LOCUS       NM_001135673            3805 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens atlastin GTPase 2 (ATL2), transcript variant 2, mRNA.
ACCESSION   NM_001135673
VERSION     NM_001135673.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3805)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3805)
  AUTHORS   Crosby,D., Mikolaj,M.R., Nyenhuis,S.B., Bryce,S., Hinshaw,J.E. and
            Lee,T.H.
  TITLE     Reconstitution of human atlastin fusion activity reveals
            autoinhibition by the C terminus
  JOURNAL   J Cell Biol 221 (2) (2022)
   PUBMED   34817557
  REMARK    GeneRIF: Reconstitution of human atlastin fusion activity reveals
            autoinhibition by the C terminus.
REFERENCE   3  (bases 1 to 3805)
  AUTHORS   Liu,N., Zhao,H., Zhao,Y.G., Hu,J. and Zhang,H.
  TITLE     Atlastin 2/3 regulate ER targeting of the ULK1 complex to initiate
            autophagy
  JOURNAL   J Cell Biol 220 (7) (2021)
   PUBMED   33988678
  REMARK    GeneRIF: Atlastin 2/3 regulate ER targeting of the ULK1 complex to
            initiate autophagy.
REFERENCE   4  (bases 1 to 3805)
  AUTHORS   Zhao,G., Zhu,P.P., Renvoise,B., Maldonado-Baez,L., Park,S.H. and
            Blackstone,C.
  TITLE     Mammalian knock out cells reveal prominent roles for atlastin
            GTPases in ER network morphology
  JOURNAL   Exp Cell Res 349 (1), 32-44 (2016)
   PUBMED   27669642
REFERENCE   5  (bases 1 to 3805)
  AUTHORS   Wang,S., Tukachinsky,H., Romano,F.B. and Rapoport,T.A.
  TITLE     Cooperation of the ER-shaping proteins atlastin, lunapark, and
            reticulons to generate a tubular membrane network
  JOURNAL   Elife 5, e18605 (2016)
   PUBMED   27619977
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3805)
  AUTHORS   Morin-Leisk,J., Saini,S.G., Meng,X., Makhov,A.M., Zhang,P. and
            Lee,T.H.
  TITLE     An intramolecular salt bridge drives the soluble domain of
            GTP-bound atlastin into the postfusion conformation
  JOURNAL   J Cell Biol 195 (4), 605-615 (2011)
   PUBMED   22065636
  REMARK    GeneRIF: The role of GTP hydrolysis in the ATL2 fusion mechanism
            also needs to be tempered by the uncertainty of whether the
            behavior of the ATL2 soluble domain, observed herein, reflects the
            behavior of the full-length, membrane-anchored protein.
REFERENCE   7  (bases 1 to 3805)
  AUTHORS   Hu,J., Shibata,Y., Zhu,P.P., Voss,C., Rismanchi,N., Prinz,W.A.,
            Rapoport,T.A. and Blackstone,C.
  TITLE     A class of dynamin-like GTPases involved in the generation of the
            tubular ER network
  JOURNAL   Cell 138 (3), 549-561 (2009)
   PUBMED   19665976
REFERENCE   8  (bases 1 to 3805)
  AUTHORS   Rismanchi,N., Soderblom,C., Stadler,J., Zhu,P.P. and Blackstone,C.
  TITLE     Atlastin GTPases are required for Golgi apparatus and ER
            morphogenesis
  JOURNAL   Hum Mol Genet 17 (11), 1591-1604 (2008)
   PUBMED   18270207
  REMARK    GeneRIF: A family of human GTPases, atlastin-2 and -3 that are
            closely related to atlastin-1 are described.
REFERENCE   9  (bases 1 to 3805)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   10 (bases 1 to 3805)
  AUTHORS   Ingley,E., Williams,J.H., Walker,C.E., Tsai,S., Colley,S.,
            Sayer,M.S., Tilbrook,P.A., Sarna,M., Beaumont,J.G. and Klinken,S.P.
  TITLE     A novel ADP-ribosylation like factor (ARL-6), interacts with the
            protein-conducting channel SEC61beta subunit
  JOURNAL   FEBS Lett 459 (1), 69-74 (1999)
   PUBMED   10508919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK225190.1, BC039050.1, AC016995.7 and AI630457.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001135673.3.
            
            Transcript Variant: This variant (2) uses an alternate splice
            acceptor site in the 3' terminal exon, compared to variant 1. The
            encoded isoform (2) is longer and has a distinct C-terminus,
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.233372.1,
                                           SRR1803612.214381.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378954.9/ ENSP00000368237.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2271              AK225190.1         4-2274
            2272-2874           BC039050.1         1456-2058
            2875-3493           AC016995.7         119356-119974
            3494-3795           AI630457.1         28-329              c
            3796-3796           AC016995.7         120277-120277
            3797-3802           AI630457.1         21-26               c
            3803-3805           AC016995.7         120284-120286
FEATURES             Location/Qualifiers
     source          1..3805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2-p22.1"
     gene            1..3805
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="atlastin GTPase 2"
                     /db_xref="GeneID:64225"
                     /db_xref="HGNC:HGNC:24047"
                     /db_xref="MIM:609368"
     exon            1..131
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1765
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ARL-6-interacting protein 2; ADP-ribosylation factor-like
                     protein 6-interacting protein 2"
                     /codon_start=1
                     /product="atlastin-2 isoform 2"
                     /protein_id="NP_001129145.1"
                     /db_xref="CCDS:CCDS46260.1"
                     /db_xref="GeneID:64225"
                     /db_xref="HGNC:HGNC:24047"
                     /db_xref="MIM:609368"
                     /translation="MAEGDEAARGQQPHQGLWRRRRTSDPSAAVNHVSSTTSLGENYE
                     DDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGA
                     FRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVWNEVFVID
                     RPNGTKVAVLLMDTQGAFDSQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHLQ
                     LFTEYGRLAMEEIYQKPFQTLMFLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQHEE
                     LQNVRKHIHNCFSNLGCFLLPHPGLKVATNPSFDGRLKDIDEDFKRELRNLVPLLLAP
                     ENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVAGARD
                     TYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSVKKMGGDEFCRRYQDQLEA
                     EIEETYANFIKHNDGKNIFYAARTPATLFAVMFAMYIISGLTGFIGLNSIAVLCNLVM
                     GLALIFLCTWAYVKYSGEFREIGTVIDQIAETLWEQVLKPLGDNLMEENIRQSVTNSI
                     KAGLTDQVSHHARLKTD"
     exon            132..376
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            377..511
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            512..616
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..667
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..724
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..817
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..956
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1084
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1141
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1213
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1645
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..3805
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2849..2854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="hexamer: ATTAAA"
     polyA_site      2874
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="major polyA site"
     regulatory      3634..3639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="hexamer: ATTAAA"
     polyA_site      3665
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
     regulatory      3777..3782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
                     /note="hexamer: ATTAAA"
     polyA_site      3805
                     /gene="ATL2"
                     /gene_synonym="aip-2; ARL3IP2; ARL6IP2; atlastin2"
ORIGIN      
        1 aaatcggtac aagatggcgg agggggacga ggcagcgcga gggcagcaac cgcaccaggg
       61 gctgtggcgc cggcgacgga ccagcgaccc aagcgccgcg gttaaccacg tctcgtccac
      121 gacctcccta ggtgagaatt atgaagatga tgacctagta aattctgatg aggttatgaa
      181 gaaaccatgt ccagtacaga ttgttcttgc tcatgaagat gaccataact ttgaacttga
      241 tgaagaagct ttggagcaga tattgctaca ggagcacata cgagatctta acatagtagt
      301 ggtatctgtg gcaggagctt ttcgtaaagg gaagtcattt ctactggact tcatgcttag
      361 atacatgtat aacaaggatt ctcaaagttg gattggtgga aacaatgaac cattgacagg
      421 ctttacatgg cgaggtggct gtgaaagaga aacaacaggc atacaagttt ggaatgaagt
      481 atttgtgatt gacagaccta atggaactaa agttgctgtg ctgcttatgg atacccaggg
      541 tgcctttgat agccagtcaa ctatcaaaga ctgtgcaacg gtgtttgctc tgagcactat
      601 gactagctct gtccaggtat ataatctgtc tcagaatatt caagaagatg atcttcaaca
      661 tttgcaatta tttacagagt atggaagact tgcgatggaa gaaatctacc agaaaccatt
      721 tcagacatta atgtttttga ttcgagattg gagctatcct tatgaacatt catatggttt
      781 ggaaggtgga aagcaatttc ttgaaaagag attacaggta aaacaaaatc aacatgaaga
      841 gcttcagaat gtaaggaagc acatacacaa ttgtttctca aatcttggtt gcttcctttt
      901 gccacatcct ggtcttaaag ttgcaactaa tcctagtttt gatgggagat tgaaagatat
      961 tgatgaagac tttaaacgag agcttcgaaa tctggttcca ttgctgcttg cccctgaaaa
     1021 tttggtagaa aaagagataa gtggatctaa agtcacttgt agagatcttg tagaatattt
     1081 taaggcttac atcaaaatct atcaaggaga agaacttcca catccaaagt ccatgcttca
     1141 ggcaacagct gaagctaata atcttgctgc agtagcagga gcaagagata cctattgtaa
     1201 aagtatggaa caggtatgtg gaggggacaa gccttacatt gcaccttcag atctggagcg
     1261 aaaacacttg gatctcaagg aagtggcgat aaaacaattt cgttcagtaa aaaagatggg
     1321 tggagatgag ttctgccgtc gttatcagga ccagcttgaa gctgaaattg aagaaaccta
     1381 tgcaaatttt ataaagcaca atgatggcaa aaatatcttc tatgctgctc gtaccccagc
     1441 cacactgttt gcggtcatgt ttgctatgta tataatctca ggactgactg gcttcattgg
     1501 cctaaactct atagctgtct tgtgtaacct tgtcatgggg ttagcactga tatttctttg
     1561 tacttgggca tatgttaaat actctgggga gttcagagaa attggaacag tgattgatca
     1621 gattgctgaa acactatggg aacaggtatt gaagcccctg ggtgataatt tgatggagga
     1681 aaacataagg cagtctgtaa caaactctat caaagcaggc ctgactgacc aggtgtctca
     1741 tcatgccaga ttaaagacag actgacagtt catctcctca cggactccac tctctttttt
     1801 tttcatgctt gctgtacaat gagaactcaa ataaaaataa accaaagttt acaatcaact
     1861 gtagaagtag tttagtgtaa ctggcttcac agatggctgc cacagagtgt gaagattgtt
     1921 tgttagtttt aagcattctt ttaatggctc ctaagacatg cagatggact gaggagcatt
     1981 ggttaatcat gcacctttgt gccatgttta actcttttat ttctttttac ttaatctaat
     2041 gttagtgaat ttgtcttatg taaaaggata tttcagggaa atattttcag aaatctattt
     2101 agagtctctt taacacagtg tcccattgaa attttaattt ttagagaatt tatgaatcac
     2161 tgtttcaaga accagattgg aaagacaatg aagcctttat tgagccacta cattaaaagt
     2221 atatattgct ttactgcctt caataccagt attacatcaa tgcatgtatc agaaacttca
     2281 cagaaattac atggcaactc ttgtagctaa gaaagtaatt ctgaggtgta catttgtctt
     2341 gcctttttaa atttataaac ttgccctaaa aggagatgca tatctgggaa actgaactgt
     2401 ctttttgcag tttagccttc atgtatataa aatatgccat taattttatt ggggaagaaa
     2461 ttccatccaa aaatgttgcc tacagctatg agttaagagt gtctgtacag tgtgtagctt
     2521 ttattttcta aaatcacaga tagggcatgt atatgactta taaatatata aatacgattt
     2581 tgtattaaaa gttttgtagt ttatggcaaa atctggtcct gtggtaggct aaataagtac
     2641 tgtccctgtg aaaggaatgt ttgtggctca tgtcagtgtg tgaatgcata gacaatttga
     2701 agtttttgat atatttgtga tatttatctt gagcactgca atctcacccc ccccccgccc
     2761 accaagggaa ttcaatggga atgtttattg tgactttgtc ctctgttgca ttttaaagtt
     2821 atttcctgta atttattttc agtacataat taaaaatttg ttgtatatat aaaatgaaac
     2881 ttgtgattct tttttaagga atttttcaag tatgtattcc acttcataaa ccacatttgt
     2941 ttatagtgaa aagagcatga gcaggaaaca ccccagttga gagctctaag gcattgtacc
     3001 tcaaaactaa gcttgtaaaa agttactttt ctgtgtctgt ctctataagg gaaaacctat
     3061 gattagccta gttgtagatg gggattgtta atttctttct ctctcttttt ttttttttgg
     3121 tggtatatgt aaggctagca ttttttcagt acttttgtgg tcttctttgt gaacaccgat
     3181 taaagtacct agttttgttt gtttcttttt tgagacggag tctctctctg tcacccaggc
     3241 tggagtgcag tggtgcgatc ttggctcact gcaacctcca cctcctgggt tcaagtgatt
     3301 ctcccgcctc agcctcctga gtagctggga ctacaggtgc gtgccaccat tcccggctaa
     3361 tgttttctat tttaagtaga gatggggttt caccgtttta gccaggatgg tctcaatcgc
     3421 ctgaccttgt gatccgcctg ccttggcctc ccaaagtgtt gggattacag gcgtgagcca
     3481 ccgcgcccgg cccttagttt gctttttaag cgaagagaat gcaggtgttg agttgcatgt
     3541 gtgaaaactc tgaatttact ttggttgata catcttcgct cccactccca ttcagattct
     3601 gtttttatat ggattgtatt tgttttcatc tgtattaaat tgctaactta tctgttctta
     3661 aagaatccac ctgaaaagtg tctttttatt tcttctgcca ccctgtttta tgaatgctgt
     3721 ggactgtttt ttatgaatga aaaaataatt tgttgtataa tagcagattt tctgaaatta
     3781 aagacagctt acttttaaaa agtta
//
