LOCUS       XM_047444489            7818 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens 5-aminoimidazole-4-carboxamide
            ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC),
            transcript variant X1, mRNA.
ACCESSION   XM_047444489
VERSION     XM_047444489.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..7818
                     /gene="ATIC"
                     /gene_synonym="AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH"
                     /note="5-aminoimidazole-4-carboxamide ribonucleotide
                     formyltransferase/IMP cyclohydrolase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 250
                     ESTs, 1002 long SRA reads, and 96% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     3 samples with support for all annotated introns"
                     /db_xref="GeneID:471"
                     /db_xref="HGNC:HGNC:794"
                     /db_xref="MIM:601731"
     CDS             85..1878
                     /gene="ATIC"
                     /gene_synonym="AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH"
                     /codon_start=1
                     /product="bifunctional purine biosynthesis protein ATIC
                     isoform X1"
                     /protein_id="XP_047300445.1"
                     /db_xref="GeneID:471"
                     /db_xref="HGNC:HGNC:794"
                     /db_xref="MIM:601731"
                     /translation="MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDA
                     GLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACN
                     LYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQS
                     SESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQ
                     LYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVG
                     IPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIIS
                     REVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNN
                     GVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQS
                     RIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKW
                     KALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRLNHEKNIRYNLAE
                     GLYKIPSYCQDHQKEKHEKLSCLEGPKEMWQ"
     polyA_site      7818
                     /gene="ATIC"
                     /gene_synonym="AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gccacatccc ggcagccctc ctacctgcgc acgtggtgcc gccgctgctg cctcccgctc
       61 gccctgaacc cagtgcctgc agccatggct cccggccagc tcgccttatt tagtgtctct
      121 gacaaaaccg gccttgtgga atttgcaaga aacctgaccg ctcttggttt gaatctggtc
      181 gcttccggag ggactgcaaa agctctcagg gatgctggtc tggcagtcag agatgtctct
      241 gagttgacgg gatttcctga aatgttgggg ggacgtgtga aaactttgca tcctgcagtc
      301 catgctggaa tcctagctcg taatattcca gaagataatg ctgacatggc cagacttgat
      361 ttcaatctta taagagttgt tgcctgcaat ctctatccct ttgtaaagac agtggcttct
      421 ccaggtgtaa ctgttgagga ggctgtggag caaattgaca ttggtggagt aaccttactg
      481 agagctgcag ccaaaaacca cgctcgagtg acagtggtgt gtgaaccaga ggactatgtg
      541 gtggtgtcca cggagatgca gagctccgag agtaaggaca cctccttgga gactagacgc
      601 cagttagcct tgaaggcatt cactcatacg gcacaatatg atgaagcaat ttcagattat
      661 ttcaggaaac agtacagcaa aggcgtatct cagatgccct tgagatatgg aatgaaccca
      721 catcagaccc ctgcccagct gtacacactg cagcccaagc ttcccatcac agttctaaat
      781 ggagcccctg gatttataaa cttgtgcgat gctttgaacg cctggcagct ggtgaaggaa
      841 ctcaaggagg ctttaggtat tccagccgct gcctctttca aacatgtcag cccagcaggt
      901 gctgctgttg gaattccact cagtgaagat gaggccaaag tctgcatggt ttatgatctc
      961 tataaaaccc tcacacccat ctcagcggca tatgcaagag caagaggggc tgataggatg
     1021 tcttcatttg gtgattttgt tgcattgtcc gatgtttgtg atgtaccaac tgcaaaaatt
     1081 atttccagag aagtatctga tggtataatt gccccaggat atgaagaaga agccttgaca
     1141 atactttcca aaaagaaaaa tggaaactat tgtgtccttc agatggacca atcttacaaa
     1201 ccagatgaaa atgaagttcg aactctcttt ggtcttcatt taagccagaa gagaaataat
     1261 ggtgtcgtcg acaagtcatt atttagcaat gttgttacca aaaataaaga tttgccagag
     1321 tctgccctcc gagacctcat cgtagccacc attgctgtca agtacactca gtctaactct
     1381 gtgtgctacg ccaagaacgg gcaggttatc ggcattggag caggacagca gtctcgtata
     1441 cactgcactc gccttgcagg agataaggca aactattggt ggcttagaca ccatccacaa
     1501 gtgctttcga tgaagtttaa aacaggagtg aagagagcag aaatctccaa tgccatcgat
     1561 caatatgtga ctggaaccat tggcgaggat gaagatttga taaagtggaa ggcactgttt
     1621 gaggaagtcc ctgagttact cactgaggca gagaagaagg aatgggttga gaaactgact
     1681 gaagtttcta tcagctctga tgccttcttc cctttccgag ataacgtaga cagagctaaa
     1741 aggcttaatc atgagaaaaa catcagatat aacctagccg aaggacttta caaaatacct
     1801 tcctactgtc aagatcatca aaaagagaag catgagaaac tttcatgcct agaagggcct
     1861 aaggagatgt ggcagtgaca tggtagcctg tcacctggcc ggagatggca tgggagatgg
     1921 aaacgggacc aagctgagcc agtgaggctc ctgcctgaag tttttactgg aaatgggagg
     1981 acacacatgt tctctttcac tactgttctt aagctggcag ggggtaaagc aagctcatgg
     2041 aggtcagtca tcaatggcac catcagcaga gaccccgctg aagcacgaag ccagtgcatg
     2101 ggaaggcacg cggagcaaga gggagtccgg gcgccattgc tggagcagcc cctgaagccg
     2161 gtgggtcctg ggactgttcc attgtgtggg ccatttttgc ttgagttgga cttttttctt
     2221 acaactaaaa tgcagcccta aataatacag tcactttctt ttttatatta gaatttaaat
     2281 attttagaca tatttctctg tttaagcaca tatgcccctt aatacctaac acaataccag
     2341 tgactacctc cttacagaat cactgaatct tgctttcata tgagaaagtg aacagtttcc
     2401 actcctgtct taaatgtttc atttagcact tgagaataga ataagtgtcg cacatgaaag
     2461 gtttcatgtg cataaataat gagaagatgc tgaagtgaga ccaaaatcaa cttcccagca
     2521 aattcattct ccatcacaca atttcatacc agaatgactg agttctaagg tcatacaatc
     2581 acagtcgttg taagtgttaa tgggagagag agagagagag agacagagag agatactgaa
     2641 ttcaatctaa attccaatct ccaattctcc tccatcagaa ttgggagcac ctccctcccc
     2701 atgtaatcac tgggggtgaa acaagatcat agtagtttcc atgggctgcc cctggtggag
     2761 ccaagacagg cccctgaaca cccctgctgc cagattaatt ttcccaaaga ctattttcca
     2821 tcatgtttct ttgcatcttg gatacctgta attggttaat gcatttggca ttaaccaatg
     2881 agtctcaccc ttgagtgtga agcatgcccc tcacccacca ggatttgggg agttgctggg
     2941 agggcatgtc ttcgttgaaa acaaagggct gtcacattcc attgcttttg agttacacat
     3001 aatttcattt tgaaatttga aatcatatta gagaaaggct tattattttt tgttatactg
     3061 ggcatatttt agaaatggtt gagaagtact ggcttaaata atgggttgcc aaggccctcc
     3121 ataagccact tcttcccatc tattttctta ccagaagaca gcaggcagag ggttggctca
     3181 ccaaagccca cctgggccag ctcctttcta tcccaggggg tgtgtctctc tgctttctcc
     3241 cctcccaact aaaccttagt catcgtaaac ctcagccagt tcatgcttct ctttcttgct
     3301 aattccagcc tacccagaac tgtatttgtc agacccactt agaacttaat tagcttgact
     3361 ttgaaatgta tgctaattta acatcttcaa ctatatcatt aagagccaag ccatttctca
     3421 tttcctctgt ttttcctata ctacttagca cagtgctaga cctataacaa gcatctgttc
     3481 tgaatcaaga gagaggttaa aagaagtggc attttcttac atctgagata ttattcaaaa
     3541 tatttaacaa cgttgccatg ggacacctgt ccatcagaat ggagttggag gcctagagct
     3601 acactgcact taacactttg ctgaaaaata gaagcagcct gagaatagta ggggagggga
     3661 gggtctcagg ctgcccagga tggggagaac cggctgaaat gaaacacatt ctatttacca
     3721 ctaattaatt tgaatagtat ctctgcttca ctatttttca gtgtaaatag tatctctgac
     3781 atgctaggga gcttaggaaa atgattctaa catcatataa atgacaggtg ttgctattaa
     3841 gaatgactca agacttgtgt ttttggtact ctacatgcca ttcattcatt ctttctacta
     3901 agagtaatag aaagaatgaa tggcatgtaa ggtagacata gagctgctct agagctctat
     3961 gtcagcagtt gtatgccaac aggaaatgtg gtattttaat acttccgaag ggtctctgcc
     4021 cctcctgtgt gtacgacaca tccttgcagg agcccaccct ttatcttatc taacttgtag
     4081 ggagcctggc acatccagtc ttacccgctg gcctccaaag catgtgcagg agcaaatggc
     4141 accgagatat tccttctgcc actgttctcc tacgtggtat gtcttcccat catcataaca
     4201 cgttgcctca tctgcatata gacacaagac agatgcacgc ataagctgag aacaatactg
     4261 cagacttgat ctaggggtgg gttctatttc tgtcctaaat ttgtatcatc acagcgcaaa
     4321 caccacatat ttatgtgaat catccctaag agcagtactg ctatacagat cttagggtgg
     4381 cacttccaaa aattagacct aatacactgg aaagggtcca acgggaagat ggaaatcata
     4441 ttttaaaagt tgaatctaca gaccaataaa gcttctttgt agcattttac tgcagataat
     4501 ggtcaaaata ctcaggttgg acaagtgcta aagtgtcctg taataacatt aaatcatgac
     4561 tcatttttga agcttgtctc cactttccca aatcaaaaga ttaagaaacc cactgttcac
     4621 tcctcaagga gacctaaagt ctccaatcat ttctgtgaat gagagttaca gcctgataat
     4681 gaaagtgaga atgcttaata aggcactaaa aatgatctgt gatgacatac gagggtcaca
     4741 cttgaattct ccttttccgt tcccaagaca tgtgcagctc atcatctggc cattttctcc
     4801 ctgacggtcc cacttctctc caatcttgta gttcacacca ttgtcatggc accatcctgt
     4861 aggggtgggg aaagtcagga ccaaaaagtt atttgtatat tctgactcac aagacagtag
     4921 gtgaactggg acgtgtcaca gggtcttcag aaccatgatc tggaaaaata gcaagttaaa
     4981 gataaaaacc cctataatgg gccatttatt ttatttattt atttactttt tatttttttt
     5041 tttttttttg agacaaagtc tttctctgtc gcccagactg gagtgaagtg gtgcaatctc
     5101 ggctcactgt aacctccatc tcctgggttc atgcagttat cctgcctcag cctcctgagt
     5161 agctgggatt acaggcactc cccacagtgc tatttttttt tttttttttt tttttgtatt
     5221 ttttgtagag atggggtttt accatgttgg gtaggctggt ctcaaactcg tgagctcagg
     5281 tgatccaccc gcctcagcct ccaaaagtgc tgggattaca ggtgtgagcc accacacctg
     5341 gccaatgggc catttctttg gttgaatttt aaaatattat tttttatcat ttaccatttt
     5401 ctagggcatt ttaagaccca atttattctg ccacaatcat gtcatcagaa tagtcaaatg
     5461 aaatgacttt catttgaatt ctcactatta agatttaaaa ttgtggaaaa ctaaagtggg
     5521 attggagtag actgttagga atagatccta gatgaaaaat cacttttgga tttgcagaaa
     5581 ccctggatac aaagtagttc aattaaccat aaaacaagga tcagctgatc tctacacgcc
     5641 accacctgtt tcatgtacat gggaagagta aaaaatgaac ccggataaaa taaaacaaaa
     5701 gcaaacaaaa tgctaaatca ttggttatta tccacatcaa ataagtctgg ttctgtggaa
     5761 tatctaaaag tcacagtttt atgcctttaa ctactataca taagggatga ctttttaacc
     5821 tccagggctt atacaacaaa acacacctca gaagcttata taacaatata ctactttttc
     5881 cattttatca acaattcagc ctgccttaag ctacaaagta aaataattag acaactgtga
     5941 tatcaaaaca aagattatgt aagttgagcc aaagagtcac ataaatgaac ttgacatccc
     6001 cgctcccaca attgcaccta agtgctcaaa caggtaataa acatacaaac ttaaacgtag
     6061 ttcgatttca ggagttaaaa accatctact tgaagtcaaa tattaaaatt tccagctcct
     6121 aaacagcatg tgatgttttt agtgtttttc attttcagat ggtcaaacat ggaagtctat
     6181 attgaaaaca ctggctggct tttacaactt cagtctggat taaatgattt caagtataca
     6241 agttaagtaa aatactttga aaatctcttt taccaagtct tatattctaa ttccacagga
     6301 tatgatttct gtatgtctat aggaggctta tttataggca taacggtcaa cacctataaa
     6361 aatgaaccaa ttgtcaataa tcatcacatc tcctaaacac aaagaataaa tgaaaggttt
     6421 ataaattcta atcctaatct caaagcataa tagatatttc ctaggcacat tttaacttaa
     6481 aaaatttgaa aattaaaacg tattagaatt tgaaaatcaa acatttatca attcaagttg
     6541 atttttaatg atctaaaagc agattatctg ttttttcttt catatttcta gcaacgttca
     6601 agctacctgg gctatgtgtg tgacgcaaaa gtgtgtgcat gggtactatg atatgtgcat
     6661 gtttggttta tgttgaagga ggctgttttt gagtctaaat gttcacctct gatctcattc
     6721 aacactgaag attaaaagag atttgaggtt tttctgtgtc tctaatactc ttaaatagac
     6781 ctggttccaa aagtctttat ccatttgttt tcacagaaaa tttcaaaaat caaattagca
     6841 ccataatctt atgtgtaatt aatagttgta ttggcataca acccttgaaa tgaagcaatg
     6901 tccaacaagt aaaatttccc atcatttttc tatgatgcaa aatattactt cgagtcaaac
     6961 agtattctct tgtttgcttc atgtttggaa gaacctgtgt cttccaaaca tgcttccttg
     7021 gcacatgagt gcatgcatgg aacttgagga gacaaacacg gaagtggatg gacaaagcaa
     7081 ctactcacta gatgaatcac atctgaaatg accacttcca aagcctaagc actggcacaa
     7141 cagtttaaag cctgattcag acattcgttc ccactcatct ccaacggcat aatgggaaac
     7201 tgtgtagggg tcaaagcacg agtcatccgt aggttggttc aagccttcgt tgactatgaa
     7261 gaaaaggaag aaaaagcaaa aagagacatc ttattaatcg atttggacca taagaagaaa
     7321 atcgaatgac tgtatacaat gacttaatct aaaacaagaa ttccaggagg attaagaggc
     7381 attcatctgt tctatcaagg cattaactgc tctaaaaaac catggttaga tgtgacacct
     7441 gtcacaggca cccgacagga agcccatctt ttatttttcc cttgcttcta agataattgc
     7501 catttctgtt gaaactactt catagaacat ggaacagatc ttgaggcaat tgaagctagt
     7561 ggagaacttt agtgggatgc aaagactaat gatgcctctc cattggtacc tgagtgacct
     7621 tgggccagct atttaatacc actctgcctt gcttccctca tctgcaatac tagcgtaata
     7681 ataaaaatat ctatacctcc tggggaatct tgtgaagatt atataaggcc atgaattcaa
     7741 aacattgacc cttttccaag acttagaaaa tgttcactaa ataaagaata attattaaag
     7801 gctgtctttt gcttataa
//
