LOCUS       NM_001330458            3560 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens atlastin GTPase 2 (ATL2), transcript variant 3, mRNA.
ACCESSION   NM_001330458 NR_024191
VERSION     NM_001330458.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3560)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3560)
  AUTHORS   Crosby,D., Mikolaj,M.R., Nyenhuis,S.B., Bryce,S., Hinshaw,J.E. and
            Lee,T.H.
  TITLE     Reconstitution of human atlastin fusion activity reveals
            autoinhibition by the C terminus
  JOURNAL   J Cell Biol 221 (2) (2022)
   PUBMED   34817557
  REMARK    GeneRIF: Reconstitution of human atlastin fusion activity reveals
            autoinhibition by the C terminus.
REFERENCE   3  (bases 1 to 3560)
  AUTHORS   Liu,N., Zhao,H., Zhao,Y.G., Hu,J. and Zhang,H.
  TITLE     Atlastin 2/3 regulate ER targeting of the ULK1 complex to initiate
            autophagy
  JOURNAL   J Cell Biol 220 (7) (2021)
   PUBMED   33988678
  REMARK    GeneRIF: Atlastin 2/3 regulate ER targeting of the ULK1 complex to
            initiate autophagy.
REFERENCE   4  (bases 1 to 3560)
  AUTHORS   Zhao,G., Zhu,P.P., Renvoise,B., Maldonado-Baez,L., Park,S.H. and
            Blackstone,C.
  TITLE     Mammalian knock out cells reveal prominent roles for atlastin
            GTPases in ER network morphology
  JOURNAL   Exp Cell Res 349 (1), 32-44 (2016)
   PUBMED   27669642
REFERENCE   5  (bases 1 to 3560)
  AUTHORS   Wang,S., Tukachinsky,H., Romano,F.B. and Rapoport,T.A.
  TITLE     Cooperation of the ER-shaping proteins atlastin, lunapark, and
            reticulons to generate a tubular membrane network
  JOURNAL   Elife 5, e18605 (2016)
   PUBMED   27619977
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3560)
  AUTHORS   Morin-Leisk,J., Saini,S.G., Meng,X., Makhov,A.M., Zhang,P. and
            Lee,T.H.
  TITLE     An intramolecular salt bridge drives the soluble domain of
            GTP-bound atlastin into the postfusion conformation
  JOURNAL   J Cell Biol 195 (4), 605-615 (2011)
   PUBMED   22065636
  REMARK    GeneRIF: The role of GTP hydrolysis in the ATL2 fusion mechanism
            also needs to be tempered by the uncertainty of whether the
            behavior of the ATL2 soluble domain, observed herein, reflects the
            behavior of the full-length, membrane-anchored protein.
REFERENCE   7  (bases 1 to 3560)
  AUTHORS   Hu,J., Shibata,Y., Zhu,P.P., Voss,C., Rismanchi,N., Prinz,W.A.,
            Rapoport,T.A. and Blackstone,C.
  TITLE     A class of dynamin-like GTPases involved in the generation of the
            tubular ER network
  JOURNAL   Cell 138 (3), 549-561 (2009)
   PUBMED   19665976
REFERENCE   8  (bases 1 to 3560)
  AUTHORS   Rismanchi,N., Soderblom,C., Stadler,J., Zhu,P.P. and Blackstone,C.
  TITLE     Atlastin GTPases are required for Golgi apparatus and ER
            morphogenesis
  JOURNAL   Hum Mol Genet 17 (11), 1591-1604 (2008)
   PUBMED   18270207
  REMARK    GeneRIF: A family of human GTPases, atlastin-2 and -3 that are
            closely related to atlastin-1 are described.
REFERENCE   9  (bases 1 to 3560)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   10 (bases 1 to 3560)
  AUTHORS   Ingley,E., Williams,J.H., Walker,C.E., Tsai,S., Colley,S.,
            Sayer,M.S., Tilbrook,P.A., Sarna,M., Beaumont,J.G. and Klinken,S.P.
  TITLE     A novel ADP-ribosylation like factor (ARL-6), interacts with the
            protein-conducting channel SEC61beta subunit
  JOURNAL   FEBS Lett 459 (1), 69-74 (1999)
   PUBMED   10508919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016995.7, AK308894.1, BC053508.1 and BC039050.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001330458.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK303985.1, SRR14038196.1121092.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC016995.7         36967-37030
            65-901              AK308894.1         67-903
            902-1558            BC053508.1         891-1547
            1559-2629           BC039050.1         988-2058
            2630-3560           AC016995.7         119356-120286
FEATURES             Location/Qualifiers
     source          1..3560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2-p22.1"
     gene            1..3560
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="atlastin GTPase 2"
                     /db_xref="GeneID:64225"
                     /db_xref="HGNC:HGNC:24047"
                     /db_xref="MIM:609368"
     exon            1..131
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            132..266
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            267..371
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1520
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="isoform 4 is encoded by transcript variant 3;
                     ARL-6-interacting protein 2; ADP-ribosylation factor-like
                     protein 6-interacting protein 2"
                     /codon_start=1
                     /product="atlastin-2 isoform 4"
                     /protein_id="NP_001317387.1"
                     /db_xref="CCDS:CCDS86831.1"
                     /db_xref="GeneID:64225"
                     /db_xref="HGNC:HGNC:24047"
                     /db_xref="MIM:609368"
                     /translation="MDTQGAFDSQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQ
                     HLQLFTEYGRLAMEEIYQKPFQTLMFLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQ
                     HEELQNVRKHIHNCFSNLGCFLLPHPGLKVATNPSFDGRLKDIDEDFKRELRNLVPLL
                     LAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVAG
                     ARDTYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSVKKMGGDEFCRRYQDQ
                     LEAEIEETYANFIKHNDGKNIFYAARTPATLFAVMFAMYIISGLTGFIGLNSIAVLCN
                     LVMGLALIFLCTWAYVKYSGEFREIGTVIDQIAETLWEQVLKPLGDNLMEENIRQSVT
                     NSIKAGLTDQVSHHARLKTD"
     exon            372..422
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..479
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..572
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..711
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..839
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            840..896
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..968
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1400
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..3560
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2604..2609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="hexamer: ATTAAA"
     polyA_site      2629
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="major polyA site"
     regulatory      3389..3394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="hexamer: ATTAAA"
     polyA_site      3420
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
     regulatory      3532..3537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="hexamer: ATTAAA"
     polyA_site      3560
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
ORIGIN      
        1 aaatcggtac aagatggcgg agggggacga ggcagcgcga gggcagcaac cgcaccaggg
       61 gctgtggcgc cggcgacgga ccagcgaccc aagcgccgcg gttaaccacg tctcgtccac
      121 gacctcccta ggattctcaa agttggattg gtggaaacaa tgaaccattg acaggcttta
      181 catggcgagg tggctgtgaa agagaaacaa caggcataca agtttggaat gaagtatttg
      241 tgattgacag acctaatgga actaaagttg ctgtgctgct tatggatacc cagggtgcct
      301 ttgatagcca gtcaactatc aaagactgtg caacggtgtt tgctctgagc actatgacta
      361 gctctgtcca ggtatataat ctgtctcaga atattcaaga agatgatctt caacatttgc
      421 aattatttac agagtatgga agacttgcga tggaagaaat ctaccagaaa ccatttcaga
      481 cattaatgtt tttgattcga gattggagct atccttatga acattcatat ggtttggaag
      541 gtggaaagca atttcttgaa aagagattac aggtaaaaca aaatcaacat gaagagcttc
      601 agaatgtaag gaagcacata cacaattgtt tctcaaatct tggttgcttc cttttgccac
      661 atcctggtct taaagttgca actaatccta gttttgatgg gagattgaaa gatattgatg
      721 aagactttaa acgagagctt cgaaatctgg ttccattgct gcttgcccct gaaaatttgg
      781 tagaaaaaga gataagtgga tctaaagtca cttgtagaga tcttgtagaa tattttaagg
      841 cttacatcaa aatctatcaa ggagaagaac ttccacatcc aaagtccatg cttcaggcaa
      901 cagctgaagc taataatctt gctgcagtag caggagcaag agatacctat tgtaaaagta
      961 tggaacaggt atgtggaggg gacaagcctt acattgcacc ttcagatctg gagcgaaaac
     1021 acttggatct caaggaagtg gcgataaaac aatttcgttc agtaaaaaag atgggtggag
     1081 atgagttctg ccgtcgttat caggaccagc ttgaagctga aattgaagaa acctatgcaa
     1141 attttataaa gcacaatgat ggcaaaaata tcttctatgc tgctcgtacc ccagccacac
     1201 tgtttgcggt catgtttgct atgtatataa tctcaggact gactggcttc attggcctaa
     1261 actctatagc tgtcttgtgt aaccttgtca tggggttagc actgatattt ctttgtactt
     1321 gggcatatgt taaatactct ggggagttca gagaaattgg aacagtgatt gatcagattg
     1381 ctgaaacact atgggaacag gtattgaagc ccctgggtga taatttgatg gaggaaaaca
     1441 taaggcagtc tgtaacaaac tctatcaaag caggcctgac tgaccaggtg tctcatcatg
     1501 ccagattaaa gacagactga cagttcatct cctcacggac tccactctct ttttttttca
     1561 tgcttgctgt acaatgagaa ctcaaataaa aataaaccaa agtttacaat caactgtaga
     1621 agtagtttag tgtaactggc ttcacagatg gctgccacag agtgtgaaga ttgtttgtta
     1681 gttttaagca ttcttttaat ggctcctaag acatgcagat ggactgagga gcattggtta
     1741 atcatgcacc tttgtgccat gtttaactct tttatttctt tttacttaat ctaatgttag
     1801 tgaatttgtc ttatgtaaaa ggatatttca gggaaatatt ttcagaaatc tatttagagt
     1861 ctctttaaca cagtgtccca ttgaaatttt aatttttaga gaatttatga atcactgttt
     1921 caagaaccag attggaaaga caatgaagcc tttattgagc cactacatta aaagtatata
     1981 ttgctttact gccttcaata ccagtattac atcaatgcat gtatcagaaa cttcacagaa
     2041 attacatggc aactcttgta gctaagaaag taattctgag gtgtacattt gtcttgcctt
     2101 tttaaattta taaacttgcc ctaaaaggag atgcatatct gggaaactga actgtctttt
     2161 tgcagtttag ccttcatgta tataaaatat gccattaatt ttattgggga agaaattcca
     2221 tccaaaaatg ttgcctacag ctatgagtta agagtgtctg tacagtgtgt agcttttatt
     2281 ttctaaaatc acagataggg catgtatatg acttataaat atataaatac gattttgtat
     2341 taaaagtttt gtagtttatg gcaaaatctg gtcctgtggt aggctaaata agtactgtcc
     2401 ctgtgaaagg aatgtttgtg gctcatgtca gtgtgtgaat gcatagacaa tttgaagttt
     2461 ttgatatatt tgtgatattt atcttgagca ctgcaatctc accccccccc cgcccaccaa
     2521 gggaattcaa tgggaatgtt tattgtgact ttgtcctctg ttgcatttta aagttatttc
     2581 ctgtaattta ttttcagtac ataattaaaa atttgttgta tatataaaat gaaacttgtg
     2641 attctttttt aaggaatttt tcaagtatgt attccacttc ataaaccaca tttgtttata
     2701 gtgaaaagag catgagcagg aaacacccca gttgagagct ctaaggcatt gtacctcaaa
     2761 actaagcttg taaaaagtta cttttctgtg tctgtctcta taagggaaaa cctatgatta
     2821 gcctagttgt agatggggat tgttaatttc tttctctctc tttttttttt tttggtggta
     2881 tatgtaaggc tagcattttt tcagtacttt tgtggtcttc tttgtgaaca ccgattaaag
     2941 tacctagttt tgtttgtttc ttttttgaga cggagtctct ctctgtcacc caggctggag
     3001 tgcagtggtg cgatcttggc tcactgcaac ctccacctcc tgggttcaag tgattctccc
     3061 gcctcagcct cctgagtagc tgggactaca ggtgcgtgcc accattcccg gctaatgttt
     3121 tctattttaa gtagagatgg ggtttcaccg ttttagccag gatggtctca atcgcctgac
     3181 cttgtgatcc gcctgccttg gcctcccaaa gtgttgggat tacaggcgtg agccaccgcg
     3241 cccggccctt agtttgcttt ttaagcgaag agaatgcagg tgttgagttg catgtgtgaa
     3301 aactctgaat ttactttggt tgatacatct tcgctcccac tcccattcag attctgtttt
     3361 tatatggatt gtatttgttt tcatctgtat taaattgcta acttatctgt tcttaaagaa
     3421 tccacctgaa aagtgtcttt ttatttcttc tgccaccctg ttttatgaat gctgtggact
     3481 gttttttatg aatgaaaaaa taatttgttg tataatagca gattttctga aattaaagac
     3541 agcttacttt taaaaagtta
//
