1921 atcctagaga aatgcagcac catcatgatc aacggcgagg agcacccact ggacaagagc
     1981 actgccaaga ccttccacac agcctacatg gagctgggcg ggttgggcga gcgtgtgctg
     2041 ggtttctgtc atctctacct gccagcagac gagtttccag aaacctactc atttgacata
     2101 gacgctatga actttccgac ctccaacctc tgttttgtgg gactcttgtc aatgatcgat
     2161 ccccctcggt ccaccgtgcc agatgcagtc accaaatgcc ggagtgcagg gatcaaggtt
     2221 attatggtta ctggtgatca tcccatcaca gccaaagcta ttgccaagag tgtggggatc
     2281 atttcagcca acagtgaaac agtggaagac attgcacatc gcctcaacat tgctgtggag
     2341 caagttaaca aacgggatgc caaggccgct gtggtgactg gcatggagct gaaggacatg
     2401 agctcagaac agctggatga gatcttagcc aactaccagg agattgtctt tgcccggaca
     2461 tccccccagc agaagctgat cattgtggag ggctgtcaga ggcaggatgc tgttgttgct
     2521 gtgaccgggg atggagttaa tgactctccg gctctaaaga aggcagacat tgggattgcc
     2581 atggggatag caggttctga tgcagccaaa aatgcagccg acatggtctt gctggacgac
     2641 aacttcgcat ccatcgtcac aggggtggag gaaggtcgcc tgatctttga caacctcaag
     2701 aagactattg cttattccct gaccaagaac attgccgagc tgtgcccctt tctgatctac
     2761 atcattgtcg ggctccccct gcccattggc accatcacca ttctgttcat tgacttgggg
     2821 acagacatta tcccctccat tgccttggcg tacgagaaag ctgaaagtga catcatgaac
     2881 aggaagcctc gccacaagaa taaggacagg ctggtgaacc agccgctcgc tgtgtactca
     2941 tacctgcaca ttggcctcat gcaagccctg ggagctttcc ttgtgtattt caccgtctat
     3001 gcacaagagg gctttctgcc ccgcactctc attaacctgc gggtagaatg ggagaaggac
     3061 tacgtgaatg acttgaaaga cagctatggg caggaatgga caaggtacca gagggaatac
     3121 ctagaatgga cgggctacac ggctttcttt gttggcatcc tagtccagca aatagcagat
     3181 ctgatcatca ggaaaacccg gaggaattcc atcttccagc agggtctctt cagaaataaa
     3241 gtcatctggg tggggatcac ctcacagatc atcattggtc tgatcctctc ctatggcctc
     3301 ggaagtgtca cagccttgag tttcaccatg cttagggctc agtactggtt tgtggctgtg
     3361 ccgcacgcca tcctgatctg ggtgtatgat gaggtgcgga agctcttcat caggctctac
     3421 cctggaagct ggtgggataa gaacatgtat tattaagacc acctcccttc ctatgtctct
     3481 cagcagcacg ttggggcaca cttgttcatc ttctgaccgt ttgctgggct attcccctgc
     3541 agtgcagaca tcgtcaaaat tcagacaaga ggaaattttc atgcagaaag ctgtatgcag
     3601 gatgctcact gatgttttgc actttaaaac tgaaattcaa ctctttatat aggattttct
     3661 tttctatctc catctcctca ttaaaaaata cgtacatttc gaggtaatgg tatagggaag
     3721 aatgtgttta tgtgtatttg aaactccttg atgttaatag tcttgtgtaa cccaggcatc
     3781 tactggggcc tgccttaagc tctagctagg attgctcaga actcctttcc acaccctatt
     3841 aaaggcccca tgacctccct aagatttctg cagatcccct gagaaggtat gttttcatgg
     3901 tctccttgct cgaaaaaggc caactcaccc gagggtctgc aggagatgga agtggcggca
     3961 ggtttacatc acagcagcac gcatgacctc agctttgact cgtttaactc tgagacgtcc
     4021 ttcttgaagg cccttgccac agtttccctg gccacgccac cccatcccac ctctggtcat
     4081 ctccccagcc ctttatgccc cgtcgccctc cacccctaca tcagctcctc caaaactgag
     4141 ctcccagttc attttgcata tcctaactca aaatgctcag ctaatccaag gggactttct
     4201 ttaccaggat tcaaccctag tagagagctg ttatggtttc aatagtcata tttatttctt
     4261 gtaaaacagt tgccaggtgc tctccagcaa taacgttttg tcagtcatgt ttcatgtttt
     4321 aacttaggtg tattcatgtg tgacacttcc atgttgacag gcccggaaag gcctcatttt
     4381 taactaaaag atgttttata aaccca
//
