LOCUS       NM_000051              12915 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ATM serine/threonine kinase (ATM), transcript variant
            2, mRNA.
ACCESSION   NM_000051
VERSION     NM_000051.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12915)
  AUTHORS   Lim,B., Matsui,Y., Jung,S., Djekidel,M.N., Qi,W., Yuan,Z.F.,
            Wang,X., Yang,X., Connolly,N., Pilehroud,A.S., Pan,H., Wang,F.,
            Pruett-Miller,S.M., Kavdia,K., Pagala,V., Fan,Y., Peng,J., Xu,B.
            and Peng,J.C.
  TITLE     Phosphorylation of the DNA damage repair factor 53BP1 by ATM kinase
            controls neurodevelopmental programs in cortical brain organoids
  JOURNAL   PLoS Biol 22 (9), e3002760 (2024)
   PUBMED   39226322
  REMARK    GeneRIF: Phosphorylation of the DNA damage repair factor 53BP1 by
            ATM kinase controls neurodevelopmental programs in cortical brain
            organoids.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12915)
  AUTHORS   Laverty,D.J., Gupta,S.K., Bradshaw,G.A., Hunter,A.S., Carlson,B.L.,
            Calmo,N.M., Chen,J., Tian,S., Sarkaria,J.N. and Nagel,Z.D.
  TITLE     ATM inhibition exploits checkpoint defects and ATM-dependent double
            strand break repair in TP53-mutant glioblastoma
  JOURNAL   Nat Commun 15 (1), 5294 (2024)
   PUBMED   38906885
  REMARK    GeneRIF: ATM inhibition exploits checkpoint defects and
            ATM-dependent double strand break repair in TP53-mutant
            glioblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12915)
  AUTHORS   Geng,A., Sun,J., Tang,H., Yu,Y., Wang,X., Zhang,J., Wang,X.,
            Sun,X., Zhou,X., Gao,N., Tan,R., Xu,Z., Jiang,Y. and Mao,Z.
  TITLE     SIRT2 promotes base excision repair by transcriptionally activating
            OGG1 in an ATM/ATR-dependent manner
  JOURNAL   Nucleic Acids Res 52 (9), 5107-5120 (2024)
   PUBMED   38554113
  REMARK    GeneRIF: SIRT2 promotes base excision repair by transcriptionally
            activating OGG1 in an ATM/ATR-dependent manner.
REFERENCE   4  (bases 1 to 12915)
  AUTHORS   Biller,M., Kabir,S., Boado,C., Nipper,S., Saffa,A., Tal,A.,
            Allen,S., Sasanuma,H., Dreau,D., Vaziri,C. and Tomida,J.
  TITLE     REV7-p53 interaction inhibits ATM-mediated DNA damage signaling
  JOURNAL   Cell Cycle 23 (4), 339-352 (2024)
   PUBMED   38557443
  REMARK    GeneRIF: REV7-p53 interaction inhibits ATM-mediated DNA damage
            signaling.
REFERENCE   5  (bases 1 to 12915)
  AUTHORS   Morrow,D.M., Tagle,D.A., Shiloh,Y., Collins,F.S. and Hieter,P.
  TITLE     TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia
            telangiectasia, is functionally related to the yeast checkpoint
            gene MEC1
  JOURNAL   Cell 82 (5), 831-840 (1995)
   PUBMED   7545545
REFERENCE   6  (bases 1 to 12915)
  AUTHORS   Veenhuis,S., van Os,N., Weemaes,C., Kamsteeg,E.J. and Willemsen,M.
  TITLE     Ataxia-Telangiectasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301790
REFERENCE   7  (bases 1 to 12915)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
REFERENCE   8  (bases 1 to 12915)
  AUTHORS   Hyams,J.S., Treem,W.R., Carey,D.E., Wyzga,N., Eddy,E.,
            Goldberg,B.D. and Moore,R.E.
  TITLE     Comparison of collagen propeptides as growth markers in children
            with inflammatory bowel disease
  JOURNAL   Gastroenterology 100 (4), 971-975 (1991)
   PUBMED   2001833
REFERENCE   9  (bases 1 to 12915)
  AUTHORS   Curry,C.J., O'Lague,P., Tsai,J., Hutchison,H.T., Jaspers,N.G.,
            Wara,D. and Gatti,R.A.
  TITLE     ATFresno: a phenotype linking ataxia-telangiectasia with the
            Nijmegen breakage syndrome
  JOURNAL   Am J Hum Genet 45 (2), 270-275 (1989)
   PUBMED   2491181
  REMARK    Erratum:[Am J Hum Genet 1989 Oct;45(4):663. Hutchinson HT
            [corrected to Hutchison HT]]
REFERENCE   10 (bases 1 to 12915)
  AUTHORS   Gatti,R.A., Berkel,I., Boder,E., Braedt,G., Charmley,P.,
            Concannon,P., Ersoy,F., Foroud,T., Jaspers,N.G., Lange,K. et al.
  TITLE     Localization of an ataxia-telangiectasia gene to chromosome
            11q22-23
  JOURNAL   Nature 336 (6199), 577-580 (1988)
   PUBMED   3200306
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001925.5, U33841.1, X91196.1,
            U26455.1 and AP005718.3.
            
            On Feb 27, 2020 this sequence version replaced NM_000051.3.
            
            Summary: The protein encoded by this gene belongs to the
            PI3/PI4-kinase family. This protein is an important cell cycle
            checkpoint kinase that phosphorylates; thus, it functions as a
            regulator of a wide variety of downstream proteins, including tumor
            suppressor proteins p53 and BRCA1, checkpoint kinase CHK2,
            checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1.
            This protein and the closely related kinase ATR are thought to be
            master controllers of cell cycle checkpoint signaling pathways that
            are required for cell response to DNA damage and for genome
            stability. Mutations in this gene are associated with ataxia
            telangiectasia, an autosomal recessive disorder. [provided by
            RefSeq, Aug 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1989742.1,
                                           SRR11853565.5862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000675843.1/ ENSP00000501606.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AP001925.5         57110-57229
            121-1809            U33841.1           160-1848
            1810-2409           X91196.1           2393-2992
            2410-7607           U33841.1           2449-7646
            7608-9156           U26455.1           3673-5221
            9157-12912          AP005718.3         41453-45208
            12913-12915         AP005718.3         45209-45211
FEATURES             Location/Qualifiers
     source          1..12915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..12915
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /note="ATM serine/threonine kinase"
                     /db_xref="GeneID:472"
                     /db_xref="HGNC:HGNC:795"
                     /db_xref="MIM:607585"
     exon            1..120
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            121..222
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..9321
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 2; TEL1,
                     telomere maintenance 1, homolog; AT mutated;
                     serine-protein kinase ATM; A-T mutated; ataxia
                     telangiectasia mutated; serine/threonine kinase ATM"
                     /codon_start=1
                     /product="serine-protein kinase ATM isoform a"
                     /protein_id="NP_000042.3"
                     /db_xref="CCDS:CCDS31669.1"
                     /db_xref="GeneID:472"
                     /db_xref="HGNC:HGNC:795"
                     /db_xref="MIM:607585"
                     /translation="MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLD
                     RHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVK
                     YFIKCANRRAPRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEIS
                     QQQWLELFSVYFRLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQ
                     CARQEKSSSGLNHILAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLK
                     EVIIELFQLQIYIHHPKGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRGKYSS
                     GFRNIAVKENLIELMADICHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIELG
                     WEVIKDHLQKSQNDFDLVPWLQIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGE
                     RTPYVLRCLTEVALCQDKRSNLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLL
                     GAIIQGSLVEVDREFWKLFTGSACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEV
                     NRSFSLKESIMKWLLFYQLEGDLENSTEVPPILHSNFPHLVLEKILVSLTMKNCKAAM
                     NFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVRECGIEKHQSSIGFSV
                     HQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSRLLVGVLGCYCYMGVIAEEEA
                     YKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMMQLCTRCLSNCTKKSPNKI
                     ASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMEDDTNGNLMEVEDQSSMN
                     LFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDMLKFLCLCVTTAQTN
                     TVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYPLPMEDVLELLKP
                     LSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVIGAFWHLTK
                     ERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLADNHHQVRML
                     AAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAENPETLDE
                     IYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSETFGYR
                     RLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLVIR
                     SHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYD
                     MLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNP
                     PHFPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKH
                     RILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLC
                     CDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDN
                     ENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTR
                     LEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVL
                     EAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDC
                     VKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKEN
                     PFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVL
                     PYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCC
                     LDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYA
                     EIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPD
                     SLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLC
                     HILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNAL
                     QSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFS
                     RSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK
                     DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQS
                     LALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKA
                     VEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKE
                     EVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEH
                     DMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFH
                     EVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDE
                     DRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPIT
                     KLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKER
                     RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWC
                     TGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQ
                     PVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELV
                     HIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQET
                     LLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSF
                     NKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV"
     exon            223..335
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..481
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..646
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..812
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1051
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1215
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1385
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1757
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1952
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2048
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2274
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2400
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2526
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2616
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2788
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2988
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3071
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3227
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3303
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3434
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3552
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3726
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3896
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3897..4143
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4144..4259
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4260..4386
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4387..4586
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4587..4761
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4762..4926
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4927..5059
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5060..5155
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5156..5327
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5328..5469
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5470..5646
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5647..5824
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5825..5912
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5913..6068
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            6069..6156
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            6157..6245
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            6246..6348
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            6349..6497
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            6498..6602
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            6603..6722
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            6723..6957
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            6958..7125
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            7126..7239
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            7240..7457
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            7458..7665
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            7666..7779
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            7780..7938
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            7939..8077
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            8078..8160
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            8161..8301
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            8302..8418
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            8419..8568
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            8569..8734
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            8735..8821
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            8822..8936
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            8937..9000
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            9001..9137
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            9138..12915
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12894..12899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /note="hexamer: AATAAA"
     polyA_site      12915
                     /gene="ATM"
                     /gene_synonym="AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1"
                     /note="major polyA site"
ORIGIN      
        1 aggtagctgc gtggctaacg gagaaaagaa gccgtggccg cgggaggagg cgagaggagt
       61 cgggatctgc gctgcagcca ccgccgcggt tgatactact ttgaccttcc gagtgcagtg
      121 acagtgatgt gtgttctgaa attgtgaacc atgagtctag tacttaatga tctgcttatc
      181 tgctgccgtc aactagaaca tgatagagct acagaacgaa agaaagaagt tgagaaattt
      241 aagcgcctga ttcgagatcc tgaaacaatt aaacatctag atcggcattc agattccaaa
      301 caaggaaaat atttgaattg ggatgctgtt tttagatttt tacagaaata tattcagaaa
      361 gaaacagaat gtctgagaat agcaaaacca aatgtatcag cctcaacaca agcctccagg
      421 cagaaaaaga tgcaggaaat cagtagtttg gtcaaatact tcatcaaatg tgcaaacaga
      481 agagcaccta ggctaaaatg tcaagaactc ttaaattata tcatggatac agtgaaagat
      541 tcatctaatg gtgctattta cggagctgat tgtagcaaca tactactcaa agacattctt
      601 tctgtgagaa aatactggtg tgaaatatct cagcaacagt ggttagaatt gttctctgtg
      661 tacttcaggc tctatctgaa accttcacaa gatgttcata gagttttagt ggctagaata
      721 attcatgctg ttaccaaagg atgctgttct cagactgacg gattaaattc caaatttttg
      781 gacttttttt ccaaggctat tcagtgtgcg agacaagaaa agagctcttc aggtctaaat
      841 catatcttag cagctcttac tatcttcctc aagactttgg ctgtcaactt tcgaattcga
      901 gtgtgtgaat taggagatga aattcttccc actttgcttt atatttggac tcaacatagg
      961 cttaatgatt ctttaaaaga agtcattatt gaattatttc aactgcaaat ttatatccat
     1021 catccgaaag gagccaaaac ccaagaaaaa ggtgcttatg aatcaacaaa atggagaagt
     1081 attttataca acttatatga tctgctagtg aatgagataa gtcatatagg aagtagagga
     1141 aagtattctt caggatttcg taatattgcc gtcaaagaaa atttgattga attgatggca
     1201 gatatctgtc accaggtttt taatgaagat accagatcct tggagatttc tcaatcttac
     1261 actactacac aaagagaatc tagtgattac agtgtccctt gcaaaaggaa gaaaatagaa
     1321 ctaggctggg aagtaataaa agatcacctt cagaagtcac agaatgattt tgatcttgtg
     1381 ccttggctac agattgcaac ccaattaata tcaaagtatc ctgcaagttt acctaactgt
     1441 gagctgtctc cattactgat gatactatct cagcttctac cccaacagcg acatggggaa
     1501 cgtacaccat atgtgttacg atgccttacg gaagttgcat tgtgtcaaga caagaggtca
     1561 aacctagaaa gctcacaaaa gtcagattta ttaaaactct ggaataaaat ttggtgtatt
     1621 acctttcgtg gtataagttc tgagcaaata caagctgaaa actttggctt acttggagcc
     1681 ataattcagg gtagtttagt tgaggttgac agagaattct ggaagttatt tactgggtca
     1741 gcctgcagac cttcatgtcc tgcagtatgc tgtttgactt tggcactgac caccagtata
     1801 gttccaggaa cggtaaaaat gggaatagag caaaatatgt gtgaagtaaa tagaagcttt
     1861 tctttaaagg aatcaataat gaaatggctc ttattctatc agttagaggg tgacttagaa
     1921 aatagcacag aagtgcctcc aattcttcac agtaattttc ctcatcttgt actggagaaa
     1981 attcttgtga gtctcactat gaaaaactgt aaagctgcaa tgaatttttt ccaaagcgtg
     2041 ccagaatgtg aacaccacca aaaagataaa gaagaacttt cattctcaga agtagaagaa
     2101 ctatttcttc agacaacttt tgacaagatg gactttttaa ccattgtgag agaatgtggt
     2161 atagaaaagc accagtccag tattggcttc tctgtccacc agaatctcaa ggaatcactg
     2221 gatcgctgtc ttctgggatt atcagaacag cttctgaata attactcatc tgagattaca
     2281 aattcagaaa ctcttgtccg gtgttcacgt cttttggtgg gtgtccttgg ctgctactgt
     2341 tacatgggtg taatagctga agaggaagca tataagtcag aattattcca gaaagccaag
     2401 tctctaatgc aatgtgcagg agaaagtatc actctgttta aaaataagac aaatgaggaa
     2461 ttcagaattg gttccttgag aaatatgatg cagctatgta cacgttgctt gagcaactgt
     2521 accaagaaga gtccaaataa gattgcatct ggctttttcc tgcgattgtt aacatcaaag
     2581 ctaatgaatg acattgcaga tatttgtaaa agtttagcat ccttcatcaa aaagccattt
     2641 gaccgtggag aagtagaatc aatggaagat gatactaatg gaaatctaat ggaggtggag
     2701 gatcagtcat ccatgaatct atttaacgat taccctgata gtagtgttag tgatgcaaac
     2761 gaacctggag agagccaaag taccataggt gccattaatc ctttagctga agaatatctg
     2821 tcaaagcaag atctactttt cttagacatg ctcaagttct tgtgtttgtg tgtaactact
     2881 gctcagacca atactgtgtc ctttagggca gctgatattc ggaggaaatt gttaatgtta
     2941 attgattcta gcacgctaga acctaccaaa tccctccacc tgcatatgta tctaatgctt
     3001 ttaaaggagc ttcctggaga agagtacccc ttgccaatgg aagatgttct tgaacttctg
     3061 aaaccactat ccaatgtgtg ttctttgtat cgtcgtgacc aagatgtttg taaaactatt
     3121 ttaaaccatg tccttcatgt agtgaaaaac ctaggtcaaa gcaatatgga ctctgagaac
     3181 acaagggatg ctcaaggaca gtttcttaca gtaattggag cattttggca tctaacaaag
     3241 gagaggaaat atatattctc tgtaagaatg gccctagtaa attgccttaa aactttgctt
     3301 gaggctgatc cttattcaaa atgggccatt cttaatgtaa tgggaaaaga ctttcctgta
     3361 aatgaagtat ttacacaatt tcttgctgac aatcatcacc aagttcgcat gttggctgca
     3421 gagtcaatca atagattgtt ccaggacacg aagggagatt cttccaggtt actgaaagca
     3481 cttcctttga agcttcagca aacagctttt gaaaatgcat acttgaaagc tcaggaagga
     3541 atgagagaaa tgtcccatag tgctgagaac cctgaaactt tggatgaaat ttataataga
     3601 aaatctgttt tactgacgtt gatagctgtg gttttatcct gtagccctat ctgcgaaaaa
     3661 caggctttgt ttgccctgtg taaatctgtg aaagagaatg gattagaacc tcaccttgtg
     3721 aaaaaggttt tagagaaagt ttctgaaact tttggatata gacgtttaga agactttatg
     3781 gcatctcatt tagattatct ggttttggaa tggctaaatc ttcaagatac tgaatacaac
     3841 ttatcttctt ttccttttat tttattaaac tacacaaata ttgaggattt ctatagatct
     3901 tgttataagg ttttgattcc acatctggtg attagaagtc attttgatga ggtgaagtcc
     3961 attgctaatc agattcaaga ggactggaaa agtcttctaa cagactgctt tccaaagatt
     4021 cttgtaaata ttcttcctta ttttgcctat gagggtacca gagacagtgg gatggcacag
     4081 caaagagaga ctgctaccaa ggtctatgat atgcttaaaa gtgaaaactt attgggaaaa
     4141 cagattgatc acttattcat tagtaattta ccagagattg tggtggagtt attgatgacg
     4201 ttacatgagc cagcaaattc tagtgccagt cagagcactg acctctgtga cttttcaggg
     4261 gatttggatc ctgctcctaa tccacctcat tttccatcgc atgtgattaa agcaacattt
     4321 gcctatatca gcaattgtca taaaaccaag ttaaaaagca ttttagaaat tctttccaaa
     4381 agccctgatt cctatcagaa aattcttctt gccatatgtg agcaagcagc tgaaacaaat
     4441 aatgtttata agaagcacag aattcttaaa atatatcacc tgtttgttag tttattactg
     4501 aaagatataa aaagtggctt aggaggagct tgggcctttg ttcttcgaga cgttatttat
     4561 actttgattc actatatcaa ccaaaggcct tcttgtatca tggatgtgtc attacgtagc
     4621 ttctcccttt gttgtgactt attaagtcag gtttgccaga cagccgtgac ttactgtaag
     4681 gatgctctag aaaaccatct tcatgttatt gttggtacac ttatacccct tgtgtatgag
     4741 caggtggagg ttcagaaaca ggtattggac ttgttgaaat acttagtgat agataacaag
     4801 gataatgaaa acctctatat cacgattaag cttttagatc cttttcctga ccatgttgtt
     4861 tttaaggatt tgcgtattac tcagcaaaaa atcaaataca gtagaggacc cttttcactc
     4921 ttggaggaaa ttaaccattt tctctcagta agtgtttatg atgcacttcc attgacaaga
     4981 cttgaaggac taaaggatct tcgaagacaa ctggaactac ataaagatca gatggtggac
     5041 attatgagag cttctcagga taatccgcaa gatgggatta tggtgaaact agttgtcaat
     5101 ttgttgcagt tatccaagat ggcaataaac cacactggtg aaaaagaagt tctagaggct
     5161 gttggaagct gcttgggaga agtgggtcct atagatttct ctaccatagc tatacaacat
     5221 agtaaagatg catcttatac caaggccctt aagttatttg aagataaaga acttcagtgg
     5281 accttcataa tgctgaccta cctgaataac acactggtag aagattgtgt caaagttcga
     5341 tcagcagctg ttacctgttt gaaaaacatt ttagccacaa agactggaca tagtttctgg
     5401 gagatttata agatgacaac agatccaatg ctggcctatc tacagccttt tagaacatca
     5461 agaaaaaagt ttttagaagt acccagattt gacaaagaaa acccttttga aggcctggat
     5521 gatataaatc tgtggattcc tctaagtgaa aatcatgaca tttggataaa gacactgact
     5581 tgtgcttttt tggacagtgg aggcacaaaa tgtgaaattc ttcaattatt aaagccaatg
     5641 tgtgaagtga aaactgactt ttgtcagact gtacttccat acttgattca tgatatttta
     5701 ctccaagata caaatgaatc atggagaaat ctgctttcta cacatgttca gggatttttc
     5761 accagctgtc ttcgacactt ctcgcaaacg agccgatcca caacccctgc aaacttggat
     5821 tcagagtcag agcacttttt ccgatgctgt ttggataaaa aatcacaaag aacaatgctt
     5881 gctgttgtgg actacatgag aagacaaaag agaccttctt caggaacaat ttttaatgat
     5941 gctttctggc tggatttaaa ttatctagaa gttgccaagg tagctcagtc ttgtgctgct
     6001 cactttacag ctttactcta tgcagaaatc tatgcagata agaaaagtat ggatgatcaa
     6061 gagaaaagaa gtcttgcatt tgaagaagga agccagagta caactatttc tagcttgagt
     6121 gaaaaaagta aagaagaaac tggaataagt ttacaggatc ttctcttaga aatctacaga
     6181 agtatagggg agccagatag tttgtatggc tgtggtggag ggaagatgtt acaacccatt
     6241 actagactac gaacatatga acacgaagca atgtggggca aagccctagt aacatatgac
     6301 ctcgaaacag caatcccctc atcaacacgc caggcaggaa tcattcaggc cttgcagaat
     6361 ttgggactct gccatattct ttccgtctat ttaaaaggat tggattatga aaataaagac
     6421 tggtgtcctg aactagaaga acttcattac caagcagcat ggaggaatat gcagtgggac
     6481 cattgcactt ccgtcagcaa agaagtagaa ggaaccagtt accatgaatc attgtacaat
     6541 gctctacaat ctctaagaga cagagaattc tctacatttt atgaaagtct caaatatgcc
     6601 agagtaaaag aagtggaaga gatgtgtaag cgcagccttg agtctgtgta ttcgctctat
     6661 cccacactta gcaggttgca ggccattgga gagctggaaa gcattgggga gcttttctca
     6721 agatcagtca cacatagaca actctctgaa gtatatatta agtggcagaa acactcccag
     6781 cttctcaagg acagtgattt tagttttcag gagcctatca tggctctacg cacagtcatt
     6841 ttggagatcc tgatggaaaa ggaaatggac aactcacaaa gagaatgtat taaggacatt
     6901 ctcaccaaac accttgtaga actctctata ctggccagaa ctttcaagaa cactcagctc
     6961 cctgaaaggg caatatttca aattaaacag tacaattcag ttagctgtgg agtctctgag
     7021 tggcagctgg aagaagcaca agtattctgg gcaaaaaagg agcagagtct tgccctgagt
     7081 attctcaagc aaatgatcaa gaagttggat gccagctgtg cagcgaacaa tcccagccta
     7141 aaacttacat acacagaatg tctgagggtt tgtggcaact ggttagcaga aacgtgctta
     7201 gaaaatcctg cggtcatcat gcagacctat ctagaaaagg cagtagaagt tgctggaaat
     7261 tatgatggag aaagtagtga tgagctaaga aatggaaaaa tgaaggcatt tctctcatta
     7321 gcccggtttt cagatactca ataccaaaga attgaaaact acatgaaatc atcggaattt
     7381 gaaaacaagc aagctctcct gaaaagagcc aaagaggaag taggtctcct tagggaacat
     7441 aaaattcaga caaacagata cacagtaaag gttcagcgag agctggagtt ggatgaatta
     7501 gccctgcgtg cactgaaaga ggatcgtaaa cgcttcttat gtaaagcagt tgaaaattat
     7561 atcaactgct tattaagtgg agaagaacat gatatgtggg tattccgact ttgttccctc
     7621 tggcttgaaa attctggagt ttctgaagtc aatggcatga tgaagagaga cggaatgaag
     7681 attccaacat ataaattttt gcctcttatg taccaattgg ctgctagaat ggggaccaag
     7741 atgatgggag gcctaggatt tcatgaagtc ctcaataatc taatctctag aatttcaatg
     7801 gatcaccccc atcacacttt gtttattata ctggccttag caaatgcaaa cagagatgaa
     7861 tttctgacta aaccagaggt agccagaaga agcagaataa ctaaaaatgt gcctaaacaa
     7921 agctctcagc ttgatgagga tcgaacagag gctgcaaata gaataatatg tactatcaga
     7981 agtaggagac ctcagatggt cagaagtgtt gaggcacttt gtgatgctta tattatatta
     8041 gcaaacttag atgccactca gtggaagact cagagaaaag gcataaatat tccagcagac
     8101 cagccaatta ctaaacttaa gaatttagaa gatgttgttg tccctactat ggaaattaag
     8161 gtggaccaca caggagaata tggaaatctg gtgactatac agtcatttaa agcagaattt
     8221 cgcttagcag gaggtgtaaa tttaccaaaa ataatagatt gtgtaggttc cgatggcaag
     8281 gagaggagac agcttgttaa gggccgtgat gacctgagac aagatgctgt catgcaacag
     8341 gtcttccaga tgtgtaatac attactgcag agaaacacgg aaactaggaa gaggaaatta
     8401 actatctgta cttataaggt ggttcccctc tctcagcgaa gtggtgttct tgaatggtgc
     8461 acaggaactg tccccattgg tgaatttctt gttaacaatg aagatggtgc tcataaaaga
     8521 tacaggccaa atgatttcag tgcctttcag tgccaaaaga aaatgatgga ggtgcaaaaa
     8581 aagtcttttg aagagaaata tgaagtcttc atggatgttt gccaaaattt tcaaccagtt
     8641 ttccgttact tctgcatgga aaaattcttg gatccagcta tttggtttga gaagcgattg
     8701 gcttatacgc gcagtgtagc tacttcttct attgttggtt acatacttgg acttggtgat
     8761 agacatgtac agaatatctt gataaatgag cagtcagcag aacttgtaca tatagatcta
     8821 ggtgttgctt ttgaacaggg caaaatcctt cctactcctg agacagttcc ttttagactc
     8881 accagagata ttgtggatgg catgggcatt acgggtgttg aaggtgtctt cagaagatgc
     8941 tgtgagaaaa ccatggaagt gatgagaaac tctcaggaaa ctctgttaac cattgtagag
     9001 gtccttctat atgatccact ctttgactgg accatgaatc ctttgaaagc tttgtattta
     9061 cagcagaggc cggaagatga aactgagctt caccctactc tgaatgcaga tgaccaagaa
     9121 tgcaaacgaa atctcagtga tattgaccag agtttcaaca aagtagctga acgtgtctta
     9181 atgagactac aagagaaact gaaaggagtg gaagaaggca ctgtgctcag tgttggtgga
     9241 caagtgaatt tgctcataca gcaggccata gaccccaaaa atctcagccg acttttccca
     9301 ggatggaaag cttgggtgtg atcttcagta tatgaattac cctttcattc agcctttaga
     9361 aattatattt tagcctttat ttttaacctg ccaacatact ttaagtaggg attaatattt
     9421 aagtgaacta ttgtgggttt ttttgaatgt tggttttaat acttgattta atcaccactc
     9481 aaaaatgttt tgatggtctt aaggaacatc tctgctttca ctctttagaa ataatggtca
     9541 ttcgggctgg gcgcagcggc tcacgcctgt aatcccagca ctttgggagg ccgaggtgag
     9601 cggatcacaa ggtcaggagt tcgagaccag cctggccaag agaccagcct ggccagtatg
     9661 gtgaaaccct gtctctacta aaaatacaaa aattagccga gcatggtggc gggcacctgt
     9721 aatcccagct actcgagagg ctgaggcagg agaatctctt gaacctggga ggtgaaggtt
     9781 gctgtgggcc aaaatcatgc cattgcactc cagcctgggt gacaagagcg aaactccatc
     9841 tcaaaaaaaa aaaaaaaaaa acagaaacgt atttggattt ttcctagtaa gatcactcag
     9901 tgttactaaa taatgaagtt gttatggaga acaaatttca aagacacagt tagtgtagtt
     9961 actatttttt taagtgtgta ttaaaacttc tcattctatt ctctttatct tttaagccct
    10021 tctgtactgt ccatgtatgt tatctttctg tgataacttc atagattgcc ttctagttca
    10081 tgaattctct tgtcagatgt atataatctc ttttacccta tccattgggc ttcttctttc
    10141 agaaattgtt tttcatttct aattatgcat catttttcag atctctgttt cttgatgtca
    10201 tttttaatgt ttttttaatg ttttttatgt cactaattat tttaaatgtc tgtacttgat
    10261 agacactgta atagttctat taaatttagt tcctgctgtt tatatctgtt gatttttgta
    10321 tttgataggc tgttcatcca gttttgtctt tttgaaaagt gagtttattt tcagcaaggc
    10381 tttatctatg ggaatcttga gtgtctgttt atgtcatatt cccagggctg ttgctgcaca
    10441 caagcccatt cttattttaa tttcttggct ttagggtttc catacctgaa gtgtagcata
    10501 aatactgata ggagatttcc caggccaagg caaacacact tcctcctcat ctccttgtgc
    10561 tagtgggcag aatatttgat tgatgccttt ttcactgaga gtataagctt ccatgtgtcc
    10621 cacctttatg gcaggggtgg aaggaggtac atttaattcc cactgcctgc ctttggcaag
    10681 ccctgggttc tttgctcccc atatagatgt ctaagctaaa agccgtgggt taatgagact
    10741 ggcaaattgt tccaggacag ctacagcatc agctcacata ttcacctctc tggtttttca
    10801 ttcccctcat ttttttctga gacagagtct tgctctgtca cccaggctgg agtgcagtgg
    10861 catgatctca gctcactgaa acctctgcct cctgggttca agcaattctc ctgcctcagc
    10921 ctcccgagta gctgggacta caggcgtgtg ccaacacgcc cggctaattt tttgtatttt
    10981 tattagagac ggagtttcac cgtgttagcc aggatggtct cgatcgcttg acctcgtgat
    11041 ccaccctcct cggcctccca aagtgctggg attacaggtg tgagccaccg cgcccggcct
    11101 cattcccctc atttttgacc gtaaggattt cccctttctt gtaagttctg ctatgtattt
    11161 aaaagaatgt tttctacatt ttatccagca tttctctgtg ttctgttgga agggaagggc
    11221 ttaggtatct agtttgatac ataggtagaa gtggaacatt tctctgtccc ccagctgtca
    11281 tcatataaga taaacatcag ataaaaagcc acctgaaagt aaaactactg actcgtgtat
    11341 tagtgagtat aatctcttct ccatccttag gaaaatgttc atcccagctg cggagattaa
    11401 caaatgggtg attgagcttt ctcctcgtat ttggaccttg aaggttatat aaattttttt
    11461 cttatgaaga gttggcattt ctttttattg ccaatggcag gcactcattc atatttgatc
    11521 tcctcacctt cccctcccct aaaaccaatc tccagaactt tttggactat aaatttcttg
    11581 gtttgacttc tggagaactg ttcagaatat tactttgcat ttcaaattac aaacttacct
    11641 tggtgtatct ttttcttaca agctgcctaa atgaatattt ggtatatatt ggtagtttta
    11701 ttactatagt aaatcaagga aatgcagtaa acttaaaatg tctttaagaa agccctgaaa
    11761 tcttcatggg tgaaattaga aattatcaac tagataatag tatagataaa tgaatttgta
    11821 gctaattctt gctagttgtt gcatccagag agctttgaat aacatcatta atctactctt
    11881 tagccttgca tggtatgcta tgaggctcct gttctgttca agtattctaa tcaatggctt
    11941 tgaaaagttt atcaaattta catacagatc acaagcctag gagaaataac taattcacag
    12001 atgacagaat taagattata aaagattttt tttttgtaat tttagtagag acagggttgc
    12061 cattgtattc cagccttggc gacagagcaa gactctgcct caaaaaaaaa aaaaaaaagg
    12121 ttttggcaag ctggaactct ttctgcaaat gactaagata gaaaactgcc aaggacaaat
    12181 gaggagtagt tagattttga aaatattaat catagaatag ttgttgtatg ctaagtcact
    12241 gacccatatt atgtacagca tttctgatct ttactttgca agattagtga tactatccca
    12301 atacactgct ggagaaatca gaatttggag aaataagttg tccaaggcaa gaagatagta
    12361 aattataagt acaagtgtaa tatggacagt atctaacttg aaaagatttc aggcgaaaag
    12421 aatctggggt ttgccagtca gttgctcaaa aggtcaatga aaaccaaata gtgaagctat
    12481 cagagaagct aataaattat agactgcttg aacagttgtg tccagattaa gggagataat
    12541 agctttccca ccctactttg tgcaggtcat acctccccaa agtgtttacc taatcagtag
    12601 gttcacaaac tcttggtcat tatagtatat gcctaaaatg tatgcactta ggaatgctaa
    12661 aaatttaaat atggtctaaa gcaaataaaa gcaaagagga aaaactttgg acagcgtaaa
    12721 gactagaata gtcttttaaa aagaaagcca gtatattggt ttgaaatata gagatgtgtc
    12781 ccaatttcaa gtattttaat tgcaccttaa tgaaattatc tattttctat agattttagt
    12841 actattgaat gtattacttt actgttacct gaatttatta taaagtgttt ttgaataaat
    12901 aattctaaaa gcata
//
