LOCUS       NM_014616               7315 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ATPase phospholipid transporting 11B (putative)
            (ATP11B), mRNA.
ACCESSION   NM_014616 XM_087254
VERSION     NM_014616.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7315)
  AUTHORS   Dong,N., Qi,W., Wu,L., Li,J., Zhang,X., Wu,H., Zhang,W., Jiang,J.,
            Zhang,S., Fu,W., Liu,Q., Qi,G., Wang,L., Lu,Y., Luo,J., Kong,Y.,
            Liu,Y., Zhao,R.C. and Wang,J.
  TITLE     LINC00606 promotes glioblastoma progression through sponge
            miR-486-3p and interaction with ATP11B
  JOURNAL   J Exp Clin Cancer Res 43 (1), 139 (2024)
   PUBMED   38725030
  REMARK    GeneRIF: LINC00606 promotes glioblastoma progression through sponge
            miR-486-3p and interaction with ATP11B.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7315)
  AUTHORS   Yu,W.K., Wang,Y.C., Gao,Y., Shi,C.H., Fan,Y., Yu,L.L., Zhao,Z.C.,
            Li,S.S., Xu,Y.M. and Li,Y.S.
  TITLE     Genetic analysis of the ATP11B gene in Chinese Han population with
            cerebral small vessel disease
  JOURNAL   BMC Genomics 23 (1), 822 (2022)
   PUBMED   36510145
  REMARK    GeneRIF: Genetic analysis of the ATP11B gene in Chinese Han
            population with cerebral small vessel disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7315)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7315)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   5  (bases 1 to 7315)
  AUTHORS   Tone,T., Nakayama,K., Takatsu,H. and Shin,H.W.
  TITLE     ATPase reaction cycle of P4-ATPases affects their transport from
            the endoplasmic reticulum
  JOURNAL   FEBS Lett 594 (3), 412-423 (2020)
   PUBMED   31571211
REFERENCE   6  (bases 1 to 7315)
  AUTHORS   Muzny,D.M., Scherer,S.E., Kaul,R., Wang,J., Yu,J., Sudbrak,R.,
            Buhay,C.J., Chen,R., Cree,A., Ding,Y., Dugan-Rocha,S., Gill,R.,
            Gunaratne,P., Harris,R.A., Hawes,A.C., Hernandez,J., Hodgson,A.V.,
            Hume,J., Jackson,A., Khan,Z.M., Kovar-Smith,C., Lewis,L.R.,
            Lozado,R.J., Metzker,M.L., Milosavljevic,A., Miner,G.R.,
            Morgan,M.B., Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z.,
            Steffen,D., Wei,S., Wheeler,D.A., Wright,M.W., Worley,K.C.,
            Yuan,Y., Zhang,Z., Adams,C.Q., Ansari-Lari,M.A., Ayele,M.,
            Brown,M.J., Chen,G., Chen,Z., Clendenning,J.,
            Clerc-Blankenburg,K.P., Chen,R., Chen,Z., Davis,C., Delgado,O.,
            Dinh,H.H., Dong,W., Draper,H., Ernst,S., Fu,G.,
            Gonzalez-Garay,M.L., Garcia,D.K., Gillett,W., Gu,J., Hao,B.,
            Haugen,E., Havlak,P., He,X., Hennig,S., Hu,S., Huang,W.,
            Jackson,L.R., Jacob,L.S., Kelly,S.H., Kube,M., Levy,R., Li,Z.,
            Liu,B., Liu,J., Liu,W., Lu,J., Maheshwari,M., Nguyen,B.V.,
            Okwuonu,G.O., Palmeiri,A., Pasternak,S., Perez,L.M., Phelps,K.A.,
            Plopper,F.J., Qiang,B., Raymond,C., Rodriguez,R.,
            Saenphimmachak,C., Santibanez,J., Shen,H., Shen,Y., Subramanian,S.,
            Tabor,P.E., Verduzco,D., Waldron,L., Wang,J., Wang,J., Wang,Q.,
            Williams,G.A., Wong,G.K., Yao,Z., Zhang,J., Zhang,X., Zhao,G.,
            Zhou,J., Zhou,Y., Nelson,D., Lehrach,H., Reinhardt,R., Naylor,S.L.,
            Yang,H., Olson,M., Weinstock,G. and Gibbs,R.A.
  TITLE     The DNA sequence, annotation and analysis of human chromosome 3
  JOURNAL   Nature 440 (7088), 1194-1198 (2006)
   PUBMED   16641997
REFERENCE   7  (bases 1 to 7315)
  AUTHORS   Paulusma,C.C. and Oude Elferink,R.P.
  TITLE     The type 4 subfamily of P-type ATPases, putative aminophospholipid
            translocases with a role in human disease
  JOURNAL   Biochim Biophys Acta 1741 (1-2), 11-24 (2005)
   PUBMED   15919184
  REMARK    Review article
REFERENCE   8  (bases 1 to 7315)
  AUTHORS   Kuhlbrandt,W.
  TITLE     Biology, structure and mechanism of P-type ATPases
  JOURNAL   Nat Rev Mol Cell Biol 5 (4), 282-295 (2004)
   PUBMED   15071553
  REMARK    Review article
REFERENCE   9  (bases 1 to 7315)
  AUTHORS   Halleck,M.S., Schlegel,R.A. and Williamson,P.L.
  TITLE     Reanalysis of ATP11B, a type IV P-type ATPase
  JOURNAL   J Biol Chem 277 (12), 9736-9740 (2002)
   PUBMED   11790799
  REMARK    GeneRIF: the region containing transmembrane domain 4,
            corresponding to exon 12, is present in the human homolog of the
            gene, ATP11B
REFERENCE   10 (bases 1 to 7315)
  AUTHORS   Halleck,M.S., Lawler,J.F. Jr., Blackshaw,S., Gao,L., Nagarajan,P.,
            Hacker,C., Pyle,S., Newman,J.T., Nakanishi,Y., Ando,H.,
            Weinstock,D., Williamson,P. and Schlegel,R.A.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI861412.1, DR000074.1, AK296750.1, AF156548.1, BX489704.1,
            AK304855.1, AL133061.1 and AB023173.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014616.2.
            
            Summary: P-type ATPases, such as ATP11B, are phosphorylated in
            their intermediate state and drive uphill transport of ions across
            membranes. Several subfamilies of P-type ATPases have been
            identified. One subfamily transports heavy metal ions, such as
            Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal
            ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily
            transports amphipaths, such as phosphatidylserine.[supplied by
            OMIM, Feb 2005].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.242189.1,
                                           SRR1803613.136294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323116.10/ ENSP00000321195.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BI861412.1         2-60
            60-60               DR000074.1         44-44
            61-830              AK296750.1         61-830
            831-1000            AF156548.1         741-910
            1001-1243           BX489704.1         417-659
            1244-4084           AK304855.1         138-2978
            4085-6421           AL133061.1         1570-3906
            6422-6422           AB023173.1         4651-4651
            6423-7315           AL133061.1         3908-4800
FEATURES             Location/Qualifiers
     source          1..7315
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.33"
     gene            1..7315
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /note="ATPase phospholipid transporting 11B (putative)"
                     /db_xref="GeneID:23200"
                     /db_xref="HGNC:HGNC:13553"
                     /db_xref="MIM:605869"
     exon            1..283
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..3790
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /EC_number="7.6.2.1"
                     /note="probable phospholipid-transporting ATPase IF;
                     ATPase IR; P4-ATPase flippase complex alpha subunit
                     ATP11B; ATPase, class VI, type 11B"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase IF"
                     /protein_id="NP_055431.1"
                     /db_xref="CCDS:CCDS33896.1"
                     /db_xref="GeneID:23200"
                     /db_xref="HGNC:HGNC:13553"
                     /db_xref="MIM:605869"
                     /translation="MWRWIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRI
                     ISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLMIDTPTSPVTSGLPLFFVITVTA
                     IKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVL
                     LSSDRLDGSCHVTTASLDGETNLKTHVAVPETALLQTVANLDTLVAVIECQQPEADLY
                     RFMGRMIITQQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKS
                     QKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAEEKWDEPWYNQKTEHQRNSSK
                     ILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTS
                     DLNEELGQVEYVFTDKTGTLTENEMQFRECSINGMKYQEINGRLVPEGPTPDSSEGNL
                     SYLSSLSHLNNLSHLTTSSSFRTSPENETELIKEHDLFFKAVSLCHTVQISNVQTDCT
                     GDGPWQSNLAPSQLEYYASSPDEKALVEAAARIGIVFIGNSEETMEVKTLGKLERYKL
                     LHILEFDSDRRRMSVIVQAPSGEKLLFAKGAESSILPKCIGGEIEKTRIHVDEFALKG
                     LRTLCIAYRKFTSKEYEEIDKRIFEARTALQQREEKLAAVFQFIEKDLILLGATAVED
                     RLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNILELINQKSDSE
                     CAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLFMEVCRNCSAVLCCRMAPL
                     QKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIAR
                     FKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLT
                     LYNICFTSLPILIYSLLEQHVDPHVLQNKPTLYRDISKNRLLSIKTFLYWTILGFSHA
                     FIFFFGSYLLIGKDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALETHFWTWINHL
                     VTWGSIIFYFVFSLFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDI
                     IKKVFDRHLHPTSTEKAQLTETNAGIKCLDSMCCFPEGEAACASVGRMLERVIGRCSP
                     THISRSWSASDPFYTNDRSILTLSTMDSSTC"
     exon            284..400
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            401..490
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            491..571
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            572..679
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            680..808
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            809..912
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            913..960
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1025
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1107
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1258
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1456
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1699
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1875
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1944
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2018
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2122
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2304
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2508
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2662
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2765
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2911
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..2971
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3099
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3238
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3304
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            3305..3408
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3574
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3708
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..7315
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4724..4729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /note="hexamer: AATAAA"
     polyA_site      4743
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /note="major polyA site"
     regulatory      7295..7300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /note="hexamer: AATAAA"
     polyA_site      7315
                     /gene="ATP11B"
                     /gene_synonym="ATPIF; ATPIR"
                     /note="major polyA site"
ORIGIN      
        1 aataatgaag gtggctgcgg cgcggcggca ggctcagctg cgccgggcgg gggcggcgcc
       61 ggggccgcgc ctgtaggact cggggccgac gccgcgggat ggggacgcgg cgcggggagt
      121 gaggcagtgg cggcggcggc ggtaagcgga acttcggccc gaggggctcg cccgctcccg
      181 cctctgtctt gtcggcctcc acctgcagcc ccgcggcccc cgcgccccgc gggacccgga
      241 cggcgacgac gggggaatgt ggcgctggat ccggcagcag ctgggttttg acccaccaca
      301 tcagagtgac acaagaacca tctacgtagc caacaggttt cctcagaatg gcctttacac
      361 acctcagaaa tttatagata acaggatcat ttcatctaag tacactgtgt ggaattttgt
      421 tccaaaaaat ttatttgaac agttcagaag agtggcaaac ttttattttc ttattatatt
      481 tttggttcag cttatgattg atacacctac cagtccagtt accagtggac ttccattatt
      541 ctttgtgata acagtaactg ccataaagca gggatatgaa gattggttac ggcataactc
      601 agataatgaa gtaaatggag ctcctgttta tgttgttcga agtggtggcc ttgtaaaaac
      661 tagatcaaaa aacattcggg tgggtgatat tgttcgaata gccaaagatg aaatttttcc
      721 tgcagacttg gtgcttctgt cctcagatcg actggatggt tcctgtcacg ttacaactgc
      781 tagtttggac ggagaaacta acctgaagac acatgtggca gttccagaaa cagcattatt
      841 acaaacagtt gccaatttgg acactctagt agctgtaata gaatgccagc aaccagaagc
      901 agacttatac agattcatgg gacgaatgat cataacccaa caaatggaag aaattgtaag
      961 acctctgggg ccggagagtc tcctgcttcg tggagccaga ttaaaaaaca caaaagaaat
     1021 ttttggtgtt gcggtataca ctggaatgga aactaagatg gcattaaatt acaagagcaa
     1081 atcacagaaa cgatctgcag tagaaaagtc aatgaataca tttttgataa tttatctagt
     1141 aattcttata tctgaagctg tcatcagcac tatcttgaag tatacatggc aagctgaaga
     1201 aaaatgggat gaaccttggt ataaccaaaa aacagaacat caaagaaata gcagtaagat
     1261 tctgagattt atttcagact tccttgcttt tttggttctc tacaatttca tcattccaat
     1321 ttcattatat gtgacagtcg aaatgcagaa atttcttgga tcatttttta ttggctggga
     1381 tcttgatctg tatcatgaag aatcagatca gaaagctcaa gtcaatactt ccgatctgaa
     1441 tgaagagctt ggacaggtag agtacgtgtt tacagataaa actggtacac tgacagaaaa
     1501 tgagatgcag tttcgggaat gttcaattaa tggcatgaaa taccaagaaa ttaatggtag
     1561 acttgtaccc gaaggaccaa caccagactc ttcagaagga aacttatctt atcttagtag
     1621 tttatcccat cttaacaact tatcccatct tacaaccagt tcctctttca gaaccagtcc
     1681 tgaaaatgaa actgaactaa ttaaagaaca tgatctcttc tttaaagcag tcagtctctg
     1741 tcacactgta cagattagca atgttcaaac tgactgcact ggtgatggtc cctggcaatc
     1801 caacctggca ccatcgcagt tggagtacta tgcatcttca ccagatgaaa aggctctagt
     1861 agaagctgct gcaaggattg gtattgtgtt tattggcaat tctgaagaaa ctatggaggt
     1921 taaaactctt ggaaaactgg aacggtacaa actgcttcat attctggaat ttgattcaga
     1981 tcgtaggaga atgagtgtaa ttgttcaggc accttcaggt gagaagttat tatttgctaa
     2041 aggagctgag tcatcaattc tccctaaatg tataggtgga gaaatagaaa aaaccagaat
     2101 tcatgtagat gaatttgctt tgaaagggct aagaactctg tgtatagcat atagaaaatt
     2161 tacatcaaaa gagtatgagg aaatagataa acgcatattt gaagccagga ctgccttgca
     2221 gcagcgggaa gagaaattgg cagctgtttt ccagttcata gagaaagacc tgatattact
     2281 tggagccaca gcagtagaag acagactaca agataaagtt cgagaaacta ttgaagcatt
     2341 gagaatggct ggtatcaaag tatgggtact tactggggat aaacatgaaa cagctgttag
     2401 tgtgagttta tcatgtggcc attttcatag aaccatgaac atccttgaac ttataaacca
     2461 gaaatcagac agcgagtgtg ctgaacaatt gaggcagctt gccagaagaa ttacagagga
     2521 tcatgtgatt cagcatgggc tggtagtgga tgggaccagc ctatctcttg cactcaggga
     2581 gcatgaaaaa ctatttatgg aagtttgcag aaattgttca gctgtattat gctgtcgtat
     2641 ggctccactg cagaaagcaa aagtaataag actaataaaa atatcacctg agaaacctat
     2701 aacattggct gttggtgatg gtgctaatga cgtaagcatg atacaagaag cccatgttgg
     2761 cataggaatc atgggtaaag aaggaagaca ggctgcaaga aacagtgact atgcaatagc
     2821 cagatttaag ttcctctcca aattgctttt tgttcatggt catttttatt atattagaat
     2881 agctaccctt gtacagtatt ttttttataa gaatgtgtgc tttatcacac cccagttttt
     2941 atatcagttc tactgtttgt tttctcagca aacattgtat gacagcgtgt acctgacttt
     3001 atacaatatt tgttttactt ccctacctat tctgatatat agtcttttgg aacagcatgt
     3061 agaccctcat gtgttacaaa ataagcccac cctttatcga gacattagta aaaaccgcct
     3121 cttaagtatt aaaacatttc tttattggac catcctgggc ttcagtcatg cctttatttt
     3181 cttttttgga tcctatttac taatagggaa agatacatct ctgcttggaa atggccagat
     3241 gtttggaaac tggacatttg gcactttggt cttcacagtc atggttatta cagtcacagt
     3301 aaagatggct ctggaaactc atttttggac ttggatcaac catctcgtta cctggggatc
     3361 tattatattt tattttgtat tttccttgtt ttatggaggg attctctggc catttttggg
     3421 ctcccagaat atgtattttg tgtttattca gctcctgtca agtggttctg cttggtttgc
     3481 cataatcctc atggttgtta catgtctatt tcttgatatc ataaagaagg tctttgaccg
     3541 acacctccac cctacaagta ctgaaaaggc acagcttact gaaacaaatg caggtatcaa
     3601 gtgcttggac tccatgtgct gtttcccgga aggagaagca gcgtgtgcat ctgttggaag
     3661 aatgctggaa cgagttatag gaagatgtag tccaacccac atcagcagat catggagtgc
     3721 atcggatcct ttctatacca acgacaggag catcttgact ctctccacaa tggactcatc
     3781 tacttgttaa aggggcagta gtactttgtg ggagccagtt cacctccttt cctaaaattc
     3841 agtgtgatca ccctgttaat ggccacacta gctctgaaat taatttccaa aatctttgta
     3901 gtagttcata cccactcaga gttataatgg caaacaaaca gaaagcatta gtacaagccc
     3961 ctcccaacac ccttaatttg aatctgaaca tgttaaaatt tgagaataaa gagacatttt
     4021 tcatctcttt gtctggtttg tcccttgtgc ttatgggact cctaatggca tttcagtctg
     4081 ttgctgaggc cattatattt taatataaat gtagaaaaaa gagagaaatc ttagtaaaga
     4141 gtatttttta gtattagctt gattattgac tcttctattt aaatctgctt ctgtaaatta
     4201 tgctgaaagt ttgccttgag aactctattt ttttattaga gttatattta aagcttttca
     4261 tgggaaaagt taatgtgaat actgaggaat tttggtccct cagtgacctg tgttgttaat
     4321 tcattaatgc attctgagtt cacagagcaa attaggagaa tcatttccaa ccattattta
     4381 ctgcagtatg gggagtaaat ttataccaat tcctctaact gtactgtaac acagcctgta
     4441 aagttagcca tataaatgca agggtatatc atatatacaa atcaggaatc aggtccgttc
     4501 accgaacttc aaattgatgt ttactaatat ttttgtgaca gagtataaag accctatagt
     4561 gggtaaatta gatactatta gcatattatt aatttaatgt ctttatcatt ggatcttttg
     4621 catgctttaa tctggttaac atatttaaat ttgctttttt tctctttacc tgaaggctct
     4681 gtgtatagta tttcatgaca tcgttgtaca gtttaactat atcaataaaa agtttggaca
     4741 gtatttaaat attgcaaata tgtttaatta tacaaatcag aatagtatgg gtaattaaat
     4801 gaatacaaaa agaagagcct ctttctgcag ccgacttaga catgctcttc cctttctata
     4861 agctagattt tagaataaag ggtttcagtt aataatctta ttttcaggtt atgtcatcta
     4921 acttatagca aactaccaca atacagtgag ttctgccagt gtcccagtac aaggcatatt
     4981 tcaggtgtgg ctgtggaatg taaaaatgct caacttgtat caggtaatgt tagcaataaa
     5041 ttaaatgcta agaatgatta atcgggtaca tgttactgta attaactcat tgcacttcaa
     5101 aacctaactt ccatcctgaa tttatcaagt agttcagtat tgtcatttgt ttttgtttta
     5161 ttgaaaagta atgttgtctt aagatttaga agtgattatt agcttgagaa ctattaccca
     5221 gctctaagca aataatgatt gtatacatat taagataatg gttaaatgcg gttttaccaa
     5281 gttttccctt gaaaatgtaa ttcctttatg gagatttatt gtgcagccct aagcttcctt
     5341 cccatttcat gaatataagg cttctagaat tggactggca ggggaaagaa tggtagagac
     5401 agaaattaag actttatcct tgtttgcttg taaactatta ttttcttgct aatgtaacat
     5461 ttgtctgttc cagtgatgta aggatattaa gttattaagc taaatattaa ttttcaaaaa
     5521 tagtccttct ttaacttaga tatttcatag ctggatttag gaagatctgt tattctggaa
     5581 gtactaaaaa gaataataca acgtacaatg tctgcattca ctaattcatg ttccagaaga
     5641 ggaaataatg aagatatact cagtagagta ctaggtggga ggatatggaa atttgctcat
     5701 aaaatctctt ataaaacgtg catataacaa aatgacaccc agtaggcctg cattacattt
     5761 acatgaccgt gtttatttgc catcaaataa actgagtact gacaccagac aaagactcca
     5821 aagtcataaa atagcctatg accaactgca gcaagacagg aggtcagctc gcctataatg
     5881 gtgcttaaag tgtgattgat gtaattttct gtactcacca tttgaagtta gttaaggaga
     5941 actttatttt tttaaaaaaa gtaaatggca accactagtg tgctcatcct gaactgttac
     6001 tccaaatcca ctccgttttt aaagcaaaat tatcttgtga ttttaagaaa agagttttct
     6061 atttatttaa gaaagtaaca atgcagtctg caagctttca gtagttttct agtgctatat
     6121 tcatcctgta aaactcttac tacgtaacca gtaatcacaa ggaaagtgtc ccctttgcat
     6181 atttctttaa aattctttct ttggaaagta tgatgttgat aattaactta cccttatctg
     6241 ccaaaaccag agcaaaatgc taaatacgtt attgctaatc agtggtctca aatcgatttg
     6301 cctccctttg cctcgtctga gggctgtaag cctgaagata gtggcaagca ccaagtcagt
     6361 ttccaaaatt gcccctcagc tgctttaagt gactcagcac cctgcctcag cttcagcagg
     6421 cgtaggctca ccctgggcgg agcaaagtat gggccaggga gaactacagc tacgaagacc
     6481 tgctgtcgag ttgagaaaag gggagaattt atggtctgaa ttttctaact gtcctctttc
     6541 ttgggtctaa agctcataat acacaaaggc ttccagacct gagccacacc caggccctat
     6601 cctgaacagg agactaaaca gaggcaaatc aaccctagga aatacttgca ttctgcccta
     6661 cggttagtac caggactgag gtcatttcta ctggaaaaga ttgtgagatt gaacttatct
     6721 gatcgcttga gactcctaat aggcaggagt caaggccact agaaaattga cagttaagag
     6781 ccaaaagttt ttaaaatatg ctactctgaa aaatctcgtg aaggctgtag gaaaagggag
     6841 aatcttccat gttggtgttt ttcctgtaaa gatcagtttg gggtatgata taagcaggta
     6901 ttaataaaaa taacacacca aagagttacg taaaacatgt tttattaatt ttggtcccca
     6961 cgtacagaca ttttatttct attttgaaat gagttatcta ttttcataaa agtaaaacac
     7021 tattaaagtg ctgttttatg tgaaataact tgaatgttgt tcctataaaa aatagatcat
     7081 aactcatgat atgtttgtaa tcatggtaat ttagattttt atgaggaatg agtatctgga
     7141 aatattgtag caatacttgg tttaaaattt tggacctgag acactgtggc tgtctaatgt
     7201 aatcctttaa aaattctctg cattgtcagt aaatgtagta tattattgta cagctactca
     7261 taatttttta aagtttatga agttatattt atcaaataaa aactttccta tataa
//
