LOCUS       NM_025182               2998 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens atos homolog B (ATOSB), transcript variant 1, mRNA.
ACCESSION   NM_025182
VERSION     NM_025182.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2998)
  AUTHORS   Emtenani,S., Martin,E.T., Gyoergy,A., Bicher,J., Genger,J.W.,
            Kocher,T., Akhmanova,M., Guarda,M., Roblek,M., Bergthaler,A.,
            Hurd,T.R., Rangan,P. and Siekhaus,D.E.
  TITLE     Macrophage mitochondrial bioenergetics and tissue invasion are
            boosted by an Atossa-Porthos axis in Drosophila
  JOURNAL   EMBO J 41 (12), e109049 (2022)
   PUBMED   35319107
REFERENCE   2  (bases 1 to 2998)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2998)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2998)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 2998)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC004406.1 and AL353795.13.
            
            On Jun 2, 2019 this sequence version replaced NM_025182.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein. Both variants 1 and
            2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004406.1, SRR7410570.435424.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146982, SAMEA2155984
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322813.10/ ENSP00000319897.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-690               BC004406.1         35-724
            691-691             AL353795.13        77578-77578         c
            692-2994            BC004406.1         726-3028
            2995-2998           AL353795.13        73834-73837         c
FEATURES             Location/Qualifiers
     source          1..2998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..2998
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /note="atos homolog B"
                     /db_xref="GeneID:80256"
                     /db_xref="HGNC:HGNC:25666"
                     /db_xref="MIM:620169"
     exon            1..58
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /inference="alignment:Splign:2.1.0"
     exon            59..202
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /inference="alignment:Splign:2.1.0"
     exon            203..1171
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1894
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /note="protein FAM214B; family with sequence similarity
                     214 member B"
                     /codon_start=1
                     /product="atos homolog protein B"
                     /protein_id="NP_079458.2"
                     /db_xref="CCDS:CCDS6578.1"
                     /db_xref="GeneID:80256"
                     /db_xref="HGNC:HGNC:25666"
                     /db_xref="MIM:620169"
                     /translation="MRHVQAEPSPSSEPEAGPSQPPVRQGALQGGLLMGYSPAGGATS
                     PGVYQVSIFSPPAGTSEPHRALKRQAPSTEGPRELKRGPGLGAREGLPPEEPSTVGLL
                     GPEGPGLGLGVASQHFSHRGLCVVEQRSSVTSSWTSGAWSPPCPPSNASCNTLHTRDW
                     ASPDPGGQGSLGESPGPAPPGQLHTLDTDLHSLAQIGGKSPVAGVGNGGSLWPRESPG
                     TANGHSPEHTPPGPGPPGPCPTKRRLLPAGEAPDVSSEEEGPAPRRRRGSLGHPTAAN
                     SSDAKATPFWSHLLPGPKEPVLDPTDCGPMGRRLKGARRLKLSPLRSLRKGPGLLSPP
                     SASPVPTPAVSRTLLGNFEESLLRGRFAPSGHIEGFTAEIGASGSYCPQHVTLPVTVT
                     FFDVSEQNAPAPFLGIVDLNPLGRKGYSVPKVGTVQVTLFNPNQTVVKMFLVTFDFSD
                     MPAAHMTFLRHRLFLVPVGEEGNANPTHRLLCYLLHLRFRSSRSGRLSLHGDIRLLFS
                     RRSLELDTGLPYELQAVTEAPHNPRYSPLP"
     exon            1172..1230
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1336
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1495
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1564
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1740
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..2998
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /note="hexamer: AATAAA"
     polyA_site      2998
                     /gene="ATOSB"
                     /gene_synonym="FAM214B; KIAA1539"
                     /note="major polyA site"
ORIGIN      
        1 agtaactgcc ccaaccacta ccacgtcccc aagtgcaacg ggacccacgg aactacaggg
       61 tcctgctgag ctcaggagct gcacggaatg gtggcagtca ccttgccagt gcagcaggca
      121 tggatcagac tgcaagctag gggcacgagg catcagttgg gaagagggga cgcacagcta
      181 ggcttgaggc ctcttcatcg ggatgtcccc aggcccccca gcccaggccc agcataaagg
      241 ccgtgttggg gggcccccct gacccaaggg gggcttcatg cgccacgtgc aggcggagcc
      301 gtctccatcc tcagagccgg aggctggccc ttcacagcct ccagtcaggc agggggccct
      361 ccagggtggc ctgctcatgg gctacagccc agcagggggg gcgacatccc ccggggtcta
      421 ccaggtatcc atcttttccc ctccggctgg tacctctgag cctcataggg ccctgaaacg
      481 acaagcccca tccactgagg gtccccggga gctgaagaga ggccctgggc tgggggccag
      541 agagggacta ccccctgaag aaccatctac tgtggggctc ttaggcccag agggaccggg
      601 gctgggacta ggtgtggcca gccagcattt ctcccaccgt ggcctctgtg ttgtggaaca
      661 gagaagtagt gtcacctcat cttggacttc gggggcctgg agtcccccct gccccccatc
      721 aaatgcttcc tgcaatactt tgcacaccag agactgggcc tccccagatc cagggggaca
      781 ggggtccctg ggggagtccc cagggccagc ccctccaggc cagctgcaca cacttgacac
      841 tgatttgcac agtcttgcac aaataggggg taagagccca gtggctgggg tgggcaatgg
      901 gggtagcctc tggcctaggg agtcccctgg cactgccaat gggcacagtc ccgagcacac
      961 accccctggc cctggacccc caggcccctg ccccaccaag cgaaggctgc ttcctgctgg
     1021 agaagcccca gatgtcagct ctgaggaaga ggggccagcc cctcggaggc gccggggatc
     1081 cctgggccac cctactgctg ccaacagttc tgatgccaaa gccacaccct tctggagcca
     1141 cctgctgcct gggcccaaag agcctgtttt ggacccaaca gactgcggtc ccatggggcg
     1201 gaggctgaaa ggagcccgtc gcctgaagct gagccccctt cgaagcctcc ggaaggggcc
     1261 aggcctgctg agccccccca gtgcctcccc tgttcctacc cctgctgtca gccgtaccct
     1321 gctgggcaac tttgaggaat cattgctgcg aggacgtttt gcaccatctg gccacattga
     1381 gggcttcaca gcagaaattg gagctagtgg gtcatactgc ccccagcacg tcacgctgcc
     1441 tgtcactgtc acattctttg atgtttctga gcaaaatgcc ccggctccct tcctgggcat
     1501 cgtggatctg aaccccttgg ggaggaaggg ttacagcgtg cccaaggtgg gcaccgtcca
     1561 agtgacctta tttaacccca accagactgt ggtaaagatg ttccttgtga cctttgactt
     1621 ctcggacatg cctgctgccc acatgacctt cctgcgccat cgcctctttt tggtgcctgt
     1681 gggtgaggag ggaaatgcta accccaccca ccgcctcctc tgctacttgc tgcacctcag
     1741 gttccggagc tcccgctcag gccgcttaag cctgcatgga gatatccgcc tgcttttttc
     1801 ccgccggagc ctggagctgg acacagggct cccctacgaa ctgcaggctg tgaccgaggc
     1861 ccctcataat ccacgttatt cacctttgcc ctgattgcca gcactctgaa cccatgcggg
     1921 ctaatgacct gcccatcctg ctccatctta gagaacatat atggagagac agcaagagac
     1981 ccttcaggct tgaattaaag ccctcaccat gctcacgccc aaatggatta tttgggtgtt
     2041 taaagcttct gattcttact acaccctgcc ctacttcggg tactccatgt gcctgtcccc
     2101 tcccttgggt ttcccaggcc agcttaggta gtagggagga actggagcta ccctgagatt
     2161 ttctcaagtt cccaggcaag ttatgccagc gttgcctccc tgtcctgggc aggggccact
     2221 tgttatttta tttattttta atttataatt tattcaaatt ggattgcctt ggtaacctcc
     2281 cacacctgat aattggcatc actcctcccc gcttcccact ctcagatatt gctccaacct
     2341 caggagttga agaggcttat gcggtggggg caggaggaga actgctttcc ctcagctgag
     2401 ggaagagggg ctattccaga gggactgagt cagtagccaa agactcagct tcccctgtcc
     2461 ttccccagtc ccttcacttc ccctaccctc tgacctatct ctgaaagcca agttatgcgt
     2521 atgtgtgtgt gcacaagctt gtctttgtgt ggtatgtgtg tgtgagtgtg catgtatgca
     2581 cacacacagg ggttaaccac ccctcaccta gggctccaga ctccagttgt ccctctcctc
     2641 ctacctgtgt ctccttgttt tggggtcctg actgaagaag gtgtccaggg ggcagagtca
     2701 gggccaagca ctggggtgcc tcctctcacc tggccagact ctgacccacc tacctcagct
     2761 ggggtgaggg gcacccctca aactcagtca tgtggttcca aactacccca ttccccactc
     2821 cagactctga cccagcctca gtcctaactc ctggggctgg gctgagggga acaagcattt
     2881 gctgaaactt gaaaaaacaa agcaaatcaa aaacaggaaa aaattgtacc tggtactttt
     2941 ttttagaaaa aaagattaaa aaagaaagaa taaattcttg tttggaaact tgaactaa
//
