LOCUS       NM_021934               1433 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens autophagy related 101 (ATG101), transcript variant 1,
            mRNA.
ACCESSION   NM_021934 XM_005269072
VERSION     NM_021934.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1433)
  AUTHORS   Patel,A. and Faesen,A.C.
  TITLE     Metamorphosis by ATG13 and ATG101 in human autophagy initiation
  JOURNAL   Autophagy 20 (4), 968-969 (2024)
   PUBMED   37394799
  REMARK    GeneRIF: Metamorphosis by ATG13 and ATG101 in human autophagy
            initiation.
REFERENCE   2  (bases 1 to 1433)
  AUTHORS   Nguyen,A. and Faesen,A.C.
  TITLE     The role of the HORMA domain proteins ATG13 and ATG101 in
            initiating autophagosome biogenesis
  JOURNAL   FEBS Lett 598 (1), 114-126 (2024)
   PUBMED   37567770
  REMARK    GeneRIF: The role of the HORMA domain proteins ATG13 and ATG101 in
            initiating autophagosome biogenesis.
            Review article
REFERENCE   3  (bases 1 to 1433)
  AUTHORS   Wang,B., Fu,J., Lin,Y., Lou,Y., Lu,A. and Yang,J.
  TITLE     ATG101-related signature predicts prognosis and therapeutic option
            in hepatocellular carcinoma
  JOURNAL   Sci Rep 12 (1), 18066 (2022)
   PUBMED   36302799
  REMARK    GeneRIF: ATG101-related signature predicts prognosis and
            therapeutic option in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1433)
  AUTHORS   Tu,Y.X.I., Sydor,A.M., Coyaud,E., Laurent,E.M.N., Dyer,D.,
            Mellouk,N., St-Germain,J., Vernon,R.M., Forman-Kay,J.D., Li,T.,
            Hua,R., Zhao,K., Ridgway,N.D., Kim,P.K., Raught,B. and Brumell,J.H.
  TITLE     Global Proximity Interactome of the Human Macroautophagy Pathway
  JOURNAL   Autophagy 18 (5), 1174-1186 (2022)
   PUBMED   34524948
REFERENCE   5  (bases 1 to 1433)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 1433)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   7  (bases 1 to 1433)
  AUTHORS   Hosokawa,N., Sasaki,T., Iemura,S., Natsume,T., Hara,T. and
            Mizushima,N.
  TITLE     Atg101, a novel mammalian autophagy protein interacting with Atg13
  JOURNAL   Autophagy 5 (7), 973-979 (2009)
   PUBMED   19597335
  REMARK    GeneRIF: These data suggest that Atg101 is a novel Atg protein that
            functions together with ULK, Atg13 and FIP200.
REFERENCE   8  (bases 1 to 1433)
  AUTHORS   Mercer,C.A., Kaliappan,A. and Dennis,P.B.
  TITLE     A novel, human Atg13 binding protein, Atg101, interacts with ULK1
            and is essential for macroautophagy
  JOURNAL   Autophagy 5 (5), 649-662 (2009)
   PUBMED   19287211
  REMARK    GeneRIF: The identification of the novel protein, Atg101, and the
            validation of Atg13 and Atg101 as ULK1-interacting proteins,
            suggests an Atg1 complex is involved in the induction of
            macroautophagy in mammalian cells.
REFERENCE   9  (bases 1 to 1433)
  AUTHORS   Jung,C.H., Jun,C.B., Ro,S.H., Kim,Y.M., Otto,N.M., Cao,J., Kundu,M.
            and Kim,D.H.
  TITLE     ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy
            machinery
  JOURNAL   Mol Biol Cell 20 (7), 1992-2003 (2009)
   PUBMED   19225151
REFERENCE   10 (bases 1 to 1433)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025259.49.
            
            On Sep 17, 2020 this sequence version replaced NM_021934.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005151.2, AK021835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336854.9/ ENSP00000338990.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AC025259.49        13479-13743         c
            266-395             AC025259.49        13238-13367         c
            396-723             AC025259.49        9819-10146          c
            724-1433            AC025259.49        6226-6935           c
FEATURES             Location/Qualifiers
     source          1..1433
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..1433
                     /gene="ATG101"
                     /gene_synonym="C12orf44"
                     /note="autophagy related 101"
                     /db_xref="GeneID:60673"
                     /db_xref="HGNC:HGNC:25679"
                     /db_xref="MIM:615089"
     exon            1..265
                     /gene="ATG101"
                     /gene_synonym="C12orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            266..395
                     /gene="ATG101"
                     /gene_synonym="C12orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            396..723
                     /gene="ATG101"
                     /gene_synonym="C12orf44"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..1128
                     /gene="ATG101"
                     /gene_synonym="C12orf44"
                     /note="Atg13-interacting protein"
                     /codon_start=1
                     /product="autophagy-related protein 101"
                     /protein_id="NP_068753.2"
                     /db_xref="CCDS:CCDS8820.1"
                     /db_xref="GeneID:60673"
                     /db_xref="HGNC:HGNC:25679"
                     /db_xref="MIM:615089"
                     /translation="MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGT
                     YSIGTVGTQDVDCDFIDFTYVRVSSEELDRALRKVVGEFKDALRNSGGDGLGQMSLEF
                     YQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMN
                     RHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQITDALGTSVTTTMRRLIKDTLAL
                     "
     exon            724..1433
                     /gene="ATG101"
                     /gene_synonym="C12orf44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1404..1409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATG101"
                     /gene_synonym="C12orf44"
                     /note="hexamer: AATAAA"
     polyA_site      1433
                     /gene="ATG101"
                     /gene_synonym="C12orf44"
                     /note="major polyA site"
ORIGIN      
        1 ccggtcccgg ctcagcctcc gacccaggtg gtctggagcc tgccgggaga gtggtggcat
       61 ctgagaggct ggtcgtggac tgtggttggg ggaggtggga gctgttttaa ccgtgtgccc
      121 cctctcctgt gccggcgtgg gcatcccccg gggcagtgga acgcgggcgc tcctccagct
      181 tccgagtcca gccagcctgg gcgcggggcg ccgcccccga gacacccgag gagtccgttc
      241 ctccctggtt acgtggactg tggagctggt ctcttgtggc tcagcgccgt gcggaggttg
      301 aagcgtacct gcggaggtcg caccagggcg tgaggaggag gaggaagggc atgagccgag
      361 cttgaggaat ccgtgctcca aactctacac tcaagggtgg cccttgggta gggtgaagat
      421 cccctgtctt tatcctagtt ccacaccttg gtgtgggtta ctgggtgcag gatgaactgt
      481 cgctcggagg tgctggaggt gtcggtggag gggcggcagg tggaggaggc catgctggct
      541 gtgctgcaca cggtgcttct gcaccgcagc acaggcaagt tccactacaa gaaggagggc
      601 acctactcca ttggcaccgt gggcacccag gatgttgact gtgacttcat cgacttcact
      661 tatgtgcgtg tctcttctga ggaactggat cgtgccctgc gcaaggttgt tggggagttc
      721 aaggatgcac tgcgcaactc tggtggcgat gggctggggc agatgtcctt ggagttctac
      781 cagaagaaga agtctcgctg gccattctca gacgagtgca tcccatggga agtgtggacg
      841 gtcaaggtgc atgtggtagc cctggccacg gagcaggagc ggcagatctg ccgggagaag
      901 gtgggtgaga aactctgcga gaagatcatc aacatcgtgg aggtgatgaa tcggcatgag
      961 tacttgccca agatgcccac acagtcggag gtggataacg tgtttgacac aggcttgcgg
     1021 gacgtgcagc cctacctgta caagatctcc ttccagatca ctgatgccct gggcacctca
     1081 gtcaccacca ccatgcgcag gctcatcaaa gacacccttg ccctctgagc gtcgctggat
     1141 ctctgggagc tccttgatgg ctcccagacc ttggcttttg ggaattgcac ttttgggcct
     1201 ttgggctctg gaacctgctc tgggtcattg gtgagacttg gaaggggcag cccccgctgg
     1261 cttcttggtt ttgtggttgc cagcctcagg tcatcctttt aatctttgct gacggttcag
     1321 tcctgcctct actgtctctc catagccctg gtggggtccc ccttctttct ccactgtaca
     1381 gaagagccac cactgggatg gggaataaag ttgagaacat gagtttgggc tga
//
