LOCUS       NM_031482               3029 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens autophagy related 10 (ATG10), transcript variant 2,
            mRNA.
ACCESSION   NM_031482
VERSION     NM_031482.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3029)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3029)
  AUTHORS   Bali,J.S., Sambyal,V., Mehrotra,S., Gupta,P., Guleria,K.,
            Uppal,M.S. and Sudan,M.
  TITLE     Association of ATG10 rs1864183, ATG16L1 rs2241880 and miR-126 with
            esophageal cancer
  JOURNAL   Mol Biol Rep 51 (1), 231 (2024)
   PUBMED   38281293
  REMARK    GeneRIF: Association of ATG10 rs1864183, ATG16L1 rs2241880 and
            miR-126 with esophageal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3029)
  AUTHORS   Li,S., Ni,Y., Li,C., Xiang,Q., Zhao,Y., Xu,H., Huang,W., Wang,Y.,
            Wang,Y., Zhan,J. and Liu,Y.
  TITLE     Long noncoding RNA SNHG1 alleviates high glucose-induced vascular
            smooth muscle cells calcification/senescence by
            post-transcriptionally regulating Bhlhe40 and autophagy via Atg10
  JOURNAL   J Physiol Biochem 79 (1), 83-105 (2023)
   PUBMED   36194366
  REMARK    GeneRIF: Long noncoding RNA SNHG1 alleviates high glucose-induced
            vascular smooth muscle cells calcification/senescence by
            post-transcriptionally regulating Bhlhe40 and autophagy via Atg10.
REFERENCE   4  (bases 1 to 3029)
  AUTHORS   Wen,J., Wan,L. and Dong,X.
  TITLE     The prognostic value of autophagy related genes with potential
            protective function in Ewing sarcoma
  JOURNAL   BMC Bioinformatics 23 (1), 306 (2022)
   PUBMED   35902797
  REMARK    GeneRIF: The prognostic value of autophagy related genes with
            potential protective function in Ewing sarcoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3029)
  AUTHORS   Huang,S., Rao,J., Wei,J., Huang,Q., Zhu,Y., Li,W. and Xue,C.
  TITLE     Analysis of rs1864182 and rs1864183 variants in ATG10 gene and
            antineutrophil cytoplasmic autoantibody-associated vasculitis in
            Chinese Guangxi population
  JOURNAL   J Clin Lab Anal 36 (2), e24193 (2022)
   PUBMED   34961976
  REMARK    GeneRIF: Analysis of rs1864182 and rs1864183 variants in ATG10 gene
            and antineutrophil cytoplasmic autoantibody-associated vasculitis
            in Chinese Guangxi population.
REFERENCE   6  (bases 1 to 3029)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   7  (bases 1 to 3029)
  AUTHORS   Nemoto,T., Tanida,I., Tanida-Miyake,E., Minematsu-Ikeguchi,N.,
            Yokota,M., Ohsumi,M., Ueno,T. and Kominami,E.
  TITLE     The mouse APG10 homologue, an E2-like enzyme for Apg12p
            conjugation, facilitates MAP-LC3 modification
  JOURNAL   J Biol Chem 278 (41), 39517-39526 (2003)
   PUBMED   12890687
REFERENCE   8  (bases 1 to 3029)
  AUTHORS   Mizushima,N., Yoshimori,T. and Ohsumi,Y.
  TITLE     Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the
            conjugation-mediated yeast two-hybrid method
  JOURNAL   FEBS Lett 532 (3), 450-454 (2002)
   PUBMED   12482611
REFERENCE   9  (bases 1 to 3029)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 3029)
  AUTHORS   Feldman,R.D., Hunninghake,G.W. and McArdle,W.L.
  TITLE     Beta-adrenergic-receptor-mediated suppression of interleukin 2
            receptors in human lymphocytes
  JOURNAL   J Immunol 139 (10), 3355-3359 (1987)
   PUBMED   2890687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114969.2, AK225969.1, BC029268.1, AC010598.6 and AI436652.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031482.4.
            
            Summary: Autophagy is a process for the bulk degradation of
            cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme
            involved in 2 ubiquitin-like modifications essential for
            autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261)
            conjugation and modification of a soluble form of MAP-LC3
            (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a
            membrane-bound form (Nemoto et al., 2003 [PubMed
            12890687]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR,
            as compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.32915.1, BC029268.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282185.8/ ENSP00000282185.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC114969.2         106908-106909       c
            3-229               AK225969.1         1-227
            230-1457            BC029268.1         198-1425
            1458-1896           AC010598.6         80926-81364         c
            1897-2290           AI436652.1         10-403              c
            2291-3029           AC010598.6         79793-80531         c
FEATURES             Location/Qualifiers
     source          1..3029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1-q14.2"
     gene            1..3029
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /note="autophagy related 10"
                     /db_xref="GeneID:83734"
                     /db_xref="HGNC:HGNC:20315"
                     /db_xref="MIM:610800"
     exon            1..284
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /inference="alignment:Splign:2.1.0"
     exon            285..404
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..959
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /note="autophagy-related protein 10; ATG10 autophagy
                     related 10 homolog; APG10 autophagy 10-like"
                     /codon_start=1
                     /product="ubiquitin-like-conjugating enzyme ATG10"
                     /protein_id="NP_113670.1"
                     /db_xref="CCDS:CCDS4057.1"
                     /db_xref="GeneID:83734"
                     /db_xref="HGNC:HGNC:20315"
                     /db_xref="MIM:610800"
                     /translation="MEEDEFIGEKTFQRYCAEFIKHSQQIGDSWEWRPSKDCSDGYMC
                     KIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLY
                     SCSYQVPVLYFRASFLDGRPLTLKDIWEGVHECYKMRLLQGPWDTITQQEHPILGQPF
                     FVLHPCKTNEFMTPVLKNSQKINKNVNYITSWLSIVGPVVGLNLPLSYAKATSQDERN
                     VP"
     exon            405..512
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /inference="alignment:Splign:2.1.0"
     exon            513..651
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /inference="alignment:Splign:2.1.0"
     exon            652..749
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /inference="alignment:Splign:2.1.0"
     exon            750..847
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /inference="alignment:Splign:2.1.0"
     exon            848..963
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /inference="alignment:Splign:2.1.0"
     exon            964..3029
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1658..1663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /note="hexamer: ATTAAA"
     polyA_site      1688
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /note="major polyA site"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /note="hexamer: GATAAA"
     polyA_site      2292
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
     regulatory      2350..2355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /note="hexamer: ATTAAA"
     polyA_site      2372
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
     regulatory      3008..3013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
                     /note="hexamer: AATAAA"
     polyA_site      3029
                     /gene="ATG10"
                     /gene_synonym="APG10; APG10L; pp12616"
ORIGIN      
        1 gcagtgcgca cgctccgact cggccgtggc ggacctgact gaaggaggcc gcggacctga
       61 ctgaaggagg ccacggccac ttctggttgg cctcggggcg cgctggctcg gctcttcctc
      121 cgccctcgag gcccccgcag tcccatcatt cagttccgta gggtcaccgg cgcggcagtg
      181 gcctcgcagg gcgctgggtc cctctcccca gctctcctcc ccctggcccc gtcgccccgc
      241 cctcgccggg ctgggctgcg gggtcagggg ccgagcggag agggttatca tttaacatgg
      301 aagaagatga gttcattgga gaaaaaacat tccaacgtta ttgtgcagaa ttcattaaac
      361 attcacaaca gataggtgat agttgggaat ggagaccatc aaaggactgt tctgatggct
      421 acatgtgcaa aatacacttt caaattaaga atgggtctgt gatgtcacat ctaggagcat
      481 ctacccatgg acagacatgt cttcccatgg aggaggcttt cgagctaccc ttggatgatt
      541 gtgaagtgat tgaaactgca gcagcgtccg aagtgattaa atatgagtat catgtcttat
      601 attcctgtag ctaccaagtg cctgtacttt actttagggc aagcttttta gatgggagac
      661 ctttaactct gaaggacata tgggaaggag ttcatgagtg ctataagatg cgactgctac
      721 agggaccatg ggacactatt acgcaacagg aacatccaat acttgggcaa cccttttttg
      781 tacttcatcc ctgcaagacg aatgaattca tgactcctgt attaaagaat tctcagaaaa
      841 tcaataagaa tgtcaactat atcacatcat ggctgagcat tgtagggcca gttgttgggc
      901 tgaatctacc tctgagttat gccaaagcaa cgtctcagga tgaacgaaat gtcccttaac
      961 aagattcttc tattgagttt aggaattgcg gcacgaagaa tgccaagagt ttacctggcc
     1021 agccctggct ttaataggac tgataccatg gaatatttca tctcaccaag atgtgacatg
     1081 gattattttt cccttggaca caaatgtcta cagcaactgg tgtttgatag gctgaatgtt
     1141 tagaagaaac acttcaaagg gatacatcat ggccaggcat ggtggctcac acctgtaatc
     1201 caagcacttt gggaggccaa ggtgggagca tcacttgatc ctgggagttc gagaccagcc
     1261 tgggcaacat ggtgaaaccc tgtcggtaca aaaaaataca aaaatttgcc tgtttatggt
     1321 ggtgtgttcc tgtagtccca gctccccagg aggctgaggt gggaggttgg ctttaaccca
     1381 ggaggcagag gttgcagtga gctgagactg tgccactgca gtccagcctg ggtgacagag
     1441 ccagacactg tctcggggaa aaaaaaaaaa aaaaaaagac acatcactat aaatagcaaa
     1501 aaaacaaatc taacttatta atactaggaa taccaacatt attagggcac ttgcaggtta
     1561 ttcttttcta ggccaagtac ttcacttcca tttgtctgac atggagattg agggagaaat
     1621 gtatttgtgt gttcatttta atgtaagata tataaaaatt aaattactgg atttacctgt
     1681 ccctgaaact ggtgttataa acatgaccta tcttaagtga ttttcccaca atcaaactca
     1741 ggaacaatag attatttctg ttttactcca aaagagagag agagagtgag tgtgagtgtg
     1801 tgtgtgtgtg tgtgtgtatg tgtgggtgtt tgtgtagata gttgtaaaac aaagaaaaaa
     1861 cacaatattt tactgtgaga taatatgttt taccagcaaa gtgtggcata gtaattagaa
     1921 gttttctaaa aagctatagg agatatttaa acattaaaat ttctttttga cctatagtaa
     1981 taaaacaatg gtcattttac ccctctgctt ctcaacccca cagctgctct gctgtactct
     2041 ttgagggctc ttgagcgagt cttcatgtcc ctgagactta ttttcctcat ctttaatttg
     2101 aaactaacaa gctacctcat agggttgctg tgagaaccac atgagatcat taatgcatga
     2161 taagatattg taaagtatta tacgaatatt cattaaatgc tcacctttct tgtatataat
     2221 tggtattcac taaggctgta aataagtttc atagccagtt aagtattaag ataaacctaa
     2281 cctggaacaa tttttttttt ggttgcttgt tttgtttttt gctttcattt gctaggagct
     2341 gaaacgaaga ttaaaatgtc attggctttt tagagagtct agattagtgt gtctttgaat
     2401 gagggatata cttaaaatca cctgaggatc gtttacagct acagatgctg gggccacctg
     2461 acacagtctc tctgggggtg attctgctct ggagaacctc tggtctggat atacctttat
     2521 tgtgacattg atttgtattg ttttgctcta ctgacaggcc ttttccaatc catacaagct
     2581 gaacttgctt cctaatgttt gtctaggcct tacatggata gtaaggaagc ttaggagaca
     2641 tgtacacaag gcagcccact tgtaggaaac tgcttcaggt gaggacatca ttcaccagtg
     2701 gatcaccgag caccgtgaca gcaccctcag tccacgtctg cagattaaga gctgaactct
     2761 cacagagaaa gtggaagtag agaaagggtt aattcaaact gctagaaaag ctaaaagtaa
     2821 attttaaaat gctgagctgc ccatattcat gctaggatga gagccggctt aaatgcttgc
     2881 tgggcatttt ggtatttacc acttagcatg ttttcaactt ctgtgaggga ttttcccccc
     2941 aatctcccta atgtaaacac agatttctca gcaagtcatt tctcaagcca tgtcatttct
     3001 agtgtaaaat aaattataat aatgtgtca
//
