LOCUS       NM_014924               4715 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens autophagy related 14 (ATG14), mRNA.
ACCESSION   NM_014924
VERSION     NM_014924.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4715)
  AUTHORS   Shi,X. and Zhang,X.
  TITLE     Control of ATG14 solubility and autophagy by
            MARCHF7/MARCH7-mediated ubiquitination
  JOURNAL   Autophagy 20 (3), 699-700 (2024)
   PUBMED   37915253
  REMARK    GeneRIF: Control of ATG14 solubility and autophagy by
            MARCHF7/MARCH7-mediated ubiquitination.
REFERENCE   2  (bases 1 to 4715)
  AUTHORS   Han,D., Huang,M., Chang,Z. and Sun,W.
  TITLE     KLF15 Transcriptionally Activates ATG14 to Promote Autophagy and
            Attenuate Damage of ox-LDL-Induced HAECs
  JOURNAL   Mol Biotechnol 66 (1), 112-122 (2024)
   PUBMED   37043109
  REMARK    GeneRIF: KLF15 Transcriptionally Activates ATG14 to Promote
            Autophagy and Attenuate Damage of ox-LDL-Induced HAECs.
REFERENCE   3  (bases 1 to 4715)
  AUTHORS   Huang,M., Zhang,Y., Park,J., Chowdhury,K., Xu,J., Lu,A., Wang,L.,
            Zhang,W., Ekser,B., Yu,L. and Dong,X.C.
  TITLE     ATG14 plays a critical role in hepatic lipid droplet homeostasis
  JOURNAL   Metabolism 148, 155693 (2023)
   PUBMED   37741434
  REMARK    GeneRIF: ATG14 plays a critical role in hepatic lipid droplet
            homeostasis.
REFERENCE   4  (bases 1 to 4715)
  AUTHORS   Zhao,Z., He,J. and Feng,C.
  TITLE     CircCBFB is a mediator of hepatocellular carcinoma cell autophagy
            and proliferation through miR-424-5p/ATG14 axis
  JOURNAL   Immunol Res 70 (3), 341-353 (2022)
   PUBMED   35066780
  REMARK    GeneRIF: CircCBFB is a mediator of hepatocellular carcinoma cell
            autophagy and proliferation through miR-424-5p/ATG14 axis.
REFERENCE   5  (bases 1 to 4715)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4715)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 4715)
  AUTHORS   Lindmo,K. and Stenmark,H.
  TITLE     Regulation of membrane traffic by phosphoinositide 3-kinases
  JOURNAL   J Cell Sci 119 (Pt 4), 605-614 (2006)
   PUBMED   16467569
  REMARK    Review article
REFERENCE   8  (bases 1 to 4715)
  AUTHORS   Stein,M.P., Feng,Y., Cooper,K.L., Welford,A.M. and
            Wandinger-Ness,A.
  TITLE     Human VPS34 and p150 are Rab7 interacting partners
  JOURNAL   Traffic 4 (11), 754-771 (2003)
   PUBMED   14617358
REFERENCE   9  (bases 1 to 4715)
  AUTHORS   Petiot,A., Ogier-Denis,E., Blommaart,E.F., Meijer,A.J. and
            Codogno,P.
  TITLE     Distinct classes of phosphatidylinositol 3'-kinases are involved in
            signaling pathways that control macroautophagy in HT-29 cells
  JOURNAL   J Biol Chem 275 (2), 992-998 (2000)
   PUBMED   10625637
  REMARK    Erratum:[J Biol Chem 2000 Apr 21;275(16):12360]
REFERENCE   10 (bases 1 to 4715)
  AUTHORS   Panaretou,C., Domin,J., Cockcroft,S. and Waterfield,M.D.
  TITLE     Characterization of p150, an adaptor protein for the human
            phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by
            phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase
            complex
  JOURNAL   J Biol Chem 272 (4), 2477-2485 (1997)
   PUBMED   8999962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131251.1, AL158801.4 and AA988343.1.
            
            On Jul 25, 2019 this sequence version replaced NM_014924.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BR000826.1, AK131251.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247178.6/ ENSP00000247178.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2048              AK131251.1         29-2076
            2049-4331           AL158801.4         10908-13190
            4332-4715           AA988343.1         18-401              c
FEATURES             Location/Qualifiers
     source          1..4715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..4715
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /note="autophagy related 14"
                     /db_xref="GeneID:22863"
                     /db_xref="HGNC:HGNC:19962"
                     /db_xref="MIM:613515"
     exon            1..229
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1487
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /note="Beclin 1-Interacting protein; autophagy-related
                     protein 14-like protein; ATG14 autophagy related 14
                     homolog"
                     /codon_start=1
                     /product="beclin 1-associated autophagy-related key
                     regulator"
                     /protein_id="NP_055739.2"
                     /db_xref="CCDS:CCDS32087.1"
                     /db_xref="GeneID:22863"
                     /db_xref="HGNC:HGNC:19962"
                     /db_xref="MIM:613515"
                     /translation="MASPSGKGARALEAPGCGPRPLARDLVDSVDDAEGLYVAVERCP
                     LCNTTRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSRLKSKQEEFQKEVLKAMEG
                     KWITDQLRWKIMSCKMRIEQLKQTICKGNEEMEKNSEGLLKTKEKNQKLYSRAQRHQE
                     KKEKIQRHNRKLGDLVEKKTIDLRSHYERLANLRRSHILELTSVIFPIEEVKTGVRDP
                     ADVSSESDSAMTSSTVSKLAEARRTTYLSGRWVCDDHNGDTSISITGPWISLPNNGDY
                     SAYYSWVEEKKTTQGPDMEQSNPAYTISAALCYATQLVNILSHILDVNLPKKLCNSEF
                     CGENLSKQKFTRAVKKLNANILYLCFSQHVNLDQLQPLHTLRNLMYLVSPSSEHLGRS
                     GPFEVRADLEESMEFVDPGVAGESDESGDERVSDEETDLGTDWENLPSPRFCDIPSQS
                     VEVSQSQSTQASPPIASSSAGGMISSAAASVTSWFKAYTGHR"
     exon            230..292
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /inference="alignment:Splign:2.1.0"
     exon            293..335
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /inference="alignment:Splign:2.1.0"
     exon            336..417
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /inference="alignment:Splign:2.1.0"
     exon            418..655
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /inference="alignment:Splign:2.1.0"
     exon            656..885
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1003
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1094
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1180
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..4715
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4697..4702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /note="hexamer: AATAAA"
     polyA_site      4715
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /note="major polyA site"
ORIGIN      
        1 aggccatcat ggcgtctccc agtgggaagg gagcccgggc gctggaggct cctggctgcg
       61 ggccccggcc gctcgcccgg gacctggtgg actccgtgga cgatgcggag gggctgtacg
      121 tggctgtgga gcgctgcccg ctgtgcaaca ctacccgccg gcggctgacc tgcgccaaat
      181 gcgttcagag cggcgatttc gtctacttcg acggccgcga ccgggagagg tttatcgaca
      241 agaaggaaag gttaagccga cttaagagca agcaagaaga atttcagaaa gaagtgttaa
      301 aagctatgga aggaaaatgg ataacagatc agttgagatg gaaaataatg tcctgcaaga
      361 tgaggattga acagttaaaa caaacaatat gtaaaggaaa tgaagaaatg gagaaaaatt
      421 ctgaaggcct tctcaaaacc aaggaaaaga atcagaagct ttacagtcga gcacaacggc
      481 accaagagaa aaaggagaag attcagaggc ataatcgcaa acttggtgac ctggtagaaa
      541 aaaagaccat tgacttaaga agtcattatg agcgtctggc aaatcttcga cgatcccata
      601 tattagagct cacctctgtc atttttccaa tcgaggaagt aaagacgggt gtgagagacc
      661 ccgcagatgt gtcttcagag agtgacagtg ccatgacctc cagcactgtg agcaagcttg
      721 ctgaagcccg gaggacaact tacctctcag gacgatgggt ctgtgacgat cacaacggag
      781 acaccagcat tagcattaca gggccttgga ttagcctccc taacaatggg gactactctg
      841 cctactacag ctgggtggag gagaagaaaa caacccaggg gcctgacatg gagcagagta
      901 accctgccta caccatcagt gctgcgctgt gctatgcaac tcagctggtc aacattctgt
      961 ctcatatact tgatgtaaat cttcccaaaa agctctgcaa cagtgaattt tgtggcgaaa
     1021 atctaagcaa gcagaaattt actcgagcag tgaagaaact gaatgcaaat attctttacc
     1081 tttgtttttc tcagcatgta aatttagatc aattacaacc actgcatacc ctcaggaatc
     1141 taatgtacct ggtcagtcca agctctgaac acctaggcag gtcagggccc tttgaagtac
     1201 gagcagacct tgaggagtcc atggaatttg tggatcccgg agttgctgga gaatcagatg
     1261 agagcggaga tgagcgcgtc agcgatgaag aaaccgacct gggcacagac tgggagaact
     1321 tgcctagtcc ccggttttgt gatatccctt cccagtctgt ggaagtctcc cagagtcaga
     1381 gcacccaggc gtccccaccc atcgcgagca gcagtgcagg tgggatgatc tcctctgcag
     1441 cagcctcggt gacctcctgg tttaaagctt acactggaca ccgttaacga gcatggacca
     1501 aaacatacca aatctgcatc aagaaagttc ttctcccact acactctagt aaacattttc
     1561 tgtttaagtt aagatagtgt ctggaacaaa gaggttaaag tgttgttttg ttttgtcttt
     1621 ttaagcaggg agacaaacat ttctatttgc caagtggcct gtgatggtga ccaacatgct
     1681 tatgataatt aagagaacag gggtcgaagg tctttctacc cagaccagtg ctggtggaag
     1741 gaggacctgt gcgtgtggcc agttctgcca aggaagcagt tgatttgggt tccctctggg
     1801 cccgggccac cgggcccaca gatatgggtc agtgtgctgg tccttgcggt gctgagactg
     1861 ttcctgacac tttaagtttt agaggttggt tgaatcacaa gaggtgattc ttgattatta
     1921 ggacatgaaa gataaaagct ctttaataag agtttttctg ccattgtttt ttgtatgaga
     1981 accagcaggc aatttaaaat ttctaatttg gtcctttgat tttgtttggg aggggtgagt
     2041 tacacgtatt ttattcatgc tgctctgtcg tagtttgtca gacattcctg tttttctttc
     2101 ccccacacac caaagaaaat gaaagtcttt ttctttagga cccacatcca taaatggaag
     2161 aaatcctggc tgcaataatg tctagagagt ttttaactat tttcttgtat tctgagggga
     2221 attaagctta ttcttaccta gttgaattcc tgccatccac actatgagca ttttgaaatt
     2281 gaacttatat tttctgggtg aaaataagtc atgaaggtca ttcccttatg taagctcaat
     2341 gcctgcctgg gcacagggga aaagccactt agttaagtgg cctctggtca ttcttgtggt
     2401 gtccactttc tttctatggg attgagtagg tggcaggtgt tttcagggga aaccatccta
     2461 cttgtttccc cgaactcttt gttgctctga ggacacagct ttgctcagaa atgcagcgca
     2521 gatccttacg gctgatgcta ctctgctctg ttctggggaa agcacaatat aaagaaagaa
     2581 tttcccagcc aggcgcagtg gctcacgcct gtaatcccag cactttagga ggccgaggca
     2641 ggcggatcac ttgaggtcag gagtttgaga gcagcctggc taacatggtg aaaccctgtt
     2701 tctactaaaa atacaaaaaa ttaccgggtg tggtggcgca cgcctgtaat cccagctact
     2761 cgggaggctg cggcaggaga atcgcttgaa ccgggaggca gaggttgcag tgagccgaga
     2821 ttgtgccatt gcactccagc ctgggcaaca agagcgaaac tccgtctcaa aaaaaaaaag
     2881 aatttccctc agcaggagat cattttcagc tcacgtgtct tgtcattctt ttagtgacaa
     2941 tcttacaaga aaactataat gagagaggca ttatgtacaa atatgtaagt agtttatttt
     3001 taataactgc aaaaaaatcc tatgtaacaa ctaccaaaag aaatcctatg aaagagtcct
     3061 aacaggcatt attaccatat cttatgtgat tggcatgata gcacctctga taaatcattc
     3121 agaggtttgc catgccccag cttcttttct catcataata attgtagttg atactttgcc
     3181 tccaagtccg aggtgctata tagcttttgc taatggtata tttggtgttt tgtatagttt
     3241 tgggtagagt tgcagaacgg agtttatttc tatccggtag tcacaaattc cttggctcta
     3301 tgaattttcc atgaaaggag gaagtaggct tttctcgttg tgggtggtct tttttttttt
     3361 tggagacgga gtctcactca gctgcccagg ctggagtgta gtggcaccat ctccgctcac
     3421 tgcaaccacc atctcctggg ttcaagcaat tcttccatct caacctcccg agtagctggg
     3481 attataggca cctgccatca tgcccagcta atttttgtat tttagtaaag acgggggttt
     3541 tcaccatgtt ggccaggctg gtcttgaact cctgacttca ggtgatccgc ttgccttggc
     3601 ctcctaaagt gctaggatta caggcctgag ccaccgcgcc cggcccctta tgggttcttc
     3661 tacactgctg ggatctctgt tttaagtgct cagcttcatg attgattgct gggcttccat
     3721 tttcccatcc agttctggag ttcgtagaga gtgaagatgg tagacttgaa cagataaata
     3781 aacttaacga tcttgtaaga gttgtctagc tacttaaaac cctcagaagt aagagcttag
     3841 tctcacgagt tgtaagagtg ggatttggag cttggtggtg gagactgact tcagctgaga
     3901 gatgcacaac agtcatggtt ttcttaagcc tcttatgaaa ccatgaatga gagatgaagc
     3961 taaagaatag aatccagaga tcacaaactc atctagagta cttccacaaa atttacaaag
     4021 atgtgggaac tttatggata ggatatattt tgtttgttgt tgttaatatc aactagaggc
     4081 actttacata gggttaagtg atcgaaccct tttgtggttt tgaacaccaa catactggct
     4141 tacactgctg aaatattttg ggtttcatta ttttgcactg gatccaccct gtaaatactc
     4201 ttaagtatac atttcaacca ctgttttttc tactcttttt gctgctcatt aaaatctttc
     4261 atgtaggtgc cagaaccata tgtaaacagc tttttaaaaa attgaagctg gtattttgtt
     4321 taaacaaaaa gccatagaac ttggtcatgt tttccatttt aaaatgattt actgaaacaa
     4381 agtaatacta ataaaaaccc acaggcacca aacaggctgc ttaaaatggt ctgttaaaga
     4441 cattttttgg ttatggaata taagaaaagt tttgcacatc tgtaaggggg aaaaacagta
     4501 tatcaccatt gggtagagtg gacgggactc atgtaaggac tcaatttggg gaagagcatt
     4561 cagtggcatg ctgttagagg actagtgtcc gagaatctcc tcacagtatc atgttgcagg
     4621 aattccccat tgctctgcaa cttccaaacc agtttgagtc atacaaatgt tttctaaact
     4681 tttattgtat tactgcaata aatcttttaa cagta
//
