LOCUS       NM_006856               6660 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens activating transcription factor 7 (ATF7), transcript
            variant 2, mRNA.
ACCESSION   NM_006856
VERSION     NM_006856.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6660)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6660)
  AUTHORS   Zhang,J., Liu,D., Deng,G., Wang,Q., Li,L., Zhang,J. and Wu,H.
  TITLE     lncRNA prostate cancer-associated transcript 18 upregulates
            activating transcription factor 7 to prevent metastasis of
            triple-negative breast cancer via sponging miR-103a-3p
  JOURNAL   Bioengineered 12 (2), 12070-12086 (2021)
   PUBMED   34787047
  REMARK    GeneRIF: lncRNA prostate cancer-associated transcript 18
            upregulates activating transcription factor 7 to prevent metastasis
            of triple-negative breast cancer via sponging miR-103a-3p.
REFERENCE   3  (bases 1 to 6660)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6660)
  AUTHORS   Song,F., Wei,M., Wang,J., Liu,Y., Guo,M., Li,X., Luo,J., Zhou,J.,
            Wang,M., Guo,D., Chen,L. and Sun,G.
  TITLE     Hepatitis B virus-regulated growth of liver cancer cells occurs
            through the microRNA-340-5p-activating transcription factor 7-heat
            shock protein A member 1B axis
  JOURNAL   Cancer Sci 110 (5), 1633-1643 (2019)
   PUBMED   30891870
  REMARK    GeneRIF: Results found that ATF7 is upregulated in hepatocellular
            carcinoma (HCC) tissue. Its expression is regulated by miR-340
            which directly binds to the mRNA encoding ATF7. Under HBV
            infection, miR-340 is downregulated resulting in increasing ATF7
            expression, leading to enhanced cell proliferation and inhibition
            of apoptosis.
REFERENCE   5  (bases 1 to 6660)
  AUTHORS   Newman,S.P., Bates,N.P., Vernimmen,D., Parker,M.G. and Hurst,H.C.
  TITLE     Cofactor competition between the ligand-bound oestrogen receptor
            and an intron 1 enhancer leads to oestrogen repression of ERBB2
            expression in breast cancer
  JOURNAL   Oncogene 19 (4), 490-497 (2000)
   PUBMED   10698518
REFERENCE   6  (bases 1 to 6660)
  AUTHORS   De Graeve,F., Bahr,A., Sabapathy,K.T., Hauss,C., Wagner,E.F.,
            Kedinger,C. and Chatton,B.
  TITLE     Role of the ATFa/JNK2 complex in Jun activation
  JOURNAL   Oncogene 18 (23), 3491-3500 (1999)
   PUBMED   10376527
REFERENCE   7  (bases 1 to 6660)
  AUTHORS   Goetz,J., Chatton,B., Mattei,M.G. and Kedinger,C.
  TITLE     Structure and expression of the ATFa gene
  JOURNAL   J Biol Chem 271 (47), 29589-29598 (1996)
   PUBMED   8939888
REFERENCE   8  (bases 1 to 6660)
  AUTHORS   Bocco,J.L., Bahr,A., Goetz,J., Hauss,C., Kallunki,T., Kedinger,C.
            and Chatton,B.
  TITLE     In vivo association of ATFa with JNK/SAP kinase activities
  JOURNAL   Oncogene 12 (9), 1971-1980 (1996)
   PUBMED   8649858
REFERENCE   9  (bases 1 to 6660)
  AUTHORS   Pescini,R., Kaszubska,W., Whelan,J., DeLamarter,J.F. and Hooft van
            Huijsduijnen,R.
  TITLE     ATF-a0, a novel variant of the ATF/CREB transcription factor
            family, forms a dominant transcription inhibitor in ATF-a
            heterodimers
  JOURNAL   J Biol Chem 269 (2), 1159-1165 (1994)
   PUBMED   8288576
REFERENCE   10 (bases 1 to 6660)
  AUTHORS   Gaire,M., Chatton,B. and Kedinger,C.
  TITLE     Isolation and characterization of two novel, closely related ATF
            cDNA clones from HeLa cells
  JOURNAL   Nucleic Acids Res 18 (12), 3467-3473 (1990)
   PUBMED   1694576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB047160.1, X52943.1, BP312300.1, BP279417.1, AC023509.42 and
            BQ184780.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006856.2.
            
            Transcript Variant: This variant (2), as well as variants 8 and 9,
            encodes isoform 2 (also known as ATFa2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1494684.1,
                                           SRR11853564.6774.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000420353.7/ ENSP00000399465.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DB047160.1         34-63
            31-2283             X52943.1           9-2261
            2284-2639           BP312300.1         63-418
            2640-2847           BP279417.1         338-545
            2848-6253           AC023509.42        106904-110309
            6254-6655           BQ184780.1         17-418              c
            6656-6660           AC023509.42        110712-110716
FEATURES             Location/Qualifiers
     source          1..6660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..6660
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="activating transcription factor 7"
                     /db_xref="GeneID:11016"
                     /db_xref="HGNC:HGNC:792"
                     /db_xref="MIM:606371"
     exon            1..104
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            105..173
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1577
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cyclic AMP-dependent transcription factor ATF-7;
                     transcription factor ATF-A"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-7
                     isoform 2"
                     /protein_id="NP_006847.1"
                     /db_xref="CCDS:CCDS44906.1"
                     /db_xref="GeneID:11016"
                     /db_xref="HGNC:HGNC:792"
                     /db_xref="MIM:606371"
                     /translation="MGDDRPFVCNAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDS
                     VIIADQTPTPTRFLKNCEEVGLFNELASSFEHEFKKAADEDEKKAAAGPLDMSLPSTP
                     DIKIKEEEPVEVDSSPPDSPASSPCSPPLKEKEVTPKPVLISTPTPTIVRPGSLPLHL
                     GYDPLHPTLPSPTSVITQAPPSNRQMGSPTGSLPLVMHLANGQTMPVLPGPPVQMPSV
                     ISLARPVSMVPNIPGIPGPPVNSSGSISPSGHPIPSEAKMRLKATLTHQVSSINGGCG
                     MVVGTASTMVTARPEQSQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDER
                     RQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLL
                     LAHKDCPVTALQKKTQGYLESPKESSEPTGSPAPVIQHSSATAPSNGLSVRSAAEAVA
                     TSVLTQMASQRTELSMPIQSHVIMTPQSQSAGR"
     exon            174..270
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            271..389
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            390..527
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            528..685
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            686..785
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            786..899
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1052
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1250
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1359
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..6660
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6638..6643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="hexamer: ATTAAA"
     polyA_site      6660
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="major polyA site"
ORIGIN      
        1 ggacgggagg aaagtatccg ttccgccaag gggggaaagg aggagctgga gacagattgt
       61 aggaccgagc gcgggcaggc gggaggcaac ggagctacca gccgctcctc tctgctatat
      121 gaaatatggg agacgacaga ccgtttgtgt gcaatgcccc gggctgtgga cagagattta
      181 caaacgagga ccacctggca gttcataaac acaagcatga gatgacattg aaatttggcc
      241 cagcccgaac tgactcagtc atcattgcag atcaaacgcc tactccaact agattcctga
      301 agaactgtga ggaggtggga ctcttcaatg aactagctag ctcctttgaa catgaattca
      361 agaaagctgc agatgaggat gagaaaaagg ctgctgctgg gccccttgac atgtctctgc
      421 cttccacacc agacatcaaa atcaaagaag aagagccagt ggaggtagac tcatccccac
      481 ctgatagccc tgcctctagt ccctgttccc caccactgaa ggagaaggag gttaccccaa
      541 agcctgttct gatctctacc cccacaccca ccattgtacg tcctggctcc ctgcctctcc
      601 acttgggcta tgatccactt catccaaccc ttccctcccc aacctctgtc atcacacagg
      661 ctccaccatc caacaggcaa atggggtctc ccactggctc cctccctctt gtcatgcatc
      721 ttgctaatgg acagaccatg cctgtgttgc cagggcctcc agtacagatg ccgtctgtta
      781 tatcgctggc cagacctgtg tccatggtgc ccaacattcc tggtatccct ggcccaccag
      841 ttaacagtag tggctccatt tctccctctg gccaccctat accatcagaa gccaagatga
      901 gactgaaagc caccctaact caccaagtct cctcaatcaa tggtggttgt ggaatggtgg
      961 tgggtactgc cagcaccatg gtgacagccc gcccagagca gagccagatt ctcatccagc
     1021 accctgatgc cccatcccct gcccagccac aggtctcacc agctcagccc acccctagta
     1081 ctggggggcg acggcggcgc acagtagatg aagatccaga tgagcgacgg cagcgctttc
     1141 tggagcgcaa ccgggctgca gcctcccgct gccgccaaaa gcgaaagctg tgggtgtcct
     1201 ccctagagaa gaaggccgaa gaactcactt ctcagaacat tcagctgagt aatgaagtca
     1261 cattactacg caatgaggtg gcccagttga aacagctact gttagctcat aaagactgcc
     1321 cagtcactgc actacagaaa aagactcaag gctatttaga aagccccaag gaaagctcag
     1381 agccaacggg ttctccagcc cctgtgattc agcacagctc agcaacagcc cctagcaatg
     1441 gcctcagtgt tcgctctgca gctgaagctg tggccacctc ggtcctcact cagatggcca
     1501 gccaaaggac agaactgagc atgccgatac aatcgcatgt aatcatgacc ccacagtccc
     1561 agtctgcggg cagatgatgc ctcctctggt ggagaggtcc tcagccagag ctcgcccgcc
     1621 caagagccaa gagagatgtc atcttatccc ctcccatctg ccttggacat ggcaatatgg
     1681 gtggggggaa ttgtgtgttg tgagtaatgg acagatatgg ggctttttag ccatgtggtc
     1741 atgtacgttt gacacctgtg ctgggggcct cccagccccg gagcctcata gatcatcccc
     1801 cagggtgggg tttctgatgc atccacagcc aaaggccttt ccagatggtc cgaacaatca
     1861 cccctgcccc atgcacgtgt atctgtctct tttaacacta acccttggca cttctaggtt
     1921 tggggtttct cagttccctc tcttcccact aagccgtggc tgttaccttt ttgttcctta
     1981 ccagcatgcc acttcctgcc agatagaggg aggctagatt tgatgacata ttacccgctg
     2041 acccagcccc agccacccca tggactcagg actcaggtct cccatagctg cttatttacc
     2101 cgtttccttt ttcctcttcc ttaattctag ttaaaacatt cacttacgga gaatgtaagg
     2161 ttacctttga tgtatgaagt agcagtattt tccagttttt ccataagctt tattccttct
     2221 ctctacctgc caccaaaaag aaagaaaccc tcaagagttc taattctttt tcatctattt
     2281 gcagagctat ttgggtacct cattttgtcc cttgacttta gtgtagtggt ggggtctttc
     2341 ccaccacccc actaagcctt ggcaacctca ttttgtggcc ttattattaa agattgcttg
     2401 gtagtgaaaa gggaagggcc cagaatctga ctggctgatt ctgtctcctc ccctccctcc
     2461 ttctttagtt taaccatcag ggcagacagg aacaaagtat ttcaaagctt gttccatcaa
     2521 gttagggatt aatcgattcc tttatgtttt ataagagttt accggccaaa gcatattgtc
     2581 atctttggtc atttttctgc tcctgcttct ctctcttcat tcccctatca acattaccgc
     2641 ccctgtctct cttctgtaac tacttcagac tcagccctcc tggaggctgt catgtagggg
     2701 actctcgagt tcctttgttc taccccatct ctccccctca cacatctgtc tgcttttctg
     2761 agctagagtc ttctgttcac aagtgcccat caccgtctgg actatcttct ttctctttca
     2821 ccaggttcct agcttagcca ctaggtcttc caggtcctcc agagtttctt caacccattt
     2881 cttctctctt ctctttacat gcagtgctcc aggatcttga agcgtcatag ccaagatgct
     2941 gagtgggttt acttgagtat aagattgaaa ggagggagga agaggagagg gaaagtgcag
     3001 aactggtccc agcaaaggac cccaggttct ggcctgggaa attggtgact attgctctca
     3061 accattctta ctttgaagag ttgggttgca gagggagcaa ttcatctctc ttgtccctct
     3121 tccacgttaa ggcttctcat ctccccttgg ctctgaacta tgcagtttct accaggacca
     3181 taggaagcaa ttcagagcca gaggcctgtg gatagatagg tcagctttaa ttgcctttcc
     3241 gtatgaaacc cttccagttg tcccagagcc actttctgcc atctgtgcaa gccaagaatg
     3301 tccttctctc catctttcct acctccatct taaacataca tacaaaataa ctgccagctt
     3361 cctttcttat tttgtctcca aaattgactg tcacagggga atgagaaaat gttctaagct
     3421 acaagattcc cgtttcctta aagtgatatc ctgtcctagt gaaccagtca ggtaacaggt
     3481 tctgctgcat ttgttttaaa tttcccctcc tgcttttcag agctggtgct gaacaggcca
     3541 cacccctaaa gacaaaggag agaaaacacg gttttctcat cctctaccat caggtaccca
     3601 acaggaatag gccctgaagt gattcagact agcaaatgtt atggcagatg gtcaggacgc
     3661 aggttaccac atccagggac ttcacttttg cctttaaaaa ttcacagccg taacttgtgc
     3721 tcaggacttc ccctttagct ggctgctccc tgggattttc tcctgcttta gagttttgtt
     3781 tcattttttt attgtcttga tttcccagta gcagccttgc cctaaagctt gactgagttt
     3841 atggctccta aggagctttc ctaagactct tgactatttt tcttccccct tcagtcaagt
     3901 gtttttacag ttaagaatta atttgtaact gcatacatgc cctgccagtc tgtccctgtg
     3961 ttgggtggct aatttatgta gcgggtcttt tttatttctt agcccccatg actaattatc
     4021 tagtcctaac ttcattttta tcagtgggaa gatgtgtacg ggacctcagt gaggagcact
     4081 gccagaacca cagtaacaaa atggcactga aataaggaag cagcaggtca gaacccccta
     4141 gatagttctt gagttggttc tcagtctcac taaggaggca gaataattgc tgccctgaaa
     4201 cttctctgat agtcaaaggt aacttcactt accttgttat tgctaccagc catgtggtca
     4261 ctctccccaa atctttgtct tccagatcca tctggaccag aaccaaacat catggaaggt
     4321 gtcacttggc ccttcctaaa gtccatggcg tttctagagg cctaagggag gacactttca
     4381 gaaaggagct gagtgtatgg tgggtgtcct gaattcgttc atgtgaatac aggactcagg
     4441 cttcccaccc cactccaatg tgagtgctcg atacacaagc actctagcta gctgccacgt
     4501 acccaaggcc acagagggag gggacagaac caggtcttct ggtctgctca ctttctgccc
     4561 cattccccta acagaaagtt tgcttagagt tgaaaagtct aagaaagcct cccacaatac
     4621 tagagaggcc aacaaaaaaa aagtcatgcc ccctttactt actcttttgc tgctggttat
     4681 gcatctcaaa tctgacttcc ttagccttca cctccctcct tggccctaag cattagacca
     4741 tgtactctaa gtagtggtta aagagggact gagcaaactg aacctcctct cgctcacttc
     4801 tctatccctg ttctgttggt tttggctcct ttcttgattc actgccctct agcaccaccc
     4861 atcctggtag atggagtgct taaccccaac cgtgccctat gtacagcctg aaccaccaaa
     4921 cagacaccaa aaaaattctt cctgtggttt ctggggctcc cctgctccac actgagaggc
     4981 tccttaaagg tgctagcccc tgatacagct atccccgcca gttttctcct tttttcataa
     5041 cttccttccc atccccaaat cattaatttt tcattaatat tgtacattat atacacagga
     5101 aggaaataca ttattttttt taaatttcat aaccagcctg tttagattcc agtcttccta
     5161 gctatatcac atatgccttg ttgatatgct ctttctgctt tctttagact taatgtttga
     5221 cgggggtggg ggtgtctgga agaacaggaa aggtggggat cctaaggcag attaaaggac
     5281 tccctccacc ccactacagc ctcccataac tctagtcatc cctctcatag tacaggactg
     5341 atttctctgt gtctgtttgt acacacaaat gtgcatacag acataaattc ccccacccca
     5401 taccaaggtg gttacctagc aggaatgagc gtaggtggct gctggccacc attaccaccg
     5461 tctgcatcag ctgtgttgtc tctctttggg gtaaagtcct accccagaat gagaaaaggc
     5521 tggggagagt agggcaggtt aaaggagctt atgtcctctg tagatgtagg tttgtatcat
     5581 agctactagg gtttattttt ttaatggggg gctaatagca cagagttatc tcaccagcag
     5641 tagctactgg tgagtgatgt tttagctgta agaagtggct atgagcaata gtttcactga
     5701 ctttacctta gggcagtgcc acagtaatct gggaacttgt tagaaataca cattctcagg
     5761 ccccatccca gacttattga atcacagact ctgggggcag ggtttaaaag cactccaagt
     5821 gattctaatg cacactaaag gttgagaacc atttcttagg gataagctgg gaaattttta
     5881 caggtgtgga ggatatttca aatacatctt ttgcctttgc actaacatgc tttcatttct
     5941 ttcagtctct tcctccattc cctttaaagt cttccccatc atatcactga tctcaaaagc
     6001 tagatttgtc ttcattttag tcgtatccct aaaaccatgc attggtctgg acaggagttg
     6061 tcccatattc ccttgcagac tggtcactcc atgttctctg ttacagtaag gaccagccaa
     6121 gcttcagctg tcccattcct ccccctacaa cacacacacc tttcaggcag ggaggagatg
     6181 agcttccagc cccaagagtg gaggctgcca catcctaaca tagtatctat tgaaaaggaa
     6241 gcagtgtgta tctatgatta tatctctgtt catctatata tttttgacat gtagcaacac
     6301 ctctccatct tatcaaggaa ctcaactcgg tctgggtctc cccagtgccc agtggtggcc
     6361 tttgacaggt aggaggatgc agtgctgcag gctattttgt tttttgttac aaaactgtct
     6421 tttccctttt cccctccacc tgattcagca tgatccctgt gagctggttc tcacaatctc
     6481 ctgggactgg gctgaggcag gggcttcgct ctattctccc taaccatact gtcttccttt
     6541 cccccttgcc acttagcagt tatcccccca gctatgcctt ctccctccct cccttgccct
     6601 ggcatatatt gtgccttatt tatgctgcaa atataacatt aaactatcaa gtgaaccact
//
