LOCUS       NM_001286515            4899 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens activating transcription factor 7 interacting protein
            (ATF7IP), transcript variant 4, mRNA.
ACCESSION   NM_001286515
VERSION     NM_001286515.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4899)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4899)
  AUTHORS   Moon,S.W., Mo,H.Y., Choi,E.J., Yoo,N.J. and Lee,S.H.
  TITLE     Mutational Alterations of DNA Methylation-related Genes CTCF,
            ZFP57, and ATF7IP Genes in Colon Cancers
  JOURNAL   Appl Immunohistochem Mol Morphol 30 (2), e16-e20 (2022)
   PUBMED   35175239
  REMARK    GeneRIF: Mutational Alterations of DNA Methylation-related Genes
            CTCF, ZFP57, and ATF7IP Genes in Colon Cancers.
REFERENCE   3  (bases 1 to 4899)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4899)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4899)
  AUTHORS   Tsusaka,T., Shimura,C. and Shinkai,Y.
  TITLE     ATF7IP regulates SETDB1 nuclear localization and increases its
            ubiquitination
  JOURNAL   EMBO Rep 20 (12), e48297 (2019)
   PUBMED   31576654
  REMARK    GeneRIF: ATF7IP promotes the nuclear localization of SETDB1.
REFERENCE   6  (bases 1 to 4899)
  AUTHORS   Morris,J.A., Kandpal,G., Ma,L. and Austin,C.P.
  TITLE     DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated
            protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL:
            regulation and loss of interaction with mutation
  JOURNAL   Hum Mol Genet 12 (13), 1591-1608 (2003)
   PUBMED   12812986
REFERENCE   7  (bases 1 to 4899)
  AUTHORS   Yamada,K., Kawata,H., Shou,Z., Hirano,S., Mizutani,T., Yazawa,T.,
            Sekiguchi,T., Yoshino,M., Kajitani,T. and Miyamoto,K.
  TITLE     Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting
            proteins: molecular cloning and characterization of a member of the
            ZHX family, ZHX3
  JOURNAL   Biochem J 373 (Pt 1), 167-178 (2003)
   PUBMED   12659632
REFERENCE   8  (bases 1 to 4899)
  AUTHORS   Fujita,N., Watanabe,S., Ichimura,T., Ohkuma,Y., Chiba,T., Saya,H.
            and Nakao,M.
  TITLE     MCAF mediates MBD1-dependent transcriptional repression
  JOURNAL   Mol Cell Biol 23 (8), 2834-2843 (2003)
   PUBMED   12665582
REFERENCE   9  (bases 1 to 4899)
  AUTHORS   Gunther,M., Laithier,M. and Brison,O.
  TITLE     A set of proteins interacting with transcription factor Sp1
            identified in a two-hybrid screening
  JOURNAL   Mol Cell Biochem 210 (1-2), 131-142 (2000)
   PUBMED   10976766
REFERENCE   10 (bases 1 to 4899)
  AUTHORS   De Graeve,F., Bahr,A., Chatton,B. and Kedinger,C.
  TITLE     A murine ATFa-associated factor with transcriptional repressing
            activity
  JOURNAL   Oncogene 19 (14), 1807-1819 (2000)
   PUBMED   10777215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA194386.1, BC063855.1, AC007782.20 and AC008114.25.
            
            On Jun 2, 2019 this sequence version replaced NM_001286515.1.
            
            Summary: ATF7IP is a multifunctional nuclear protein that
            associates with heterochromatin. It can act as a transcriptional
            coactivator or corepressor depending upon its binding partners
            (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM,
            Nov 2010].
            
            Transcript Variant: This variant (4) differs in both the 5' and 3'
            UTRs and contains multiple differences in the coding region,
            compared to variant 1. It initiates translation at a downstream
            in-frame start codon. The encoded isoform (4) has a distinct
            C-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063855.1, SRR18074969.1687441.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA194386.1         51-61
            12-1738             BC063855.1         1-1727
            1739-1739           AC007782.20        139665-139665
            1740-3705           BC063855.1         1729-3694
            3706-4335           BC063855.1         3699-4328
            4336-4899           AC008114.25        4388-4951
FEATURES             Location/Qualifiers
     source          1..4899
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..4899
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /note="activating transcription factor 7 interacting
                     protein"
                     /db_xref="GeneID:55729"
                     /db_xref="HGNC:HGNC:20092"
                     /db_xref="MIM:613644"
     exon            1..146
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            147..1711
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..3471
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /note="isoform 4 is encoded by transcript variant 4;
                     activating transcription factor 7-interacting protein 1;
                     MBD1-containing chromatin-associated factor 1;
                     ATF-interacting protein; ATFa-associated modulator;
                     ATF7-interacting protein"
                     /codon_start=1
                     /product="activating transcription factor 7-interacting
                     protein 1 isoform 4"
                     /protein_id="NP_001273444.1"
                     /db_xref="CCDS:CCDS73449.1"
                     /db_xref="GeneID:55729"
                     /db_xref="HGNC:HGNC:20092"
                     /db_xref="MIM:613644"
                     /translation="MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLL
                     NGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKETPCILSVNVKNK
                     QDDDLNCEPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPT
                     SSEPSSSDAASGDATSGDAPSGDVSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVE
                     PISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATGELAS
                     DELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDS
                     LDEKNKADNNIDANEETLETDDTTICSDRPPENEKKVEEDIITELALGEDAISSSMEI
                     DQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELT
                     CFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDES
                     EVISQNETCSPEVESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKRSKSEDMDNVQS
                     KRRRYMEEEYEAEFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTR
                     VEKIECNKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEHPPNPPVSPGKTVNDVNS
                     NNNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTP
                     VTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHVPVAVSSQPQLLQ
                     SHPGTLVTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQR
                     NPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQMKIPISA
                     FSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSGVIDLTMDD
                     EESGASQDPKKLNHTPVSTMSSSQPVSRPLQPIQPAPPLQPSGVPTSGPSQTTIHLLP
                     TAPTTVNVTHRPVTQVTTRLPVPRAPANHQVVYTTLPAPPAQAPLRGTVMQAPAVRQV
                     NPQNSKRFFLYMAPRYM"
     exon            1712..1795
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1941
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2079
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2145
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2219
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2308
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2947
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3012
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3091
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3247
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..4899
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4794..4799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /note="hexamer: ATTAAA"
     polyA_site      4823
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /note="major polyA site"
     regulatory      4875..4880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /note="hexamer: ATTAAA"
     polyA_site      4899
                     /gene="ATF7IP"
                     /gene_synonym="AM; ATF-IP; ATF7IP1; MCAF; MCAF1; p621"
                     /note="major polyA site"
ORIGIN      
        1 gaatctgcgg aggcggcggc ggtggcagcg gcggcgcggc gactgaagcg cgcgaaaagc
       61 tgaggcggca acgtcgggga cggctgcgcg ggacggctct gtaggaagga acttggttcc
      121 ccctccctca gcttccgccc caaaagattc agaatggaca gtttagaaga acctcagaaa
      181 aaagtcttta aggctcgaaa aacgatgaga gtgagtgatc gtcagcaact tgaagcagtg
      241 tacaaggtca aagaagaact gttgaaaact gatgtcaagc tgttaaatgg caaccatgaa
      301 aatggagatt tggacccaac ctcacctttg gaaaacatgg attacattaa agacaaggaa
      361 gaggtgaatg gcattgaaga gatttgtttt gatcctgaag gaagtaaagc agaatggaag
      421 gaaacaccct gtatcctaag tgttaatgta aaaaacaagc aggatgatga tttaaattgt
      481 gaacctttgt ctccccataa tataactcca gaaccagtct ctaaactgcc tgctgaacca
      541 gtttctggtg atccagcccc tggtgatctg gatgccggag atccagcctc cggagtactg
      601 gcctctggtg attccacctc tggtgatccc acctctagcg agccctcctc tagtgatgct
      661 gcctctggtg atgcaacctc tggtgatgcc ccttctggtg atgtgtcccc tggtgatgcc
      721 acctctggtg atgccactgc tgatgatctc tcctctggtg atcccacctc tagtgatccc
      781 atcccaggtg aaccggtccc tgttgaaccc atttctggtg attgtgccgc tgatgatata
      841 gcctctagtg aaataacttc tgttgatctg gcttctggag caccagcttc cactgatcca
      901 gcctctgatg atctggcctc tggtgatcta tcctctagtg aactggcctc tgatgatctg
      961 gccactggtg aactggcctc tgatgagctg acttctgaat caacctttga tcgtaccttt
     1021 gaaccaaagt ctgtaccagt ttgtgaacca gttcctgaaa ttgacaatat agaaccaagt
     1081 agcaataaag atgatgattt tcttgaaaaa aatggagctg atgaaaaatt agagcaaatt
     1141 cagagtaaag actcattgga tgagaaaaat aaagctgata ataatattga tgctaatgaa
     1201 gaaactctag aaacagatga tacaactatt tgttcagatc gacctcctga aaatgaaaag
     1261 aaggtagagg aagatattat cacagagctt gctcttggag aagatgctat atctagcagt
     1321 atggaaattg accaaggtga aaagaatgaa gatgaaactt ctgcagatct tgtagaaacg
     1381 attaatgaaa atgttattga agataacaaa agtgagaata tcttagaaaa tacagactct
     1441 atggagacag atgaaatcat tcctattttg gaaaagcttg caccttctga ggatgaactt
     1501 acttgctttt ctaaaacatc tctccttcca atcgatgaga caaatccaga tttggaagag
     1561 aaaatggaaa gttcttttgg ttcaccatct aaacaagaaa gtagtgagag tttgccaaaa
     1621 gaagcctttc tggtcctctc tgatgaagag gatatttcgg gtgaaaaaga tgagtctgaa
     1681 gttatatcgc aaaatgaaac gtgctctcca gaagtagaaa gtaatgaaaa ggacaacaaa
     1741 cctgaggaag aagagcaagt aatacatgaa gatgatgaaa gaccttctga gaaaaatgaa
     1801 ttttctagac gaaaacgttc taaatcagaa gacatggaca atgtacagtc taaacgtcgt
     1861 cgatatatgg aagaagaata tgaggcagaa tttcaagtaa agattacagc caaaggagac
     1921 attaaccaga aacttcaaaa ggttatacag tggttgctgg aagaaaaatt gtgtgcgctg
     1981 cagtgtgctg tatttgataa gactttggca gaattgaaaa cacgagtgga aaagattgaa
     2041 tgtaacaaga ggcataaaac agttctcact gaactacagg ccaagatagc caggttaacc
     2101 aaacgctttg aagcagccaa agaagatctt aagaaaagac atgaacatcc acccaaccca
     2161 ccagtatcac caggaaaaac tgtaaatgat gtcaacagca ataataacat gtcttacaga
     2221 aatgcaggca cagtgagaca gatgctggag tccaaaagaa atgtaagcga gagtgcacca
     2281 ccatcctttc aaactcctgt gaatacagta tcttcaacca atcttgtcac tcctccagca
     2341 gttgtcagta gtcaacctaa attgcagact ccagtgactt cgggttccct cacagcaacg
     2401 tcagttcttc ctgcacccaa tacagctact gtagttgcta ctactcaggt gcctagtgga
     2461 aatccccagc ctacaatctc tttacagcct ttgccagtga ttttgcatgt acctgttgca
     2521 gtatcctccc agcctcagct tctacagagc catccaggga ctttggtgac taatcaacca
     2581 tctggcaatg ttgaattcat ttctgtgcaa agcccaccta cagtgagtgg tcttaccaaa
     2641 aatccagtat ccttgccatc cttgccaaat cccactaaac caaacaacgt tccttctgtg
     2701 cccagtccta gtattcaaag gaaccctact gccagtgctg caccattggg aacaacactt
     2761 gctgtgcagg ctgttccaac agcacactct attgtacaag ccacaaggac ttctttaccc
     2821 acagtgggcc catcaggact ctatagtcca tcaactaatc gaggtcctat acagatgaaa
     2881 attccaattt ctgcatttag tacttcgtct gctgcagaac agaacagcaa taccacccca
     2941 agaattgaaa accagacaaa caaaacaata gatgcttctg tcagtaagaa agcagctgat
     3001 agcacatcac agtgtggaaa agccactggc agtgattcaa gtggtgtcat tgatctcaca
     3061 atggatgatg aagagagtgg agcttcacaa gaccccaaaa aactaaatca cactcctgta
     3121 tcaaccatga gttcttctca gcctgtgtca cgaccattgc aacccataca accagcaccg
     3181 cctcttcaac catctggggt gccaacaagt ggaccatctc agaccaccat acacttacta
     3241 cctacagctc caactaccgt gaatgtaaca catcgtccag taactcaggt gaccacaaga
     3301 ctccctgtac caagagctcc tgcaaaccac caggtggttt atacaactct tcctgcacca
     3361 ccagctcagg ctcccttgcg aggaactgtt atgcaggctc ctgctgttcg gcaggtcaat
     3421 ccccaaaata gtaagagatt tttcttgtat atggccccaa gatacatgta gttctcttca
     3481 gcatttagtt ggaatggcat ataataatgt taaattttgc aaaaatttct tataatgtca
     3541 tattaaaagt attgttataa gttcaagaga tctgtactac aacatagaaa ctatagtata
     3601 gttaaaatca atgtagtata ttcttgaaaa tagctgatag agcagatttt aagtattgtc
     3661 accacacaca aaaaaggtaa gtatgtgaga tcatgcatat gtcagctaga tttagccatt
     3721 ctgcagtgta tgcatatttc aaacatgttg tataccataa atatatataa tttttgtcaa
     3781 ttaaaaaata gttttcaaaa aagaaatggc agtataacca aaactaatct attattattt
     3841 ttcttccctt aggagagtta aacagagaaa attgttgatg tatactagtt gatttgtgct
     3901 ctgagtgttg tctttaattt aactttattt atggcctgta ttagtatagt acacaatttg
     3961 atattggtat attctctact ctattaagaa acaccttacc tagttagagt gggaatggtc
     4021 aattgtgatt taccccagat gatggaaatc atggtaaagg atagccttca atgagagtct
     4081 taaagatatg gaaagtggct gagaaaagaa gggaaaatgt taaagaaagc ttgtagtttc
     4141 ttgtatatat catatattag ttacatacat atgttacatg catgttacat atgtagatga
     4201 cattttaaaa ttatatatta accacatgta tataagcagt agtagaatat atcacataaa
     4261 cacaagctta tataaaaggt atatttaaac tttaaagtaa agaaaaataa taaaatgaac
     4321 tacgtatgaa ctcttcatca ggttaagaag tagaaatttt tcagtatcct gtaagtggtc
     4381 ttgtattcct gtcttgacta catccctttt cctttccatc aaaggtaacc actgttccta
     4441 cttttctatt agtcattctg cttttcttta tgattttgcc accaaaattg atatcattta
     4501 aacatactag ggttctctag aggacagaac taacaggata aatagatata taaaggggag
     4561 tttactaagt attaacttac atgatcacaa ggtccctcaa taggctgtct gcaagctgag
     4621 caaggaaagc cagactgaat ccccaaactg aagaatttgg agtccagtgt cgaagggcag
     4681 gaagcatcca gcacaggaga aagatgtagg ctggaaggct agccagtctc tccatttcat
     4741 gtttttctgc ctgctttgta ttcattgaca gctgattaga ttgtgcccac cagattaaag
     4801 gtggatctgc cttctccagc ccattttctg cctgctttgt attcattgat agctgattag
     4861 attgtgcaca ccagattaaa ggtggatctg ccttcccca
//
