LOCUS       NM_025153               7565 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ATPase phospholipid transporting 10B (putative)
            (ATP10B), transcript variant 1, mRNA.
ACCESSION   NM_025153 XM_927593 XM_940711
VERSION     NM_025153.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7565)
  AUTHORS   Diaz-Belloso,R., Munoz-Delgado,L., Martin-Bornez,M., Ojeda,E.,
            Perinan,M.T., Garcia-Diaz,S., Bonilla-Toribio,M., Buiza-Rueda,D.,
            Pineda-Sanchez,R., Jesus,S., Macias-Garcia,D., Adarmes-Gomez,A.,
            Carrillo,F., Mir,P. and Gomez-Garre,P.
  TITLE     Role of ATP10B in Parkinson disease in a cohort from southern Spain
  JOURNAL   Parkinsonism Relat Disord 124, 106989 (2024)
   PUBMED   38754220
  REMARK    GeneRIF: Role of ATP10B in Parkinson disease in a cohort from
            southern Spain.
REFERENCE   2  (bases 1 to 7565)
  AUTHORS   Wouters,R., Beletchi,I., Van den Haute,C., Baekelandt,V.,
            Martin,S., Eggermont,J. and Vangheluwe,P.
  TITLE     The lipid flippase ATP10B enables cellular lipid uptake under
            stress conditions
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119652 (2024)
   PUBMED   38086447
  REMARK    GeneRIF: The lipid flippase ATP10B enables cellular lipid uptake
            under stress conditions.
            Review article
REFERENCE   3  (bases 1 to 7565)
  AUTHORS   Ishiguro,M., Yoshino,H., Li,Y., Ikeda,A., Funayama,M., Nishioka,K.
            and Hattori,N.
  TITLE     Genetic analysis of ATP10B for Parkinson's disease in Japan
  JOURNAL   Parkinsonism Relat Disord 88, 10-12 (2021)
   PUBMED   34091411
  REMARK    GeneRIF: Genetic analysis of ATP10B for Parkinson's disease in
            Japan.
REFERENCE   4  (bases 1 to 7565)
  AUTHORS   Martin,S., Smolders,S., Van den Haute,C., Heeman,B., van Veen,S.,
            Crosiers,D., Beletchi,I., Verstraeten,A., Gossye,H., Gelders,G.,
            Pals,P., Hamouda,N.N., Engelborghs,S., Martin,J.J., Eggermont,J.,
            De Deyn,P.P., Cras,P., Baekelandt,V., Vangheluwe,P. and Van
            Broeckhoven,C.
  CONSRTM   BELNEU consortium
  TITLE     Mutated ATP10B increases Parkinson's disease risk by compromising
            lysosomal glucosylceramide export
  JOURNAL   Acta Neuropathol 139 (6), 1001-1024 (2020)
   PUBMED   32172343
  REMARK    GeneRIF: Mutated ATP10B increases Parkinson's disease risk by
            compromising lysosomal glucosylceramide export.
REFERENCE   5  (bases 1 to 7565)
  AUTHORS   Segawa,K., Kurata,S. and Nagata,S.
  TITLE     Human Type IV P-type ATPases That Work as Plasma Membrane
            Phospholipid Flippases and Their Regulation by Caspase and Calcium
  JOURNAL   J Biol Chem 291 (2), 762-772 (2016)
   PUBMED   26567335
REFERENCE   6  (bases 1 to 7565)
  AUTHORS   Naito,T., Takatsu,H., Miyano,R., Takada,N., Nakayama,K. and
            Shin,H.W.
  TITLE     Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and
            Is Involved in Plasma Membrane Dynamics
  JOURNAL   J Biol Chem 290 (24), 15004-15017 (2015)
   PUBMED   25947375
REFERENCE   7  (bases 1 to 7565)
  AUTHORS   Takatsu,H., Baba,K., Shima,T., Umino,H., Kato,U., Umeda,M.,
            Nakayama,K. and Shin,H.W.
  TITLE     ATP9B, a P4-ATPase (a putative aminophospholipid translocase),
            localizes to the trans-Golgi network in a CDC50 protein-independent
            manner
  JOURNAL   J Biol Chem 286 (44), 38159-38167 (2011)
   PUBMED   21914794
  REMARK    Erratum:[J Biol Chem. 2015 Jan 9;290(2):886]
REFERENCE   8  (bases 1 to 7565)
  AUTHORS   Schmutz,J., Martin,J., Terry,A., Couronne,O., Grimwood,J.,
            Lowry,S., Gordon,L.A., Scott,D., Xie,G., Huang,W., Hellsten,U.,
            Tran-Gyamfi,M., She,X., Prabhakar,S., Aerts,A., Altherr,M.,
            Bajorek,E., Black,S., Branscomb,E., Caoile,C., Challacombe,J.F.,
            Chan,Y.M., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Grigoriev,I., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Israni,S.,
            Jett,J., Kadner,K., Kimball,H., Kobayashi,A., Lopez,F., Lou,Y.,
            Martinez,D., Medina,C., Morgan,J., Nandkeshwar,R., Noonan,J.P.,
            Pitluck,S., Pollard,M., Predki,P., Priest,J., Ramirez,L.,
            Retterer,J., Rodriguez,A., Rogers,S., Salamov,A., Salazar,A.,
            Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N., Wheeler,J.,
            Wu,K., Yang,J., Dickson,M., Cheng,J.F., Eichler,E.E., Olsen,A.,
            Pennacchio,L.A., Rokhsar,D.S., Richardson,P., Lucas,S.M.,
            Myers,R.M. and Rubin,E.M.
  TITLE     The DNA sequence and comparative analysis of human chromosome 5
  JOURNAL   Nature 431 (7006), 268-274 (2004)
   PUBMED   15372022
REFERENCE   9  (bases 1 to 7565)
  AUTHORS   Halleck,M.S., Lawler,J.F. Jr., Blackshaw,S., Gao,L., Nagarajan,P.,
            Hacker,C., Pyle,S., Newman,J.T., Nakanishi,Y., Ando,H.,
            Weinstock,D., Williamson,P. and Schlegel,R.A.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK090832.1, AB018258.2, AC011363.6 and AK025294.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025153.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018258.2 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327245.10/ ENSP00000313600.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AK090832.1         2-173
            173-709             AB018258.2         1-537
            710-712             AC011363.6         51557-51559         c
            713-813             AB018258.2         541-641
            814-814             AC011363.6         51455-51455         c
            815-1254            AB018258.2         643-1082
            1255-1257           AC011363.6         48821-48823         c
            1258-1358           AB018258.2         1086-1186
            1359-1359           AC011363.6         33308-33308         c
            1360-1390           AB018258.2         1188-1218
            1391-1393           AC011363.6         33274-33276         c
            1394-1494           AB018258.2         1222-1322
            1495-1495           AC011363.6         33172-33172         c
            1496-7552           AB018258.2         1324-7380
            7553-7565           AK025294.1         3793-3805
FEATURES             Location/Qualifiers
     source          1..7565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q34"
     gene            1..7565
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /note="ATPase phospholipid transporting 10B (putative)"
                     /db_xref="GeneID:23120"
                     /db_xref="HGNC:HGNC:13543"
                     /db_xref="MIM:619791"
     exon            1..271
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            272..516
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            517..642
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            643..826
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1121
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     CDS             847..5232
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /EC_number="7.6.2.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable phospholipid-transporting ATPase VB; P4-ATPase
                     flippase complex alpha subunit ATP10B; ATPase, class V,
                     type 10B"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase VB isoform 1"
                     /protein_id="NP_079429.2"
                     /db_xref="CCDS:CCDS43394.1"
                     /db_xref="GeneID:23120"
                     /db_xref="HGNC:HGNC:13543"
                     /db_xref="MIM:619791"
                     /translation="MALSVDSSWHRWQWRVRDGFPHCPSETTPLLSPEKGRQSYNLTQ
                     QRVVFPNNSIFHQDWEEVSRRYPGNRTCTTKYTLFTFLPRNLFEQFHRWANLYFLFLV
                     ILNWMPSMEVFHREITMLPLAIVLFVIMIKDGMEDFKRHRFDKAINCSNIRIYERKEQ
                     TYVQKCWKDVRVGDFIQMKCNEIVPADILLLFSSDPNGICHLETASLDGETNLKQRCV
                     VKGFSQQEVQFEPELFHNTIVCEKPNNHLNKFKGYMEHPDQTRTGFGCESLLLRGCTI
                     RNTEMAVGIVIYAGHETKAMLNNSGPRYKRSKIERRMNIDIFFCIGILILMCLIGAVG
                     HSIWNGTFEEHPPFDVPDANGSFLPSALGGFYMFLTMIILLQVLIPISLYVSIELVKL
                     GQVFFLSNDLDLYDEETDLSIQCRALNIAEDLGQIQYIFSDKTGTLTENKMVFRRCTI
                     MGSEYSHQENAKRLETPKELDSDGEEWTQYQCLSFSARWAQDPATMRSQKGAQPLRRS
                     QSARVPIQGHYRQRSMGHRESSQPPVAFSSSIEKDVTPDKNLLTKVRDAALWLETLSD
                     SRPAKASLSTTSSIADFFLALTICNSVMVSTTTEPRQRVTIKPSSKALGTSLEKIQQL
                     FQKLKLLSLSQSFSSTAPSDTDLGESLGANVATTDSDERDDASVCSGGDSTDDGGYRS
                     SMWDQGDILESGSGTSLEEALEAPATDLARPEFCYEAESPDEAALVHAAHAYSFTLVS
                     RTPEQVTVRLPQGTCLTFSLLCTLGFDSVRKRMSVVVRHPLTGEIVVYTKGADSVIMD
                     LLEDPACVPDINMEKKLRKIRARTQKHLDLYARDGLRTLCIAKKVVSEEDFRRWASFR
                     REAEASLDNRDELLMETAQHLENQLTLLGATGIEDRLQEGVPDTIATLREAGIQLWVL
                     TGDKQETAVNIAHSCRLLNQTDTVYTINTENQETCESILNCALEELKQFRELQKPDRK
                     LFGFRLPSKTPSITSEAVVPEAGLVIDGKTLNAIFQGKLEKKFLELTQYCRSVLCCRS
                     TPLQKSMIVKLVRDKLRVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAI
                     TRFKHLKKLLLVHGHWCYSRLARMVVYYLYKNVCYVNLLFWYQFFCGFSSSTMIDYWQ
                     MIFFNLFFTSLPPLVFGVLDKDISAETLLALPELYKSGQNSECYNLSTFWISMVDAFY
                     QSLICFFIPYLAYKGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTIFHGVVLLGSF
                     LMYFLVSLLYNATCVICNSPTNPYWVMEGQLSNPTFYLVCFLTPVVALLPRYFFLSLQ
                     GTCGKSLISKAQKIDKLPPDKRNLEIQSWRSRQRPAPVPEVARPTHHPVSSITGQDFS
                     ASTPKSSNPPKRKHVEESVLHEQRCGTECMRDDSCSGDSSAQLSSGEHLLGPNRIMAY
                     SRGQTDMCRCSKRSSHRRSQSSLTI"
     exon            1122..1316
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1521
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1607
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1714
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1846
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1974
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2227
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2466
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2658
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..3262
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3372
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3499
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3684
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..4006
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4083
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4209
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4410
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            4411..4491
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            4492..4596
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            4597..4784
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     exon            4785..7565
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7534..7539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /note="hexamer: AATAAA"
     polyA_site      7565
                     /gene="ATP10B"
                     /gene_synonym="ATPVB"
                     /note="major polyA site"
ORIGIN      
        1 ctttcactct tgggcctagc gaggcagctt atttttcctt tttctttcat tggtcacagt
       61 tatttctttt cagtgtgtca tcttctctaa gtttctgagg gagtgttagc ttgaggcctt
      121 gccttgacat aatcagatat aatcagaaaa atgaaaaatt ccataggaaa gagaactatt
      181 ttagccaagg tgtgcgagag aaataccgcc actttcaagc actgttttct tctactggag
      241 tctgctcaat agggacgtca gctttgctgg ggcttccttt gacaagagaa tcagaaccga
      301 ctggtgacat ttgtttcaat gaaagcaaca gtgtgaagag taagtagttt ttcctattat
      361 tcatctcact cagtggagat aatgaactcc tctccactgc caagatgaga aactaccatt
      421 tcttacacat ggacacaaag atgagaacaa taaacactga gacttcaaaa aggagggaag
      481 gagaaagagg aacaagactt gaaatctacc tatcagaact tgcaatttat tctgatcaac
      541 aatttgccca gctaaagtac tacatctgcc ccctcttcct gtggctgtag gggcacagca
      601 aaggtcactg gtctaacctc cttaaaggga ctccgctaac agaaaccacc aaatggagtg
      661 gagaaaaaga aaagggatcc cctatcccca actccagcca tctagattaa gaaaagccag
      721 ctgactggac agtagcacag cccagtcacc tcatggacaa atttcctagg aaagaacctc
      781 tcccatctat tctacttatc actctccttt gaggttccgg ccacagatct tcgcctgctg
      841 ctggaaatgg ccctctcagt ggactcatcg tggcatcggt ggcagtggag agtcagagat
      901 ggcttccccc attgtccatc ggaaaccaca ccgctgctct ctccagagaa agggagacag
      961 agctacaact tgacacagca gcgggtcgtg ttccccaaca acagcatatt ccatcaagat
     1021 tgggaagagg tctccaggag ataccctggc aacagaacct gcacaaccaa atacaccctc
     1081 ttcaccttcc tgccccggaa tctctttgag caatttcata gatgggctaa cctctatttc
     1141 ctgttcctgg tgattttgaa ctggatgccc tccatggaag tcttccacag agaaatcacc
     1201 atgttaccat tggccattgt cctgttcgtc atcatgatca aggatggcat ggaggacttc
     1261 aagagacacc gctttgataa agcaataaac tgctccaaca ttcgaattta tgaaagaaaa
     1321 gagcagacct atgtgcagaa gtgctggaag gatgtgcgcg tgggagactt catccaaatg
     1381 aaatgcaatg agattgtccc agcagacata ctcctccttt tttcctctga ccccaatggg
     1441 atatgccatc tggaaactgc cagcttggat ggagagacaa acctcaagca aagatgtgtc
     1501 gtgaagggct tctcacagca ggaggtacag ttcgaaccag agcttttcca caataccatc
     1561 gtgtgtgaga aacccaacaa ccacctcaac aaatttaagg gttatatgga gcatcctgac
     1621 cagaccagga ctggctttgg ctgtgagagt cttctgcttc gaggctgcac catcagaaac
     1681 accgagatgg ctgttggcat tgtcatctat gcaggccatg agacgaaagc catgctgaac
     1741 aacagtggcc cccggtacaa acgcagcaag attgagcggc gcatgaatat agacatcttc
     1801 ttctgcattg ggatcctcat cctcatgtgc cttattggag ctgtaggtca cagcatctgg
     1861 aatgggacct ttgaagaaca ccctcccttc gatgtgccag atgccaatgg cagcttcctt
     1921 cccagtgccc ttgggggctt ctacatgttc ctcacaatga tcatcctgct ccaggtgctg
     1981 atccccatct ctttgtatgt ctccattgag ctggtgaagc tcgggcaagt gttcttcttg
     2041 agcaatgacc ttgacctgta tgatgaagag accgatttat ccattcaatg tcgagccctc
     2101 aacatcgcag aggacttggg ccagatccag tacatcttct ccgataagac ggggaccctg
     2161 acagagaaca agatggtgtt ccgacgttgc accatcatgg gcagcgagta ttctcaccaa
     2221 gaaaatgcta agcgactgga gaccccaaag gagctggact cagatggtga agagtggacc
     2281 caataccaat gcctgtcctt ctcggctaga tgggcccagg atccagcaac tatgagaagc
     2341 caaaaaggtg ctcagcctct gaggaggagc cagagtgccc gggtgcccat ccagggccac
     2401 taccggcaaa ggtctatggg gcaccgtgaa agctcacagc ctcctgtggc cttcagcagc
     2461 tccatagaaa aagatgtaac tccagataaa aacctactga ccaaggttcg agatgctgcc
     2521 ctgtggttgg agaccttgtc agacagcaga cctgccaagg cttccctctc caccacctcc
     2581 tccattgctg atttcttcct tgccttaacc atctgcaact ctgtcatggt gtccacaacc
     2641 accgagccca ggcagagggt caccatcaaa ccctcaagca aggctctggg gacgtccctg
     2701 gagaagattc agcagctctt ccagaagttg aagctattga gcctcagcca gtcattctca
     2761 tccactgcac cctctgacac agacctcggg gagagcttag gggccaacgt ggccaccaca
     2821 gactcggatg agagagatga tgcatctgtg tgcagtggag gtgactccac tgatgacggt
     2881 ggctacagga gcagcatgtg ggaccagggc gacatcctgg agtctgggtc aggcacttcc
     2941 ttggaggagg cattggaggc cccagccaca gacctggcca ggcctgagtt ctgttacgag
     3001 gctgagagcc ctgatgaggc cgccctggtg cacgctgccc atgcctacag cttcacacta
     3061 gtgtcccgga cacctgagca ggtgactgtg cgcctgcccc agggcacctg cctcaccttc
     3121 agcctcctct gcaccctggg ctttgactct gtcaggaaga gaatgtctgt ggttgtgagg
     3181 cacccactga ctggcgagat tgttgtctac accaagggtg ctgactcggt catcatggac
     3241 ctgctggaag acccagcctg cgtacctgac attaatatgg aaaagaagct gagaaaaatc
     3301 cgagcccgga cccaaaagca tctagacttg tatgcaagag atggcctgcg cacactatgc
     3361 attgccaaga aggttgtaag cgaagaggac ttccggagat gggccagttt ccggcgtgag
     3421 gctgaggcat ccctcgacaa ccgagatgag cttctcatgg aaactgcaca gcatctggag
     3481 aatcaactca ccttacttgg agccactggg atcgaagacc ggctgcagga aggagttcca
     3541 gatacgattg ccactctgcg ggaggctggg atccagctct gggtcctgac tggagataag
     3601 caggagacag cggtcaacat tgcccattcc tgcagactgt taaatcagac cgacactgtt
     3661 tataccatca atacagagaa tcaggagacc tgtgaatcca tcctcaattg tgcattggaa
     3721 gagctaaagc aatttcgtga actacagaag ccagaccgca agctctttgg attccgctta
     3781 ccttccaaga caccatccat cacctcagaa gctgtggttc cagaagctgg attggtcatc
     3841 gatgggaaga cattgaatgc catcttccag ggaaagctag agaagaagtt tctggaattg
     3901 acccagtatt gtcggtccgt cctgtgctgc cgctccacgc cactccagaa gagtatgata
     3961 gtcaagctgg tgcgagacaa gttgcgcgtc atgacccttt ccataggtga tggagcaaat
     4021 gatgtaagca tgattcaagc tgctgatatt ggaattggaa tatctggaca ggaaggcatg
     4081 caggctgtca tgtccagcga ctttgccatc acccgcttta agcatctcaa gaagttgctg
     4141 ctcgtgcatg gccactggtg ttactcgcgc ctggccagga tggtggtgta ctacctctac
     4201 aagaacgtgt gctacgtcaa cctgctcttc tggtatcagt tcttctgtgg tttctccagc
     4261 tccaccatga ttgattactg gcagatgata ttcttcaatc tcttctttac ctccttgcct
     4321 cctcttgtct ttggagtcct tgacaaagac atctctgcag aaacactcct ggcattgcct
     4381 gagctataca agagtggcca gaactctgag tgctataacc tgtcgacttt ctggatttct
     4441 atggtggatg cattctacca gagcctcatc tgtttcttta tcccttacct ggcctataag
     4501 ggctctgata tagatgtctt tacctttggg acaccaatca acaccatctc cctcaccaca
     4561 atccttttgc accaggcaat ggaaatgaag acatggacca ttttccacgg agtcgtgctc
     4621 ctcggcagct tcctgatgta ctttctggta tccctcctgt acaatgccac ctgcgtcatc
     4681 tgcaacagcc ccaccaatcc ctattgggtg atggaaggcc agctctcaaa ccccactttc
     4741 tacctcgtct gctttctcac accagttgtt gctcttctcc caagatactt tttcctgtct
     4801 ctgcaaggaa cttgtgggaa gtctctaatc tcaaaagctc agaaaattga caaactcccc
     4861 ccagacaaaa gaaacctgga aatccagagt tggagaagca gacagaggcc tgcccctgtc
     4921 cccgaagtgg ctcgaccaac tcaccaccca gtgtcatcta tcacaggaca ggacttcagt
     4981 gccagcaccc caaagagctc taaccctccc aagaggaagc atgtggaaga gtcagtactc
     5041 cacgaacaga gatgtggcac ggagtgcatg agggatgact catgctcagg ggactcctca
     5101 gctcaactct catccgggga gcacctgctg ggacctaaca ggataatggc ctactcaaga
     5161 ggacagactg atatgtgccg gtgctcaaag aggagcagcc atcgccgatc ccagagttca
     5221 ctgaccatat gaggagctgc agaaatctgt acaaactcaa cagaggccac ctagtcactg
     5281 gtccacataa cccttgaccc cttcttcttc atagaggaaa caatgtgcca gtcttattct
     5341 tttcttcaac aaccttgact tccatggagg aagtgctggc cccaaggggt ctgacacaaa
     5401 gacgggaaac ccagtcggcc tctagttttc tgctgctctc aggcagcaca tcttgcaaac
     5461 agtttggaga aggaggctgt ttttgttgaa tcgagttctc aaatcggttt agaccaaagc
     5521 cattcttctg accctctaga taagcgtagc ctacaaccca gtgccgtaag tttccaagat
     5581 tcaagaagtg tatcaaccca ggcaatatct caggatatgg aagtttctgg gtttatttac
     5641 ccctcagtgc ccagagttaa agtttcagaa gagacttgtg cacataaggg cttcatctca
     5701 agtgtattgc agtaatggct gaatcggggt taacatccct tccaggcaca gcgagttggt
     5761 tctgcttttt gcctgtaagc caaagaaaag ccacatctaa aaagctacta ctaaaagcca
     5821 gaaagaaaag tggatttgaa ctcagtgtca cagactcttc tgagtgtttt agggtcacag
     5881 ctagtgtaag aggcatgaag aatagacatg caaaagggaa cgggtgcacc agagacccct
     5941 gttttggctg acagaccata tgtcccacca gctggggaat ctgacaagag gacataggtg
     6001 gcactctttt tttaaagcta tttattgtat ctatttttaa ataaaattgc ccatcctcat
     6061 tcagctctta gaacaaaagc aaaaaaccct gtaaatcagg agatataagc acatctgcac
     6121 ccagaatagg cccatatgat agggcaaccc tgagcttaaa caatgacatc ttcaagggta
     6181 gaactaatct gaaaccccat tcagcctatt ccagaatggg gataggctga aacccccttc
     6241 cagcctctgg aagacactgg cctgcatcag ttagagtcag agcaagtgtc acttcacagg
     6301 gaaaagaagg attatataga cttcctatcc ctagagttta taaatgtcaa ctatataaaa
     6361 aaagctcaaa acagtgttaa aggaatgaac agtagaattt taataggctg tccaaagaag
     6421 ccaggtctgc tgtgggcaag tatagcctaa ccctagtctt gtaaaataag ccagaaaggg
     6481 ttactgagcc accttaagct agtacctata tagtaggcaa aaagtacaga aatagatgca
     6541 ataagtgtgg tgagtctttg agcctacgag tcatgccacc agccataagt tgacctatca
     6601 cttgagaacc tcctcagcaa agatgccaga aaacattcaa tcaagttggc aaatgacaca
     6661 gggagctggc cctctgacca tcttcctggc aaacctggac tggaagggcc atttgcagca
     6721 ctgtcctgga gctaatacac tgtttcactg cctctgccat ataatgatgc cagcactagc
     6781 cagctggtgg gtatttggag gaatcctgca tgaggattgc ccaataaggg gcaggtacac
     6841 atacctggca aagtgatgat gatgtgaatt gtttccagtg aggggattga gtcaaaactt
     6901 ggatctcagg tacctcaatt tttcccccaa tttctggcta ctactaaaag ccagaaagaa
     6961 cagaacagtg gcctcaggag atctgagttt gaatccttgc tctctaggat gcaggtggct
     7021 tgaagcagaa tgccacacct gcaagttgat tagaactgcc tttcttccca ggcttgacat
     7081 aggtattaag tcaaaattac atgaaaccca gtggtaaaaa agcctctgaa agctgtaaca
     7141 ccctcagtaa taacaaaagg gatttttatt tcacagctaa agggaaaata ggtggagaag
     7201 ttaaaaaata atgtctgatc ctgttcctaa gttccaaact atagccaaca ctctgatgct
     7261 gctctttttc ttgtaggacc aaccgtccca gtttgcctgg gactttctca tttttacaga
     7321 gtcccaaatc ctaggaaact ggagcaactg gtacaactgg tcacctactc ttgcccctct
     7381 gtaaatcaag ccaactgtga ccatccaatg tgccatctta cagggaaaag ttataaccac
     7441 tattccccta taacataatg ctaatgattg tacttagtac atttttatac ttttatgata
     7501 ttttactgat tggaaatgtc atcctttatt aaaaataaac atggttttcc atagttgcct
     7561 gccaa
//
