LOCUS       NM_004849               3185 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens autophagy related 5 (ATG5), transcript variant 1,
            mRNA.
ACCESSION   NM_004849
VERSION     NM_004849.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3185)
  AUTHORS   Li,S., Zhang,B.W., Lou,Q.Q., Liu,Y., Wei,Z.J., Huang,J., Yao,K.H.,
            Xu,Q.R., Fan,J., Xi,Y., Yang,L. and Chen,S.
  TITLE     ATG5 nonautophagically regulates inflammation and differentiation
            in mouse embryonic stem cells
  JOURNAL   Autophagy 20 (8), 1897-1898 (2024)
   PUBMED   38477302
  REMARK    GeneRIF: ATG5 nonautophagically regulates inflammation and
            differentiation in mouse embryonic stem cells.
REFERENCE   2  (bases 1 to 3185)
  AUTHORS   Li,Q., Wen,W., Wang,Y., Gong,T., Wang,X., Tan,Q., Fan,B., Xie,H.,
            Li,Y., Li,S., Yang,C., Zhou,Z., Duan,X., Lin,W. and Chen,L.
  TITLE     Autophagy-related protein 5 (ATG5) interacts with bone marrow
            stromal cell antigen 2 (BST2) to stimulate HBV replication through
            antagonizing the antiviral activity of BST2
  JOURNAL   J Med Virol 96 (5), e29659 (2024)
   PUBMED   38747016
  REMARK    GeneRIF: Autophagy-related protein 5 (ATG5) interacts with bone
            marrow stromal cell antigen 2 (BST2) to stimulate HBV replication
            through antagonizing the antiviral activity of BST2.
REFERENCE   3  (bases 1 to 3185)
  AUTHORS   Chen,F., Wu,L., Zhang,M., Kan,M., Chen,H., Wang,X. and Qu,J.
  TITLE     Autophagy-related 5 in acute ischemic stroke: Variation and linkage
            with neurofunction, and survival
  JOURNAL   Ann Clin Transl Neurol 11 (4), 856-865 (2024)
   PUBMED   38530706
  REMARK    GeneRIF: Autophagy-related 5 in acute ischemic stroke: Variation
            and linkage with neurofunction, and survival.
REFERENCE   4  (bases 1 to 3185)
  AUTHORS   Qu,J., Wu,L., Zhang,M., Kan,M., Chen,H., Shi,Y., Wang,S., Wang,X.
            and Chen,F.
  TITLE     Serum autophagy-related gene 5 level in stroke patients:
            correlation with CD4+ T cells and cognition impairment during a
            3-year follow-up
  JOURNAL   Braz J Med Biol Res 57, e13019 (2024)
   PUBMED   38511768
  REMARK    GeneRIF: Serum autophagy-related gene 5 level in stroke patients:
            correlation with CD4+ T cells and cognition impairment during a
            3-year follow-up.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3185)
  AUTHORS   Zuo,X., Shao,Y., Liang,Y., Huo,C. and Wang,S.
  TITLE     MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage Polarization and
            Proliferation of Hepatocellular Carcinoma Cells
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (3), 17-26 (2024)
   PUBMED   38305285
  REMARK    GeneRIF: MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage
            Polarization and Proliferation of Hepatocellular Carcinoma Cells.
REFERENCE   6  (bases 1 to 3185)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Ueno,T. and Kominami,E.
  TITLE     The human homolog of Saccharomyces cerevisiae Apg7p is a
            Protein-activating enzyme for multiple substrates including human
            Apg12p, GATE-16, GABARAP, and MAP-LC3
  JOURNAL   J Biol Chem 276 (3), 1701-1706 (2001)
   PUBMED   11096062
REFERENCE   7  (bases 1 to 3185)
  AUTHORS   Schmeiser,K., Armstrong,S., Hammond,E.M. and Grand,R.J.
  TITLE     Assignment of the yeast APG5 human homologue APG5L to chromosome
            band 6q21 by fluorescence in situ hybridisation
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 213-214 (1999)
   PUBMED   10702672
REFERENCE   8  (bases 1 to 3185)
  AUTHORS   Mizushima,N., Sugita,H., Yoshimori,T. and Ohsumi,Y.
  TITLE     A new protein conjugation system in human. The counterpart of the
            yeast Apg12p conjugation system essential for autophagy
  JOURNAL   J Biol Chem 273 (51), 33889-33892 (1998)
   PUBMED   9852036
REFERENCE   9  (bases 1 to 3185)
  AUTHORS   Hammond,E.M., Brunet,C.L., Johnson,G.D., Parkhill,J., Milner,A.E.,
            Brady,G., Gregory,C.D. and Grand,R.J.
  TITLE     Homology between a human apoptosis specific protein and the product
            of APG5, a gene involved in autophagy in yeast
  JOURNAL   FEBS Lett 425 (3), 391-395 (1998)
   PUBMED   9563500
REFERENCE   10 (bases 1 to 3185)
  AUTHORS   Grand,R.J., Milner,A.E., Mustoe,T., Johnson,G.D., Owen,D.,
            Grant,M.L. and Gregory,C.D.
  TITLE     A novel protein expressed in mammalian cells undergoing apoptosis
  JOURNAL   Exp Cell Res 218 (2), 439-451 (1995)
   PUBMED   7796880
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Y11588.1 and BX537904.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004849.3.
            
            Summary: The protein encoded by this gene, in combination with
            autophagy protein 12, functions as an E1-like activating enzyme in
            a ubiquitin-like conjugating system. The encoded protein is
            involved in several cellular processes, including autophagic
            vesicle formation, mitochondrial quality control after oxidative
            damage, negative regulation of the innate antiviral immune
            response, lymphocyte development and proliferation, MHC II antigen
            presentation, adipocyte differentiation, and apoptosis. Several
            transcript variants encoding different protein isoforms have been
            found for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Both variants 1 and
            2 encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y11588.1, SRR14038191.2970881.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369076.8/ ENSP00000358072.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2393              Y11588.1           34-2426
            2394-3185           BX537904.1         1921-2712
FEATURES             Location/Qualifiers
     source          1..3185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3185
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /note="autophagy related 5"
                     /db_xref="GeneID:9474"
                     /db_xref="HGNC:HGNC:589"
                     /db_xref="MIM:604261"
     exon            1..235
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /inference="alignment:Splign:2.1.0"
     exon            236..401
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1121
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /note="isoform a is encoded by transcript variant 1;
                     apoptosis-specific protein; ATG5 autophagy related 5
                     homolog; APG5 autophagy 5-like"
                     /codon_start=1
                     /product="autophagy protein 5 isoform a"
                     /protein_id="NP_004840.1"
                     /db_xref="CCDS:CCDS5055.1"
                     /db_xref="GeneID:9474"
                     /db_xref="HGNC:HGNC:589"
                     /db_xref="MIM:604261"
                     /translation="MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSY
                     LTLVTDKVKKHFQKVMRQEDISEIWFEYEGTPLKWHYPIGLLFDLLASSSALPWNITV
                     HFKSFPEKDLLHCPSKDAIEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQND
                     RFDQFWAINRKLMEYPAEENGFRYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLGDL
                     LKEVCPSAIDPEDGEKKNQVMIHGIEPMLETPLQWLSEHLSYPDNFLHISIIPQPTD"
     exon            402..529
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /inference="alignment:Splign:2.1.0"
     exon            530..608
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /inference="alignment:Splign:2.1.0"
     exon            609..771
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /inference="alignment:Splign:2.1.0"
     exon            772..866
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /inference="alignment:Splign:2.1.0"
     exon            867..984
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /inference="alignment:Splign:2.1.0"
     exon            985..3185
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1711..1716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /note="hexamer: AATAAA"
     polyA_site      1747
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /note="major polyA site"
     regulatory      2413..2418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /note="hexamer: ATTATA"
     polyA_site      2429
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
                     /note="hexamer: ATTAAA"
     polyA_site      3185
                     /gene="ATG5"
                     /gene_synonym="APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25"
ORIGIN      
        1 agcgttgccg gttgtattcg ctggatacca gagggcggaa gtgcagcagg gttcagctcc
       61 gacctccgcg ccggtgcttt ttgcggctgc gcgggcttcc tggagtcctg ctaccgcgtc
      121 cccgcaggac agtgtgtcag gcgggcagct tgccccgccg ccccaccgga gcgcggaatc
      181 tgggcgtccc caccagtgcg gggagccgga aggaggagcc atagcttgga gtaggtttgg
      241 ctttggttga aataagaatt tagcctgtat gtactgcttt aactcctgga agaatgacag
      301 atgacaaaga tgtgcttcga gatgtgtggt ttggacgaat tccaacttgt ttcacgctat
      361 atcaggatga gataactgaa agggaagcag aaccatacta tttgcttttg ccaagagtaa
      421 gttatttgac gttggtaact gacaaagtga aaaagcactt tcagaaggtt atgagacaag
      481 aagacattag tgagatatgg tttgaatatg aaggcacacc actgaaatgg cattatccaa
      541 ttggtttgct atttgatctt cttgcatcaa gttcagctct tccttggaac atcacagtac
      601 attttaagag ttttccagaa aaagaccttc tgcactgtcc atctaaggat gcaattgaag
      661 ctcattttat gtcatgtatg aaagaagctg atgctttaaa acataaaagt caagtaatca
      721 atgaaatgca gaaaaaagat cacaagcaac tctggatggg attgcaaaat gacagatttg
      781 accagttttg ggccatcaat cggaaactca tggaatatcc tgcagaagaa aatggatttc
      841 gttatatccc ctttagaata tatcagacaa cgactgaaag acctttcatt cagaagctgt
      901 ttcgtcctgt ggctgcagat ggacagttgc acacactagg agatctcctc aaagaagttt
      961 gtccttctgc tattgatcct gaagatgggg aaaaaaagaa tcaagtgatg attcatggaa
     1021 ttgagccaat gttggaaaca cctctgcagt ggctgagtga acatctgagc tacccggata
     1081 attttcttca tattagtatc atcccacagc caacagattg aaggatcaac tatttgcctg
     1141 aacagaatca tccttaaatg ggatttatca gagcatgtca cccttttgct tcaatcaggt
     1201 ttggtggagg caacctgacc agaaacactt cgctgctgca agccagacag gaaaaagatt
     1261 ccatgtcaga taaggcaact gggctggtct tactttgcat cacctctgct ttcctccact
     1321 gccatcatta aacctcagct gtgacatgaa agacttaccg gaccactgaa ggtcttctgt
     1381 aaaatataat gaagctgaaa cctttggcct aagaagaaaa tggaagtatg tgccactcga
     1441 tttgtatttc tgattaacaa ataaacaggg gtatttccta aggtgaccat ggttgaactt
     1501 tagctcatga aagtggaaac attggtttaa ttttcaagag aattaagaaa gtaaaagaga
     1561 aattctgtta tcaataactt gcaagtaatt ttttgtaaaa gattgaatta cagtaaaccc
     1621 atctttcctt aacgaaaatt tcctatgttt acagtctgtc tattggtatg caatcttgta
     1681 actttgataa tgaacagtga gagattttta aataaagcct ctaaatatgt tttgtcattt
     1741 aataacatac agttttgtca cttttcaagt actttctgac tcacatacag tagatcactt
     1801 tttactctgt gttaccattt tgactggtcg tcattggcat ggggtggata tagggcatag
     1861 gattacttgt ctcagaagct gtcatagaat ttcttgctgc caattaaaaa acctgtgttc
     1921 tttacacact acacgtataa atattgtaac tgttcatctt tgttgtttta tcactgtaag
     1981 cctgtcaaat catagtatcc taagcatctg taaatgctaa ttttgcattt ttggaaaaac
     2041 ccattccttc caagctagtg tttttcattg gctccaggtc taatttttca ctgtggtccc
     2101 tggcagccag tcttttgaag tttaaagatt acctgtctct tgactgcagt accttttctt
     2161 taatttttac caaaaatatc cagaggttac tggagttctt attcaatata aggaaagttt
     2221 gctgcacttt attaccaagc ctctgggatt ttaccagtca aacatatttg tgcattacat
     2281 ttcatttctt gtgagctagc tggctgtcca tattgaatgt tgacccattt gagtacgcta
     2341 aaaggcttac agtatcagac acgatcatgg ttttagatcc cataataaaa atgaatgttt
     2401 ttcttataaa aaattataca aatgctgaag tgagattcta ctattgttca ttgcttcctt
     2461 ttctttttcc ttttgcgatt ttcactgatt aatagcacat ttcttcacaa aattagataa
     2521 agttggtcaa agaccagata ttctggaatg gaaattgtaa agcttaatca aaaagaatag
     2581 ccagtacagc atacaatctc agaaacttag aagcaagtag aaaataattg gttgatgtaa
     2641 acgaaagtgc cattttagta aaggcaggaa aaaaatagca atatttgagt tatgtaagga
     2701 taaaaaatcc actgacttgt atttttgcac aagaggctgg tctgaatatg attgttcaca
     2761 ttaagagtgt ttattcgtcg gttcattttg gggattttcc cccttgatgt tttgacagat
     2821 tgaagtgagc tttagtgagc aaaaggatca gaatgcaggg aacactaagc tgtgatgaag
     2881 aaagtgtggt aaaaagccag agtagtttta tacagacaaa accagtgtca ggcctttgca
     2941 gtaggcttga gtgaacttct gatctagatt tgaaagtaaa ttttatgaag acattgccca
     3001 tttttacttc ctcattcatt attgtaccag catcatagct ttattactct aatcccaggt
     3061 aagtcaagcc tacaatgccc tagaggaaga gtaaaaccag aaattcatgc tggcttaaat
     3121 aatctatttt tgtttctttt catttgaata tttaaatttt atggtttatt aaaaaattaa
     3181 ataaa
//
