LOCUS       NM_015251               4881 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ATM interactor (ATMIN), transcript variant 1, mRNA.
ACCESSION   NM_015251 XM_375375
VERSION     NM_015251.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4881)
  AUTHORS   Fang,X.L., Li,Q.J., Lin,J.Y., Huang,C.L., Huang,S.Y., Tan,X.R.,
            He,S.W., Zhu,X.H., Li,J.Y., Gong,S., Qiao,H., Li,Y.Q., Liu,N.,
            Ma,J., Zhao,Y. and Tang,L.L.
  TITLE     Transcription factor ATMIN facilitates chemoresistance in
            nasopharyngeal carcinoma
  JOURNAL   Cell Death Dis 15 (2), 112 (2024)
   PUBMED   38321024
  REMARK    GeneRIF: Transcription factor ATMIN facilitates chemoresistance in
            nasopharyngeal carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4881)
  AUTHORS   Li,Y.J., Yang,C.N., Kuo,M.Y., Lai,W.T., Wu,T.S. and Lin,B.R.
  TITLE     ATMIN Suppresses Metastasis by Altering the WNT-Signaling Pathway
            via PARP1 in MSI-High Colorectal Cancer
  JOURNAL   Ann Surg Oncol 28 (13), 8544-8554 (2021)
   PUBMED   34148137
  REMARK    GeneRIF: ATMIN Suppresses Metastasis by Altering the WNT-Signaling
            Pathway via PARP1 in MSI-High Colorectal Cancer.
REFERENCE   3  (bases 1 to 4881)
  AUTHORS   Jia,J., Ouyang,Z., Wang,M., Ma,W., Liu,M., Zhang,M. and Yu,M.
  TITLE     MicroRNA-361-5p slows down gliomas development through regulating
            UBR5 to elevate ATMIN protein expression
  JOURNAL   Cell Death Dis 12 (8), 746 (2021)
   PUBMED   34321465
  REMARK    GeneRIF: MicroRNA-361-5p slows down gliomas development through
            regulating UBR5 to elevate ATMIN protein expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4881)
  AUTHORS   Foster,H., Ruiz,E.J., Moore,C., Stamp,G.W.H., Nye,E.L., Li,N.,
            Pan,Y., He,Y., Downward,J. and Behrens,A.
  TITLE     ATMIN Is a Tumor Suppressor Gene in Lung Adenocarcinoma
  JOURNAL   Cancer Res 79 (20), 5159-5166 (2019)
   PUBMED   31481498
  REMARK    GeneRIF: ATMIN is located close to FRA16D and is commonly lost in
            lung adenocarcinoma (LUAD)and was associated with reduced patient
            survival. ATMIN is a tumor suppressor in LUAD; fragility at
            chr16q23 correlates with loss of ATMIN in human LUAD.
REFERENCE   5  (bases 1 to 4881)
  AUTHORS   Li,C.G., Mahon,C., Sweeney,N.M., Verschueren,E., Kantamani,V.,
            Li,D., Hennigs,J.K., Marciano,D.P., Diebold,I., Abu-Halawa,O.,
            Elliott,M., Sa,S., Guo,F., Wang,L., Cao,A., Guignabert,C.,
            Sollier,J., Nickel,N.P., Kaschwich,M., Cimprich,K.A. and
            Rabinovitch,M.
  TITLE     PPARgamma Interaction with UBR5/ATMIN Promotes DNA Repair to
            Maintain Endothelial Homeostasis
  JOURNAL   Cell Rep 26 (5), 1333-1343 (2019)
   PUBMED   30699358
  REMARK    GeneRIF: PPARgamma promotes ATM signaling and is essential for UBR5
            activity targeting ATM interactor (ATMIN).
REFERENCE   6  (bases 1 to 4881)
  AUTHORS   Kanu,N. and Behrens,A.
  TITLE     ATMINistrating ATM signalling: regulation of ATM by ATMIN
  JOURNAL   Cell Cycle 7 (22), 3483-3486 (2008)
   PUBMED   19001856
  REMARK    Review article
REFERENCE   7  (bases 1 to 4881)
  AUTHORS   Heierhorst,J.
  TITLE     Mdt1/ASCIZ: a new DNA damage response protein family
  JOURNAL   Cell Cycle 7 (17), 2654-2660 (2008)
   PUBMED   18728389
  REMARK    GeneRIF: ASCIZ (ATMIN) is structurally related to the yeast ATM/ATR
            substrate Mdt1 (Pin4/Ybl051c); both proteins contain SQ/TQ cluster
            domains and interact with N-terminal FHA domains of CHK2/Rad53
            kinases.
            Review article
REFERENCE   8  (bases 1 to 4881)
  AUTHORS   Oka,H., Sakai,W., Sonoda,E., Nakamura,J., Asagoshi,K., Wilson,S.H.,
            Kobayashi,M., Yamamoto,K., Heierhorst,J., Takeda,S. and
            Taniguchi,Y.
  TITLE     DNA damage response protein ASCIZ links base excision repair with
            immunoglobulin gene conversion
  JOURNAL   Biochem Biophys Res Commun 371 (2), 225-229 (2008)
   PUBMED   18433721
  REMARK    GeneRIF: These data suggest that ASCIZ may affect the choice
            between competing base repair pathways in a manner that reduces the
            amount of substrates available for Ig gene conversion.
            Erratum:[Biochem Biophys Res Commun. 2008 Dec 5;377(1):326]
REFERENCE   9  (bases 1 to 4881)
  AUTHORS   Kanu,N. and Behrens,A.
  TITLE     ATMIN defines an NBS1-independent pathway of ATM signalling
  JOURNAL   EMBO J 26 (12), 2933-2941 (2007)
   PUBMED   17525732
  REMARK    GeneRIF: ATMIN defines a novel NBS1-independent pathway of ATM
            signalling.
REFERENCE   10 (bases 1 to 4881)
  AUTHORS   McNees,C.J., Conlan,L.A., Tenis,N. and Heierhorst,J.
  TITLE     ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis
            after methylating DNA damage
  JOURNAL   EMBO J 24 (13), 2447-2457 (2005)
   PUBMED   15933716
  REMARK    GeneRIF: ASCIZ acts as a lesion-specific focus scaffold in a
            Rad51-dependent pathway that resolves cytotoxic repair
            intermediates, most likely single-stranded DNA gaps, resulting from
            MLH1-dependent processing of base lesions.
            GeneRIF: ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein
            (ASCIZ) required for repair of abasic sites after methylating and
            oxidative DNA damage but not double-strand breaks.  Forms DNA
            damage-induced foci with RAD51 and ssDNA.  ASCIZ foci depend on
            MLH1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092718.3, BX343387.2, BX375235.2, CF593326.1, BC002701.2,
            AB007891.1, BI259534.1 and BM693775.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015251.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.195099.1,
                                           SRR1803614.97989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299575.5/ ENSP00000299575.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC092718.3         146981-146991       c
            12-43               BX343387.2         1-32
            44-64               BX375235.2         32-52
            65-113              BX343387.2         54-102
            114-124             CF593326.1         120-130
            125-238             BX375235.2         113-226
            239-895             BC002701.2         45-701
            896-1840            AB007891.1         1362-2306
            1841-1843           BI259534.1         776-778
            1844-2708           BC002701.2         1650-2514
            2709-2769           AB007891.1         3175-3235
            2770-2770           BM693775.1         653-653
            2771-4877           AC092718.3         135487-137593       c
            4878-4881           AC092718.3         135483-135486       c
FEATURES             Location/Qualifiers
     source          1..4881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.2"
     gene            1..4881
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
                     /note="ATM interactor"
                     /db_xref="GeneID:23300"
                     /db_xref="HGNC:HGNC:29034"
                     /db_xref="MIM:614693"
     exon            1..365
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..2501
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATM/ATR-Substrate Chk2-Interacting Zn++-finger protein;
                     ATM INteracting protein; zinc finger protein 822;
                     ATM/ATR-substrate CHK2-interacting zinc finger protein;
                     ATM/ATR-substrate CHEK2-interacting zinc finger protein"
                     /codon_start=1
                     /product="ATM interactor isoform 1"
                     /protein_id="NP_056066.2"
                     /db_xref="CCDS:CCDS32494.1"
                     /db_xref="GeneID:23300"
                     /db_xref="HGNC:HGNC:29034"
                     /db_xref="MIM:614693"
                     /translation="MAASEAAAAAGSAALAAGARAVPAATTGAAAAASGPWVPPGPRL
                     RGSRPRPAGATQQPAVPAPPAGELIQPSVSELSRAVRTNILCTVRGCGKILPNSPALN
                     MHLVKSHRLQDGIVNPTIRKDLKTGPKFYCCPIEGCPRGPERPFSQFSLVKQHFMKMH
                     AEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRCTCGCPYASRTALQSHIYRTGHEIPA
                     EHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIKLEPSFEDSCG
                     SNTDKQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPTADSSAQPVVLGVDQ
                     GSATGAVHLMPLSVGTLILGLDSEACSLKESLPLFKIANPIAGEPISTGVQVNFGKSP
                     SNPLQELGNTCQKNSISSINVQTDLSYASQNFIPSAQWATADSSVSSCSQTDLSFDSQ
                     VSLPISVHTQTFLPSSKVTSSIAAQTDAFMDTCFQSGGVSRETQTSGIESPTDDHVQM
                     DQAGMCGDIFESVHSSYNVATGNIISNSLVAETVTHSLLPQNEPKTLNQDIEKSAPII
                     NFSAQNSMLPSQNMTDNQTQTIDLLSDLENILSSNLPAQTLDHRSLLSDTNPGPDTQL
                     PSGPAQNPGIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFLLADTS
                     AQSYGCRGNSNFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHSSFSVSTDSSDTET
                     QTEGVSTAKNIPALESKVQLNSTETQTMSSGFETLGSLFFTSNETQTAMDDFLLADLA
                     WNTMESQFSSVETQTSAEPHTVSNF"
     exon            366..491
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
                     /inference="alignment:Splign:2.1.0"
     exon            492..691
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
                     /inference="alignment:Splign:2.1.0"
     exon            692..4881
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2683..2688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
                     /note="hexamer: TATAAA"
     polyA_site      2708
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
                     /note="major polyA site"
     regulatory      4746..4751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
                     /note="hexamer: ATTAAA"
     polyA_site      4768
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
                     /note="major polyA site"
     regulatory      4857..4862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
                     /note="hexamer: GATAAA"
     polyA_site      4881
                     /gene="ATMIN"
                     /gene_synonym="ASCIZ; ZNF822"
ORIGIN      
        1 gaactgggcc gggcggccgt gcgggagcca tggcggcctc ggaggcggcg gcggcggcgg
       61 ggtccgcggc tctggcggcg ggtgcccggg ccgtcccggc ggccacgaca ggagccgccg
      121 ccgccgcctc gggcccgtgg gtgcccccgg gaccccgact gaggggcagc cggccgcggc
      181 ccgcgggggc gacgcagcag cccgctgtcc ccgcgccgcc ggcgggggag ctgatccagc
      241 cgtcggtgag cgagctgtcc cgggccgtgc ggaccaacat cctgtgcacc gtgcgcggct
      301 gcggcaagat cctgcccaac agccccgcgc tcaacatgca cctagtcaag agccaccgcc
      361 tgcaggatgg catagtcaat ccaacaataa gaaaagattt gaaaactgga ccgaaattct
      421 actgctgtcc aattgaaggc tgccccagag gccctgagag accgttttct cagttttctc
      481 tcgtaaaaca gcactttatg aaaatgcatg ctgagaagaa gcacaaatgt agtaagtgca
      541 gcaattcgta cggtacagaa tgggacctga aaagacatgc agaggactgt ggcaagacct
      601 tccggtgcac atgcggctgt ccctacgcca gtagaacagc actgcagtct cacatctacc
      661 gaactgggca cgagatacct gcagaacaca gggacccacc tagtaagaaa aggaaaatgg
      721 aaaactgtgc acaaaaccag aagttatcca acaagaccat tgaatcattg aacaaccaac
      781 caatccctag accagacact caagaactag aagcttcaga aataaagcta gaaccatctt
      841 ttgaagactc ttgtggctct aacactgaca agcagactct tacaacacca ccgagatatc
      901 ctcagaagtt gcttttacca aagcccaaag tggctttggt taaactaccc gtgatgcagt
      961 tttctgtcat gcctgtcttt gtgcctacag ccgactcctc agcccagcct gtggtgttag
     1021 gtgttgatca gggctctgcc acaggggctg tgcacttaat gcccttgtca gtaggaaccc
     1081 tgatcctcgg cctagattca gaggcttgct ctcttaagga gagcctacct cttttcaaaa
     1141 ttgctaatcc tattgctggt gagccaataa gtactggtgt tcaagtgaac tttggtaaaa
     1201 gtccatctaa tcctttacaa gaactaggga acacgtgtca aaagaatagc atttcttcaa
     1261 tcaacgtgca gacagatctg tcttatgcct cacaaaactt tataccttct gcacagtggg
     1321 ccactgctga ttcctctgtg tcgtcttgtt ctcaaactga tttgtcgttt gattctcaag
     1381 tgtctcttcc cattagtgtt cacactcaga catttttgcc cagctctaag gtaacttcat
     1441 ctatagctgc tcagactgat gcatttatgg acacctgttt ccagtcaggt ggggtctcca
     1501 gagaaactca aaccagtggg atagaaagtc caacggatga ccatgtacag atggaccaag
     1561 ctggaatgtg cggagacatt tttgagagtg ttcattcatc atataatgtt gctacaggta
     1621 acattataag caacagttta gtagcagaga cagtaactca tagtttgtta cctcagaatg
     1681 agcctaagac tttaaatcaa gatattgaga aatctgcacc aattataaat ttcagtgcac
     1741 agaatagtat gcttccttca cagaacatga cagataatca gacccaaacc atagatttat
     1801 taagtgattt ggaaaacatc ttgtcaagta atctgcctgc tcagacattg gatcatcgta
     1861 gtcttttgtc tgacacaaat cctggacctg acacccagct cccatctggc ccagcccaga
     1921 accccggaat cgattttgat atcgaagagt tcttttcggc ctcaaatatc cagactcaaa
     1981 ctgaagagag tgaacttagc accatgacca ccgagccagt cttggagtca ctggacatag
     2041 agactcaaac ggacttctta ctcgcagata cctctgctca gtcctatggg tgtaggggaa
     2101 attctaactt cttaggcctt gagatgtttg acacacagac acagacagac ttaaactttt
     2161 tcttagacag tagccctcat ctgcctctgg gaagtattct gaaacactcc agcttttccg
     2221 tgagtactga ttcatctgac acagagaccc aaactgaagg agtctccact gctaaaaata
     2281 tacctgctct agaaagcaaa gttcagttga acagtacaga aacacagacc atgagttctg
     2341 ggtttgaaac cctggggagc ttgttcttca ccagcaacga aactcagaca gcaatggatg
     2401 actttcttct ggctgatctg gcctggaaca cgatggagtc tcagttcagc tctgtagaaa
     2461 cccagacttc tgcggaacca cacacagtct ccaacttcta aaactaacgg tggagtccat
     2521 gtgtgaaatg gcatctacca tttcctctgg attaaaacta cggactgggg acaacagtat
     2581 taattcgatt gaatgtggct gatgatgcag ttgcttagct tctttgtgtt tctttgcctt
     2641 ttgtacttgt aaacagaaat ttgcgtataa atgtgagtgt attataaagt ttgagatgtt
     2701 gatctaaatt gtttttgtgt tgcctacatt tgccttttca cagctagtct tttcatgtta
     2761 aaaaaaaaaa tgtatttcat atctataaaa cctatatagc catttagctg aagcccagct
     2821 taccaggttc aagggtacaa acttctcaaa tcttcaaaac attttagtca aagtgtaata
     2881 tacttaaact gcacctaaaa tatctttggc actgcttgtt agaaattcct gattcctgtt
     2941 actaatcact aaagaaaccg gatgctgcca ccgtaggatt taagcagtag tgcttccatg
     3001 ctcttaagac tcctgctgcc tggaccttcg tcagctttga cacctctttt ctgatttaaa
     3061 gacaccaagg aaaactacaa ctgtctttag ctttgaagca gttttcatgt aatcattgcc
     3121 acctcttcgc tacatgaact actattgata ccagcataca agtgtacagc actttacaca
     3181 caagaggttt attgatgtaa aattatcggc tagggaagca gcagcgggcc aggtgtggtg
     3241 gcttacccct gtaatcccag cactttggga ggccaaagca ggacgatcac ttgagcccag
     3301 gagttcaaca ccagcttggg caacgtaaga agaccgtgtc tctggaattt tttttttttt
     3361 ttaattagcc aggcacagtg gcatgcgcct gtgatcccag ctacttggaa ggctgaggtg
     3421 agaggatcac tcgaggagat tggggctgcc atgagccatg gtcttggcac tgtactccaa
     3481 cctgggtaac agggcaagac cctatctcaa aaaaaaaaaa agtcgccagc aacaagcacg
     3541 tagtgtagtg ttcctgctaa atgagcgtag gttatccaaa ccttgggaac agggagttat
     3601 ggaaacatgc ctatgacttc atcttggggt gtgtcctatg aagatccttt ctggtctcca
     3661 cagtaggcca gagttggggg ctctggagct gtttccccaa gtgcatccac aagctggatc
     3721 tgagttttgt cactctaaaa ttaaacaaga aaaaaagtgg gaaaagggca tcccccatta
     3781 ggtttcaata ctttgcactt ctactaagct tgatagggca ggagtgcaat ctacaattat
     3841 tttaaagtga atttccttcc attcaccatt ctttatcttt tctttgaata agaaaaagta
     3901 tctagcaagg atattacttg tgccttgagg ctagcaatta taggatagat tcatctaaaa
     3961 tatggtattc tgcattttgg ttttttttct taagtgaata ataccagtct tcaaagaaaa
     4021 caaggtgaag acctattgct tcaataatca agaatgcttt gtgtgttttg aggtaggagc
     4081 atgatcaagt atgctttggg gattttctgt atttaggaga tcctggattc ttaattgttg
     4141 gctaagttcc agtcaagtag gaatcagtgc agcctgtaag ttctccacat tgacacacac
     4201 acacacacac acacacacac acgacatgct cctttctgtg gcacatgcct gtattactga
     4261 aagctaaatc ctcaaaacct agtaagggga ctaatgattc attaaagtaa attgatggtt
     4321 ttgctactaa ttcctatccc atacatttga cacaaaagaa gtgttggtaa tggataaata
     4381 acatatcccg ggcagatgag ctcaacctag taggtaagag tttggtttgg tcacagttgc
     4441 ctatgagtgt gggtttcaaa agaaacataa agccttaact tagaatttca ttatgtttta
     4501 gaatcatcac tgccttaata ttcaagcatc tatttaagtc ctaataaagg agaaatgcat
     4561 gtttatggct tttttgtaaa tataaatgca gtgatctatg gcttaaaaaa tttgtttctg
     4621 tgacaatgtt tgtaaatcta gccaatagag tcatttacag aagaaaaatg agcatgtaat
     4681 aatacaagaa ctgtttcccc ctcaaaacct gaacctgaat tatttgtaaa aactgaaatt
     4741 taatgattaa agagaagcca gaattgtacc cttttttgtg aattcttgaa cgtactcata
     4801 aatatgactt attgtattgc cttaagtttt cactcattgt cttttgaaag ccatatgata
     4861 aaatgatttt atttaataat a
//
