LOCUS       NM_001353812            7019 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ATPase phospholipid transporting 11C (ATP11C),
            transcript variant 5, mRNA.
ACCESSION   NM_001353812 XM_017029444
VERSION     NM_001353812.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7019)
  AUTHORS   van Dijk,M.J., van Oirschot,B.A., Harrison,A.N., Recktenwald,S.M.,
            Qiao,M., Stommen,A., Cloos,A.S., Vanderroost,J., Terrasi,R.,
            Dey,K., Bos,J., Rab,M.A.E., Bogdanova,A., Minetti,G.,
            Muccioli,G.G., Tyteca,D., Egee,S., Kaestner,L., Molday,R.S., van
            Beers,E.J. and van Wijk,R.
  TITLE     A novel missense variant in ATP11C is associated with reduced red
            blood cell phosphatidylserine flippase activity and mild hereditary
            hemolytic anemia
  JOURNAL   Am J Hematol 98 (12), 1877-1887 (2023)
   PUBMED   37671681
  REMARK    GeneRIF: A novel missense variant in ATP11C is associated with
            reduced red blood cell phosphatidylserine flippase activity and
            mild hereditary hemolytic anemia.
REFERENCE   2  (bases 1 to 7019)
  AUTHORS   Yabas,M., Bostanci,A. and Aral,S.
  TITLE     ATP11C promotes the differentiation of pre-B cells into immature B
            cells but does not affect their IL-7-dependent proliferation
  JOURNAL   Immunol Res 71 (4), 609-616 (2023)
   PUBMED   36753036
  REMARK    GeneRIF: ATP11C promotes the differentiation of pre-B cells into
            immature B cells but does not affect their IL-7-dependent
            proliferation.
REFERENCE   3  (bases 1 to 7019)
  AUTHORS   Miyata,Y., Yamada,K., Nagata,S. and Segawa,K.
  TITLE     Two types of type IV P-type ATPases independently re-establish the
            asymmetrical distribution of phosphatidylserine in plasma membranes
  JOURNAL   J Biol Chem 298 (11), 102527 (2022)
   PUBMED   36162506
  REMARK    GeneRIF: Two types of type IV P-type ATPases independently
            re-establish the asymmetrical distribution of phosphatidylserine in
            plasma membranes.
REFERENCE   4  (bases 1 to 7019)
  AUTHORS   Pereira-Martins,D.A., Coelho-Silva,J.L., Domingos,I.F.,
            Weinhauser,I., Franca-Neto,P.L., Araujo,A.S., Franca,R.F.,
            Bezerra,M.A. and Lucena-Araujo,A.R.
  TITLE     The ratio of ATP11C/PLSCR1 mRNA transcripts has clinical
            significance in sickle cell anemia
  JOURNAL   Ann Hematol 101 (2), 281-287 (2022)
   PUBMED   34651249
  REMARK    GeneRIF: The ratio of ATP11C/PLSCR1 mRNA transcripts has clinical
            significance in sickle cell anemia.
REFERENCE   5  (bases 1 to 7019)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 7019)
  AUTHORS   Paulusma,C.C. and Oude Elferink,R.P.
  TITLE     The type 4 subfamily of P-type ATPases, putative aminophospholipid
            translocases with a role in human disease
  JOURNAL   Biochim Biophys Acta 1741 (1-2), 11-24 (2005)
   PUBMED   15919184
  REMARK    Review article
REFERENCE   7  (bases 1 to 7019)
  AUTHORS   Andrew Nesbit,M., Bowl,M.R., Harding,B., Schlessinger,D.,
            Whyte,M.P. and Thakker,R.V.
  TITLE     X-linked hypoparathyroidism region on Xq27 is evolutionarily
            conserved with regions on 3q26 and 13q34 and contains a novel
            P-type ATPase
  JOURNAL   Genomics 84 (6), 1060-1070 (2004)
   PUBMED   15533723
REFERENCE   8  (bases 1 to 7019)
  AUTHORS   Kuhlbrandt,W.
  TITLE     Biology, structure and mechanism of P-type ATPases
  JOURNAL   Nat Rev Mol Cell Biol 5 (4), 282-295 (2004)
   PUBMED   15071553
  REMARK    Review article
REFERENCE   9  (bases 1 to 7019)
  AUTHORS   Halleck,M.S., Lawler,J.F. Jr., Blackshaw,S., Gao,L., Nagarajan,P.,
            Hacker,C., Pyle,S., Newman,J.T., Nakanishi,Y., Ando,H.,
            Weinstock,D., Williamson,P. and Schlegel,R.A.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 7019)
  AUTHORS   Yokoi,H., Hadano,S., Kogi,M., Kang,X., Wakasa,K. and Ikeda,J.E.
  TITLE     Isolation of expressed sequences encoded by the human Xq terminal
            portion using microclone probes generated by laser microdissection
  JOURNAL   Genomics 20 (3), 404-411 (1994)
   PUBMED   8034313
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590077.19, AL356785.18 and AL161777.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001353812.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.295519.1,
                                           SRR18074967.44744.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682941.1/ ENSP00000507250.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1038              AL590077.19        23250-24287         c
            1039-1158           AL356785.18        81510-81629         c
            1159-1248           AL356785.18        74144-74233         c
            1249-1329           AL356785.18        71669-71749         c
            1330-1437           AL356785.18        69684-69791         c
            1438-1566           AL356785.18        59277-59405         c
            1567-1670           AL356785.18        57042-57145         c
            1671-1721           AL356785.18        54866-54916         c
            1722-1786           AL356785.18        53485-53549         c
            1787-1868           AL356785.18        53079-53160         c
            1869-2019           AL356785.18        51982-52132         c
            2020-2217           AL356785.18        51079-51276         c
            2218-2379           AL356785.18        44133-44294         c
            2380-2531           AL356785.18        42998-43149         c
            2532-2603           AL356785.18        41979-42050         c
            2604-2677           AL356785.18        40032-40105         c
            2678-2781           AL356785.18        37970-38073         c
            2782-2963           AL356785.18        37353-37534         c
            2964-3227           AL356785.18        29496-29759         c
            3228-3402           AL356785.18        23066-23240         c
            3403-3505           AL356785.18        18122-18224         c
            3506-3651           AL356785.18        16767-16912         c
            3652-3711           AL356785.18        12614-12673         c
            3712-3839           AL356785.18        4831-4958           c
            3840-3975           AL356785.18        528-663             c
            3976-4041           AL161777.4         58421-58486         c
            4042-4145           AL161777.4         55853-55956         c
            4146-4299           AL161777.4         52778-52931         c
            4300-4404           AL161777.4         46513-46617         c
            4405-7019           AL161777.4         41210-43824         c
FEATURES             Location/Qualifiers
     source          1..7019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.1"
     gene            1..7019
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /note="ATPase phospholipid transporting 11C"
                     /db_xref="GeneID:286410"
                     /db_xref="HGNC:HGNC:13554"
                     /db_xref="MIM:300516"
     exon            1..1038
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     CDS             1012..4401
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /EC_number="7.6.2.1"
                     /note="isoform e is encoded by transcript variant 5;
                     probable phospholipid-transporting ATPase IG; P4-ATPase
                     flippase complex alpha subunit ATP11C; ATPase, class VI,
                     type 11C"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase IG isoform e"
                     /protein_id="NP_001340741.2"
                     /db_xref="CCDS:CCDS94677.1"
                     /db_xref="GeneID:286410"
                     /db_xref="HGNC:HGNC:13554"
                     /db_xref="MIM:300516"
                     /translation="MFRRSLNRFCAGEEKRVGTRTVFVGNHPVSETEAYIAQRFCDNR
                     IVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVDTPTSPVTSGLPLFFVITVT
                     AIKQGYEDCLRHRADNEVNKSTVYIIENAKRVRKESEKIKVGDVVEVQADETFPCDLI
                     LLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAESIDTLRAAIECEQPQPDL
                     YKFVGRINIYSNSLEAVARSLGPENLLLKGATLKNTEKIYGVAVYTGMETKMALNYQG
                     KSQKRSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSTPYNDEPWYNQKTQKERET
                     LKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFYDEEINEGALVN
                     TSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGVTQEVDGLSQTDGTLTY
                     FDKVDKNREELFLRALCLCHTVEIKTNDAVDGATESAELTYISSSPDEIALVKGAKRY
                     GFTFLGNRNGYMRVENQRKEIEEYELLHTLNFDAVRRRMSVIVKTQEGDILLFCKGAD
                     SAVFPRVQNHEIELTKVHVERNAMDGYRTLCVAFKEIAPDDYERINRQLIEAKMALQD
                     REEKMEKVFDDIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAK
                     STCYACRLFQTNTELLELTTKTIEESERKEDRLHELLIEYRKKLLHEFPKSTRSFKKA
                     WTEHQEYGLIIDGSTLSLILNSSQDSSSNNYKSIFLQICMKCTAVLCCRMAPLQKAQI
                     VRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLK
                     KLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNIC
                     FTSLPILAYSLLEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFLAAFEGTVFFF
                     GTYFLFQTASLEENGKVYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSL
                     AFYVFFSFFWGGIIWPFLKQQRMYFVFAQMLSSVSTWLAIILLIFISLFPEILLIVLK
                     NVRRRSARRNLSCRRASDSLSARPSVRPLLLRTFSDESNVL"
     exon            1039..1158
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1248
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1329
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1437
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1566
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1670
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1721
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1786
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1868
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2019
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2217
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2379
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2531
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2603
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2677
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2781
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2963
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3227
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3402
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3505
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3651
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..3711
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3839
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            3840..3975
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            3976..4041
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            4042..4145
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4299
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            4300..4404
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..7019
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4560..4565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /note="hexamer: AATAAA"
     polyA_site      4584
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /note="major polyA site"
     regulatory      6994..6999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /note="hexamer: AATAAA"
     polyA_site      7019
                     /gene="ATP11C"
                     /gene_synonym="ATPIG; ATPIQ; HACXL"
                     /note="major polyA site"
ORIGIN      
        1 gacacaaagc ctgactttac aacctcagag aaagtggaag taagaaggct taggtgggca
       61 ggcaggacga gagaaagact gagaggaggg aaagccgcgt aggtgggagt acagcggcgc
      121 gagggtcgag ggggaaccct cgtcggtgca gatgaggagg gtgggctttc agaactagtc
      181 ccccctcgca ccccgccccg cccctcccgc gctggggtct tcacggtgcc ctgcctcaga
      241 gcccggctcc accacgcccg gaagagggag tctggccgtc ggctggctca gggcgggccg
      301 gttggctgta cccaggctcc ctggcccgag tgcgggacca gagcgcgggg cggcgcggca
      361 gccgcggacc gaggaggggc tgcgagcgaa acggcgcggc gcggcacggc ggacgagtta
      421 gggccggggc gagggaggct gtggctcccg acagagacag gggagtagtg tcgggctgag
      481 gcgaggtgag gcgcggggtg cctcgggagg gttccccgtg ccccgagggg ggcggccgcg
      541 gagtccagcg gggaggcggg cggtggtgcc gcgtcgggga agagcgcatc ccgcggggtg
      601 ccgagcccgg cgctggcgga gagacggggg cgccccctcc ccacaggagg agcctcgcgc
      661 tcctccgcca tccttccccc gcgcggcggg ctcgccttct cagtgggtgc tgcgcgagct
      721 gccggcccgg ggtgccgggg ccagataagg gcgatccgcg gggccgccgc ccccgggtca
      781 ggcaggccgg gggcgggccg cgagtgaggc ggggcggcgg ctaggctgcg ggcggctggg
      841 gggcggggga gcgcggagag ccgagggggg caggcggcga gcgggtggcc cggccgcccg
      901 cctcgctgct ccgcttggcg ccgccggccc acgccgcagt gtgttttgtg gacggcgcct
      961 tcccagacag cccggtagag cccagctcag cgcccggcag ccttcgacgc gatgttccgc
     1021 cggagcttga atcgtttttg tgctggagaa gagaaacgag ttggcacacg cacagtgttt
     1081 gttggcaatc atccagtttc ggaaacagaa gcttacattg cacaaagatt ttgtgataat
     1141 agaatagtct catctaagta tacactttgg aattttctcc caaagaatct gtttgaacag
     1201 tttagaagaa ttgcaaattt ttattttctc ataatcttcc ttgtacaggt cacagtagac
     1261 acaccaacta gcccagttac cagtggactt ccacttttct ttgttataac tgttacagcc
     1321 atcaagcagg gatatgagga ttgtctgaga cacagagctg acaatgaagt caacaaaagc
     1381 actgtttaca ttattgaaaa tgcaaagcga gtgagaaaag aaagtgaaaa aatcaaggtt
     1441 ggtgatgtag tagaagtaca ggcagatgaa acctttccct gtgatcttat tcttctatca
     1501 tcttgcacca ctgatggaac ctgttatgtc actacagcca gtcttgatgg ggaatccaat
     1561 tgcaagacac attatgcagt acgtgatacc attgcactgt gtacagcaga atccatcgat
     1621 accctccgag cagcaattga atgtgaacag cctcaacctg acctctacaa atttgttggg
     1681 cgaatcaata tctacagtaa tagtcttgag gctgttgcca ggtctttggg acctgaaaat
     1741 ctcttgctga aaggagctac gctaaaaaat accgagaaga tatatggagt tgctgtttac
     1801 actggaatgg aaaccaaaat ggctttgaac taccaaggga aatctcagaa acgttctgct
     1861 gttgaaaaat ctattaatgc tttcctgatt gtatatttat ttatcttact gaccaaagct
     1921 gcagtatgca ctactctaaa gtatgtttgg caaagtaccc catacaatga tgaaccttgg
     1981 tataaccaaa agactcagaa agagcgagag accttgaagg ttttaaaaat gttcaccgac
     2041 ttcctatcat ttatggttct attcaacttt atcattcctg tctccatgta cgtcacagta
     2101 gaaatgcaga aattcttggg ctccttcttc atctcatggg ataaggactt ttatgatgaa
     2161 gaaattaatg aaggagccct ggttaacaca tcagacctta atgaagaact tggtcaggtg
     2221 gattatgtat ttacagataa gactggaaca ctcactgaaa acagcatgga attcattgaa
     2281 tgctgcatag atggccacaa atataaaggt gtaactcaag aggttgatgg attatctcaa
     2341 actgatggaa ctttaacata ttttgacaaa gtagataaga atcgagaaga gctgtttcta
     2401 cgtgccttgt gtttatgtca tactgtagaa atcaaaacaa acgatgctgt tgatggagct
     2461 acagaatcag ctgaattaac ctatatctcc tcttcaccag atgaaatagc tttggtgaaa
     2521 ggagctaaaa ggtacgggtt cacattttta ggaaatcgaa atggatatat gagagtagag
     2581 aaccaaagaa aagaaataga agaatatgaa cttcttcaca ccttaaactt tgatgctgtc
     2641 cggcgacgta tgagtgtaat tgtgaagact caagaaggag acatacttct cttttgtaaa
     2701 ggagcagact cggcagtttt tcccagagtg caaaatcatg aaattgagtt aactaaagtc
     2761 catgtggaac gtaatgcaat ggatgggtat cggacactct gtgtagcctt caaagaaatt
     2821 gctccagatg attatgaaag aattaacaga cagctcatag aggcaaaaat ggccttacaa
     2881 gacagagaag aaaaaatgga aaaagttttc gatgatattg agacaaacat gaatttaatt
     2941 ggagccactg cagttgaaga caagctacaa gatcaagctg cagagaccat tgaagctctg
     3001 catgcagcag gcctgaaagt ctgggtgctc actggggaca agatggagac agctaaatcc
     3061 acatgctatg cctgccgcct tttccagacc aacactgagc tcttagaact aaccacaaaa
     3121 accattgaag aaagtgaaag gaaagaagat cgattacatg aattattgat agaatatcgc
     3181 aagaaattgc tgcatgagtt tcctaaaagt actagaagct ttaaaaaagc atggacagaa
     3241 catcaggaat atggattaat catagatggc tccacattgt cactcatact aaattctagt
     3301 caagactcta gttcaaacaa ttacaaaagc attttcctac aaatatgtat gaagtgtact
     3361 gcagtgctct gctgtcggat ggcaccatta cagaaagccc agattgtcag aatggtgaag
     3421 aatttaaaag gcagcccaat aactctgtcg ataggtgatg gtgccaatga tgttagtatg
     3481 atcttggaat cccatgtggg aataggtatt aaaggcaaag aaggtcgcca agcagctagg
     3541 aatagcgatt attctgttcc aaagtttaaa cacttaaaga aactgctgtt ggctcatgga
     3601 catctatatt atgtgagaat agcacacctt gtacagtact tcttctataa gaacctttgt
     3661 ttcattttgc cacagttttt gtaccagttc ttctgtggat tctcacaaca gccactgtat
     3721 gatgctgctt accttacaat gtacaatatc tgcttcacat ccttgcccat cctggcctat
     3781 agtctactgg aacagcacat caacattgac actctgacct cagatccccg attgtatatg
     3841 aaaatttctg gcaatgccat gctacagttg ggccccttct tatattggac atttctggct
     3901 gcctttgaag ggacagtgtt cttctttggg acttactttc tttttcagac tgcatcccta
     3961 gaagaaaatg gaaaggtata cggaaactgg acttttggaa ccattgtttt tacagtctta
     4021 gtattcactg taaccctgaa gcttgccttg gatacccgat tctggacgtg gataaatcac
     4081 tttgtgattt ggggttcttt agccttctat gtatttttct cattcttctg gggaggaatt
     4141 atttggcctt ttctcaagca acagagaatg tattttgtat ttgcccaaat gctgtcttct
     4201 gtatccacat ggttggctat aattcttcta atatttatca gcctgttccc tgagattctt
     4261 ctgatagtat taaagaatgt aagaagaaga agtgccagga gaaatctgag ctgtagaagg
     4321 gcatctgact cattatccgc cagaccttca gtcagacctc ttcttttacg aacattctca
     4381 gacgaatcta atgtattgta acagaatccg aatcttgaac tgcctatgtt attgtcctac
     4441 aagcatactg acagtggtta cagctaaaaa agaaagcatg aagaaacaac tacaaaaagt
     4501 tatcatctca ggatacttga tacgcaacac actaaaccac tctcatgtct agagttcaca
     4561 ataaatgttc attaaaatac caaatgattc tcttaagcat ttaccattat tgtaagtagc
     4621 ctttatggcc aaagctgtaa gttaagaatt atatgaaagt tgaaagcaag aatacttaga
     4681 attctggctt tagttagagt aatataactc aaatgggtgc tcttttaacc catgaacttt
     4741 gtgaatggat ttaaatacaa tagtatgaag tagaagttat gcaatgagaa tgaatagatt
     4801 ttgctaatac tacttttttt gcctggcaga agaaatagac tatttggatc acatttctca
     4861 ttcctcctaa atgatcatct taattttttt tcccaagtac ataaggaata cttgaaaata
     4921 cagaataact aaatagtatc aatgcatcag acagaatagt taatcccttc tgtttaccca
     4981 tgtgctacta atgtcttggt agaatattct tgccaaaaaa ataccttgaa cgcttatgtg
     5041 gaaagtgtta acttacgggt atttttgtgg gaatagaaaa aaattgttta ttttttattc
     5101 ttctgaatta aaccccactt atgggtgtaa gcctactaga cttgaaaata aagtataaaa
     5161 catttccaat cacttagtag cccctcaaag tagttagaaa ataaacagat ttttccagtg
     5221 ttgattttac tgggatctgc agtaaggtgg tttaaaccat agttatataa aaataaaggt
     5281 cattctgaat atcagccttt tataatttta tgtgaagagg aagaaatata gcttatttta
     5341 aacttttgac ggtttttatt tgaaagagat tgcatttatg catatatgca gtgctttttc
     5401 ttaaacttgg ccaatttgga aagggggaag gagccacccc aaaacggtgg ttcagcttgt
     5461 agagccatga ctctgtgaag atgaatgttg tctcttaact tggacaggga aatggtctaa
     5521 ctctaaacca tgtaactgac cttagtaaag tccttgacta actgaactag aaggaaggtt
     5581 tagccttcta attagttcac ttgaaacata aatgtgaaat gtcttcattc aatgttaaac
     5641 acatactttt ttggatataa atgaccatat ttatttgact gctagttttt ttgttttttt
     5701 tttgtctttc tggcatgcct gtactattat taatgtttat attgtacctt gatttggaaa
     5761 agtattggag ttaatctgta ttatatttat atagtccata tggcacattt gattcttcca
     5821 catatatttt gtgttaatgt ttaggtatga tttttttcta aattctagaa aagaacataa
     5881 tttcagttat cagaagccat tccatcatta tagacccttt ttcattattt catttgctct
     5941 catatatcag tattattttt gagcattttg ttacatgtca ttcacaactt acctaagtgt
     6001 gctgtgttct ggtagcccgt atttgaggta agctgctgaa aacaaaagtc tctatattct
     6061 ttgcctattc caaagagcta aaaaagtcta acccaggaaa gcttttgata ttttgtgttt
     6121 gttttcttgt tcttatggtt gttgttgctg tattatgatt gctgttttac ataaaatcta
     6181 tgggaactgt gaatacagac aagagagcca cagtagagag gcttgtttaa tgcagtacca
     6241 ttggagagtt aacagaataa tctagtagaa aaataactgg ttgcatgtaa aattccttcc
     6301 agccagaaag aaagaaagac aaggagtaag ggggatttag agttatgtct cagctacaca
     6361 ttacattgtg atactgcagc tcaaattcag aatggcaatg atacatgata tcatggccta
     6421 gatccttgag agggacctgg ctttcctttt taaaagatat tttactgaag agctaaaaac
     6481 tggccagtgt ggggttagca gatcgaataa cttgaaatag accatgcagt attcctagca
     6541 ctcaatgtaa tcaccctatt tgtgacagag aaagggaaaa aaatataata agatcatcta
     6601 cctataattt gaataatttt gagctatcaa aatgtctttg taattttcac aaccgctgtc
     6661 cattgtttga ggatgttacc tactaaactg aaaacattca ttccatatct acttacacat
     6721 acaccagcaa cagtataaat gtaagcctaa ctttgcaaaa ttcgtaataa tttagtgatg
     6781 gaatttttta ataacatgca gtatataaat gtgcagattt tatgcgtgtt gacaaaatca
     6841 tttttcagct tgcaaaatgg gactgcaata ttacattttt cacttaagca gttttttaca
     6901 tctacgttgt tgctttctaa aatgaatgtg aatgccatct tttatgactg caacttgcct
     6961 tttccattac agaaattttt gtttgatgta atcaataaac tttggtatga tatgattga
//
