LOCUS       NM_001385016            4726 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens atos homolog A (ATOSA), transcript variant 7, mRNA.
ACCESSION   NM_001385016 XM_005254548
VERSION     NM_001385016.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4726)
  AUTHORS   Emtenani,S., Martin,E.T., Gyoergy,A., Bicher,J., Genger,J.W.,
            Kocher,T., Akhmanova,M., Guarda,M., Roblek,M., Bergthaler,A.,
            Hurd,T.R., Rangan,P. and Siekhaus,D.E.
  TITLE     Macrophage mitochondrial bioenergetics and tissue invasion are
            boosted by an Atossa-Porthos axis in Drosophila
  JOURNAL   EMBO J 41 (12), e109049 (2022)
   PUBMED   35319107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009754.10 and AC025917.8.
            
            On Jul 8, 2020 this sequence version replaced XM_005254548.2.
            
            Transcript Variant: This variant (7) differs in the 5' UTR compared
            to variant 1. Variants 1 and 4-9 all encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.132881.1,
                                           SRR14038195.1401313.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619572.5/ ENSP00000484641.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-561               AC009754.10        158689-159249       c
            562-678             AC009754.10        157867-157983       c
            679-863             AC009754.10        93534-93718         c
            864-1066            AC009754.10        91436-91638         c
            1067-1192           AC009754.10        90991-91116         c
            1193-3008           AC009754.10        88429-90244         c
            3009-3122           AC009754.10        84994-85107         c
            3123-3202           AC025917.8         145507-145586       c
            3203-3311           AC025917.8         144548-144656       c
            3312-3470           AC025917.8         137999-138157       c
            3471-3539           AC025917.8         131572-131640       c
            3540-3739           AC025917.8         129166-129365       c
            3740-4726           AC025917.8         125742-126728       c
FEATURES             Location/Qualifiers
     source          1..4726
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2-q21.3"
     gene            1..4726
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /note="atos homolog A"
                     /db_xref="GeneID:56204"
                     /db_xref="HGNC:HGNC:25609"
                     /db_xref="MIM:620168"
     exon            1..561
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     exon            562..678
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     CDS             663..3893
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /note="isoform 1 is encoded by transcript variant 7;
                     protein FAM214A; family with sequence similarity 214
                     member A; atos homolog protein A"
                     /codon_start=1
                     /product="atos homolog protein A isoform 1"
                     /protein_id="NP_001371945.1"
                     /db_xref="CCDS:CCDS45263.1"
                     /db_xref="GeneID:56204"
                     /db_xref="HGNC:HGNC:25609"
                     /db_xref="MIM:620168"
                     /translation="MKPDRDTLDEYFEYDAEEFLVSLALLITEGRTPECSVKGRTESF
                     HCPPAQSCYPVTTKHECSDKLAQCRQARRTRSEVTLLWKNNLPIMVEMMLLPDCCYSD
                     DGPTTEGIDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKTLLLAVRSFVFFSQLS
                     AWLSVSHGAIPRNILYRISAADVDLQWNFSQTPIEHVFPVPNVSHNVALKVSVQSLPR
                     QSNYPVLTCSIHTNIGLYEKRIQQHKLKTHQHHNPNEAEQCGTNSSQRLCSKQTWTMA
                     PESVLHAKSGPSPEYTAAVKNIKLYPGTGSKSDHGTSQANILGFSGIGDIKSQETSVR
                     TLKSFSMVDSSISNRQSFWQSAGETNPLIGSLIQERQEIIARIAQHLIHCDPSTSHVS
                     GRPFNTQESSSLHSKLFRVSQENENVGKGKEAFSMTFGSPEFSSPEDTNEGKIRLKPE
                     TPRSETCISNDFYSHMPVGETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPRQSF
                     NMHDSSSVASKVFRSSYEDKNLLKKNKDESSVSISHTKCSLLGDISDGKNLVPNKCFT
                     SFKNNSKEKCSLKHQTRNQCQNNPSEIIQSTYQETQNKSSSLSTSSILSQHKENNLDL
                     TSRFKEQEMSNGIDKQYSNCTTIDKQICTNKYKEKIINENYNPKFFGNLQSDDSKKND
                     SKIKVTVLEMSEYLNKYESMSSNKDSKRPKTCEQNTQLNSIENYLNKDNEGFKCKKSD
                     QLKNEQDKQEDPTNEKSQNYSQRRSIKDCLSTCEQPKNTEVLRTTLKHSNVWRKHNFH
                     SLDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDSSLLHLKSFSSRSPRPCLNIED
                     DPDIHEKPFLSSSAPPITSLSLLGNFEESVLNYRFDPLGIVDGFTAEVGASGAFCPTH
                     LTLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTVVKMF
                     VVIYDLRDMPANHQTFLRQRTFSVPVKQEVKRSVNKENIRHTEERLLRYLIHLRFQSS
                     KSGKIYLHRDVRLLFSRKSMEVDSGAAYELKSYTESPTNPQFSPRC"
     exon            679..863
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1066
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1192
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..3008
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3122
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3202
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3311
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3470
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3539
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3739
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..4726
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4357..4362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /note="hexamer: AATAAA"
     polyA_site      4385
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /note="major polyA site"
     regulatory      4706..4711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /note="hexamer: AATATA"
     polyA_site      4726
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /note="major polyA site"
ORIGIN      
        1 agtgttttga cagggcaaac agcagagaaa gaactggccg agcgaggggg acggggagcc
       61 ggggcgccag agctagagac agcgggcggg caaggagctg gcagaggcgc tgggcaagag
      121 ggccggccgg ggctacgggc gggggaagcc cgggggtcgc ggggctcggg tgccagtcag
      181 gcagggcgga ggggctgagc gcagggagcg gagcgaggcg gtggctgagg cgcgggtgga
      241 tggccacagg ggcgccgggg agccgcttcg ggctggtcgt ctcgggtccc cacggtcacc
      301 tgaggcagcc gcgggggccg ctgcgctcca tactccgctc ccgctggccc tgcgcctctc
      361 ggagcctggg gtctgaggtg ggagtgtgat gtgagctgct gggcgagcgg tggagagaag
      421 tgccaagagg aggcgggatt gggacgggag aggagagcga gttagtcagc agaggtcggc
      481 cgagggagcg gaggagccgg ccagctcgag agcgccatga aaacaactct ccagcgggga
      541 gaggggcaga cgcggcgctc gcattttgaa agcgaagcag aagccgtaga atcagcggcg
      601 agcctgttga aagaacccac aggtgcattt cacagcactc tgggcgaaaa ttggatgtga
      661 aaatgaagcc agaccgagat actctggatg aatattttga atatgatgca gaggagttct
      721 tggtctcttt ggccttgctg ataacagaag gacgaacacc tgaatgttct gtaaaaggtc
      781 gaacagaaag ctttcattgc cctccagcac agtcttgtta cccagtaact accaaacatg
      841 aatgtagtga caagctggcc cagtgccgcc aagccagacg aactaggtct gaggtcacat
      901 tgttgtggaa gaataacctt ccaatcatgg tggaaatgat gctactacca gactgctgct
      961 acagcgatga tgggcccacc acagagggaa ttgatctaaa tgatcctgcg attaagcaag
     1021 atgcattatt attagaaaga tggatcttgg agccagttcc tcgacagaat ggtgaccgat
     1081 ttattgaaga gaagacgctt ctgttggctg tccgctcatt tgtgtttttt tctcagttaa
     1141 gtgcatggct gagtgtttct catggtgcta ttccacgaaa tattctctac agaatcagtg
     1201 ctgctgatgt agacctacag tggaattttt cacagactcc aattgagcat gtgtttcctg
     1261 ttcccaatgt ttctcacaat gttgccttga aagtcagtgt tcagtccttg cccagacaat
     1321 ctaattatcc agttttgacg tgcagtattc acactaatat tggcctttat gagaaaagaa
     1381 ttcaacaaca taaacttaaa actcatcagc accataaccc aaatgaagca gaacaatgtg
     1441 gtacaaacag ttcacagcgt ctgtgtagca aacaaacttg gaccatggca cctgaaagtg
     1501 tgttacatgc aaaaagtggc ccaagtccag aatatactgc agctgtcaaa aatatcaaac
     1561 tatatccagg cactggcagt aaatctgacc atgggacatc tcaagccaat attctaggct
     1621 ttagtggtat aggtgatata aaatcacaag aaacatcagt gagaacttta aaatcatttt
     1681 caatggttga ttccagtatc tctaaccgcc agagtttctg gcagtcagct ggtgagacta
     1741 accctttaat aggctcttta attcaggagc ggcaagaaat cattgcaaga attgcccaac
     1801 atttgattca ttgtgatcca agcacttcac atgtttctgg acgtccattt aatactcaag
     1861 agtctagttc actccattca aaacttttcc gggtttcaca agaaaatgag aacgtgggaa
     1921 aaggtaaaga agctttctcc atgacttttg gtagtccaga gtttagttcc ccagaagaca
     1981 ccaatgaggg gaaaattcga ctaaaaccag aaactcctcg aagtgaaact tgtatttcta
     2041 atgactttta ttctcatatg cctgttggag agactaatcc tttgataggc tctttactcc
     2101 aggagcggca agatgttatt gcaaggattg ctcaacactt ggagcacatt gatccaacag
     2161 catcacatat cccccggcag tcattcaaca tgcatgactc cagttcggtt gcatctaaag
     2221 tgtttaggag ttcatatgaa gacaaaaatt tgttgaagaa aaataaggat gagtcctcag
     2281 tttccatttc tcacacaaaa tgttccttgt taggagacat cagtgatggg aaaaacttag
     2341 tacctaataa atgttttact tcttttaaaa ataatagtaa agaaaagtgt tctttgaaac
     2401 atcaaacaag aaatcagtgt cagaacaatc ctagtgaaat catccaaagt acgtatcagg
     2461 agacacagaa caaaagttct agtttatcaa cttcctcaat tttgtctcag cacaaagaaa
     2521 ataacttaga tttgacaagc agattcaagg agcaagaaat gagcaatgga attgataaac
     2581 agtattcaaa ttgcaccact attgacaaac agatttgtac aaataagtat aaggaaaaaa
     2641 taataaatga gaactataat ccaaaattct ttggcaatct tcagtctgat gattccaaaa
     2701 aaaatgactc aaaaataaaa gttactgtgt tggaaatgtc tgaatatttg aacaaatatg
     2761 aaagcatgtc ctcaaataaa gactcaaaaa ggcctaagac atgtgagcaa aatactcaac
     2821 ttaatagcat agagaattat ctcaataaag ataatgaagg tttcaaatgt aaaaagtcag
     2881 accaattaaa aaatgaacaa gataagcaag aagatccaac taatgaaaaa tcccaaaact
     2941 attctcagag aagaagtata aaagactgtt tgtctacatg tgagcaacca aaaaatacag
     3001 aggtattgag gactacactg aaacattcaa atgtgtggcg aaaacataat tttcattcct
     3061 tggatggaac ttcaaccaga gcctttcatc ctcaaactgg attgcctctt ctttcaagcc
     3121 ctgttcctca aagaaaaaca caatcaggtt gctttgatct ggattcttca ttactacatc
     3181 tgaaaagctt ctcatctaga agtcctcgac catgtttaaa cattgaagat gatccagata
     3241 ttcatgaaaa accatttttg agttctagtg ctccacctat aacaagtctt agtctcctag
     3301 gaaattttga ggaatctgtc ttgaactatc gtttcgatcc tctcggcatt gttgatggtt
     3361 ttactgccga ggtaggggca agtggtgctt tctgccccac acatttgact cttccagttg
     3421 aagtgtcatt ctacagtgtt tcagatgaca atgctccctc tccttatatg ggtgtgatta
     3481 ctttagagtc ccttggtaaa aggggttatc gagtacctcc ttcaggaaca atacaagtga
     3541 ccttatttaa tcctaataag actgtggtga agatgtttgt tgtgatatat gatttacgag
     3601 atatgccagc caatcatcag acattcctac gacaaagaac tttttctgta cctgttaaac
     3661 aagaagtgaa gagaagtgtt aataaagaga acatccgaca cacagaagaa cggttattac
     3721 gctacctcat acatctgagg ttccagagtt ctaaatctgg aaagatctac ctccatagag
     3781 acgtacggct cctgttctct agaaagtcaa tggaggttga tagcggtgct gcatatgaac
     3841 tcaaatctta cactgaatca ccaacaaacc ctcagttttc accaagatgt tgataaggag
     3901 tgatgattta aagtatttac tcagtaccca agtttgcaag taaaaattag catagaatgg
     3961 agtgtaccaa attaacaatc aggagagtgg attctctcct gttatcctgg accagttttt
     4021 atgaaaggat tcctgaaatg aaatccatat attccatgta gactggaaaa actcatgtcc
     4081 taatcctttt tgtactgttg aaaccacttc attggacatg ttgcaatagc aaaaccccca
     4141 gttagattag tgtttacaca ttttctcagt tatttaatat ttaatgtttt ccttaatact
     4201 caagtgatgt ttgtctctag tgttctaatg tagcacaaat cctatgtaaa atcatactat
     4261 gtatttttga cattaatgtt gaaatcaaat atatgcacaa gtctttaatt ttgtgtaatg
     4321 tgttaagtgc tgttcattta agttattgaa aatgagaata aaatgttgag cttctttaaa
     4381 agtaacacac tatgcaagca tgtgtacttt ttatatctct catgtttagt ttttataaca
     4441 ccatatccag gttgctatct cacatagtag tcctttaaca tattgtatta gcagtgcaat
     4501 gtggactaag ctgcttcact ttccctttgc aagttcagat catcatgccc attcatagcc
     4561 aggattcctt atccccaaaa cagttctatt tttccttaat cactactata gagtctttac
     4621 attaaattac tgtcgtatgc tagataattt tctcaaattg ttaaaagaat atgtactttg
     4681 gaaacaaatt agtatttata ttgtaaatat attcaaaaaa aactaa
//
