LOCUS       NM_032827               5658 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens atonal bHLH transcription factor 8 (ATOH8), mRNA.
ACCESSION   NM_032827
VERSION     NM_032827.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5658)
  AUTHORS   Thapa,R., Druessel,L., Ma,L., Torry,D.S. and Bany,B.M.
  TITLE     ATOH8 Expression Is Regulated by BMP2 and Plays a Key Role in Human
            Endometrial Stromal Cell Decidualization
  JOURNAL   Endocrinology 165 (1) (2023)
   PUBMED   38060684
  REMARK    GeneRIF: ATOH8 Expression Is Regulated by BMP2 and Plays a Key Role
            in Human Endometrial Stromal Cell Decidualization.
REFERENCE   2  (bases 1 to 5658)
  AUTHORS   Liu,X., Fan,Z., Chen,L., Yang,J. and Cheng,J.
  TITLE     ATOH8 promotes HBV immune tolerance by inhibiting the pyroptotic
            pathway in hepatocytes
  JOURNAL   Mol Med Rep 28 (1) (2023)
   PUBMED   37232357
  REMARK    GeneRIF: ATOH8 promotes HBV immune tolerance by inhibiting the
            pyroptotic pathway in hepatocytes.
REFERENCE   3  (bases 1 to 5658)
  AUTHORS   Liu,X., Li,X., Wang,S., Liu,Q., Feng,X., Wang,W., Huang,Z.,
            Huang,Y., Wu,J., Cai,M., Cai,X., Xu,X., Cai,J. and Li,M.
  TITLE     ATOH8 binds SMAD3 to induce cellular senescence and prevent
            Ras-driven malignant transformation
  JOURNAL   Proc Natl Acad Sci U S A 120 (3), e2208927120 (2023)
   PUBMED   36626550
  REMARK    GeneRIF: ATOH8 binds SMAD3 to induce cellular senescence and
            prevent Ras-driven malignant transformation.
REFERENCE   4  (bases 1 to 5658)
  AUTHORS   Xu,M., Huang,S., Dong,X., Chen,Y., Li,M., Shi,W., Wang,G.,
            Huang,C., Wang,Q., Liu,Y., Sun,P., Yang,S., Xiang,R. and Chang,A.
  TITLE     A novel isoform of ATOH8 promotes the metastasis of breast cancer
            by regulating RhoC
  JOURNAL   J Mol Cell Biol 13 (1), 59-71 (2021)
   PUBMED   33049034
  REMARK    GeneRIF: A novel isoform of ATOH8 promotes the metastasis of breast
            cancer by regulating RhoC.
REFERENCE   5  (bases 1 to 5658)
  AUTHORS   Liu,F., Song,D.Y., Huang,J., Yang,H.Q., You,D. and Ni,J.D.
  TITLE     Long non-coding RNA CIR inhibits chondrogenic differentiation of
            mesenchymal stem cells by epigenetically suppressing ATOH8 via
            methyltransferase EZH2
  JOURNAL   Mol Med 27 (1), 12 (2021)
   PUBMED   33546582
  REMARK    GeneRIF: Long non-coding RNA CIR inhibits chondrogenic
            differentiation of mesenchymal stem cells by epigenetically
            suppressing ATOH8 via methyltransferase EZH2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5658)
  AUTHORS   Patel,N., Varghese,J., Masaratana,P., Latunde-Dada,G.O., Jacob,M.,
            Simpson,R.J. and McKie,A.T.
  TITLE     The transcription factor ATOH8 is regulated by erythropoietic
            activity and regulates HAMP transcription and cellular pSMAD1,5,8
            levels
  JOURNAL   Br J Haematol 164 (4), 586-596 (2014)
   PUBMED   24236640
REFERENCE   7  (bases 1 to 5658)
  AUTHORS   Chen,J., Dai,F., Balakrishnan-Renuka,A., Leese,F., Schempp,W.,
            Schaller,F., Hoffmann,M.M., Morosan-Puopolo,G., Yusuf,F.,
            Bisschoff,I.J., Chankiewitz,V., Xue,J., Chen,J., Ying,K. and
            Brand-Saberi,B.
  TITLE     Diversification and molecular evolution of ATOH8, a gene encoding a
            bHLH transcription factor
  JOURNAL   PLoS One 6 (8), e23005 (2011)
   PUBMED   21857980
  REMARK    GeneRIF: Data show that in ATOH8 was hosted in one chromosome which
            is a fusion product of two orthologous chromosomes in non-human.
            primates.
REFERENCE   8  (bases 1 to 5658)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   9  (bases 1 to 5658)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 5658)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA629171.1, BC094832.1, BM671127.1, AC012454.8 and BQ018438.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032827.6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021207.2, AK027614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306279.4/ ENSP00000304676.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               DA629171.1         206-330
            126-2247            BC094832.1         1-2122
            2248-2341           BM671127.1         15-108              c
            2342-5112           AC012454.8         180236-183006
            5113-5658           BQ018438.1         18-563              c
FEATURES             Location/Qualifiers
     source          1..5658
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..5658
                     /gene="ATOH8"
                     /gene_synonym="bHLHa21; HATH6"
                     /note="atonal bHLH transcription factor 8"
                     /db_xref="GeneID:84913"
                     /db_xref="HGNC:HGNC:24126"
                     /db_xref="MIM:619820"
     exon            1..967
                     /gene="ATOH8"
                     /gene_synonym="bHLHa21; HATH6"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1165
                     /gene="ATOH8"
                     /gene_synonym="bHLHa21; HATH6"
                     /note="basic helix loop helix transcription factor 6;
                     atonal homolog 6; protein atonal homolog 8;
                     helix-loop-helix protein hATH-6; class A basic
                     helix-loop-helix protein 21; atonal homolog bHLH
                     transcription factor 8"
                     /codon_start=1
                     /product="transcription factor ATOH8"
                     /protein_id="NP_116216.2"
                     /db_xref="CCDS:CCDS1985.1"
                     /db_xref="GeneID:84913"
                     /db_xref="HGNC:HGNC:24126"
                     /db_xref="MIM:619820"
                     /translation="MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFR
                     LDLEAPEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAP
                     EVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPP
                     ARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEAT
                     AASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIAC
                     NYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE"
     exon            968..1159
                     /gene="ATOH8"
                     /gene_synonym="bHLHa21; HATH6"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..5658
                     /gene="ATOH8"
                     /gene_synonym="bHLHa21; HATH6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2315..2320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATOH8"
                     /gene_synonym="bHLHa21; HATH6"
                     /note="hexamer: AGTAAA"
     polyA_site      2341
                     /gene="ATOH8"
                     /gene_synonym="bHLHa21; HATH6"
                     /note="major polyA site"
     regulatory      5631..5636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATOH8"
                     /gene_synonym="bHLHa21; HATH6"
                     /note="hexamer: AATAAA"
     polyA_site      5658
                     /gene="ATOH8"
                     /gene_synonym="bHLHa21; HATH6"
ORIGIN      
        1 agatgacact ctgagcgctc cgggaacgga cagcccggcg gcttcccgaa gccggcggcg
       61 cagctgcccg gggcgagggg gagaaaggga gagagggagg gggagggcgg gcgaagcggg
      121 agagccagag actcctcggc gctgagcgcg gcggcggccc gggcagcccc acgcccctgc
      181 ctcgcgcgcc gcccgcgcca tgaagcacat cccggtcctc gaggacgggc cgtggaagac
      241 cgtgtgcgtg aaggagctga acggccttaa gaagctcaag cggaaaggca aggagccggc
      301 gcggcgcgcg aacggctata aaactttccg actggacttg gaagcgcccg agccccgcgc
      361 cgtagccacc aacgggctgc gggacaggac ccatcggctg cagccggtcc cggtaccggt
      421 gccggtgcca gtcccagtgg cgccggccgt tcccccaaga gggggcacgg acacagccgg
      481 ggagcgcggg ggctctcggg cgcccgaggt ctccgacgcg cggaaacgct gcttcgccct
      541 aggcgcagtg gggccaggac tccccacgcc gccgccgccg ccgcctcctg cgccccagag
      601 ccaggcacct gggggcccag aggcacagcc tttccgggag ccgggtctgc gtcctcgcat
      661 cttgctgtgc gcaccgcccg cgcgccccgc gccgtcagca cccccagcac cgccagcgcc
      721 cccggagtcc actgtgcgcc ctgcgccccc gacgcgcccc ggggaaagtt cctactcgtc
      781 aatttcacac gtaatttaca ataaccacca ggattcctcc gcgtcgccta ggaaacgacc
      841 gggcgaagcg actgccgcct cctccgagat caaagccctg cagcagaccc ggaggctcct
      901 ggcgaacgcc agggagcgga cgcgggtgca caccatcagc gcagccttcg aggcgctcag
      961 gaagcaggtg ccgtgctact catatgggca gaagctgtcc aaactggcca tcctgaggat
     1021 cgcctgtaac tacatcctgt ccctggcgcg gctggctgac cttgactaca gtgccgacca
     1081 cagcaacctc agcttctccg agtgtgtgca gcgctgcacc cgcaccctgc aggccgaggg
     1141 acgtgccaag aagcgcaagg agtgactggc tgcaggcaag accaaggcca ccactgtggg
     1201 ccctccttcc agtcaggcct gaggacaagg tgagctcgct gagtccagcc tcgtggtctt
     1261 ctccaagatg ccgccagatg cccagcctac agcctctcag ggtcggatcg gagcacgcct
     1321 gcctccctct cccctccgcc ctcacccagc caatccgagg ctgcttcgca ctttgccctc
     1381 tgcctggtgg ggaggggaga gctcagcccc cgactcactc agaccccaag gcccactgtc
     1441 cagctgcaga aattcgttgc caaagattgg acagagacac cgaaggaaat ggggtggtga
     1501 aaccccacag cgaaaagcca caccgttgct ctgtgacttt tgctcctcct gttgcctgag
     1561 ccccatctca agccaaagat gagtcagtgg ttctgctagg aactcatgga atggatgggc
     1621 atttgatgac ccctgggggt catcttggcc ctctgacctg gtgctctctc tccactgggc
     1681 cttgtgctgg ctgagtgcaa gacaagcctt aggggctgtg agagggaggc tggggtgcct
     1741 gggcggggct gggagtggga cctgagatcc ctgcccactc tctccccttc attggctgcc
     1801 caggccactg gccccagttc tcagtgtccc ttgggtccag gctccttggg ccctaagcat
     1861 caccagaagg gagtaagcag ggagagaagc aatattactc cctcccctac accagggact
     1921 tgccccaggg cagctaccta tgggtctttg cttccccagc cagcctctcc tcactgtgac
     1981 ccacccccat gggcccccgt cccaggcagc cagcaccatg ggcaggccct gccatggaca
     2041 gaaaaagagt ttttctcttg ttcagcctgc acgtggcctg aggaaggagt agaggctggg
     2101 ttggctggag ccgtcctact gggcaagatg gcgccccact tggagggcgg tggtctgtta
     2161 cagggtgtgc aggggcagag aaggaaggga ccaggggact gggccagtat gtggaggatg
     2221 gggcctgcgt gttcaaagcc aaggcccgcc ccttccttgt gctcaaatgg ccaaagctgt
     2281 tcacgtctgt gctcaaccat ctgcttcaaa ttgaagtaaa agccccaaaa tgtcaagaaa
     2341 atacttgtgt tgagtggact ctgtgggtga ccaggacttt ggccggtcat cagctgggga
     2401 gtgtgaggga gggggttggt ttctacctac aggttgagag cccttcagga tcaggcgctg
     2461 tccgagtgag agtgtgtgtg tctgtgtgtg gaagggggtg gagggcggtt cccacagtag
     2521 tctcagcctg gactagtgac caggaggcct ggtcaggaac acatgaggag ccctctctgt
     2581 ccgcactgca ctcaatctgt accatggatt tatgagatag gggcccctat tattaacccc
     2641 gtttcacaga tggggtaact gaggcctcaa gtagacaggg tcagtcggtg acagagccag
     2701 tcatcgaatc aggatgggct cacttcaaat cctgtgctct caaacctttt ccagccccat
     2761 caccagtccc agcccaaagt ctcttgtgtg gccttgtcac attgcttcac ctcagcgggc
     2821 ctaaggtagg gacaataaag gcccattggg actgggggaa ggggtgataa gataaaaaat
     2881 aggagagcac tgtcaaggca gaagggacag ggctggccaa ggaaaggggg ataggagggg
     2941 accggaggct gcagccatac aggacacagt ttgtcccttg gtttcaccag tgtcactttc
     3001 tcgtctctgc tgctcagact cctgggctgg gctggggctg gctgcaggga gccccccttg
     3061 cagtagcgtt tctcaggctg gccctttacc aaggaccaca gtgtccatgc tgtcttggat
     3121 ccctaggctg gcacagaaac aggggaccca ggtggccctg agcactcctc agagcaaagg
     3181 tgctctggaa gcagactgga cagagtgggc atggaatggg gccaggaggg tctgttagga
     3241 aggttcagcc accctgtgaa gctggcacag ataacagcac tgctctgttg tccctcggag
     3301 cctctgagta accctgatgg cacttcctaa ggcagcagga catgtggact gaccagcatc
     3361 aaactgttga catagaagac catttctatt accaaaggga gtgtacccca ttctgctgcc
     3421 aagggagcaa acccatggcc ttaccaccca gaaagagccc atcctccacc tcccatcccc
     3481 ctcctgcata catacttcat tacatgtttc cctttcattc tgaagcatca ttgatgacca
     3541 gctgcctgtc agacactaag ataggcagtg ggaatgaaga gatggatctt gtgtcatgca
     3601 tggcatcacg gagctctggg ttctgtacgg agggtgggac agacaggtag acaagcaaat
     3661 aattatgatt atagcagatg actaaggtgt tgtcgggagc ttcaggaaag gaagaactaa
     3721 ctcttgggga ggttctcagg aaggatttcc ctggaaagta gccatgggac ttgcgtctta
     3781 aatggtgagt aaaagctttc tgagcagggg agtaggaaaa gggctttcta tgcagaggag
     3841 cactcagcgc tggcaggaaa ttggaatcac ccaaggagat tattaaatat taaatattga
     3901 tatgaagtat tgatgcccaa tttcatctcc agaaattctg atgtattggt ctagggtgtt
     3961 gcctggtcat tgggattttt acaagctcct caagtgatct taatgtgcag gcaaggttga
     4021 agccgctggt ctaagtgggg tctggtctac gataagaaag tgactttgag ccatcgattt
     4081 gggagacagg ctctgggtgg atgtgtgtgt gtgcacacat atgtatgtat gtggatgact
     4141 aaaagtgcat gctctcctct cctttcccag cttcctctcc agcacagcaa cttgtgttcg
     4201 tatgcacaca catgcatact ctctctcatg ggcacatgca tacccacaca cacactcgtg
     4261 tacatttcca gaaaatggaa ttacatttca gatagattca gattccaacg gcagtcttct
     4321 aaacactttt atgcaagcag ccattcaagg agaccctcag caaaatataa atgacgagga
     4381 gctgccctca tggggccctg tgaaagcact ttgcagtcca gccttgggtt tgtggtcaca
     4441 gagtcacctg tggatgtttg tagcacactc tccttgtctt gtctgctctg ggtcaccagg
     4501 cacaggccat aaagggatga gggggccctc tccagggacc cgcaagatct tcctgggtat
     4561 gtctgcatga agccccacgt gtgcacaccc atcttcatgt gtgtgtgtgc cagcctcctg
     4621 ctctctgcag aacaaaacca gaaggaatgg ctctgggagt tggagatctc agctcacagg
     4681 ccaagctttg caagactctc caaagactgc ccacagactg tgctgcttcc tgggtctggc
     4741 ctgagactat cccagaagag agggttaaat tctggaggtg aggttttgag caagtgttca
     4801 tccccccaca ctatgctcct tcctgtctcc atggccacat ccttcaaggc tctgtgctgt
     4861 tctctttttt tctggatttc tccacctcca ccaagttccc ctttctcaca gctagtggag
     4921 gcatgagtag gcaggtccca ggggctggga actgggtagc attgccatgt gcagggactg
     4981 tgttgggagc tgcaggtaca gagctcctct gtgctcaaga gcttgccggt gagcctggac
     5041 ggaggcatag gtgcagctaa ttaggataag acaggggccg cgctgtggtc agccgtggga
     5101 agccggcgag gggactggag ttggggctac acttgcctcc ctcctatgct gcttcctgag
     5161 ccacgaagtg gtcattgcca gcatcccagg caacaaacag caagactcag acatctccaa
     5221 ggaaaccctt tgagtggatc tgtaccgttg ttctcgtctt gctctcttgc tgccctgcca
     5281 ccttcacagc tgctttctgt ttcctggttc caggaagaca gcggggcaca gggtccctgc
     5341 tttgtgagga gcagctggct tctccctttg cccccaggtt ttgccctccc acatgtctcc
     5401 cttctggtga cccggacccc agacaaacta tgcctgcctc cctgaagcca ggcatcctga
     5461 ggaacttgat agacaaacaa tgacagtgtt ttccagaact gtgggtacgt gtctaatctc
     5521 agatggtact atgaattcct ggagatcaaa gtttggatct aattcaaccc ctgatcctcg
     5581 aaacggcttt cttgcaaagt gtatatattg gtttctttgc tgaatgaatg aataaaacat
     5641 ggaaaatgtg gtaattca
//
