LOCUS       NM_015104               6318 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens autophagy related 2A (ATG2A), transcript variant 1,
            mRNA.
ACCESSION   NM_015104 XM_290517
VERSION     NM_015104.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6318)
  AUTHORS   Wang,Y., Dahmane,S., Ti,R., Mai,X., Zhu,L., Carlson,L.A. and
            Stjepanovic,G.
  TITLE     Structural basis for lipid transfer by the ATG2A-ATG9A complex
  JOURNAL   Nat Struct Mol Biol 32 (1), 35-47 (2025)
   PUBMED   39174844
REFERENCE   2  (bases 1 to 6318)
  AUTHORS   Chu,F., Wu,P., Mu,M., Hu,S. and Niu,C.
  TITLE     MGCG regulates glioblastoma tumorigenicity via hnRNPK/ATG2A and
            promotes autophagy
  JOURNAL   Cell Death Dis 14 (7), 443 (2023)
   PUBMED   37460467
  REMARK    GeneRIF: MGCG regulates glioblastoma tumorigenicity via
            hnRNPK/ATG2A and promotes autophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6318)
  AUTHORS   Broadbent,D.G., Barnaba,C., Perez,G.I. and Schmidt,J.C.
  TITLE     Quantitative analysis of autophagy reveals the role of ATG9 and
            ATG2 in autophagosome formation
  JOURNAL   J Cell Biol 222 (7) (2023)
   PUBMED   37115157
  REMARK    GeneRIF: Quantitative analysis of autophagy reveals the role of
            ATG9 and ATG2 in autophagosome formation.
REFERENCE   4  (bases 1 to 6318)
  AUTHORS   Ghanbarpour,A., Valverde,D.P., Melia,T.J. and Reinisch,K.M.
  TITLE     A model for a partnership of lipid transfer proteins and
            scramblases in membrane expansion and organelle biogenesis
  JOURNAL   Proc Natl Acad Sci U S A 118 (16) (2021)
   PUBMED   33850023
  REMARK    GeneRIF: A model for a partnership of lipid transfer proteins and
            scramblases in membrane expansion and organelle biogenesis.
REFERENCE   5  (bases 1 to 6318)
  AUTHORS   Li,Q., Ni,Y., Zhang,L., Jiang,R., Xu,J., Yang,H., Hu,Y., Qiu,J.,
            Pu,L., Tang,J. and Wang,X.
  TITLE     HIF-1alpha-induced expression of m6A reader YTHDF1 drives
            hypoxia-induced autophagy and malignancy of hepatocellular
            carcinoma by promoting ATG2A and ATG14 translation
  JOURNAL   Signal Transduct Target Ther 6 (1), 76 (2021)
   PUBMED   33619246
  REMARK    GeneRIF: HIF-1alpha-induced expression of m6A reader YTHDF1 drives
            hypoxia-induced autophagy and malignancy of hepatocellular
            carcinoma by promoting ATG2A and ATG14 translation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6318)
  AUTHORS   Yamada,Y., Sakuma,J., Takeuchi,I., Yasukochi,Y., Kato,K., Oguri,M.,
            Fujimaki,T., Horibe,H., Muramatsu,M., Sawabe,M., Fujiwara,Y.,
            Taniguchi,Y., Obuchi,S., Kawai,H., Shinkai,S., Mori,S., Arai,T. and
            Tanaka,M.
  TITLE     Identification of C21orf59 and ATG2A as novel determinants of renal
            function-related traits in Japanese by exome-wide association
            studies
  JOURNAL   Oncotarget 8 (28), 45259-45273 (2017)
   PUBMED   28410202
  REMARK    GeneRIF: Among polymorphisms identified in the present study,
            rs76974938 [C/T (D67N)] of C21orf59 and rs188780113 [G/A (R478C)]
            of ATG2A may be novel determinants of estimated glomerular
            filtration rate and chronic kidney disease or of the serum
            concentration of uric acid, respectively.
REFERENCE   7  (bases 1 to 6318)
  AUTHORS   Pfisterer,S.G., Bakula,D., Frickey,T., Cezanne,A., Brigger,D.,
            Tschan,M.P., Robenek,H. and Proikas-Cezanne,T.
  TITLE     Lipid droplet and early autophagosomal membrane targeting of Atg2A
            and Atg14L in human tumor cells
  JOURNAL   J Lipid Res 55 (7), 1267-1278 (2014)
   PUBMED   24776541
  REMARK    GeneRIF: These data provide evidence for additional roles of Atg2A
            and Atg14L in the formation of early autophagosomal membranes and
            also in lipid metabolism.
REFERENCE   8  (bases 1 to 6318)
  AUTHORS   Velikkakath,A.K., Nishimura,T., Oita,E., Ishihara,N. and
            Mizushima,N.
  TITLE     Mammalian Atg2 proteins are essential for autophagosome formation
            and important for regulation of size and distribution of lipid
            droplets
  JOURNAL   Mol Biol Cell 23 (5), 896-909 (2012)
   PUBMED   22219374
  REMARK    GeneRIF: Depletion of both Atg2A and Atg2B causes clustering of
            enlarged lipid droplets in an autophagy-independent manner. These
            data suggest that mammalian Atg2 proteins function both in
            autophagosome formation and regulation of lipid droplet morphology
            and dispersion.
REFERENCE   9  (bases 1 to 6318)
  AUTHORS   Romanyuk,D., Polak,A., Maleszewska,A., Sienko,M., Grynberg,M. and
            Zoladek,T.
  TITLE     Human hAtg2A protein expressed in yeast is recruited to
            preautophagosomal structure but does not complement autophagy
            defects of atg2Delta strain
  JOURNAL   Acta Biochim Pol 58 (3), 365-374 (2011)
   PUBMED   21887408
  REMARK    GeneRIF: human hAtg2A can not function in autophagy in yeast,
            however, it is recruited to the preautophagosomal structure
REFERENCE   10 (bases 1 to 6318)
  AUTHORS   Guru,S.C., Agarwal,S.K., Manickam,P., Olufemi,S.E., Crabtree,J.S.,
            Weisemann,J.M., Kester,M.B., Kim,Y.S., Wang,Y., Emmert-Buck,M.R.,
            Liotta,L.A., Spiegel,A.M., Boguski,M.S., Roe,B.A., Collins,F.S.,
            Marx,S.J., Burns,L. and Chandrasekharappa,S.C.
  TITLE     A transcript map for the 2.8-Mb region containing the multiple
            endocrine neoplasia type 1 locus
  JOURNAL   Genome Res 7 (7), 725-735 (1997)
   PUBMED   9253601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC110650.1 and AP001187.5.
            
            On Nov 23, 2018 this sequence version replaced NM_015104.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110650.1, AB007864.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377264.8/ ENSP00000366475.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               BC110650.1         42-180
            140-140             AP001187.5         122870-122870       c
            141-718             BC110650.1         182-759
            719-719             AP001187.5         119147-119147       c
            720-2040            BC110650.1         761-2081
            2041-2041           AP001187.5         115621-115621       c
            2042-3929           BC110650.1         2083-3970
            3930-3930           AP001187.5         108108-108108       c
            3931-6318           BC110650.1         3972-6359
FEATURES             Location/Qualifiers
     source          1..6318
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..6318
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /note="autophagy related 2A"
                     /db_xref="GeneID:23130"
                     /db_xref="HGNC:HGNC:29028"
                     /db_xref="MIM:616225"
     exon            1..245
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..5891
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     autophagy-related protein 2 homolog A; ATG2 autophagy
                     related 2 homolog A; bridge-like lipid transfer protein
                     family member 4A"
                     /codon_start=1
                     /product="autophagy-related protein 2 homolog A isoform 1"
                     /protein_id="NP_055919.2"
                     /db_xref="CCDS:CCDS31602.1"
                     /db_xref="GeneID:23130"
                     /db_xref="HGNC:HGNC:29028"
                     /db_xref="MIM:616225"
                     /translation="MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYK
                     GSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALLTDHCTVRVSGLQ
                     LTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTI
                     ETVLRRIKVTFLDTVVRVEHSPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQ
                     PPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEAFPGPKL
                     EVAGQLGSLHLLLTPRQLQQLQELLSAVSLTDHEGLADKLNKSRPLGAEDLWLIEQDL
                     NQQLQAGAVAEPLSPDPLTNPLLNLDNTDLFFSMAGLTSSVASALSELSLSDVDLASS
                     VRSDMASRRLSAQAHPAGKMAPNPLLDTMRPDSLLKMTLGGVTLTLLQTSAPSSGPPD
                     LATHFFTEFDATKDGPFGSRDFHHLRPRFQRACPCSHVRLTGTAVQLSWELRTGSRGR
                     RTTSMEVHFGQLEVLECLWPRGTSEPEYTEILTFPGTLGSQASARPCAHLRHTQILRR
                     VPKSRPRRSVACHCHSELALDLANFQADVELGALDRLAALLRLATVPAEPPAGLLTEP
                     LPAMEQQTVFRLSAPRATLRLRFPIADLRPEPDPWAGQAVRAEQLRLELSEPQFRSEL
                     SSGPGPPVPTHLELTCSDLHGIYEDGGKPPVPCLRVSKALDPKSTGRKYFLPQVVVTV
                     NPQSSSTQWEVAPEKGEELELSVESPCELREPEPSPFSSKRTMYETEEMVIPGDPEEM
                     RTFQSRTLALSRCSLEVILPSVHIFLPSKEVYESIYNRINNDLLMWEPADLLPTPDPA
                     AQPSGFPGPSGFWHDSFKMCKSAFKLANCFDLTPDSDSDDEDAHFFSVGASGGPQAAA
                     PEAPSLHLQSTFSTLVTVLKGRITALCETKDEGGKRLEAVHGELVLDMEHGTLFSVSQ
                     YCGQPGLGYFCLEAEKATLYHRAAVDDYPLPSHLDLPSFAPPAQLAPTIYPSEEGVTE
                     RGASGRKGQGRGPHMLSTAVRIHLDPHKNVKEFLVTLRLHKATLRHYMALPEQSWHSQ
                     LLEFLDVLDDPVLGYLPPTVITILHTHLFSCSVDYRPLYLPVRVLITAETFTLSSNII
                     MDTSTFLLRFILDDSALYLSDKCEVETLDLRRDYVCVLDVDLLELVIKTWKGSTEGKL
                     SQPLFELRCSNNVVHVHSCADSCALLVNLLQYVMSTGDLHPPPRPPSPTEIAGQKLSE
                     SPASLPSCPPVETALINQRDLADALLDTERSLRELAQPSGGHLPQASPISVYLFPGER
                     SGAPPPSPPVGGPAGSLGSCSEEKEDEREEEGDGDTLDSDEFCILDAPGLGIPPRDGE
                     PVVTQLHPGPIVVRDGYFSRPIGSTDLLRAPAHFPVPSTRVVLREVSLVWHLYGGRDF
                     GPHPGHRARTGLSGPRSSPSRCSGPNRPQNSWRTQGGSGRQHHVLMEIQLSKVSFQHE
                     VYPAEPATGPAAPSQELEERPLSRQVFIVQELEVRDRLASSQINKFLYLHTSERMPRR
                     AHSNMLTIKALHVAPTTNLGGPECCLRVSLMPLRLNVDQDALFFLKDFFTSLVAGINP
                     VVPGETSAEARPETRAQPSSPLEGQAEGVETTGSQEAPGGGHSPSPPDQQPIYFREFR
                     FTSEVPIWLDYHGKHVTMDQVGTFAGLLIGLAQLNCSELKLKRLCCRHGLLGVDKVLG
                     YALNEWLQDIRKNQLPGLLGGVGPMHSVVQLFQGFRDLLWLPIEQYRKDGRLMRGLQR
                     GAASFGSSTASAALELSNRLVQAIQATAETVYDILSPAAPVSRSLQDKRSARRLRRGQ
                     QPADLREGVAKAYDTVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKP
                     LILATEATSSLLGGMRNQIVPDAHKDHALKWRSDSAQD"
     exon            246..408
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            409..561
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            562..664
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            665..800
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            801..899
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            900..996
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1161
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1302
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1540
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1688
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1781
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1937
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2181
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2278
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2438
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2581
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2721
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2906
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3057
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3257
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3338
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3445
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3538
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3609
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3610..3686
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..3851
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3852..3978
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4193
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            4194..4402
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            4403..4538
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            4539..4745
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            4746..4847
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            4848..4932
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            4933..5068
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            5069..5141
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            5142..5224
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            5225..5346
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            5347..5501
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            5502..5654
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     exon            5655..6318
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6300..6305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /note="hexamer: AATAAA"
     polyA_site      6318
                     /gene="ATG2A"
                     /gene_synonym="BLTP4A"
                     /note="major polyA site"
ORIGIN      
        1 agtgaacagc ggagccggac ggggatcgcc ggcgggcggc aagcggaggc ggcccaggcc
       61 cggcggtctc cgagatgtca cgatggctgt ggccatggtc aaactgtgtg aaagagcggg
      121 tctgccgcta cttgctgcac cactacttag gtcacttctt ccaagagcac ctcagcctgg
      181 accagctcag cctcgatctg tacaagggca gcgttgccct gcgagacatc cacctggaaa
      241 tctggtctgt gaacgaggtg ctggagtcaa tggagtcacc gctggagctg gtggaaggct
      301 tcgtgggctc catcgaggtg gccgtgccct gggctgctct gctcaccgac cactgcacag
      361 tgcgcgtgtc cggcctccag ctcaccttgc agccccgccg gggtccagcg ccaggggctg
      421 ccgactcaca gagctgggcc tcatgcatga ccacaagcct gcagctggcc caggagtgtc
      481 tgcgggatgg gctaccggag ccctctgagc caccacagcc cctggagggg ctggagatgt
      541 ttgcccagac cattgagact gtgcttcgga ggatcaaagt gaccttcctg gacactgtcg
      601 tgagggtgga gcactctccg ggtgatgggg aacgtggtgt ggccgtcgag gtccgtgtgc
      661 agagactgga gtactgtgat gaggcagtgc gggacccaag ccaggcgccg ccggtggacg
      721 tgcatcagcc gcctgccttc ctgcacaagc tgctgcagct ggcaggggtc cgcctgcact
      781 acgaggagct cccggcacag gaagagcctc cagagccccc cttgcagatc ggcagctgct
      841 cagggtacat ggagctgatg gtgaagttga agcaaaatga ggccttccct ggccccaagt
      901 tggaggtggc gggacagctg ggctccctgc acctgctcct gaccccgagg cagctccagc
      961 aacttcagga actgctcagc gccgtgagcc ttacagacca cgagggcctg gctgacaagc
     1021 tgaacaagag ccgcccgcta ggtgccgaag acctgtggct gattgagcag gacctgaacc
     1081 agcagctgca ggcaggggca gtggctgagc ccctcagccc agaccccctt accaaccccc
     1141 ttctcaacct ggataacact gacctcttct tctccatggc tggcctcaca agcagtgtgg
     1201 cctcagccct ctctgagctc tccctctccg atgtagacct ggcctcctct gtgcgcagcg
     1261 acatggcctc ccgccggctc tctgcccagg cccacccagc tggcaagatg gcccccaacc
     1321 ccctcctgga caccatgcgc cctgactcgc tgctgaagat gaccttgggg ggtgtgaccc
     1381 tgaccttgct tcagacgtct gccccatctt ccggaccacc tgacctcgcc acgcactttt
     1441 tcaccgagtt tgatgccacc aaggatgggc ccttcggttc ccgagacttc catcaccttc
     1501 gaccacgctt ccagagggcc tgtccctgta gccatgttcg gctaacgggc acagccgtgc
     1561 agctgtcctg ggagctgcgg acgggcagtc ggggccggcg gacaaccagc atggaagtgc
     1621 acttcgggca gctggaggtg ctggagtgtc tgtggccccg gggcacctct gagcctgagt
     1681 acacggagat cctgaccttt cctggtacgc tgggctccca ggcctcagct cggccctgcg
     1741 cccatctgcg ccacacacag atcctgcgcc gtgtgcctaa gagccgaccc cggcgctcag
     1801 ttgcctgcca ttgccactca gaactggccc tggacctggc caacttccag gcggacgtgg
     1861 agctgggggc cctggaccgg ctggccgccc tactgcgcct ggccaccgta cctgctgagc
     1921 ctccagccgg cctgctgaca gagcccctgc cggcgatgga gcagcagacg gtatttcggc
     1981 tctctgcacc ccgggccacg ctgcggctgc gcttccccat tgccgacctg cggcctgagc
     2041 cggacccctg ggcgggccag gccgtgcggg ctgagcagct tcggctggag ctgagtgagc
     2101 cccagttccg gtcagagctt agcagtgggc ctggtccccc agtccccacc cacctggaac
     2161 tcacctgctc cgacctacat ggtatctatg aagatggagg gaagccacct gtcccttgcc
     2221 tgcgtgtctc caaagccctg gaccccaaga gcactgggcg caagtacttc ctgccccagg
     2281 tagtggtgac tgtgaacccc cagtccagca gcacacagtg ggaggtggcc ccggagaagg
     2341 gagaggaact ggagctgtca gtggagagtc cctgtgagct gcgggaacct gagccctcgc
     2401 ccttctcctc taagaggacc atgtatgaga cagaggagat ggtgatccct ggagaccctg
     2461 aggagatgag gacgttccag agccggaccc tggcactgtc ccgctgcagc ctggaagtga
     2521 tcctgcccag tgtccacatc tttctgccca gcaaggaggt ctacgagagc atctacaaca
     2581 ggatcaacaa cgacctgctc atgtgggagc ctgcagatct gcttcccacc cccgaccccg
     2641 ccgcccagcc ctcgggcttc cccggcccct caggcttctg gcacgacagc tttaagatgt
     2701 gcaagtcagc cttcaagctg gccaactgct ttgatctcac cccagactcg gactcggatg
     2761 acgaggatgc ccacttcttc tcagtggggg catcaggtgg cccacaggcc gctgcccctg
     2821 aggccccaag tcttcacttg cagagcacct tctctacact ggtgacagtg ctgaaggggc
     2881 ggatcacagc cctctgtgag accaaggatg agggtgggaa gcggctggag gctgtgcacg
     2941 gggagctggt gctggacatg gagcacggta ccctcttcag cgtctcccag tactgtggcc
     3001 agccaggact tggctacttc tgtctggaag ctgaaaaggc aacactctac caccgagcgg
     3061 ccgtggatga ctacccgctg cccagtcacc tggaccttcc cagtttcgct cccccggctc
     3121 agctggcccc aaccatctac ccatcggagg aaggggtgac cgagcgggga gcctcgggcc
     3181 gcaagggcca gggccgggga ccccacatgt tgtccactgc tgtgcgcatc cacctggacc
     3241 cccacaagaa tgtgaaggag ttcctggtga cactgcggtt gcacaaagcc accttgcgcc
     3301 actacatggc cctgcccgag cagagctggc attcccagtt gttggagttc ctagacgtgc
     3361 tggatgaccc tgtgctgggc tacctgcccc cgacggtcat caccatcctg cacacacacc
     3421 tgttctcctg ctctgtggac tataggccac tctacctccc agtgcgtgtc ctcatcaccg
     3481 cggagacctt cactctctcc agcaacatca tcatggacac ctccaccttc ctgctcaggt
     3541 tcatcctcga tgactccgcc ttgtacctgt ccgacaagtg tgaggtggag accctggacc
     3601 tgcggcgaga ttatgtctgt gttttggatg ttgacctctt ggaacttgtg attaaaacct
     3661 ggaaagggag caccgagggc aaactgagcc agccactatt cgagctgcgc tgctccaaca
     3721 atgtggtaca cgtgcacagc tgtgccgact cctgtgccct gctggtcaac ctgctccagt
     3781 acgtaatgag cacaggcgat ctgcaccccc caccccggcc ccccagcccc acggagatcg
     3841 ccggccagaa gctctcggag agtcctgcct ctctgccctc gtgcccccca gtggagacgg
     3901 ccctcatcaa ccagcgtgac ctggccgacg ccctcctgga caccgagcgc agcctacggg
     3961 agctggccca gccttcaggt ggccacctcc ctcaggcgtc gcccatctcc gtctacctat
     4021 tcccaggtga acggagtggg gccccacccc cttcaccacc tgtcgggggc cctgctggca
     4081 gcttagggtc atgctcagag gagaaggaag atgaaaggga agaggagggc gatggagaca
     4141 ccctggacag tgatgagttc tgcatccttg atgctcccgg cctgggcatc ccgccccgag
     4201 atggggagcc tgtggtgaca cagctgcatc ccggccccat cgttgtgagg gacggttact
     4261 tctcacggcc gatcggcagc acggacttgc tgcgggcacc tgcccatttc ccagtgccca
     4321 gcactcgggt ggtgctacgt gaggtctccc tcgtctggca cctctatggg ggccgagact
     4381 ttggccccca ccccggccac agggcaagaa ctggcctctc aggtcccagg agctcccctt
     4441 cccgctgctc tggccccaac cggccccaga actcatggcg cacgcagggg ggcagcgggc
     4501 ggcagcacca tgtcctcatg gagatccagc tgagcaaggt aagcttccag cacgaggtgt
     4561 acccagcgga gccagccaca ggccctgcgg cccccagcca ggagctggag gagcgaccgc
     4621 tgtcccgtca ggtgttcatc gtgcaggagc tggaggtccg agaccggctc gcctcctccc
     4681 agatcaacaa gttcctgtac ctacacacga gtgagcggat gccgcgacgt gcccactcta
     4741 acatgctcac catcaaagcg ctgcatgtgg cccccactac caacctgggt gggcctgagt
     4801 gctgtctccg cgtctcgctg atgcccctgc ggctcaatgt ggaccaggat gccctcttct
     4861 tcctcaagga cttcttcact agtctggtgg ccggcatcaa ccccgtggtc ccaggggaga
     4921 cctccgctga ggctcgcccc gagactcgag cccagcccag cagccccctg gaagggcagg
     4981 ccgaaggcgt agagaccact ggttcgcagg aggccccagg aggtggacac agcccctccc
     5041 ctcctgacca gcagcccatc tacttcagag agttccgctt cacgtctgag gtccccatct
     5101 ggctggatta ccatggcaag cacgtcacga tggaccaggt gggcactttt gctggcctcc
     5161 tcatcggcct ggcccaactc aactgctccg agctgaagct aaagcggctc tgttgcaggc
     5221 acgggctcct gggtgtggac aaggtgctgg gctatgccct caacgagtgg ctgcaggaca
     5281 tccgcaagaa ccagctgccc ggcctgctgg gaggcgtggg ccccatgcac tcggttgtcc
     5341 agctcttcca agggttccgg gacctgctgt ggctgcccat tgagcagtac aggaaggatg
     5401 gccgcctcat gcgggggctg cagcgagggg ctgcctcctt tggctcatcc acagcctctg
     5461 ccgccctgga actcagcaac cggttggtac aggctatcca ggccacagct gagaccgtgt
     5521 atgacatcct gtccccggca gcccccgtct cccgctccct gcaggataag cgctctgcgc
     5581 ggaggctgcg caggggccag cagcctgccg acctgcggga gggtgtggcc aaggcctacg
     5641 acacagtgcg agagggcatc ttggatacag ctcagaccat ctgtgacgtg gcatcgcggg
     5701 gccatgagca gaaggggctg acgggcgccg tggggggcgt gatccgccag ctgcccccga
     5761 ctgtggtgaa gccgctcatc ctggccacgg aggccacgtc cagcctgctc gggggcatgc
     5821 gcaaccagat tgtccccgac gcccacaagg accacgccct caagtggcgc tcggacagtg
     5881 cccaagactg agcctggggt gcccggcacc cagagggtgc tgcccaccat gctcctgagc
     5941 ctcccaagag ctgcagccca cgggcccggc ccggcctggc ccttcagggg atggccactg
     6001 tgaaggacgc cttcccagcc tgcccgttgc caatctgctg tgagaggggg gcctccctgc
     6061 cttggggcct tagccctggc tctgcacttt tcctccgggg agaaaggaca ctgcccctcc
     6121 cccgacctgg gcccacactg ctgccttctc ccaggacgga ggcttttgga ccctcggacc
     6181 ccatcccact cagccaagtg tctttctgtg tctgggggga ggaggggatg atatccgtgt
     6241 ggttcgatgt attattttta agctccgtga gtgcgtgggt cagtgtctgc atgaagtgga
     6301 ataaactgcc caccgcca
//
