LOCUS       XM_047444490            3488 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens 5-aminoimidazole-4-carboxamide
            ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC),
            transcript variant X3, mRNA.
ACCESSION   XM_047444490
VERSION     XM_047444490.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..3488
                     /gene="ATIC"
                     /gene_synonym="AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH"
                     /note="5-aminoimidazole-4-carboxamide ribonucleotide
                     formyltransferase/IMP cyclohydrolase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 243
                     ESTs, 1827 long SRA reads, and 99% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     5 samples with support for all annotated introns"
                     /db_xref="GeneID:471"
                     /db_xref="HGNC:HGNC:794"
                     /db_xref="MIM:601731"
     CDS             85..1872
                     /gene="ATIC"
                     /gene_synonym="AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH"
                     /codon_start=1
                     /product="bifunctional purine biosynthesis protein ATIC
                     isoform X2"
                     /protein_id="XP_047300446.1"
                     /db_xref="GeneID:471"
                     /db_xref="HGNC:HGNC:794"
                     /db_xref="MIM:601731"
                     /translation="MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDA
                     GLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACN
                     LYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQS
                     SESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQ
                     LYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVG
                     IPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIIS
                     REVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNN
                     GVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQS
                     RIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKW
                     KALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRLNHEKNIRYNLAE
                     GLYKIPSYCQDHQKEKHEKLSCLEGPKEM"
     polyA_site      3488
                     /gene="ATIC"
                     /gene_synonym="AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gccacatccc ggcagccctc ctacctgcgc acgtggtgcc gccgctgctg cctcccgctc
       61 gccctgaacc cagtgcctgc agccatggct cccggccagc tcgccttatt tagtgtctct
      121 gacaaaaccg gccttgtgga atttgcaaga aacctgaccg ctcttggttt gaatctggtc
      181 gcttccggag ggactgcaaa agctctcagg gatgctggtc tggcagtcag agatgtctct
      241 gagttgacgg gatttcctga aatgttgggg ggacgtgtga aaactttgca tcctgcagtc
      301 catgctggaa tcctagctcg taatattcca gaagataatg ctgacatggc cagacttgat
      361 ttcaatctta taagagttgt tgcctgcaat ctctatccct ttgtaaagac agtggcttct
      421 ccaggtgtaa ctgttgagga ggctgtggag caaattgaca ttggtggagt aaccttactg
      481 agagctgcag ccaaaaacca cgctcgagtg acagtggtgt gtgaaccaga ggactatgtg
      541 gtggtgtcca cggagatgca gagctccgag agtaaggaca cctccttgga gactagacgc
      601 cagttagcct tgaaggcatt cactcatacg gcacaatatg atgaagcaat ttcagattat
      661 ttcaggaaac agtacagcaa aggcgtatct cagatgccct tgagatatgg aatgaaccca
      721 catcagaccc ctgcccagct gtacacactg cagcccaagc ttcccatcac agttctaaat
      781 ggagcccctg gatttataaa cttgtgcgat gctttgaacg cctggcagct ggtgaaggaa
      841 ctcaaggagg ctttaggtat tccagccgct gcctctttca aacatgtcag cccagcaggt
      901 gctgctgttg gaattccact cagtgaagat gaggccaaag tctgcatggt ttatgatctc
      961 tataaaaccc tcacacccat ctcagcggca tatgcaagag caagaggggc tgataggatg
     1021 tcttcatttg gtgattttgt tgcattgtcc gatgtttgtg atgtaccaac tgcaaaaatt
     1081 atttccagag aagtatctga tggtataatt gccccaggat atgaagaaga agccttgaca
     1141 atactttcca aaaagaaaaa tggaaactat tgtgtccttc agatggacca atcttacaaa
     1201 ccagatgaaa atgaagttcg aactctcttt ggtcttcatt taagccagaa gagaaataat
     1261 ggtgtcgtcg acaagtcatt atttagcaat gttgttacca aaaataaaga tttgccagag
     1321 tctgccctcc gagacctcat cgtagccacc attgctgtca agtacactca gtctaactct
     1381 gtgtgctacg ccaagaacgg gcaggttatc ggcattggag caggacagca gtctcgtata
     1441 cactgcactc gccttgcagg agataaggca aactattggt ggcttagaca ccatccacaa
     1501 gtgctttcga tgaagtttaa aacaggagtg aagagagcag aaatctccaa tgccatcgat
     1561 caatatgtga ctggaaccat tggcgaggat gaagatttga taaagtggaa ggcactgttt
     1621 gaggaagtcc ctgagttact cactgaggca gagaagaagg aatgggttga gaaactgact
     1681 gaagtttcta tcagctctga tgccttcttc cctttccgag ataacgtaga cagagctaaa
     1741 aggcttaatc atgagaaaaa catcagatat aacctagccg aaggacttta caaaatacct
     1801 tcctactgtc aagatcatca aaaagagaag catgagaaac tttcatgcct agaagggcct
     1861 aaggagatgt gatatcaagg ctttaagcaa gattcagatg aagggcctgc tttaccagct
     1921 cacctatgaa tatggaagca tcagcttact ttttgcagca catgtgtctc agggggttgt
     1981 cccttcccac agtgtgtaga ttggcatcga gatgacgttc tctctccagg gtgcagtgat
     2041 gaccgacata tgtgagacag tcgtttaata tcacctttat tttgtacttt ctgtgatttt
     2101 taaaaaacat acagagcagc tctcttggtg actattgggc tgataaagct taaagatcag
     2161 taataaatag aagtccaggg gctgggtctg tatttcgcta aggaaacctc atctgagctt
     2221 catgccctgt aaaattaagc tctaaaacct cccctaaatg agatagctaa atgtcaaagc
     2281 attttataaa ctgtaaatca attcaaatgg gagttagtat tttttttttt caaatgaaca
     2341 tgaggaagta tctttctgta tttagtttta atattctttg ccaggtgttt attgaaatac
     2401 cttctttcat tgtacattag tatatttaaa aagtgctttg catgtcttgt ttattatgaa
     2461 ctactaattt tttactaata attatttcca tttccactat ttactattct gaatgtcaca
     2521 tttatttatt tatgtttttt gggatggagt cttgctctgt cccccatgct ggagttcaat
     2581 ggcacaatct cagctcactg caacctccgc cttctgggtt caagccattc tcctacctca
     2641 gccttctgag tagccgggac caaagacgcc cactgccatg cctggtaaca tttgtatttt
     2701 taatagagac aaggtttcac catgttggcc aggctggtct caaactcctg acctcaggtg
     2761 atccacctgc ctcagcctcc caaagtgctg ggattagagg tgtgagccac tgcgcctggc
     2821 ctgaatgtca aatttaatcc caaagtttgt ttcctcaatg ttaaattgaa aaagaaatga
     2881 cctttacaga tcaggagtaa acaaactgtt tagctgggag tttatcaagc catgccaaaa
     2941 gtgtcagctg acccaaagta agacatgtta gatgggggtt atcataccat ggggtttccc
     3001 taagataaaa ctcctccata ttatactatt caaatacttt taatatctta gtcattttta
     3061 tttcccttgc aggcaatctc tttgaacaga ggtttattca atgaaggaaa ggtggaggga
     3121 agaagggaag aattacaatg gttagaaaag agcaactaaa gattatttct attatacttc
     3181 tgaacggtaa actagcaatt ttaataaata ttggggtcca cttaaatcta ttaaagcaga
     3241 aagtgtaaag ctatctccat tagtgaagag atgaagtgac aaaaaccaat cagtttttgt
     3301 agcaactgat ttagaaaatc ttgtactgaa atcaacaatt agacttgcac atcatagatt
     3361 ttcaaatgtt tgctgaattg aaaaagaata ttcacaggaa ttatttcccc cgaaggtgtc
     3421 ttatatcaaa tagatgaact tcaagttgtg gaatgtaaat cttttattaa aacagttgtc
     3481 tttccaca
//
