LOCUS       NM_018179               8823 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens activating transcription factor 7 interacting protein
            (ATF7IP), transcript variant 2, mRNA.
ACCESSION   NM_018179 NM_018005
VERSION     NM_018179.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8823)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 8823)
  AUTHORS   Moon,S.W., Mo,H.Y., Choi,E.J., Yoo,N.J. and Lee,S.H.
  TITLE     Mutational Alterations of DNA Methylation-related Genes CTCF,
            ZFP57, and ATF7IP Genes in Colon Cancers
  JOURNAL   Appl Immunohistochem Mol Morphol 30 (2), e16-e20 (2022)
   PUBMED   35175239
  REMARK    GeneRIF: Mutational Alterations of DNA Methylation-related Genes
            CTCF, ZFP57, and ATF7IP Genes in Colon Cancers.
REFERENCE   3  (bases 1 to 8823)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 8823)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 8823)
  AUTHORS   Tsusaka,T., Shimura,C. and Shinkai,Y.
  TITLE     ATF7IP regulates SETDB1 nuclear localization and increases its
            ubiquitination
  JOURNAL   EMBO Rep 20 (12), e48297 (2019)
   PUBMED   31576654
  REMARK    GeneRIF: ATF7IP promotes the nuclear localization of SETDB1.
REFERENCE   6  (bases 1 to 8823)
  AUTHORS   Morris,J.A., Kandpal,G., Ma,L. and Austin,C.P.
  TITLE     DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated
            protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL:
            regulation and loss of interaction with mutation
  JOURNAL   Hum Mol Genet 12 (13), 1591-1608 (2003)
   PUBMED   12812986
REFERENCE   7  (bases 1 to 8823)
  AUTHORS   Yamada,K., Kawata,H., Shou,Z., Hirano,S., Mizutani,T., Yazawa,T.,
            Sekiguchi,T., Yoshino,M., Kajitani,T. and Miyamoto,K.
  TITLE     Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting
            proteins: molecular cloning and characterization of a member of the
            ZHX family, ZHX3
  JOURNAL   Biochem J 373 (Pt 1), 167-178 (2003)
   PUBMED   12659632
REFERENCE   8  (bases 1 to 8823)
  AUTHORS   Fujita,N., Watanabe,S., Ichimura,T., Ohkuma,Y., Chiba,T., Saya,H.
            and Nakao,M.
  TITLE     MCAF mediates MBD1-dependent transcriptional repression
  JOURNAL   Mol Cell Biol 23 (8), 2834-2843 (2003)
   PUBMED   12665582
REFERENCE   9  (bases 1 to 8823)
  AUTHORS   Gunther,M., Laithier,M. and Brison,O.
  TITLE     A set of proteins interacting with transcription factor Sp1
            identified in a two-hybrid screening
  JOURNAL   Mol Cell Biochem 210 (1-2), 131-142 (2000)
   PUBMED   10976766
REFERENCE   10 (bases 1 to 8823)
  AUTHORS   De Graeve,F., Bahr,A., Chatton,B. and Kedinger,C.
  TITLE     A murine ATFa-associated factor with transcriptional repressing
            activity
  JOURNAL   Oncogene 19 (14), 1807-1819 (2000)
   PUBMED   10777215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK025060.1, AK074868.1, BX648096.1, AK027575.1 and AC008114.25.
            
            On Aug 13, 2020 this sequence version replaced NM_018179.4.
            
            Summary: ATF7IP is a multifunctional nuclear protein that
            associates with heterochromatin. It can act as a transcriptional
            coactivator or corepressor depending upon its binding partners
            (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM,
            Nov 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (2) has a shorter N-terminus than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.553542.1,
                                           SRR1803613.130229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261168.9/ ENSP00000261168.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-645               AK025060.1         8-652
            646-1196            AK074868.1         1-551
            1197-1738           AK025060.1         1204-1745
            1739-2872           BX648096.1         1654-2787
            2873-4426           AK027575.1         1133-2686
            4427-8823           AC008114.25        20831-25227
FEATURES             Location/Qualifiers
     source          1..8823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..8823
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /note="activating transcription factor 7 interacting
                     protein"
                     /db_xref="GeneID:55729"
                     /db_xref="HGNC:HGNC:20092"
                     /db_xref="MIM:613644"
     exon            1..146
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            147..1711
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..3966
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /note="isoform 2 is encoded by transcript variant 2;
                     activating transcription factor 7-interacting protein 1;
                     MBD1-containing chromatin-associated factor 1;
                     ATF-interacting protein; ATFa-associated modulator;
                     ATF7-interacting protein"
                     /codon_start=1
                     /product="activating transcription factor 7-interacting
                     protein 1 isoform 2"
                     /protein_id="NP_060649.3"
                     /db_xref="CCDS:CCDS8663.1"
                     /db_xref="GeneID:55729"
                     /db_xref="HGNC:HGNC:20092"
                     /db_xref="MIM:613644"
                     /translation="MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLL
                     NGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKETPCILSVNVKNK
                     QDDDLNCEPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPT
                     SSEPSSSDAASGDATSGDAPSGDVSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVE
                     PISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATGELAS
                     DELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDS
                     LDEKNKADNNIDANEETLETDDTTICSDRPPENEKKVEEDIITELALGEDAISSSMEI
                     DQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELT
                     CFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDES
                     EVISQNETCSPAEVESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKRSKSEDMDNVQ
                     SKRRRYMEEEYEAEFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKT
                     RVEKIECNKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEHPPNPPVSPGKTVNDVN
                     SNNNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQT
                     PVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHVPVAVSSQPQLL
                     QSHPGTLVTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQ
                     RNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQMKIPIS
                     AFSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSGVIDLTMD
                     DEESGASQDPKKLNHTPVSTMSSSQPVSRPLQPIQPAPPLQPSGVPTSGPSQTTIHLL
                     PTAPTTVNVTHRPVTQVTTRLPVPRAPANHQVVYTTLPAPPAQAPLRGTVMQAPAVRQ
                     VNPQNSVTVRVPQTTTYVVNNGLTLGSTGPQLTVHHRPPQVHTEPPRPVHPAPLPEAP
                     QPQRLPPEAASTSLPQKPHLKLARVQSQNGIVLSWSVLEVDRSCATVDSYHLYAYHEE
                     PSATVPSQWKKIGEVKALPLPMACTLTQFVSGSKYYFAVRAKDIYGRFGPFCDPQSTD
                     VISSTQSS"
     exon            1712..1798
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1944
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2082
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2148
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2222
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2311
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2950
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3015
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3094
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3250
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3433
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3546
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..8823
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4119..4124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /note="hexamer: AATAAA"
     polyA_site      4141
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
     regulatory      8802..8807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /note="hexamer: AATAAA"
     polyA_site      8823
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /note="major polyA site"
ORIGIN      
        1 gaatctgcgg aggcggcggc ggtggcagcg gcggcgcggc gactgaagcg cgcgaaaagc
       61 tgaggcggca acgtcgggga cggctgcgcg ggacggctct gtaggaagga acttggttcc
      121 ccctccctca gcttccgccc caaaagattc agaatggaca gtttagaaga acctcagaaa
      181 aaagtcttta aggctcgaaa aacgatgaga gtgagtgatc gtcagcaact tgaagcagtg
      241 tacaaggtca aagaagaact gttgaaaact gatgtcaagc tgttaaatgg caaccatgaa
      301 aatggagatt tggacccaac ctcacctttg gaaaacatgg attacattaa agacaaggaa
      361 gaggtgaatg gcattgaaga gatttgtttt gatcctgaag gaagtaaagc agaatggaag
      421 gaaacaccct gtatcctaag tgttaatgta aaaaacaagc aggatgatga tttaaattgt
      481 gaacctttgt ctccccataa tataactcca gaaccagtct ctaaactgcc tgctgaacca
      541 gtttctggtg atccagcccc tggtgatctg gatgccggag atccagcctc cggagtactg
      601 gcctctggtg attccacctc tggtgatccc acctctagcg agccctcctc tagtgatgct
      661 gcctctggtg atgcaacctc tggtgatgcc ccttctggtg atgtgtcccc tggtgatgcc
      721 acctctggtg atgccactgc tgatgatctc tcctctggtg atcccacctc tagtgatccc
      781 atcccaggtg aaccggtccc tgttgaaccc atttctggtg attgtgccgc tgatgatata
      841 gcctctagtg aaataacttc tgttgatctg gcttctggag caccagcttc cactgatcca
      901 gcctctgatg atctggcctc tggtgatcta tcctctagtg aactggcctc tgatgatctg
      961 gccactggtg aactggcctc tgatgagctg acttctgaat caacctttga tcgtaccttt
     1021 gaaccaaagt ctgtaccagt ttgtgaacca gttcctgaaa ttgacaatat agaaccaagt
     1081 agcaataaag atgatgattt tcttgaaaaa aatggagctg atgaaaaatt agagcaaatt
     1141 cagagtaaag actcattgga tgagaaaaat aaagctgata ataatattga tgctaatgaa
     1201 gaaactctag aaacagatga tacaactatt tgttcagatc gacctcctga aaatgaaaag
     1261 aaggtagagg aagatattat cacagagctt gctcttggag aagatgctat atctagcagt
     1321 atggaaattg accaaggtga aaagaatgaa gatgaaactt ctgcagatct tgtagaaacg
     1381 attaatgaaa atgttattga agataacaaa agtgagaata tcttagaaaa tacagactct
     1441 atggagacag atgaaatcat tcctattttg gaaaagcttg caccttctga ggatgaactt
     1501 acttgctttt ctaaaacatc tctccttcca atcgatgaga caaatccaga tttggaagag
     1561 aaaatggaaa gttcttttgg ttcaccatct aaacaagaaa gtagtgagag tttgccaaaa
     1621 gaagcctttc tggtcctctc tgatgaagag gatatttcgg gtgaaaaaga tgagtctgaa
     1681 gttatatcgc aaaatgaaac gtgctctcca gcagaagtag aaagtaatga aaaggacaac
     1741 aaacctgagg aagaagagca agtaatacat gaagatgatg aaagaccttc tgagaaaaat
     1801 gaattttcta gacgaaaacg ttctaaatca gaagacatgg acaatgtaca gtctaaacgt
     1861 cgtcgatata tggaagaaga atatgaggca gaatttcaag taaagattac agccaaagga
     1921 gacattaacc agaaacttca aaaggttata cagtggttgc tggaagaaaa attgtgtgcg
     1981 ctgcagtgtg ctgtatttga taagactttg gcagaattga aaacacgagt ggaaaagatt
     2041 gaatgtaaca agaggcataa aacagttctc actgaactac aggccaagat agccaggtta
     2101 accaaacgct ttgaagcagc caaagaagat cttaagaaaa gacatgaaca tccacccaac
     2161 ccaccagtat caccaggaaa aactgtaaat gatgtcaaca gcaataataa catgtcttac
     2221 agaaatgcag gcacagtgag acagatgctg gagtccaaaa gaaatgtaag cgagagtgca
     2281 ccaccatcct ttcaaactcc tgtgaataca gtatcttcaa ccaatcttgt cactcctcca
     2341 gcagttgtca gtagtcaacc taaattgcag actccagtga cttcgggttc cctcacagca
     2401 acgtcagttc ttcctgcacc caatacagct actgtagttg ctactactca ggtgcctagt
     2461 ggaaatcccc agcctacaat ctctttacag cctttgccag tgattttgca tgtacctgtt
     2521 gcagtatcct cccagcctca gcttctacag agccatccag ggactttggt gactaatcaa
     2581 ccatctggca atgttgaatt catttctgtg caaagcccac ctacagtgag tggtcttacc
     2641 aaaaatccag tatccttgcc atccttgcca aatcccacta aaccaaacaa cgttccttct
     2701 gtgcccagtc ctagtattca aaggaaccct actgccagtg ctgcaccatt gggaacaaca
     2761 cttgctgtgc aggctgttcc aacagcacac tctattgtac aagccacaag gacttcttta
     2821 cccacagtgg gcccatcagg actctatagt ccatcaacta atcgaggtcc tatacagatg
     2881 aaaattccaa tttctgcatt tagtacttcg tctgctgcag aacagaacag caataccacc
     2941 ccaagaattg aaaaccagac aaacaaaaca atagatgctt ctgtcagtaa gaaagcagct
     3001 gatagcacat cacagtgtgg aaaagccact ggcagtgatt caagtggtgt cattgatctc
     3061 acaatggatg atgaagagag tggagcttca caagacccca aaaaactaaa tcacactcct
     3121 gtatcaacca tgagttcttc tcagcctgtg tcacgaccat tgcaacccat acaaccagca
     3181 ccgcctcttc aaccatctgg ggtgccaaca agtggaccat ctcagaccac catacactta
     3241 ctacctacag ctccaactac cgtgaatgta acacatcgtc cagtaactca ggtgaccaca
     3301 agactccctg taccaagagc tcctgcaaac caccaggtgg tttatacaac tcttcctgca
     3361 ccaccagctc aggctccctt gcgaggaact gttatgcagg ctcctgctgt tcggcaggtc
     3421 aatccccaaa atagtgttac agttcgagtg cctcaaacaa ccacatatgt tgtaaacaat
     3481 ggactaaccc tgggatcaac aggacctcag ctcacagtgc atcaccgacc accacaagtg
     3541 catactgagc ccccacgccc cgtgcaccca gcacccttac cagaagctcc acaaccacag
     3601 cgtctgcccc cagaagctgc cagcacatct ctgcctcaga agccacactt gaagttagca
     3661 cgcgttcaga gtcaaaatgg catagtactg tcatggagtg tcctggaggt ggatcgaagc
     3721 tgtgccactg ttgatagcta ccatctctat gcttaccatg aggaacccag tgccactgtg
     3781 ccctcacaat ggaaaaagat tggggaagtc aaggcacttc ccttgcccat ggcatgtact
     3841 ctcacccagt ttgtatctgg tagcaaatac tactttgcag tacgagccaa ggatatttat
     3901 ggacgttttg ggcctttctg tgatcctcag tcaacagatg tgatctcttc tacccagagc
     3961 agttaaacct tggagccttt atattttcct cttttaaaat ttccaccttt tggtcttgtt
     4021 tttaatcttg tgcatgatac cccatgtaaa atccaccttg tgcaagattt cttggacaga
     4081 tgtgtgtata cactacattt gtttataacc agaagcaaaa taaactcagc ccacaaagct
     4141 agaatctttt cctggacagt ttaggctttg gggtttggaa atgtaaatgt gtaccttgct
     4201 ttagttttga ggctggggaa tatgtgtggg tgtttatgtg tgtttttcct tatgtaggtg
     4261 ttattgcatt ggagtctccc attttcattc tcaaatttac ctcttaaagt acgaagtaag
     4321 tagatcaaag gatttgagat gtgtaactgg catgattctg cttttgaagg atctatagta
     4381 tcattttagt taagtgggtc aaacagaatc aaaacaaaac ccaaagaaat aaataaaaaa
     4441 caaaatggct aaatagttta aaataggtta attcgaacac aggaaaggat ctatttgttg
     4501 tttcttttgt ctggtctcct gagttgttaa ttaggtgaaa aaagatctgc aatggccccc
     4561 tccctttcct aatctggctt ttacatttat tttgtgcctt aaagattaac tacaaagata
     4621 aacatggcca aaaataaata aataaatatg gccatatgtc cgttgttgct tagtcttccc
     4681 ttgcagcctt ttacccttga tttctccttc atctctacca aatatagcac aactcctcaa
     4741 gtaatttttt ttttttaaga tggagttttg ctcttgttgc ccaggctaga gtgcggtggc
     4801 acaatcttgg ctcactgcaa cctctgcctc ctgggttcaa gcaattcttc tgtctcagcc
     4861 ccagagtagc tgggattaca ggcacctgtc accatgcccg gctaattttt gtatttttag
     4921 tagagatggg gtttcaccat gttggccagg ctggtcttga actcctgacc tcaggtgatc
     4981 cacccgcctc ggcctcccag agtgctgcga ttacagttgt gagccactgt atccagccta
     5041 ctcaagtgat ttttaaacca aggtgtgtgt atgtacatgg atgtgtatgt acacacacac
     5101 acaggtgcat gcatagtctc atcttagccg ggcatggtgg cgacaatcac atttaactcc
     5161 aaaaatttga cgtgctattt tcttctaaaa ctatagatgc ttttattttt ggtcactatt
     5221 taactttgtg taaagtggac caagagaaaa ccatattgtg gaagacagtt tttcacacat
     5281 tttagtatcc gtgttgcaca ctgtgttaga gattatgaaa accattctag ttcagtttat
     5341 cacccaaagc tatcacccaa cactaactcc ttagtattct ttcaaaggaa gcaaatagta
     5401 agattacaat atagaatgag ctaaaatatc aaggggaaag cttcatttcc tctttattct
     5461 ctttatcgtc cttcccattt taacctttta actttgtttt gatggtgcca agttgagtct
     5521 gatgtaccca ttgttagctt tggatagaat ttaaagtata tcccagaatt agctgggcat
     5581 gttggtgcat gcctgtaatc ccagctactc aggaggcaag gctggagaat cgcttgaacc
     5641 cgggaggcgg aggttgcagt gagctgagat tgcgccattg cactccatcc tgggagacaa
     5701 gagcgaaact ctgcctcaaa aaaaaaagaa tttaaagtat atcctttgag gtcattttat
     5761 gtaacaatta gatataacct cctgtgtatc tctctgttcc tcttcaaagt tattaaaatt
     5821 cagcttaggt catggatttt taatatgagg gccagctgta ctggtgtcag gtaggtgttt
     5881 tgggtgtaga taatttagga ctggagggct gagttaagtt ttaggaggag aatgtggttg
     5941 agaatatttt gaaaggaatt tatggagttt gtgaaataac ttcgaagtcc tcttccttta
     6001 caatatttga attcatattt gtaccttctc aaaatagtga ttcatttttc ctagaattac
     6061 aggagggagc tcttttacta atgttgtttt gtttgcaact ttgatggctt ataataggaa
     6121 gtattctagt tgtaaagaaa actctttaga gacttttgac tggtcagtat actgaggtgt
     6181 gagatttgat tcatgatgaa gaaagcctat agattgccaa aaaattaatt ctccaaacca
     6241 cctttcactc tcagaaaatg agaccacaaa ggagtatgct ataaatcaaa tttgccaacc
     6301 aattatgtag atattactca ttctaggact aatgatgatg gtaaagaagt tgccagtgtt
     6361 atggcaatga aaatttcaga aaggaggagt tgatgatctt ctagatgtat atgaacacct
     6421 gtctatatct gcatgtatat gttttgacct gcagtggttg caatgttgat atgtgttcaa
     6481 gattattcct gtctacaaaa ctgaaggccc atgttcaaat tgttctttat tgggtgtttt
     6541 tatggtcacg tggtaacaat tttcttacct aacctacaaa aggttctctt gatgaacatt
     6601 tttatttata tttactaatc ttttttaaaa aaagctttca tagcattata taatcagatg
     6661 aagaaagccc agtagaataa aaaaaaaatt cattagccta gcctatatta tgttttctgt
     6721 caaaggaaaa caaattctca aataggaatt ctaaaaatat ttactaaagt aaaataacta
     6781 cttaaaatgt tttattccag ttggaaggaa ggtacaggga gaaatcgcaa ttatttaggg
     6841 gagaagtata tttattataa gatggtgtcc tcaaattagc ctaccatggc acgtaggggc
     6901 agcagctata ttagatttac tagaggtgct aagttagaac actaggcttt tattgaggca
     6961 ggttttaata ttgatagatg ctttttgttt ggtttgtttc ttctgggaga gaatggagga
     7021 cttaagtaga agtagctact gataacagac tttctagtag cagtttccac tccacggtta
     7081 cctttttagt ttcatagtat cttttcacaa agtattacaa ataagctaga ttctcccagt
     7141 ttgggaatgc aagtttgcta catttttagc ctggcaatat ttgtgtaggt attgccttat
     7201 tggaaattct ggaaacctga tactgcaacc tgcaatgtag gatgtttgta tggcatttaa
     7261 aggtaatggt gatgtttatt attctatact ttgcattctg tgagagtaat tttcactctg
     7321 tcttaagtgt gagtaagcct cttctaaaaa tcttgttctt gccaagaaat ttataaatca
     7381 catacgaaga cgtctgttgc taacagttaa ctttatgagg taactatatc cttctatttc
     7441 tctggactca tttttaaaaa atatgccgaa tactgcatac tgtttaaggt agtatataag
     7501 tttatgagag aagtggagag ctttcttcct tgaaaagtcg gtatttgttg agataccatt
     7561 tgcctcacag agaggtgttc cccactccca tccccattgc cagataataa atattttgag
     7621 aaaagtgacc taaaacagct gaaatcttag gtgcatctgt ctgcagacct ccttaagcag
     7681 gctgtatctt acaattccct tactgcactg ggtaagtgtt aacttagttt ttgttgtttg
     7741 ctcttttgct ttaaatattc tccaaattac catttatgca acatggttag ggttaatact
     7801 gcatggtatt catttatctt gtttcatgaa ctttccagta ctgtacaagg tcaacaaagt
     7861 aatgcctgtg gtatcctcat ctctcacttt tttactctgt gattttagca cagtaaggta
     7921 ctgcaaagac cttccttcca aatgttctcc ttgactttat ttcttgggcc aattcagtat
     7981 cctcaacatc ctaagatttt gttgttttat cactgacctg tggttggcct gttttattct
     8041 aatttccaga aaagtcaagt cccagtattt gcaatatcaa ataactctaa aaccgatgtg
     8101 tgattctacc ttccttacta tttttactgg gcaaatgccc tattttttta attattatta
     8161 tttttaactt ttgggacaca caaaaatcag caattctcat gaagcgtttg ttagtgtggc
     8221 agacttgtct aattcctgaa actcattcat ccccttgagc cagccaatgg ggaggaatag
     8281 gataatgcaa acacatgttt tgttttctca ttttcaaata atttaccatg ttaaaataaa
     8341 cttttctttg ttttttattt gtagagtcag ctaagtaccc atatttaaat gccgtcttta
     8401 ttattttttt gaggtctttg tttttgtctg tttttgtttt gttttgtttt gtaaataagg
     8461 taactgggca atcaaacacc ttttggggat tctggcttta gtattttatc agccatttta
     8521 aaattaaata taaaaatcct ttgtaagaaa cttgcatcct aatttttctt tattgcaatt
     8581 gaaagtgtaa ataataagac aatgtaagta agaccttcct aatgtctaat acaaactggg
     8641 ctccagcaag tggccctatt tttattaggg ttttgaaggt ttgtgtgtgt gtgtgcgtgc
     8701 gtgtgtgtgt ttttcttttt taaatgtata gtagagtggt gtctgtataa gtgttacctg
     8761 tagtggggtt ttgtccagca agcctgaaat ttatactttg aaataaaact actgggtttt
     8821 taa
//
