LOCUS       NM_004381               2626 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens activating transcription factor 6 beta (ATF6B),
            transcript variant 1, mRNA.
ACCESSION   NM_004381
VERSION     NM_004381.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2626)
  AUTHORS   Jin,S., Jin,B., Ishikawa,T., Ninagawa,S., Okada,T., Koyasu,S.,
            Harada,H. and Mori,K.
  TITLE     Loss of ATF6alpha in a human carcinoma cell line is compensated not
            by its paralogue ATF6beta but by sustained activation of the IRE1
            and PERK arms for tumor growth in nude mice
  JOURNAL   Mol Biol Cell 34 (3), ar20 (2023)
   PUBMED   36696173
  REMARK    GeneRIF: Loss of ATF6alpha in a human carcinoma cell line is
            compensated not by its paralogue ATF6beta but by sustained
            activation of the IRE1 and PERK arms for tumor growth in nude mice.
REFERENCE   2  (bases 1 to 2626)
  AUTHORS   Hien,L.T. and Back,S.H.
  TITLE     Establishment of a reporter system for monitoring activation of the
            ER stress transducer ATF6beta
  JOURNAL   Biochem Biophys Res Commun 558, 1-7 (2021)
   PUBMED   33894672
  REMARK    GeneRIF: Establishment of a reporter system for monitoring
            activation of the ER stress transducer ATF6beta.
REFERENCE   3  (bases 1 to 2626)
  AUTHORS   Moudi,M., Sargazi,S., Heidari Nia,M., Saravani,R., Shirvaliloo,M.
            and Shakiba,M.
  TITLE     Polymorphism in the 3'-UTR of LIF but Not in the ATF6B Gene
            Associates with Schizophrenia Susceptibility: a Case-Control Study
            and In Silico Analyses
  JOURNAL   J Mol Neurosci 70 (12), 2093-2101 (2020)
   PUBMED   32504404
  REMARK    GeneRIF: Polymorphism in the 3'-UTR of LIF but Not in the ATF6B
            Gene Associates with Schizophrenia Susceptibility: a Case-Control
            Study and In Silico Analyses.
REFERENCE   4  (bases 1 to 2626)
  AUTHORS   Stauffer,W.T., Arrieta,A., Blackwood,E.A. and Glembotski,C.C.
  TITLE     Sledgehammer to Scalpel: Broad Challenges to the Heart and Other
            Tissues Yield Specific Cellular Responses via Transcriptional
            Regulation of the ER-Stress Master Regulator ATF6alpha
  JOURNAL   Int J Mol Sci 21 (3), 1134 (2020)
   PUBMED   32046286
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2626)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 2626)
  AUTHORS   Yoshida,H., Haze,K., Yanagi,H., Yura,T. and Mori,K.
  TITLE     Identification of the cis-acting endoplasmic reticulum stress
            response element responsible for transcriptional induction of
            mammalian glucose-regulated proteins. Involvement of basic leucine
            zipper transcription factors
  JOURNAL   J Biol Chem 273 (50), 33741-33749 (1998)
   PUBMED   9837962
  REMARK    Erratum:[J Biol Chem 1999 Jan 22;274(4):2592]
REFERENCE   7  (bases 1 to 2626)
  AUTHORS   Speek,M., Barry,F. and Miller,W.L.
  TITLE     Alternate promoters and alternate splicing of human tenascin-X, a
            gene with 5' and 3' ends buried in other genes
  JOURNAL   Hum Mol Genet 5 (11), 1749-1758 (1996)
   PUBMED   8923003
REFERENCE   8  (bases 1 to 2626)
  AUTHORS   Khanna,A. and Campbell,R.D.
  TITLE     The gene G13 in the class III region of the human MHC encodes a
            potential DNA-binding protein
  JOURNAL   Biochem J 319 (Pt 1) (Pt 1), 81-89 (1996)
   PUBMED   8870652
REFERENCE   9  (bases 1 to 2626)
  AUTHORS   Min,J., Shukla,H., Kozono,H., Bronson,S.K., Weissman,S.M. and
            Chaplin,D.D.
  TITLE     A novel Creb family gene telomeric of HLA-DRA in the HLA complex
  JOURNAL   Genomics 30 (2), 149-156 (1995)
   PUBMED   8586413
REFERENCE   10 (bases 1 to 2626)
  AUTHORS   Bristow,J., Tee,M.K., Gitelman,S.E., Mellon,S.H. and Miller,W.L.
  TITLE     Tenascin-X: a novel extracellular matrix protein encoded by the
            human XB gene overlapping P450c21B
  JOURNAL   J Cell Biol 122 (1), 265-278 (1993)
   PUBMED   7686164
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662884.11, X98054.1 and
            BC077075.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004381.4.
            
            Summary: The protein encoded by this gene is a transcription factor
            in the unfolded protein response (UPR) pathway during ER stress.
            Either as a homodimer or as a heterodimer with ATF6-alpha, the
            encoded protein binds to the ER stress response element,
            interacting with nuclear transcription factor Y to activate UPR
            target genes. The protein is normally found in the membrane of the
            endoplasmic reticulum; however, under ER stress, the N-terminal
            cytoplasmic domain is cleaved from the rest of the protein and
            translocates to the nucleus. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC077075.1, X98054.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375203.8/ ENSP00000364349.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL662884.11        41068-41073         c
            7-47                X98054.1           1-41
            48-2014             BC077075.1         15-1981
            2015-2243           X98054.1           2009-2237
            2244-2244           AL662884.11        28473-28473         c
            2245-2622           X98054.1           2238-2615
            2623-2626           AL662884.11        28091-28094         c
FEATURES             Location/Qualifiers
     source          1..2626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..2626
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /note="activating transcription factor 6 beta"
                     /db_xref="GeneID:1388"
                     /db_xref="HGNC:HGNC:2349"
                     /db_xref="MIM:600984"
     exon            1..130
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..2151
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /note="isoform a is encoded by transcript variant 1;
                     Creb-related protein; cyclic AMP-dependent transcription
                     factor ATF-6 beta; protein G13; cAMP-dependent
                     transcription factor ATF-6 beta; cAMP-responsive
                     element-binding protein-like 1; cAMP response
                     element-binding protein-related protein"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-6
                     beta isoform a"
                     /protein_id="NP_004372.3"
                     /db_xref="CCDS:CCDS4737.1"
                     /db_xref="GeneID:1388"
                     /db_xref="HGNC:HGNC:2349"
                     /db_xref="MIM:600984"
                     /translation="MAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEE
                     QTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQVKSEPSSPCSSSSLSS
                     ESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSD
                     VQTKIEPVSPCSSVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSL
                     GAVQISMGPSLDGSSGKALPTRKPPLQPKPVVLTTVPMPSRAVPPSTTVLLQSLVQPP
                     PVSPVVLIQGAIRVQPEGPAPSLPRPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIK
                     NRESACQSRRKKKEYLQGLEARLQAVLADNQQLRRENAALRRRLEALLAENSELKLGS
                     GNRKVVCIMVFLLFIAFNFGPVSISEPPSAPISPRMNKGEPQPRRHLLGFSEQEPVQG
                     VEPLQGSSQGPKEPQPSPTDQPSFSNLTAFPGGAKELLLRDLDQLFLSSDCRHFNRTE
                     SLRLADELSGWVQRHQRGRRKIPQRAQERQKSQPRKKSPPVKAVPIQPPGPPERDSVG
                     QLQLYRHPDRSQPAFLDAIDRREDTFYVVSFRRDHLLLPAISHNKTSRPKMSLVMPAM
                     APNETLSGRGAPGDYEEMMQIECEVMDTRVIHIKTSTVPPSLRKQPSPTPGNATGGPL
                     PVSAASQAHQASHQPLYLNHP"
     exon            131..210
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            211..289
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            290..381
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            382..517
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            518..603
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            604..739
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            740..871
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1005
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1191
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1283
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1463
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1571
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1653
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1724
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1836
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1921
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2626
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2598..2603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /note="hexamer: AATAAA"
     polyA_site      2626
                     /gene="ATF6B"
                     /gene_synonym="ATF6beta; CREB-RP; CREBL1; G13"
                     /note="major polyA site"
ORIGIN      
        1 cttgggaacc gtctcctggt tggggggtgg gggggaaaga tggcggagct gatgctgctc
       61 agcgagattg ctgacccgac gcgtttcttc accgacaacc tgcttagccc ggaggactgg
      121 ggtctgcaga acagcacctt gtattctggc ctagatgaag tggccgagga gcagacgcag
      181 ctcttccgtt gcccggagca ggatgtcccg tttgacggca gctccctgga cgtggggatg
      241 gatgtcagcc cctctgagcc cccatgggaa ctcctgccga tcttcccaga tcttcaggtg
      301 aagtctgagc catcttcccc ctgctcttcc tcctccctca gctccgagtc atcgcgtctc
      361 tccacagagc catccagcga ggctcttggg gtaggggagg tgctccatgt gaagacagag
      421 tccttggcac ccccactgtg tctcctggga gatgacccaa catcctcatt tgaaaccgtc
      481 cagatcaacg ttatccccac ctctgatgat tcctcagatg tccagaccaa gatagaacct
      541 gtctctccat gttcttccgt caactctgag gcctccctgc tctcagccga ctcctccagc
      601 caggctttta taggagagga ggtcctggaa gtgaagacag agtccctgtc cccttcagga
      661 tgcctcctgt gggatgtccc agccccctca cttggagctg tccagatcag catgggccca
      721 tcccttgatg gctcctcagg caaagccctg cccacccgga agccgccact gcagcccaaa
      781 cctgtagtgc taaccactgt cccaatgcca tccagagctg tgcctcccag caccacagtc
      841 cttctgcagt ccctcgtcca gccaccccca gtgtccccag ttgtcctcat ccagggtgct
      901 attcgagtcc agcctgaagg gccggctccc tctctaccac ggcctgagag gaagagcatc
      961 gttcccgctc ctatgcctgg aaactcctgc ccgcctgaag tggatgcaaa gctgctgaag
     1021 cggcagcagc gaatgatcaa gaaccgggag tcagcctgcc agtcccggag aaagaagaaa
     1081 gagtatctgc agggactgga ggctcggctg caagcagtac tggctgacaa ccagcagctc
     1141 cgccgagaga atgctgccct ccggcggcgg ctggaggccc tgctggctga aaacagcgag
     1201 ctcaagttag ggtctggaaa caggaaggtg gtctgcatca tggtcttcct tctcttcatt
     1261 gccttcaact ttggacctgt cagcatcagt gagcctcctt cagctcccat ctctcctcgg
     1321 atgaacaagg gggagcctca accccggaga cacttgctgg ggttctcaga gcaagagcca
     1381 gttcagggag ttgaacctct ccaggggtcc tcccagggcc ctaaggagcc ccagcccagc
     1441 cccacagacc agcccagttt cagcaacctg acagccttcc ctgggggcgc caaggagcta
     1501 ctactaagag acctagacca gctcttcctc tcctctgatt gccggcactt caaccgcact
     1561 gagtccctga ggcttgctga cgagttgagt ggctgggtcc agcgccacca gagaggccgg
     1621 aggaagatcc ctcagagggc ccaggagaga cagaagtctc agccacggaa gaagtcacct
     1681 ccagttaagg cagtccccat ccaaccccct ggacccccag aaagggattc tgtgggccag
     1741 ctgcaactat atcgccaccc agaccgttcg cagccagcat tcttggatgc aattgaccga
     1801 cgggaagaca cattttatgt tgtctctttc cgaagggacc acctgctgct cccagccatc
     1861 agccacaaca agacctcccg gcccaagatg tccctggtga tgcctgccat ggcccccaat
     1921 gagaccctgt caggccgtgg ggccccgggg gactatgagg agatgatgca gatcgagtgt
     1981 gaggtcatgg acaccagggt gattcacatc aagacctcca cagtgccccc ctcgctccga
     2041 aaacagccat ccccaacccc aggcaatgcc acaggtggcc ccttgccagt ctctgcagcc
     2101 agccaggccc accaggcctc ccaccagccc ctctacctca atcatccctg acctctgcca
     2161 ttcacactga cttagaacgg ggggaggggg taccaggtgg ccaggtggga ctgtttcaaa
     2221 tttccctgat ccccaggctt ggggcaattg gtaaaggaaa gagcaggtgt gggggttaag
     2281 cacttatttg aggtgggggt gttcacctct cttctcatcc cttttcagaa tatagggctc
     2341 ctctcattcc tgtgaacccc cagtcctggc ttctttgttt gaggggattg tgtgaggttc
     2401 agttgtgggg tgggtggtga gctgctgcat attttttatt ttgtttctct agtgttatgg
     2461 cagtggaggt gggaatttag tccccaggtg ggacaaggga agttttttca ttttggagct
     2521 agttactggg agtaagggag ggtggggtgg gggggagttc aggtttatgt gtgtgcattt
     2581 cttttttatt attattaaat aaacaacttg gagggagttg aaggaa
//
