LOCUS       NM_020453               6668 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ATPase phospholipid transporting 10D (putative)
            (ATP10D), mRNA.
ACCESSION   NM_020453
VERSION     NM_020453.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6668)
  AUTHORS   Roland,B.P., Naito,T., Best,J.T., Arnaiz-Yepez,C., Takatsu,H.,
            Yu,R.J., Shin,H.W. and Graham,T.R.
  TITLE     Yeast and human P4-ATPases transport glycosphingolipids using
            conserved structural motifs
  JOURNAL   J Biol Chem 294 (6), 1794-1806 (2019)
   PUBMED   30530492
REFERENCE   2  (bases 1 to 6668)
  AUTHORS   Naito,T., Takatsu,H., Miyano,R., Takada,N., Nakayama,K. and
            Shin,H.W.
  TITLE     Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and
            Is Involved in Plasma Membrane Dynamics
  JOURNAL   J Biol Chem 290 (24), 15004-15017 (2015)
   PUBMED   25947375
REFERENCE   3  (bases 1 to 6668)
  AUTHORS   Kengia,J.T., Ko,K.C., Ikeda,S., Hiraishi,A., Mieno-Naka,M.,
            Arai,T., Sato,N., Muramatsu,M. and Sawabe,M.
  TITLE     A gene variant in the Atp10d gene associates with atherosclerotic
            indices in Japanese elderly population
  JOURNAL   Atherosclerosis 231 (1), 158-162 (2013)
   PUBMED   24125428
  REMARK    GeneRIF: The rs2351791 SNP in the Atp10d gene affects the
            susceptibility for cardiac and intracranial vascular stenosis in
            the elderly Japanese population.
REFERENCE   4  (bases 1 to 6668)
  AUTHORS   Demirkan,A., van Duijn,C.M., Ugocsai,P., Isaacs,A.,
            Pramstaller,P.P., Liebisch,G., Wilson,J.F., Johansson,A., Rudan,I.,
            Aulchenko,Y.S., Kirichenko,A.V., Janssens,A.C., Jansen,R.C.,
            Gnewuch,C., Domingues,F.S., Pattaro,C., Wild,S.H., Jonasson,I.,
            Polasek,O., Zorkoltseva,I.V., Hofman,A., Karssen,L.C.,
            Struchalin,M., Floyd,J., Igl,W., Biloglav,Z., Broer,L., Pfeufer,A.,
            Pichler,I., Campbell,S., Zaboli,G., Kolcic,I., Rivadeneira,F.,
            Huffman,J., Hastie,N.D., Uitterlinden,A., Franke,L., Franklin,C.S.,
            Vitart,V., Nelson,C.P., Preuss,M., Bis,J.C., O'Donnell,C.J.,
            Franceschini,N., Witteman,J.C., Axenovich,T., Oostra,B.A.,
            Meitinger,T., Hicks,A.A., Hayward,C., Wright,A.F., Gyllensten,U.,
            Campbell,H. and Schmitz,G.
  CONSRTM   DIAGRAM Consortium; CARDIoGRAM Consortium; CHARGE Consortium;
            EUROSPAN consortium
  TITLE     Genome-wide association study identifies novel loci associated with
            circulating phospho- and sphingolipid concentrations
  JOURNAL   PLoS Genet 8 (2), e1002490 (2012)
   PUBMED   22359512
REFERENCE   5  (bases 1 to 6668)
  AUTHORS   Takatsu,H., Baba,K., Shima,T., Umino,H., Kato,U., Umeda,M.,
            Nakayama,K. and Shin,H.W.
  TITLE     ATP9B, a P4-ATPase (a putative aminophospholipid translocase),
            localizes to the trans-Golgi network in a CDC50 protein-independent
            manner
  JOURNAL   J Biol Chem 286 (44), 38159-38167 (2011)
   PUBMED   21914794
  REMARK    Erratum:[J Biol Chem. 2015 Jan 9;290(2):886]
REFERENCE   6  (bases 1 to 6668)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6668)
  AUTHORS   Hicks,A.A., Pramstaller,P.P., Johansson,A., Vitart,V., Rudan,I.,
            Ugocsai,P., Aulchenko,Y., Franklin,C.S., Liebisch,G., Erdmann,J.,
            Jonasson,I., Zorkoltseva,I.V., Pattaro,C., Hayward,C., Isaacs,A.,
            Hengstenberg,C., Campbell,S., Gnewuch,C., Janssens,A.C.,
            Kirichenko,A.V., Konig,I.R., Marroni,F., Polasek,O., Demirkan,A.,
            Kolcic,I., Schwienbacher,C., Igl,W., Biloglav,Z., Witteman,J.C.,
            Pichler,I., Zaboli,G., Axenovich,T.I., Peters,A., Schreiber,S.,
            Wichmann,H.E., Schunkert,H., Hastie,N., Oostra,B.A., Wild,S.H.,
            Meitinger,T., Gyllensten,U., van Duijn,C.M., Wilson,J.F.,
            Wright,A., Schmitz,G. and Campbell,H.
  TITLE     Genetic determinants of circulating sphingolipid concentrations in
            European populations
  JOURNAL   PLoS Genet 5 (10), e1000672 (2009)
   PUBMED   19798445
REFERENCE   8  (bases 1 to 6668)
  AUTHORS   Paulusma,C.C. and Oude Elferink,R.P.
  TITLE     The type 4 subfamily of P-type ATPases, putative aminophospholipid
            translocases with a role in human disease
  JOURNAL   Biochim Biophys Acta 1741 (1-2), 11-24 (2005)
   PUBMED   15919184
  REMARK    Review article
REFERENCE   9  (bases 1 to 6668)
  AUTHORS   Kuhlbrandt,W.
  TITLE     Biology, structure and mechanism of P-type ATPases
  JOURNAL   Nat Rev Mol Cell Biol 5 (4), 282-295 (2004)
   PUBMED   15071553
  REMARK    Review article
REFERENCE   10 (bases 1 to 6668)
  AUTHORS   Flamant,S., Pescher,P., Lemercier,B., Clement-Ziza,M., Kepes,F.,
            Fellous,M., Milon,G., Marchal,G. and Besmond,C.
  TITLE     Characterization of a putative type IV aminophospholipid
            transporter P-type ATPase
  JOURNAL   Mamm Genome 14 (1), 21-30 (2003)
   PUBMED   12532265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107398.4, AJ441078.1 and BC131535.1.
            
            On May 17, 2019 this sequence version replaced NM_020453.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ441078.1, SRR1660807.234887.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273859.8/ ENSP00000273859.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC107398.4         52877-52994
            119-706             AJ441078.1         1-588
            707-3999            BC131535.1         567-3859
            4000-4487           AJ441078.1         3882-4369
            4488-4946           BC131535.1         4348-4806
            4947-6668           AJ441078.1         4829-6550
FEATURES             Location/Qualifiers
     source          1..6668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p12"
     gene            1..6668
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /note="ATPase phospholipid transporting 10D (putative)"
                     /db_xref="GeneID:57205"
                     /db_xref="HGNC:HGNC:13549"
                     /db_xref="MIM:619815"
     exon            1..245
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            246..572
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..4563
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /EC_number="7.6.2.1"
                     /note="type IV aminophospholipid transporting ATPase;
                     probable phospholipid-transporting ATPase VD; P4-ATPase
                     flippase complex alpha subunit ATP10D; ATPase, class V,
                     type 10D"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase VD"
                     /protein_id="NP_065186.3"
                     /db_xref="CCDS:CCDS3476.1"
                     /db_xref="GeneID:57205"
                     /db_xref="HGNC:HGNC:13549"
                     /db_xref="MIM:619815"
                     /translation="MTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTP
                     KLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVPRNLFEQFHRAANLY
                     FLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVY
                     SRKEKKYIDRCWKDVTVGDFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNL
                     KQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLEHSNKERVGLSKENLLL
                     RGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLWCVMLLVIMCL
                     TGAVGHGIWLSRYEKMHFFNVPEPDGHIISPLLAGFYMFWTMIILLQVLIPISLYVSI
                     EIVKLGQIYFIQSDVDFYNEKMDSIVQCRALNIAEDLGQIQYLFSDKTGTLTENKMVF
                     RRCSVAGFDYCHEENARRLESYQEAVSEDEDFIDTVSGSLSNMAKPRAPSCRTVHNGP
                     LGNKPSNHLAGSSFTLGSGEGASEVPHSRQAAFSSPIETDVVPDTRLLDKFSQITPRL
                     FMPLDETIQNPPMETLYIIDFFIALAICNTVVVSAPNQPRQKIRHPSLGGLPIKSLEE
                     IKSLFQRWSVRRSSSPSLNSGKEPSSGVPNAFVSRLPLFSRMKPASPVEEEVSQVCES
                     PQCSSSSACCTETEKQHGDAGLLNGKAESLPGQPLACNLCYEAESPDEAALVYAARAY
                     QCTLRSRTPEQVMVDFAALGPLTFQLLHILPFDSVRKRMSVVVRHPLSNQVVVYTKGA
                     DSVIMELLSVASPDGASLEKQQMIVREKTQKHLDDYAKQGLRTLCIAKKVMSDTEYAE
                     WLRNHFLAETSIDNREELLLESAMRLENKLTLLGATGIEDRLQEGVPESIEALHKAGI
                     KIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQSKDACGMLMSTILKELQKKTQAL
                     PEQVSLSEDLLQPPVPRDSGLRAGLIITGKTLEFALQESLQKQFLELTSWCQAVVCCR
                     ATPLQKSEVVKLVRSHLQVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQAVMASDFA
                     VSQFKHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYW
                     VLIFFNLLFTSAPPVIYGVLEKDVSAETLMQLPELYRSGQKSEAYLPHTFWITLLDAF
                     YQSLVCFFVPYFTYQGSDTDIFAFGNPLNTAALFIVLLHLVIESKSLTWIHLLVIIGS
                     ILSYFLFAIVFGAMCVTCNPPSNPYWIMQEHMLDPVFYLVCILTTSIALLPRFVYRVL
                     QGSLFPSPILRAKHFDRLTPEERTKALKKWRGAGKMNQVTSKYANQSAGKSGRRPMPG
                     PSAVFAMKSASSCAIEQGNLSLCETALDQGYSETKAFEMAGPSKGKES"
     exon            573..767
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            768..972
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1058
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1165
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1297
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1425
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1678
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1917
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2106
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2716
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2823
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2950
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3135
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3445
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3522
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3648
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3849
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            3850..3930
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4035
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4223
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..6668
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6039..6044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /note="hexamer: AATAAA"
     regulatory      6055..6060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /note="hexamer: AATAAT"
     polyA_site      6059
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /note="major polyA site"
     polyA_site      6073
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
     regulatory      6584..6589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
                     /note="hexamer: AATATA"
     polyA_site      6602
                     /gene="ATP10D"
                     /gene_synonym="ATPVD"
ORIGIN      
        1 gcagcctggc ggagacggga ggaggagcgg agggagaagt aggttgcgag ctcagcacag
       61 gctccggcgc tggctcccgc agctgagttt gggagatgtc taagtgattt tttttttttc
      121 ccggaaggca aatggctggc gtggaagcac aacccgcttt cactcttcga atttgtgctt
      181 agctcttttc ttgtaccttg cgactcgtga ccaacatgct gtgatgtgtg ccgagggagg
      241 aattggtcag ctacacaacc tggatcttac cacagtttgg atatgactga ggctctccaa
      301 tgggccagat atcactggcg acggctgatc agaggtgcaa ccagggatga tgattcaggg
      361 ccatacaact attcctcgtt gctcgcctgt gggcgcaagt cctctcagac ccctaaactg
      421 tcaggaaggc accggattgt tgttccccac atccagccct tcaaggatga gtatgagaag
      481 ttctccggag cctatgtgaa caatcgaata cgaacaacaa agtacacact tctgaatttt
      541 gtgccaagaa atttatttga acaatttcac agagctgcca atttatattt cctgttccta
      601 gttgtcctga actgggtacc tttggtagaa gccttccaaa aggaaatcac catgttgcct
      661 ctggtggtgg tccttacaat tatcgcaatt aaagatggcc tggaagatta tcggaaatac
      721 aaaattgaca aacagatcaa taatttaata actaaagttt atagtaggaa agagaaaaaa
      781 tacattgacc gatgctggaa agacgttact gttggggact ttattcgcct ctcctgcaac
      841 gaggtcatcc ctgcagacat ggtactactc ttttccactg atccagatgg aatctgtcac
      901 attgagactt ctggtcttga tggagagagc aatttaaaac agaggcaggt ggttcgggga
      961 tatgcagaac aggactctga agttgatcct gagaagtttt ccagtaggat agaatgtgaa
     1021 agcccaaaca atgacctcag cagattccga ggcttcctag aacattccaa caaagaacgc
     1081 gtgggtctca gtaaagaaaa tttgttgctt agaggatgca ccattagaaa cacagaggct
     1141 gttgtgggca ttgtggttta tgcaggccat gaaaccaaag caatgctgaa caacagtggg
     1201 ccacggtata agcgcagcaa attagaaaga agagcaaaca cagatgtcct ctggtgtgtc
     1261 atgcttctgg tcataatgtg cttaactggc gcagtaggtc atggaatctg gctgagcagg
     1321 tatgaaaaga tgcatttttt caatgttccc gagcctgatg gacatatcat atcaccactg
     1381 ttggcaggat tttatatgtt ttggaccatg atcattttgt tacaggtctt gattcctatt
     1441 tctctctatg tttccatcga aattgtgaag cttggacaaa tatatttcat tcaaagtgat
     1501 gtggatttct acaatgaaaa aatggattct attgttcagt gccgagccct gaacatcgcc
     1561 gaggatctgg gacagattca gtacctcttt tccgataaga caggaaccct cactgagaat
     1621 aagatggttt ttcgaagatg tagtgtggca ggatttgatt actgccatga agaaaatgcc
     1681 aggaggttgg agtcctatca ggaagctgtc tctgaagatg aagattttat agacacagtc
     1741 agtggttccc tcagcaatat ggcaaaaccg agagccccca gctgcaggac agttcataat
     1801 gggcctttgg gaaataagcc ctcaaatcat cttgctggga gctcttttac tctaggaagt
     1861 ggagaaggag ccagtgaagt gcctcattcc agacaggctg ctttcagtag ccccattgaa
     1921 acagacgtgg taccagacac caggctttta gacaaattta gtcagattac acctcggctc
     1981 tttatgccac tagatgagac catccaaaat ccaccaatgg aaactttgta cattatcgac
     2041 tttttcattg cattggcaat ttgcaacaca gtagtggttt ctgctcctaa ccaaccccga
     2101 caaaagatca gacacccttc actggggggg ttgcccatta agtctttgga agagattaaa
     2161 agtcttttcc agagatggtc tgtccgaaga tcaagttctc catcgcttaa cagtgggaaa
     2221 gagccatctt ctggagttcc aaacgccttt gtgagcagac tccctctctt tagtcgaatg
     2281 aaaccagctt cacctgtgga ggaagaggtc tcccaggtgt gtgagagccc ccagtgctcc
     2341 agtagctcag cttgctgcac agaaacagag aaacaacacg gtgatgcagg cctcctgaat
     2401 ggcaaggcag agtccctccc tggacagcca ttggcctgca acctgtgtta tgaggccgag
     2461 agcccagacg aagcggcctt agtgtatgcc gccagggctt accaatgcac tttacggtct
     2521 cggacaccag agcaggtcat ggtggacttt gctgctttgg gaccattaac atttcaactc
     2581 ctacacatcc tgccctttga ctcagtaaga aaaagaatgt ctgttgtggt ccgacaccct
     2641 ctttccaatc aagttgtggt gtatacgaaa ggcgctgatt ctgtgatcat ggagttactg
     2701 tcggtggctt ccccagatgg agcaagtctg gagaaacaac agatgatagt aagggagaaa
     2761 acccagaagc acttggatga ctatgccaaa caaggccttc gtactttatg tatagcaaag
     2821 aaggtcatga gtgacactga atatgcagag tggctgagga atcatttttt agctgaaacc
     2881 agcattgaca acagggaaga attactactt gaatctgcca tgaggttgga gaacaaactt
     2941 acattacttg gtgctactgg cattgaagac cgtctgcagg agggagtccc tgaatctata
     3001 gaagctcttc acaaagcggg catcaagatc tggatgctga caggggacaa gcaggagaca
     3061 gctgtcaaca tagcttatgc atgcaaacta ctggagccag atgacaagct ttttatcctc
     3121 aatacccaaa gtaaagatgc ctgtgggatg ctgatgagca caattttgaa agaacttcag
     3181 aagaaaactc aagccctgcc agagcaagtg tcattaagtg aagatttact tcagcctcct
     3241 gtcccccggg actcagggtt acgagctgga ctcattatca ctgggaagac cctggagttt
     3301 gccctgcaag aaagtctgca aaagcagttc ctggaactga catcttggtg tcaagctgtg
     3361 gtctgctgcc gagccacacc gctgcagaaa agtgaagtgg tgaaattggt ccgcagccat
     3421 ctccaggtga tgacccttgc tattggtgat ggtgccaatg atgttagcat gatacaagtg
     3481 gcagacattg ggataggggt ctcaggtcaa gaaggcatgc aggctgtgat ggccagtgac
     3541 tttgccgttt ctcagttcaa acatctcagc aagctccttc ttgtccatgg acactggtgt
     3601 tatacacggc tttccaacat gattctctat tttttctata agaatgtggc ctatgtgaac
     3661 ctccttttct ggtaccagtt cttttgtgga ttttcaggaa catccatgac tgattactgg
     3721 gttttgatct tcttcaacct cctcttcaca tctgcccctc ctgtcattta tggtgttttg
     3781 gagaaagatg tgtctgcaga gaccctcatg caactgcctg aactttacag aagtggtcag
     3841 aaatcagagg catacttacc ccataccttc tggatcacct tattggatgc tttttatcaa
     3901 agcctggtct gcttctttgt gccttatttt acctaccagg gctcagatac tgacatcttt
     3961 gcatttggaa accccctgaa cacagccgct ctgttcatcg ttctcctcca tctggtcatt
     4021 gaaagcaaga gtttgacttg gattcacttg ctggtcatca ttggtagcat cttgtcttat
     4081 tttttatttg ccatagtttt tggagccatg tgtgtaactt gcaacccacc atccaaccct
     4141 tactggatta tgcaggagca catgctggat ccagtattct acttagtttg tatcctcacg
     4201 acgtccattg ctcttctgcc caggtttgta tacagagttc ttcagggatc cctgtttcca
     4261 tctccaattc tgagagctaa gcactttgac agactaactc cagaggagag gactaaagct
     4321 ctcaagaagt ggagaggggc tggaaagatg aatcaagtga catcaaagta tgctaaccaa
     4381 tcagctggca agtcaggaag aagacccatg cctggccctt ctgctgtatt tgcaatgaag
     4441 tcagcaagtt cctgtgctat tgagcaagga aacttatctc tgtgtgaaac tgctttagat
     4501 caaggctact ctgaaactaa ggcctttgag atggctggac cctccaaagg taaagaaagc
     4561 tagataccct ccttggagtt gcaagtattc tttcaaggtt ggaagaggga ttttgaagag
     4621 gtatctctcc aagcaagaat gacttgtttt tccataaggg acatgagcat tttactaggc
     4681 ttggaagagc tgacatgatg agcattattg tatgtttgta tatacatttg tgatagaggg
     4741 ctagagtttg acctagagag agtttaagga agtgaaatat ttaattcaga accaaatgct
     4801 tttgtaaaac tttttggatt ttgtaaaagc attttcattc tcttagaaat tcaagtattt
     4861 tcaaggggag tcatttgaga tatatttatt ttactaggag atcttatatt ctagggaaat
     4921 gctttaaatg gtcaggctcc agtcggaatt tttttaagaa aaaagtagtt tttaatacat
     4981 tggttaggac tcagaggaaa tacggaaaaa acattgtaga tggttaattt acagataaaa
     5041 tcccaagagc cttttaaaca acaaggtacc taaaataggg tataattata ctgcttaaaa
     5101 tacagttagt gcctattaat agctttttat ttcctatggg aagatgcttt tggtcttctg
     5161 gctgaagatg taggcatacc tctcactcat ttcaatgttt tcctgaggtg gagccttcat
     5221 tggaaagggg aaagagggat tctagggttt catcagggac caggaatgca ttcctctgtc
     5281 aggttccaat caagagaaga ccttttatga gatctgcctc tgtatagatg ttgtcagtta
     5341 ggaaactgaa gccataggtc aggcagacat cagctcagcc tgtggcccat tgggtgattt
     5401 cctgtatttt aaaactgaca gtagcctgat caaagtgata caatcaattt caaaacaatc
     5461 ttccagagac cacttgaagg ttcatagttt ttacaatacc ctgagacttt tcaggtgttg
     5521 gagcctctaa aatatgagat ataaacagaa actaatacaa gttgttctct ggaggtttct
     5581 atgaggttct tagaaaaatt tggttttaaa atcatttgag gacaggaatg tctatagcaa
     5641 gtttactcct attgcgaatc atgtatgctg gctttagttg taacaaacga ttttattcta
     5701 agtaaggcca ggtgctacta taaaatcata tattcctgtt gaagttcttt tgaagtccta
     5761 tctctattta ttatatttga aagttgtcag ccaccagtca tccagaattt ccttcctgaa
     5821 tctccatgct catatgcaat gtctacatca aggtcttctt aatgactatt attctcaggg
     5881 tttagttttc taccttctgc ctactatttt ggtctgacat ttttgtagcc ttctgttatt
     5941 attggaaata gtctcttaca taagctgatt tcgagaactt tcaaaatctc acatagctaa
     6001 tggaagttgc tttctgcttt cttatgactg tttttataaa taaactgttt cataaataat
     6061 gtatactgga aaattgtcat cactcttgta aacatttgcc aaatccaact gtaattagta
     6121 ccagaactta gaaggaaagt cacaaagcat gccttttacc agaatattgc tttgcctttt
     6181 cttatatgga aaatcactga tgtcatatca tttattatcc tcacagcagc tggcattcat
     6241 tccctgaaat cgtcgtctcc tgataaacaa taatttagag atatgttcac ttgtaaataa
     6301 aaaggttaga atctaaggac aaagaatgat ccaaaaatac taaggaaaaa gaacaatttt
     6361 caattttcag aaatgaatta tctgtacata tgaatagagg aaaatactga gtgctaatgt
     6421 tacagggcca caatctcata tccacaattc caaaatctcc aaacctctga aaactgaaat
     6481 atttttcata aattaggcgt aaattctatg ccctgaacaa atgtaaagct atttatgtac
     6541 tttgcttaat gtaatcattc atatactttg ctacaaaaat attaatatat ttcattactg
     6601 aatgctaaac tgtatttctt tttaaaattt ggaaaatttt taattctgaa acacaatcta
     6661 gaccttag
//
