LOCUS       NM_001206683             776 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens activating transcription factor 7 (ATF7), transcript
            variant 5, mRNA.
ACCESSION   NM_001206683
VERSION     NM_001206683.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 776)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 776)
  AUTHORS   Zhang,J., Liu,D., Deng,G., Wang,Q., Li,L., Zhang,J. and Wu,H.
  TITLE     lncRNA prostate cancer-associated transcript 18 upregulates
            activating transcription factor 7 to prevent metastasis of
            triple-negative breast cancer via sponging miR-103a-3p
  JOURNAL   Bioengineered 12 (2), 12070-12086 (2021)
   PUBMED   34787047
  REMARK    GeneRIF: lncRNA prostate cancer-associated transcript 18
            upregulates activating transcription factor 7 to prevent metastasis
            of triple-negative breast cancer via sponging miR-103a-3p.
REFERENCE   3  (bases 1 to 776)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 776)
  AUTHORS   Song,F., Wei,M., Wang,J., Liu,Y., Guo,M., Li,X., Luo,J., Zhou,J.,
            Wang,M., Guo,D., Chen,L. and Sun,G.
  TITLE     Hepatitis B virus-regulated growth of liver cancer cells occurs
            through the microRNA-340-5p-activating transcription factor 7-heat
            shock protein A member 1B axis
  JOURNAL   Cancer Sci 110 (5), 1633-1643 (2019)
   PUBMED   30891870
  REMARK    GeneRIF: Results found that ATF7 is upregulated in hepatocellular
            carcinoma (HCC) tissue. Its expression is regulated by miR-340
            which directly binds to the mRNA encoding ATF7. Under HBV
            infection, miR-340 is downregulated resulting in increasing ATF7
            expression, leading to enhanced cell proliferation and inhibition
            of apoptosis.
REFERENCE   5  (bases 1 to 776)
  AUTHORS   Newman,S.P., Bates,N.P., Vernimmen,D., Parker,M.G. and Hurst,H.C.
  TITLE     Cofactor competition between the ligand-bound oestrogen receptor
            and an intron 1 enhancer leads to oestrogen repression of ERBB2
            expression in breast cancer
  JOURNAL   Oncogene 19 (4), 490-497 (2000)
   PUBMED   10698518
REFERENCE   6  (bases 1 to 776)
  AUTHORS   De Graeve,F., Bahr,A., Sabapathy,K.T., Hauss,C., Wagner,E.F.,
            Kedinger,C. and Chatton,B.
  TITLE     Role of the ATFa/JNK2 complex in Jun activation
  JOURNAL   Oncogene 18 (23), 3491-3500 (1999)
   PUBMED   10376527
REFERENCE   7  (bases 1 to 776)
  AUTHORS   Goetz,J., Chatton,B., Mattei,M.G. and Kedinger,C.
  TITLE     Structure and expression of the ATFa gene
  JOURNAL   J Biol Chem 271 (47), 29589-29598 (1996)
   PUBMED   8939888
REFERENCE   8  (bases 1 to 776)
  AUTHORS   Bocco,J.L., Bahr,A., Goetz,J., Hauss,C., Kallunki,T., Kedinger,C.
            and Chatton,B.
  TITLE     In vivo association of ATFa with JNK/SAP kinase activities
  JOURNAL   Oncogene 12 (9), 1971-1980 (1996)
   PUBMED   8649858
REFERENCE   9  (bases 1 to 776)
  AUTHORS   Pescini,R., Kaszubska,W., Whelan,J., DeLamarter,J.F. and Hooft van
            Huijsduijnen,R.
  TITLE     ATF-a0, a novel variant of the ATF/CREB transcription factor
            family, forms a dominant transcription inhibitor in ATF-a
            heterodimers
  JOURNAL   J Biol Chem 269 (2), 1159-1165 (1994)
   PUBMED   8288576
REFERENCE   10 (bases 1 to 776)
  AUTHORS   Gaire,M., Chatton,B. and Kedinger,C.
  TITLE     Isolation and characterization of two novel, closely related ATF
            cDNA clones from HeLa cells
  JOURNAL   Nucleic Acids Res 18 (12), 3467-3473 (1990)
   PUBMED   1694576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB490927.2, BC042363.1, AC023509.42 and AA679547.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR, 3'
            coding region and 3' UTR, compared to variant 2, resulting in an
            isoform (4) with a distinct and shorter C-terminus, compared to
            isoform 2. Variants 4, 5, and 13 all encode the same isoform (4).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI596298.1, DB490927.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB490927.2         1-2
            3-100               BC042363.1         1-98
            101-101             AC023509.42        21803-21803
            102-195             BC042363.1         100-193
            196-196             AC023509.42        70213-70213
            197-774             BC042363.1         195-772
            775-776             AA679547.1         2-3                 c
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..776
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="activating transcription factor 7"
                     /db_xref="GeneID:11016"
                     /db_xref="HGNC:HGNC:792"
                     /db_xref="MIM:606371"
     exon            1..46
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            47..115
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..421
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="isoform 4 is encoded by transcript variant 5;
                     cyclic AMP-dependent transcription factor ATF-7;
                     transcription factor ATF-A"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-7
                     isoform 4"
                     /protein_id="NP_001193612.1"
                     /db_xref="CCDS:CCDS58238.1"
                     /db_xref="GeneID:11016"
                     /db_xref="HGNC:HGNC:792"
                     /db_xref="MIM:606371"
                     /translation="MGDDRPFVCNAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDS
                     VIIADQTPTPTRFLKNCEEVGLFNELASSFEHEFKKAADEDEKKARSRTVAKKLVVFR
                     PRLFLLCFGIIFLIG"
     exon            116..212
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     exon            213..776
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      749..754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="hexamer: AATAAA"
     polyA_site      776
                     /gene="ATF7"
                     /gene_synonym="ATFA"
                     /note="major polyA site"
ORIGIN      
        1 ggggggaagg cggggccaga ggcttgaagt gtggggagaa cttggtctcc tctctgctat
       61 atgaaatatg ggagacgaca gaccgtttgt gtgcaatgcc ccgggctgtg gacagagatt
      121 tacaaacgag gaccacctgg cagttcataa acacaagcat gagatgacat tgaaatttgg
      181 cccagcccga actgactcag tcatcattgc agatcaaacg cctactccaa ctagattcct
      241 gaagaactgt gaggaggtgg gactcttcaa tgaactagct agctcctttg aacatgaatt
      301 caagaaagct gcagatgagg atgagaaaaa ggcaagaagc aggactgttg ccaaaaaact
      361 ggtggtattc agacctaggc tatttttatt gtgctttggg ataattttct taattggtta
      421 aaacacaaaa tcatgggctt agtagagtaa aaccagtaaa accagatagt agtcactaat
      481 cccagtcagc cattcaggtc tttaggagtt ccagatgatg gatcagcaca agtctgtcgt
      541 caccgaaaat tagtcctctt gttcttccag gggagtatta gtttaataat cggtttttta
      601 aaaaatattt atattataaa tatgttgaag atgttaaaag gtgataaatt actcagattt
      661 tgttggataa catatttgtt gccaaattcc actcttttct gagctgatca gacttctcag
      721 ctacactgtt tttttgaatc agcaagtcaa taaacattta tcaaatttcc actctt
//
