LOCUS       NM_015205               9086 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ATPase phospholipid transporting 11A (ATP11A),
            transcript variant 1, mRNA.
ACCESSION   NM_015205 XM_085028 XM_495964
VERSION     NM_015205.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9086)
  AUTHORS   Higuchi,T., Oka,S., Furukawa,H., Shimada,K., Tsunoda,S., Ito,S.,
            Okamoto,A., Fujimori,M., Nakamura,T., Katayama,M., Saisho,K.,
            Shinohara,S., Matsui,T., Migita,K., Nagaoka,S. and Tohma,S.
  TITLE     Association of a Single Nucleotide Variant in TERT with Airway
            Disease in Japanese Rheumatoid Arthritis Patients
  JOURNAL   Genes (Basel) 14 (11), 2084 (2023)
   PUBMED   38003027
  REMARK    GeneRIF: Association of a Single Nucleotide Variant in TERT with
            Airway Disease in Japanese Rheumatoid Arthritis Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9086)
  AUTHORS   Chepurwar,S., von Loh,S.M., Wigger,D.C., Neef,J., Frommolt,P.,
            Beutner,D., Lang-Roth,R., Kubisch,C., Strenzke,N. and Volk,A.E.
  TITLE     A mutation in ATP11A causes autosomal-dominant auditory neuropathy
            type 2
  JOURNAL   Hum Mol Genet 32 (7), 1083-1089 (2023)
   PUBMED   36300302
  REMARK    GeneRIF: A mutation in ATP11A causes autosomal-dominant auditory
            neuropathy type 2.
REFERENCE   3  (bases 1 to 9086)
  AUTHORS   Kousathanas,A., Pairo-Castineira,E., Rawlik,K., Stuckey,A.,
            Odhams,C.A., Walker,S., Russell,C.D., Malinauskas,T., Wu,Y.,
            Millar,J., Shen,X., Elliott,K.S., Griffiths,F., Oosthuyzen,W.,
            Morrice,K., Keating,S., Wang,B., Rhodes,D., Klaric,L., Zechner,M.,
            Parkinson,N., Siddiq,A., Goddard,P., Donovan,S., Maslove,D.,
            Nichol,A., Semple,M.G., Zainy,T., Maleady-Crowe,F., Todd,L.,
            Salehi,S., Knight,J., Elgar,G., Chan,G., Arumugam,P., Patch,C.,
            Rendon,A., Bentley,D., Kingsley,C., Kosmicki,J.A., Horowitz,J.E.,
            Baras,A., Abecasis,G.R., Ferreira,M.A.R., Justice,A., Mirshahi,T.,
            Oetjens,M., Rader,D.J., Ritchie,M.D., Verma,A., Fowler,T.A.,
            Shankar-Hari,M., Summers,C., Hinds,C., Horby,P., Ling,L.,
            McAuley,D., Montgomery,H., Openshaw,P.J.M., Elliott,P., Walsh,T.,
            Tenesa,A., Fawkes,A., Murphy,L., Rowan,K., Ponting,C.P., Vitart,V.,
            Wilson,J.F., Yang,J., Bretherick,A.D., Scott,R.H., Hendry,S.C.,
            Moutsianas,L., Law,A., Caulfield,M.J. and Baillie,J.K.
  CONSRTM   GenOMICC investigators; 23andMe investigators; COVID-19 Human
            Genetics Initiative
  TITLE     Whole-genome sequencing reveals host factors underlying critical
            COVID-19
  JOURNAL   Nature 607 (7917), 97-103 (2022)
   PUBMED   35255492
REFERENCE   4  (bases 1 to 9086)
  AUTHORS   Pater,J.A., Penney,C., O'Rielly,D.D., Griffin,A., Kamal,L.,
            Brownstein,Z., Vona,B., Vinkler,C., Shohat,M., Barel,O.,
            French,C.R., Singh,S., Werdyani,S., Burt,T., Abdelfatah,N.,
            Houston,J., Doucette,L.P., Squires,J., Glaser,F., Roslin,N.M.,
            Vincent,D., Marquis,P., Woodland,G., Benoukraf,T., Hawkey-Noble,A.,
            Avraham,K.B., Stanton,S.G. and Young,T.L.
  TITLE     Autosomal dominant non-syndromic hearing loss maps to DFNA33
            (13q34) and co-segregates with splice and frameshift variants in
            ATP11A, a phospholipid flippase gene
  JOURNAL   Hum Genet 141 (3-4), 431-444 (2022)
   PUBMED   35278131
  REMARK    GeneRIF: Autosomal dominant non-syndromic hearing loss maps to
            DFNA33 (13q34) and co-segregates with splice and frameshift
            variants in ATP11A, a phospholipid flippase gene.
REFERENCE   5  (bases 1 to 9086)
  AUTHORS   Segawa,K., Kikuchi,A., Noji,T., Sugiura,Y., Hiraga,K., Suzuki,C.,
            Haginoya,K., Kobayashi,Y., Matsunaga,M., Ochiai,Y., Yamada,K.,
            Nishimura,T., Iwasawa,S., Shoji,W., Sugihara,F., Nishino,K.,
            Kosako,H., Ikawa,M., Uchiyama,Y., Suematsu,M., Ishikita,H., Kure,S.
            and Nagata,S.
  TITLE     A sublethal ATP11A mutation associated with neurological
            deterioration causes aberrant phosphatidylcholine flipping in
            plasma membranes
  JOURNAL   J Clin Invest 131 (18) (2021)
   PUBMED   34403372
  REMARK    GeneRIF: A sublethal ATP11A mutation associated with neurological
            deterioration causes aberrant phosphatidylcholine flipping in
            plasma membranes.
REFERENCE   6  (bases 1 to 9086)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 9086)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   8  (bases 1 to 9086)
  AUTHORS   Andrew Nesbit,M., Bowl,M.R., Harding,B., Schlessinger,D.,
            Whyte,M.P. and Thakker,R.V.
  TITLE     X-linked hypoparathyroidism region on Xq27 is evolutionarily
            conserved with regions on 3q26 and 13q34 and contains a novel
            P-type ATPase
  JOURNAL   Genomics 84 (6), 1060-1070 (2004)
   PUBMED   15533723
REFERENCE   9  (bases 1 to 9086)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   10 (bases 1 to 9086)
  AUTHORS   Halleck,M.S., Lawler,J.F. Jr., Blackshaw,S., Gao,L., Nagarajan,P.,
            Hacker,C., Pyle,S., Newman,J.T., Nakanishi,Y., Ando,H.,
            Weinstock,D., Williamson,P. and Schlegel,R.A.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139384.17, BE675783.1,
            BC024154.2, AL356752.13, AB028944.2, AI703438.1, AL161996.1 and
            AL356740.19.
            
            On Aug 13, 2020 this sequence version replaced NM_015205.2.
            
            Summary: The protein encoded by this gene is an integral membrane
            ATPase. The encoded protein is probably phosphorylated in its
            intermediate state and likely drives the transport of ions such as
            calcium across membranes. [provided by RefSeq, Apr 2022].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968189,
                              SAMEA1968832 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000375645.8/ ENSP00000364796.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AL139384.17        2673-2963           c
            292-889             BE675783.1         1-598
            890-1320            BC024154.2         435-865
            1321-1328           AL356752.13        102957-102964
            1329-2616           AB028944.2         855-2142
            2617-2730           AI703438.1         132-245
            2731-3516           AB028944.2         2257-3042
            3517-4230           AL161996.1         1272-1985
            4231-9086           AL356740.19        16354-21209
FEATURES             Location/Qualifiers
     source          1..9086
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..9086
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /note="ATPase phospholipid transporting 11A"
                     /db_xref="GeneID:23250"
                     /db_xref="HGNC:HGNC:13552"
                     /db_xref="MIM:605868"
     exon            1..418
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..3784
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /EC_number="7.6.2.1"
                     /note="isoform a is encoded by transcript variant 1;
                     probable phospholipid-transporting ATPase IH; potential
                     phospholipid-transporting ATPase IH;
                     phospholipid-translocating ATPase; P4-ATPase flippase
                     complex alpha subunit ATP11A; ATPase, class VI, type 11A"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase IH isoform a"
                     /protein_id="NP_056020.2"
                     /db_xref="CCDS:CCDS32011.1"
                     /db_xref="GeneID:23250"
                     /db_xref="HGNC:HGNC:13552"
                     /db_xref="MIM:605868"
                     /translation="MDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQR
                     YPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLIIDTPTSPVTSGLPLFF
                     VITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETF
                     PCDLIFLSSNRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQ
                     PQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMA
                     LNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTE
                     SERQRNLFLKAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGE
                     GPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPHVICNGQVLPES
                     SGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSS
                     PDEVALVEGVQRLGFTYLRLKDNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKS
                     ATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQEEYEGI
                     CKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIK
                     VWVLTGDKMETAAATCYACKLFRRNTQLLELTTKRIEEQSLHDVLFELSKTVLRHSGS
                     LTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCR
                     MAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDY
                     AIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDT
                     AYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLG
                     LFDALVFFFGAYFVFENTTVTSNGQIFGNWTFGTLVFTVMVFTVTLKLALDTHYWTWI
                     NHFVIWGSLLFYVVFSLLWGGVIWPFLNYQRMYYVFIQMLSSGPAWLAIVLLVTISLL
                     PDVLKKVLCRQLWPTATERVQTKSQCLSVEQSTIFMLSQTSSSLSF"
     exon            419..541
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            542..631
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            632..712
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            713..820
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            821..949
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1053
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1104
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1169
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1251
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1402
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1600
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1774
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1938
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2010
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2084
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2188
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2370
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2622
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2797
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2900
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3046
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3106
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3234
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3370
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3436
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3540
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3706
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3793
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..9086
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9044..9049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /note="hexamer: AATAAA"
     regulatory      9068..9073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /note="hexamer: TATAAA"
     polyA_site      9081
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
     polyA_site      9086
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /note="major polyA site"
ORIGIN      
        1 agagggcggc gggcagggga ggaggagact cgggaggagc agagcgcagg ctccgccgcg
       61 gccggggtgc tccagccgag cccaaccgag cgggcggacc gacggggaga gagaaggcgc
      121 cagagcgcgc gcgcgcggcc ccgagcagca gccttgccgc cagtggagca gctgccgacg
      181 cgcggggccg cggacccagc attcgccggc cgggccgggc atgagcgcgg aggggccgcg
      241 gccgccccct gcaccgcccg gcgcgccgag gccgtgaccg gagcgggggg cgcggccgca
      301 ctagtacccc ggagcccatg ggcgcgccga gccgggcgcg ggggcgctga acggcggagc
      361 gggagcggcc ggaggagcca tggactgcag cctcgtgcgg acgctcgtgc acagatactg
      421 tgcaggagaa gagaattggg tggacagcag gaccatctac gtgggacaca gggagccacc
      481 tccgggcgca gaggcctaca tcccacagag atacccagac aacaggatcg tctcgtccaa
      541 gtacacattt tggaacttta tacccaagaa tttatttgaa caattcagaa gagtagccaa
      601 cttttatttc cttatcatat ttctggtgca gttgattatt gatacaccca caagtccagt
      661 gacaagcgga cttccactct tctttgtcat tactgtgacg gctatcaaac agggttatga
      721 agactggctt cgacataaag cagacaatgc catgaaccag tgtcctgttc atttcattca
      781 gcacggcaag ctcgttcgga aacaaagtcg aaagctgcga gttggggaca ttgtcatggt
      841 taaggaggac gagacctttc cctgcgactt gatcttcctt tccagcaacc ggggagatgg
      901 gacgtgccac gtcaccaccg ccagcttgga tggagaatcc agccataaaa cgcattacgc
      961 ggtccaggac accaaaggct tccacacaga ggaggatatc ggcggacttc acgccaccat
     1021 cgagtgtgag cagccccagc ccgacctcta caagttcgtg ggtcgcatca acgtttacag
     1081 tgacctgaat gaccccgtgg tgaggccctt aggatcggaa aacctgctgc ttagaggagc
     1141 tacactgaag aacactgaga aaatctttgg tgtggctatt tacacgggaa tggaaaccaa
     1201 gatggcatta aattatcaat caaaatctca gaagcgatct gccgtggaaa aatcgatgaa
     1261 tgcgttcctc attgtgtatc tctgcattct gatcagcaaa gccctgataa acactgtgct
     1321 gaaatacatg tggcagagtg agccctttcg ggatgagccg tggtataatc agaaaacgga
     1381 gtcggaaagg cagaggaatc tgttcctcaa ggcattcacg gacttcctgg ccttcatggt
     1441 cctctttaac tacatcatcc ctgtgtccat gtacgtcacg gtcgagatgc agaagttcct
     1501 cggctcttac ttcatcacct gggacgaaga catgtttgac gaggagactg gcgaggggcc
     1561 tctggtgaac acgtcggacc tcaatgaaga gctgggacag gtggagtaca tcttcacaga
     1621 caagaccggc accctcacgg aaaacaacat ggagttcaag gagtgctgca tcgaaggcca
     1681 tgtctacgtg ccccacgtca tctgcaacgg gcaggtcctc ccagagtcgt caggaatcga
     1741 catgattgac tcgtccccca gcgtcaacgg gagggagcgc gaggagctgt ttttccgggc
     1801 cctctgtctc tgccacaccg tccaggtgaa agacgatgac agcgtagacg gccccaggaa
     1861 atcgccggac ggggggaaat cctgtgtgta catctcatcc tcgcccgacg aggtggcgct
     1921 ggtcgaaggt gtccagagac ttggctttac ctacctaagg ctgaaggaca attacatgga
     1981 gatattaaac agggagaacc acatcgaaag gtttgaattg ctggaaattt tgagttttga
     2041 ctcagtcaga aggagaatga gtgtaattgt aaaatctgct acaggagaaa tttatctgtt
     2101 ttgcaaagga gcagattctt cgatattccc ccgagtgata gaaggcaaag ttgaccagat
     2161 ccgagccaga gtggagcgta acgcagtgga ggggctccga actttgtgtg ttgcttataa
     2221 aaggctgatc caagaagaat atgaaggcat ttgtaagctg ctgcaggctg ccaaagtggc
     2281 ccttcaagat cgagagaaaa agttagcaga agcctatgag caaatagaga aagatcttac
     2341 tctgcttggt gctacagctg ttgaggaccg gctgcaggag aaagctgcag acaccatcga
     2401 ggccctgcag aaggccggga tcaaagtctg ggttctcacg ggagacaaga tggagacggc
     2461 cgcggccacg tgctacgcct gcaagctctt ccgcaggaac acgcagctgc tggagctgac
     2521 caccaagagg atcgaggagc agagcctgca cgacgtcctg ttcgagctga gcaagacggt
     2581 cctgcgccac agcgggagcc tgaccagaga caacctgtcc ggactttcag cagatatgca
     2641 ggactacggt ttaattatcg acggagctgc actgtctctg ataatgaagc ctcgagaaga
     2701 cgggagttcc ggcaactaca gggagctctt cctggaaatc tgccggagct gcagcgcggt
     2761 gctctgctgc cgcatggcgc ccttgcagaa ggctcagatt gttaaattaa tcaaattttc
     2821 aaaagagcac ccaatcacgt tagcaattgg cgatggtgca aatgatgtca gcatgattct
     2881 ggaagcgcac gtgggcatag gtgtcatcgg caaggaaggc cgccaggctg ccaggaacag
     2941 cgactatgca atcccaaagt ttaagcattt gaagaagatg ctgcttgttc acgggcattt
     3001 ttattacatt aggatctctg agctcgtgca gtacttcttc tataagaacg tctgcttcat
     3061 cttccctcag tttttatacc agttcttctg tgggttttca caacagactt tgtacgacac
     3121 cgcgtatctg accctctaca acatcagctt cacctccctc cccatcctcc tgtacagcct
     3181 catggagcag catgttggca ttgacgtgct caagagagac ccgaccctgt acagggacgt
     3241 cgccaagaat gccctgctgc gctggcgcgt gttcatctac tggacgctcc tgggactgtt
     3301 tgacgcactg gtgttcttct ttggtgctta tttcgtgttt gaaaatacaa ctgtgacaag
     3361 caacgggcag atatttggaa actggacgtt tggaacgctg gtattcaccg tgatggtgtt
     3421 cacagttaca ctaaagcttg cattggacac acactactgg acttggatca accattttgt
     3481 catctggggg tcgctgctgt tctacgttgt cttttcgctt ctctggggag gagtgatctg
     3541 gccgttcctc aactaccaga ggatgtacta cgtgttcatc cagatgctgt ccagcgggcc
     3601 cgcctggctg gccatcgtgc tgctggtgac catcagcctc cttcccgacg tcctcaagaa
     3661 agtcctgtgc cggcagctgt ggccaacagc aacagagaga gtccagacta agagccagtg
     3721 cctttctgtc gagcagtcaa ccatctttat gctttctcag acttccagca gcctgagttt
     3781 ctgatggaac aagagcccag gctaccagag cacctgtccc tcggccgcct ggtacagctc
     3841 ccactctcag caggtgacac tcgcggcctg gaaggagaag gtgtccacgg agcccccacc
     3901 catcctcggc ggttcccatc accactgcag ttccatccca agtcacagct gccctaggtc
     3961 ccgtgtggga atgctcgtgt gatggatggt cctaagcctg tggagactgt gcacgtgcct
     4021 cttcctggcc cccagcaggc aaggaggggg gtcacaggcc ttgccctcga gcatggcacc
     4081 ctggccgcct ggacccagca ctgtggttgt tgagccacac cagtggcctc tgggcattcg
     4141 gctcaacgca ggagggacat tctgctggcc caccctgcgc gctgtcatgc agaggccatt
     4201 cccccaggcc tgtgtcttca cccacctgcc atcattggcc tttgctgtca ctgggagaga
     4261 agagccgtcc agggacccat ggtggcccac atgtggatgc cacatgctgc tgtttcctgc
     4321 ttgcccggcc accacccatg ccctccatag ggtgaggtgg agccatggtg gtgcgtcctt
     4381 tactcaacaa ccctccaatc cggatgctgt gggaagggcc gggtcactcg gataccatca
     4441 tccctgcgga tgcaccgccg taccctgctc atctgggagt ggtttccctg cggttacgtc
     4501 caagcccgcc tgccctgtgt gttggggctg gctgagtttc ggtctcccca tcaccggccg
     4561 cctcgtggag aaggcagtgc cacgtgggag gacaaggcca cgccggcagc ttccagccct
     4621 gccgcagaag tgccaggatg tccatcagcc actcgccagg gcacggagcc gtcagtccac
     4681 tgttacggga gaatgttgat ttcgcgggtg cgagggccgg gagacagata cttggctgtg
     4741 atgagcagac atcctctgtc cccgtggagg ggtcaacacc aaggtggtgt tcgtgcacca
     4801 gaacctgtct cgggctgacg ggggtggcac acaggacacg ggtggatccc aacaggcagc
     4861 accgcacctc tgcccgcctc ccgcactgca gctccgcccg ccgggctctg cgtccccacg
     4921 tcccctcgtc ccatccccac gtcccctcat cccgtcacct cgtccccaca tccccttgcc
     4981 ccgtcacctc gtcctcatgt ccccttgtcc tgtcacctcg tccccacgtc ccctcgtctc
     5041 ctcatcccca cgtcctctcg tccccttgtc ccgtccccac ataccctcgt ccccatgtcc
     5101 ccacgcaggg ctctccttcg tcttaggatc tgtccagcgc tgctctgggt gggttagcaa
     5161 ccccagggct gctgtgatag gaagtccctg ttgttctccg tactggcatt tctatttcta
     5221 gaaataatat ttgacatagc cttaatggtc cttaaagaag acatttcagt gtgagattca
     5281 gacttcagac gctgaaactg ctgcctttca ggaaagcacc accaacgctg gaggaggagc
     5341 cggccctcac gcccgccccg cgccacgctg tggaacgggg ctccggcaag tgaaacccag
     5401 agggtgtttc cgaggtgctc gacagtaggt atttttggaa gctcagattt caccatttga
     5461 ttgtataatc ttttacctat aaaatattta tttgaagtag agggtaaatc agcggtaaga
     5521 acagtgaaca cagtggttgg gataaaataa ggtgacaaac atcacaccaa agatgagggt
     5581 agcgagcaac tggcttgagc agacagaacg gggaagactc cactctgtcc cgaggggcca
     5641 gccgcaggcg tccccagggc caccctgccc tgaggtcctt gtgtggccgc cctggcttgg
     5701 cagccctgcc cacgctgccc ccgcaaacaa tggtgtgtgc gtttttacag ccctttttag
     5761 gaacccaata tgggcataaa tgtaacacct gtagcggggg cagattctct gtatgttcag
     5821 ttaacaaatt atttgtaatg tattttttta gaaatcttaa aattgccttt gcactgaagt
     5881 attttcatag ctgtttatat ctcttttatt catttattta acatactgtc taattttaaa
     5941 aataggtttt taaagctttc atttttaagt ttatgaaatt ttggccactt tacatttaga
     6001 ttctggtgag agttttgact gaatgttcca atctctgatg aatgcgaatt ttcagatttg
     6061 attttattct ctacacacac ctcttctttt cttggtattt ctggtggcag tgattagttg
     6121 aacagcacat ttaaggcacg ataatttgct acactttttc tttacaattt gttgcaattt
     6181 catctgcttt ctatgtttca ttgttaattg ccatccttca gccttaaaaa tagaagattc
     6241 tcacgtgaag gtttagtaag ttgggtccca gctctgcctg tgtggagata gtcaccatgt
     6301 acctctgaca acaagtttta gtgtgaaagt cactaaactt ttacacactc ccaaacgtct
     6361 ttttaaaaat tgcttgggaa attattaaat gaatgtgcct gatgatttga aatagacaag
     6421 gggcacgaga taaaaaagaa aaggatgaga agatcctcag tgaatgacgt tgcagggtct
     6481 tcatgcaatt ttccacctcg cagtagttag tatttacttg ccttaaacta actttgaagc
     6541 aagtaatgtc aactttgagc actttgttga gttttgaaaa atcttatttg ttgctgcaca
     6601 ggttaataaa ttatcaattt gtaattcagc atgttggtca gagacacggt cactgattca
     6661 cacccagtcc ctgccacaga ccgtctcaga cacgcacagt gggcctgctg catgattcac
     6721 acccagtccc tgccacagac cgtctcagac acgcacagtg ggcctgctgc atgattcaca
     6781 cccagtccct gccacagacc gtctcagaca cgcacagtgg gcctgctgca tgcgtgttac
     6841 ctggcttttg gctccacgct cactcatagc catgtccaca tgggggcttg cacacaggat
     6901 cactcacata tgtacatgta cccaccacaa acgtgcaagc tcctgcacac atgcatgcac
     6961 acaaacgtgt acacaagtgt gagctcctac acgcatacac acacacacgt gtacatgcac
     7021 caaagcatgt gtgacctaca gacatgcaga acatgcacgt gtacacatac cacagacacg
     7081 cgtgtgcatg ctcctacaca atacatatgc acatatcatg aacagcgtaa gttcctacac
     7141 acggacgtgt gatacacaca tgcatgtaca ggtaagcaca catgtacaag ctcctacagg
     7201 cttgctctca cacacgtgta tgcacagcag agagacgtat gagcttctac tgcacacatg
     7261 cacacacaca cgcacacgta cattcactac aaacgtgcag cctcctgcac acgtgcacat
     7321 tcatgtgtac accacaaatg agttcccaga cgtgtaaaca cacgtgcaca catcgtacac
     7381 atgtgagctc ccacacgtac acacagatgc acatggacac accccaaaca cgcacaggct
     7441 cctacacaca tgcacacacg tgtacaccac aaacgagctc ccagacatgt aaacacacgt
     7501 ctcccacacg tgagctccca cacgtacaca tgcacatgta cgcaccacaa acacatgcgc
     7561 aggctcctgc aggcgtgaat acacacatgc acacacatat acacacatgt gccacaaaca
     7621 agtgcacact gtcctggtgt cctgcactgc atcctgcctc cttgctgagg ggcccctgtg
     7681 agaggcctct ggatgggcat gggaagatgg gctccctggc ccccagccca tgcctccctg
     7741 ggatgaagag tccccctcct ggcagaatgt ctgggctttg cagagcaggc cccgggggtg
     7801 aagtcgcagc ttcacttaca ccagctgctc tgtgagcaag gcttggtgcc ctggacaagg
     7861 cccttcccct ttagggaggt ccagcctcgc aagctgaaac ctcccctcgg ctcagcccta
     7921 taccaggcgg ccacagcagg actggccaca cccacgccgc acctcatccg tgcacgcgtc
     7981 ggagcacggc cagccttccg ccacgagcca gctgggaagg gccgcggccg cctaaagccc
     8041 cagtcaaccc agcctgtgtc tgagcagaca gggcgaacaa gcaggccaca ccgtctcgag
     8101 ggaggaggcc agatgcggcc agcgtctcca acagggtgac catccgctcg gcttgctgag
     8161 cgtttaaaca aatgtttaga caggctgtgg ggactcccct gagttgagcc ttggccaggg
     8221 gtccggtgct gtcgcgggaa acctccagcc ttgttcttca aaccactcag ctcatgtgtt
     8281 ttgcactgac tagtactgaa taatacaacc actcttattt aatgttagta ttatttattt
     8341 gacaactcag tgtctaacag cttgatatgc aggtccttgc atcctacatt tctttaggaa
     8401 gttacccatt tgtaacttta aaaacaggaa aaatatcagt tggcaaatgc aatctttttt
     8461 ttttttaagc taaaggtggg tgaactggaa tgaaaatctt tctgatgttg tgtctataag
     8521 cagccttgat gggatatgtt agaagtgtca tgaaagtgtg attctacttt tgcagaaaaa
     8581 tctaaagatc aatttatata gctttatttt ttactttatc aaagtataca gaattttaat
     8641 atgcatatat tgtgtctgac ttaaaattat aatgtctgcg tcaccattta aaatgtctgt
     8701 tcattatgta atgtaataaa agaaggtctt caaaaatgta tttaacatga atggtatcca
     8761 tagttgtcat catcataaat actggagttt atttttaaat tattaaacat agtaggtgca
     8821 ttaacataaa tcagtctcca cacagtaaca tttaactgat aattcattaa tcagctttga
     8881 aaaattaaat tgttaattaa accaatctaa catttcagta aagtttattt tgtatgcttc
     8941 tgtttttaac ttttatttct gtagataaac tgactggata atattatatt ggacttttct
     9001 ctagattatc taagcaggag acctgaatct gcttgcaata aagaataaaa gtctgcttca
     9061 gtttctttat aaagaaactc acacaa
//
