LOCUS       NM_001366561            6488 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens activating transcription factor 7 (ATF7), transcript
            variant 12, mRNA.
ACCESSION   NM_001366561
VERSION     NM_001366561.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6488)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6488)
  AUTHORS   Zhang,J., Liu,D., Deng,G., Wang,Q., Li,L., Zhang,J. and Wu,H.
  TITLE     lncRNA prostate cancer-associated transcript 18 upregulates
            activating transcription factor 7 to prevent metastasis of
            triple-negative breast cancer via sponging miR-103a-3p
  JOURNAL   Bioengineered 12 (2), 12070-12086 (2021)
   PUBMED   34787047
  REMARK    GeneRIF: lncRNA prostate cancer-associated transcript 18
            upregulates activating transcription factor 7 to prevent metastasis
            of triple-negative breast cancer via sponging miR-103a-3p.
REFERENCE   3  (bases 1 to 6488)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6488)
  AUTHORS   Song,F., Wei,M., Wang,J., Liu,Y., Guo,M., Li,X., Luo,J., Zhou,J.,
            Wang,M., Guo,D., Chen,L. and Sun,G.
  TITLE     Hepatitis B virus-regulated growth of liver cancer cells occurs
            through the microRNA-340-5p-activating transcription factor 7-heat
            shock protein A member 1B axis
  JOURNAL   Cancer Sci 110 (5), 1633-1643 (2019)
   PUBMED   30891870
  REMARK    GeneRIF: Results found that ATF7 is upregulated in hepatocellular
            carcinoma (HCC) tissue. Its expression is regulated by miR-340
            which directly binds to the mRNA encoding ATF7. Under HBV
            infection, miR-340 is downregulated resulting in increasing ATF7
            expression, leading to enhanced cell proliferation and inhibition
            of apoptosis.
REFERENCE   5  (bases 1 to 6488)
  AUTHORS   Newman,S.P., Bates,N.P., Vernimmen,D., Parker,M.G. and Hurst,H.C.
  TITLE     Cofactor competition between the ligand-bound oestrogen receptor
            and an intron 1 enhancer leads to oestrogen repression of ERBB2
            expression in breast cancer
  JOURNAL   Oncogene 19 (4), 490-497 (2000)
   PUBMED   10698518
REFERENCE   6  (bases 1 to 6488)
  AUTHORS   De Graeve,F., Bahr,A., Sabapathy,K.T., Hauss,C., Wagner,E.F.,
            Kedinger,C. and Chatton,B.
  TITLE     Role of the ATFa/JNK2 complex in Jun activation
  JOURNAL   Oncogene 18 (23), 3491-3500 (1999)
   PUBMED   10376527
REFERENCE   7  (bases 1 to 6488)
  AUTHORS   Goetz,J., Chatton,B., Mattei,M.G. and Kedinger,C.
  TITLE     Structure and expression of the ATFa gene
  JOURNAL   J Biol Chem 271 (47), 29589-29598 (1996)
   PUBMED   8939888
REFERENCE   8  (bases 1 to 6488)
  AUTHORS   Bocco,J.L., Bahr,A., Goetz,J., Hauss,C., Kallunki,T., Kedinger,C.
            and Chatton,B.
  TITLE     In vivo association of ATFa with JNK/SAP kinase activities
  JOURNAL   Oncogene 12 (9), 1971-1980 (1996)
   PUBMED   8649858
REFERENCE   9  (bases 1 to 6488)
  AUTHORS   Pescini,R., Kaszubska,W., Whelan,J., DeLamarter,J.F. and Hooft van
            Huijsduijnen,R.
  TITLE     ATF-a0, a novel variant of the ATF/CREB transcription factor
            family, forms a dominant transcription inhibitor in ATF-a
            heterodimers
  JOURNAL   J Biol Chem 269 (2), 1159-1165 (1994)
   PUBMED   8288576
REFERENCE   10 (bases 1 to 6488)
  AUTHORS   Gaire,M., Chatton,B. and Kedinger,C.
  TITLE     Isolation and characterization of two novel, closely related ATF
            cDNA clones from HeLa cells
  JOURNAL   Nucleic Acids Res 18 (12), 3467-3473 (1990)
   PUBMED   1694576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073594.31 and AC023509.42.
            
            On Jun 2, 2019 this sequence version replaced NM_001366561.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.152896.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC073594.31        5524-5627           c
            105-173             AC023509.42        21749-21817
            174-217             AC023509.42        79322-79365
            218-355             AC023509.42        85218-85355
            356-513             AC023509.42        88111-88268
            514-613             AC023509.42        89511-89610
            614-727             AC023509.42        90147-90260
            728-880             AC023509.42        90874-91026
            881-1078            AC023509.42        98009-98206
            1079-1187           AC023509.42        99386-99494
            1188-6488           AC023509.42        105416-110716
FEATURES             Location/Qualifiers
     source          1..6488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..6488
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="activating transcription factor 7"
                     /db_xref="GeneID:11016"
                     /db_xref="HGNC:HGNC:792"
                     /db_xref="MIM:606371"
     exon            1..104
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            105..173
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1405
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="isoform 8 is encoded by transcript variant 12;
                     cyclic AMP-dependent transcription factor ATF-7;
                     transcription factor ATF-A"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-7
                     isoform 8"
                     /protein_id="NP_001353490.1"
                     /db_xref="GeneID:11016"
                     /db_xref="HGNC:HGNC:792"
                     /db_xref="MIM:606371"
                     /translation="MKYGRRQTVCVQCPGLWTDQTPTPTRFLKNCEEAAAGPLDMSLP
                     STPDIKIKEEEPVEVDSSPPDSPASSPCSPPLKEKEVTPKPVLISTPTPTIVRPGSLP
                     LHLGYDPLHPTLPSPTSVITQAPPSNRQMGSPTGSLPLVMHLANGQTMPVLPGPPVQM
                     PSVISLARPVSMVPNIPGIPGPPVNSSGSISPSGHPIPSEAKMRLKATLTHQVSSING
                     GCGMVVGTASTMVTARPEQSQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDP
                     DERRQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLK
                     QLLLAHKDCPVTALQKKTQGYLESPKESSEPTGSPAPVIQHSSATAPSNGLSVRSAAE
                     AVATSVLTQMASQRTELSMPIQSHVIMTPQSQSAGR"
     exon            174..217
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            218..355
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            356..513
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            514..613
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            614..727
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            728..880
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1078
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1187
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..6488
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6466..6471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="hexamer: ATTAAA"
     polyA_site      6488
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="major polyA site"
ORIGIN      
        1 ggacgggagg aaagtatccg ttccgccaag gggggaaagg aggagctgga gacagattgt
       61 aggaccgagc gcgggcaggc gggaggcaac ggagctacca gccgctcctc tctgctatat
      121 gaaatatggg agacgacaga ccgtttgtgt gcaatgcccc gggctgtgga cagatcaaac
      181 gcctactcca actagattcc tgaagaactg tgaggaggct gctgctgggc cccttgacat
      241 gtctctgcct tccacaccag acatcaaaat caaagaagaa gagccagtgg aggtagactc
      301 atccccacct gatagccctg cctctagtcc ctgttcccca ccactgaagg agaaggaggt
      361 taccccaaag cctgttctga tctctacccc cacacccacc attgtacgtc ctggctccct
      421 gcctctccac ttgggctatg atccacttca tccaaccctt ccctccccaa cctctgtcat
      481 cacacaggct ccaccatcca acaggcaaat ggggtctccc actggctccc tccctcttgt
      541 catgcatctt gctaatggac agaccatgcc tgtgttgcca gggcctccag tacagatgcc
      601 gtctgttata tcgctggcca gacctgtgtc catggtgccc aacattcctg gtatccctgg
      661 cccaccagtt aacagtagtg gctccatttc tccctctggc caccctatac catcagaagc
      721 caagatgaga ctgaaagcca ccctaactca ccaagtctcc tcaatcaatg gtggttgtgg
      781 aatggtggtg ggtactgcca gcaccatggt gacagcccgc ccagagcaga gccagattct
      841 catccagcac cctgatgccc catcccctgc ccagccacag gtctcaccag ctcagcccac
      901 ccctagtact ggggggcgac ggcggcgcac agtagatgaa gatccagatg agcgacggca
      961 gcgctttctg gagcgcaacc gggctgcagc ctcccgctgc cgccaaaagc gaaagctgtg
     1021 ggtgtcctcc ctagagaaga aggccgaaga actcacttct cagaacattc agctgagtaa
     1081 tgaagtcaca ttactacgca atgaggtggc ccagttgaaa cagctactgt tagctcataa
     1141 agactgccca gtcactgcac tacagaaaaa gactcaaggc tatttagaaa gccccaagga
     1201 aagctcagag ccaacgggtt ctccagcccc tgtgattcag cacagctcag caacagcccc
     1261 tagcaatggc ctcagtgttc gctctgcagc tgaagctgtg gccacctcgg tcctcactca
     1321 gatggccagc caaaggacag aactgagcat gccgatacaa tcgcatgtaa tcatgacccc
     1381 acagtcccag tctgcgggca gatgatgcct cctctggtgg agaggtcctc agccagagct
     1441 cgcccgccca agagccaaga gagatgtcat cttatcccct cccatctgcc ttggacatgg
     1501 caatatgggt ggggggaatt gtgtgttgtg agtaatggac agatatgggg ctttttagcc
     1561 atgtggtcat gtacgtttga cacctgtgct gggggcctcc cagccccgga gcctcataga
     1621 tcatccccca gggtggggtt tctgatgcat ccacagccaa aggcctttcc agatggtccg
     1681 aacaatcacc cctgccccat gcacgtgtat ctgtctcttt taacactaac ccttggcact
     1741 tctaggtttg gggtttctca gttccctctc ttcccactaa gccgtggctg ttaccttttt
     1801 gttccttacc agcatgccac ttcctgccag atagagggag gctagatttg atgacatatt
     1861 acccgctgac ccagccccag ccaccccatg gactcaggac tcaggtctcc catagctgct
     1921 tatttacccg tttccttttt cctcttcctt aattctagtt aaaacattca cttacggaga
     1981 atgtaaggtt acctttgatg tatgaagtag cagtattttc cagtttttcc ataagcttta
     2041 ttccttctct ctacctgcca ccaaaaagaa agaaaccctc aagagttcta attctttttc
     2101 atctatttgc agagctattt gggtacctca ttttgtccct tgactttagt gtagtggtgg
     2161 ggtctttccc accaccccac taagccttgg caacctcatt ttgtggcctt attattaaag
     2221 attgcttggt agtgaaaagg gaagggccca gaatctgact ggctgattct gtctcctccc
     2281 ctccctcctt ctttagttta accatcaggg cagacaggaa caaagtattt caaagcttgt
     2341 tccatcaagt tagggattaa tcgattcctt tatgttttat aagagtttac cggccaaagc
     2401 atattgtcat ctttggtcat ttttctgctc ctgcttctct ctcttcattc ccctatcaac
     2461 attaccgccc ctgtctctct tctgtaacta cttcagactc agccctcctg gaggctgtca
     2521 tgtaggggac tctcgagttc ctttgttcta ccccatctct ccccctcaca catctgtctg
     2581 cttttctgag ctagagtctt ctgttcacaa gtgcccatca ccgtctggac tatcttcttt
     2641 ctctttcacc aggttcctag cttagccact aggtcttcca ggtcctccag agtttcttca
     2701 acccatttct tctctcttct ctttacatgc agtgctccag gatcttgaag cgtcatagcc
     2761 aagatgctga gtgggtttac ttgagtataa gattgaaagg agggaggaag aggagaggga
     2821 aagtgcagaa ctggtcccag caaaggaccc caggttctgg cctgggaaat tggtgactat
     2881 tgctctcaac cattcttact ttgaagagtt gggttgcaga gggagcaatt catctctctt
     2941 gtccctcttc cacgttaagg cttctcatct ccccttggct ctgaactatg cagtttctac
     3001 caggaccata ggaagcaatt cagagccaga ggcctgtgga tagataggtc agctttaatt
     3061 gcctttccgt atgaaaccct tccagttgtc ccagagccac tttctgccat ctgtgcaagc
     3121 caagaatgtc cttctctcca tctttcctac ctccatctta aacatacata caaaataact
     3181 gccagcttcc tttcttattt tgtctccaaa attgactgtc acaggggaat gagaaaatgt
     3241 tctaagctac aagattcccg tttccttaaa gtgatatcct gtcctagtga accagtcagg
     3301 taacaggttc tgctgcattt gttttaaatt tcccctcctg cttttcagag ctggtgctga
     3361 acaggccaca cccctaaaga caaaggagag aaaacacggt tttctcatcc tctaccatca
     3421 ggtacccaac aggaataggc cctgaagtga ttcagactag caaatgttat ggcagatggt
     3481 caggacgcag gttaccacat ccagggactt cacttttgcc tttaaaaatt cacagccgta
     3541 acttgtgctc aggacttccc ctttagctgg ctgctccctg ggattttctc ctgctttaga
     3601 gttttgtttc atttttttat tgtcttgatt tcccagtagc agccttgccc taaagcttga
     3661 ctgagtttat ggctcctaag gagctttcct aagactcttg actatttttc ttcccccttc
     3721 agtcaagtgt ttttacagtt aagaattaat ttgtaactgc atacatgccc tgccagtctg
     3781 tccctgtgtt gggtggctaa tttatgtagc gggtcttttt tatttcttag cccccatgac
     3841 taattatcta gtcctaactt catttttatc agtgggaaga tgtgtacggg acctcagtga
     3901 ggagcactgc cagaaccaca gtaacaaaat ggcactgaaa taaggaagca gcaggtcaga
     3961 accccctaga tagttcttga gttggttctc agtctcacta aggaggcaga ataattgctg
     4021 ccctgaaact tctctgatag tcaaaggtaa cttcacttac cttgttattg ctaccagcca
     4081 tgtggtcact ctccccaaat ctttgtcttc cagatccatc tggaccagaa ccaaacatca
     4141 tggaaggtgt cacttggccc ttcctaaagt ccatggcgtt tctagaggcc taagggagga
     4201 cactttcaga aaggagctga gtgtatggtg ggtgtcctga attcgttcat gtgaatacag
     4261 gactcaggct tcccacccca ctccaatgtg agtgctcgat acacaagcac tctagctagc
     4321 tgccacgtac ccaaggccac agagggaggg gacagaacca ggtcttctgg tctgctcact
     4381 ttctgcccca ttcccctaac agaaagtttg cttagagttg aaaagtctaa gaaagcctcc
     4441 cacaatacta gagaggccaa caaaaaaaaa gtcatgcccc ctttacttac tcttttgctg
     4501 ctggttatgc atctcaaatc tgacttcctt agccttcacc tccctccttg gccctaagca
     4561 ttagaccatg tactctaagt agtggttaaa gagggactga gcaaactgaa cctcctctcg
     4621 ctcacttctc tatccctgtt ctgttggttt tggctccttt cttgattcac tgccctctag
     4681 caccacccat cctggtagat ggagtgctta accccaaccg tgccctatgt acagcctgaa
     4741 ccaccaaaca gacaccaaaa aaattcttcc tgtggtttct ggggctcccc tgctccacac
     4801 tgagaggctc cttaaaggtg ctagcccctg atacagctat ccccgccagt tttctccttt
     4861 tttcataact tccttcccat ccccaaatca ttaatttttc attaatattg tacattatat
     4921 acacaggaag gaaatacatt atttttttta aatttcataa ccagcctgtt tagattccag
     4981 tcttcctagc tatatcacat atgccttgtt gatatgctct ttctgctttc tttagactta
     5041 atgtttgacg ggggtggggg tgtctggaag aacaggaaag gtggggatcc taaggcagat
     5101 taaaggactc cctccacccc actacagcct cccataactc tagtcatccc tctcatagta
     5161 caggactgat ttctctgtgt ctgtttgtac acacaaatgt gcatacagac ataaattccc
     5221 ccaccccata ccaaggtggt tacctagcag gaatgagcgt aggtggctgc tggccaccat
     5281 taccaccgtc tgcatcagct gtgttgtctc tctttggggt aaagtcctac cccagaatga
     5341 gaaaaggctg gggagagtag ggcaggttaa aggagcttat gtcctctgta gatgtaggtt
     5401 tgtatcatag ctactagggt ttattttttt aatggggggc taatagcaca gagttatctc
     5461 accagcagta gctactggtg agtgatgttt tagctgtaag aagtggctat gagcaatagt
     5521 ttcactgact ttaccttagg gcagtgccac agtaatctgg gaacttgtta gaaatacaca
     5581 ttctcaggcc ccatcccaga cttattgaat cacagactct gggggcaggg tttaaaagca
     5641 ctccaagtga ttctaatgca cactaaaggt tgagaaccat ttcttaggga taagctggga
     5701 aatttttaca ggtgtggagg atatttcaaa tacatctttt gcctttgcac taacatgctt
     5761 tcatttcttt cagtctcttc ctccattccc tttaaagtct tccccatcat atcactgatc
     5821 tcaaaagcta gatttgtctt cattttagtc gtatccctaa aaccatgcat tggtctggac
     5881 aggagttgtc ccatattccc ttgcagactg gtcactccat gttctctgtt acagtaagga
     5941 ccagccaagc ttcagctgtc ccattcctcc ccctacaaca cacacacctt tcaggcaggg
     6001 aggagatgag cttccagccc caagagtgga ggctgccaca tcctaacata gtatctattg
     6061 aaaaggaagc agtgtgtatc tatgattata tctctgttca tctatatatt tttgacatgt
     6121 agcaacacct ctccatctta tcaaggaact caactcggtc tgggtctccc cagtgcccag
     6181 tggtggcctt tgacaggtag gaggatgcag tgctgcaggc tattttgttt tttgttacaa
     6241 aactgtcttt tcccttttcc cctccacctg attcagcatg atccctgtga gctggttctc
     6301 acaatctcct gggactgggc tgaggcaggg gcttcgctct attctcccta accatactgt
     6361 cttcctttcc cccttgccac ttagcagtta tccccccagc tatgccttct ccctccctcc
     6421 cttgccctgg catatattgt gccttattta tgctgcaaat ataacattaa actatcaagt
     6481 gaaccact
//
