LOCUS       NM_007348               7470 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens activating transcription factor 6 (ATF6), transcript
            variant 1, mRNA.
ACCESSION   NM_007348
VERSION     NM_007348.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7470)
  AUTHORS   Klyosova,E., Azarova,I., Petrukhina,I., Khabibulin,R. and
            Polonikov,A.
  TITLE     The rs2341471-G/G genotype of activating transcription factor 6
            (ATF6) is the risk factor of type 2 diabetes in subjects with
            obesity or overweight
  JOURNAL   Int J Obes (Lond) 48 (11), 1638-1649 (2024)
   PUBMED   39134692
  REMARK    GeneRIF: The rs2341471-G/G genotype of activating transcription
            factor 6 (ATF6) is the risk factor of type 2 diabetes in subjects
            with obesity or overweight.
REFERENCE   2  (bases 1 to 7470)
  AUTHORS   Mori,K.
  TITLE     Divest yourself of a preconceived idea: transcription factor ATF6
            is not a soluble protein!
  JOURNAL   Mol Biol Cell 21 (9), 1435-1438 (2010)
   PUBMED   20219975
  REMARK    GeneRIF: Studies show that ATF6, rather than being a soluble
            nuclear protein, was an active transcription factor and synthesized
            as a transmembrane protein embedded in the ER.
REFERENCE   3  (bases 1 to 7470)
  AUTHORS   Meex,S.J., Weissglas-Volkov,D., van der Kallen,C.J., Thuerauf,D.J.,
            van Greevenbroek,M.M., Schalkwijk,C.G., Stehouwer,C.D.,
            Feskens,E.J., Heldens,L., Ayoubi,T.A., Hofker,M.H., Wouters,B.G.,
            Vlietinck,R., Sinsheimer,J.S., Taskinen,M.R., Kuusisto,J.,
            Laakso,M., de Bruin,T.W., Pajukanta,P. and Glembotski,C.C.
  TITLE     The ATF6-Met[67]Val substitution is associated with increased
            plasma cholesterol levels
  JOURNAL   Arterioscler Thromb Vasc Biol 29 (9), 1322-1327 (2009)
   PUBMED   19667116
  REMARK    GeneRIF: The ATF6-Met[67]Val substitution is associated with
            increased plasma cholesterol levels.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 7470)
  AUTHORS   Schewe,D.M. and Aguirre-Ghiso,J.A.
  TITLE     ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor
            cells in vivo
  JOURNAL   Proc Natl Acad Sci U S A 105 (30), 10519-10524 (2008)
   PUBMED   18650380
  REMARK    GeneRIF: ATF6alpha-Rheb-mTOR signaling promotes survival of dormant
            tumor cells in vivo
REFERENCE   5  (bases 1 to 7470)
  AUTHORS   Kerbiriou,M., Le Drevo,M.A., Ferec,C. and Trouve,P.
  TITLE     Coupling cystic fibrosis to endoplasmic reticulum stress:
            Differential role of Grp78 and ATF6
  JOURNAL   Biochim Biophys Acta 1772 (11-12), 1236-1249 (2007)
   PUBMED   18022401
  REMARK    GeneRIF: The aim was to study the activation of ATF6 and Grp78 in
            transfected human epithelial cells expressing the DeltaF508-CFTR
            protein.
REFERENCE   6  (bases 1 to 7470)
  AUTHORS   Haze,K., Yoshida,H., Yanagi,H., Yura,T. and Mori,K.
  TITLE     Mammalian transcription factor ATF6 is synthesized as a
            transmembrane protein and activated by proteolysis in response to
            endoplasmic reticulum stress
  JOURNAL   Mol Biol Cell 10 (11), 3787-3799 (1999)
   PUBMED   10564271
REFERENCE   7  (bases 1 to 7470)
  AUTHORS   Yoshida,H., Haze,K., Yanagi,H., Yura,T. and Mori,K.
  TITLE     Identification of the cis-acting endoplasmic reticulum stress
            response element responsible for transcriptional induction of
            mammalian glucose-regulated proteins. Involvement of basic leucine
            zipper transcription factors
  JOURNAL   J Biol Chem 273 (50), 33741-33749 (1998)
   PUBMED   9837962
  REMARK    Erratum:[J Biol Chem 1999 Jan 22;274(4):2592]
REFERENCE   8  (bases 1 to 7470)
  AUTHORS   Zhu,C., Johansen,F.E. and Prywes,R.
  TITLE     Interaction of ATF6 and serum response factor
  JOURNAL   Mol Cell Biol 17 (9), 4957-4966 (1997)
   PUBMED   9271374
REFERENCE   9  (bases 1 to 7470)
  AUTHORS   Kohl,S., Jagle,H., Wissinger,B. and Zobor,D.
  TITLE     Achromatopsia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301591
REFERENCE   10 (bases 1 to 7470)
  AUTHORS   Hai,T.W., Liu,F., Coukos,W.J. and Green,M.R.
  TITLE     Transcription factor ATF cDNA clones: an extensive family of
            leucine zipper proteins able to selectively form DNA-binding
            heterodimers
  JOURNAL   Genes Dev 3 (12B), 2083-2090 (1989)
   PUBMED   2516827
  REMARK    Erratum:[Genes Dev 1990 Apr;4(4):682]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP380917.1, BC014969.1,
            AK290498.1, AB015856.1, AL391825.15 and BM683233.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007348.3.
            
            Summary: This gene encodes a transcription factor that activates
            target genes for the unfolded protein response (UPR) during
            endoplasmic reticulum (ER) stress. Although it is a transcription
            factor, this protein is unusual in that it is synthesized as a
            transmembrane protein that is embedded in the ER. It functions as
            an ER stress sensor/transducer, and following ER stress-induced
            proteolysis, it functions as a nuclear transcription factor via a
            cis-acting ER stress response element (ERSE) that is present in the
            promoters of genes encoding ER chaperones. This protein has been
            identified as a survival factor for quiescent but not proliferative
            squamous carcinoma cells. There have been conflicting reports about
            the association of polymorphisms in this gene with diabetes in
            different populations, but another polymorphism has been associated
            with increased plasma cholesterol levels. This gene is also thought
            to be a potential therapeutic target for cystic fibrosis. [provided
            by RefSeq, Aug 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290498.1, SRR14038194.1191928.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367942.4/ ENSP00000356919.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BP380917.1         77-98
            23-239              BC014969.1         1-217
            240-289             AK290498.1         240-289
            290-624             BC014969.1         268-602
            625-2380            AB015856.1         652-2407
            2381-6823           AL391825.15        163809-168251
            6824-7470           BM683233.1         18-664              c
FEATURES             Location/Qualifiers
     source          1..7470
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..7470
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /note="activating transcription factor 6"
                     /db_xref="GeneID:22926"
                     /db_xref="HGNC:HGNC:791"
                     /db_xref="MIM:605537"
     exon            1..123
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2054
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclic AMP-dependent transcription factor ATF-6 alpha;
                     cAMP-dependent transcription factor ATF-6 alpha"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-6
                     alpha isoform 1"
                     /protein_id="NP_031374.2"
                     /db_xref="CCDS:CCDS1235.1"
                     /db_xref="GeneID:22926"
                     /db_xref="HGNC:HGNC:791"
                     /db_xref="MIM:605537"
                     /translation="MGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDEL
                     QLEAANETYENNFDNLDFDLDLMPWESDIWDINNQICTVKDIKAEPQPLSPASSSYSV
                     SSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNK
                     TENGLTPKKKIQVNSKPSIQPKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQ
                     PIISLQPAPTKGQTVLLSQPTVVQLQAPGVLPSAQPVLAVAGGVTQLPNHVVNVVPAP
                     SANSPVNGKLSVTKPVLQSTMRNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGL
                     EARLKAALSENEQLKKENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNY
                     GPMSMLEQDSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKA
                     LMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTR
                     ILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTF
                     YVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTR
                     ILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATHVVSTIPESLQ"
     exon            124..200
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            201..288
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            289..395
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            396..525
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            526..729
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            730..950
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1136
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1228
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1360
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1474
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1574
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1645
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1760
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1845
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..7470
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2395..2400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /note="hexamer: AATAAT"
     polyA_site      2426
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /note="major polyA site"
     regulatory      2437..2442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /note="hexamer: CATAAA"
     polyA_site      2462
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /note="major polyA site"
     polyA_site      2483
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
     regulatory      7450..7455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /note="hexamer: AATAAA"
     polyA_site      7470
                     /gene="ATF6"
                     /gene_synonym="ACHM7; ATF6A; ATP6alpha"
                     /note="major polyA site"
ORIGIN      
        1 agatattaat cacggagttc cagggagaag gaacttgtga aatgggggag ccggctgggg
       61 ttgccggcac catggagtca ccttttagcc cgggactctt tcacaggctg gatgaagatt
      121 gggattctgc tctctttgct gaactcggtt atttcacaga cactgatgag ctgcaattgg
      181 aagcagcaaa tgagacgtat gaaaacaatt ttgataatct tgattttgat ttggatttga
      241 tgccttggga gtcagacatt tgggacatca acaaccaaat ctgtacagtt aaagatatta
      301 aggcagaacc tcagccactt tctccagcct cctcaagtta ttcagtctcg tctcctcggt
      361 cagtggactc ttattcttca actcagcatg ttcctgagga gttggatttg tcttctagtt
      421 ctcagatgtc tcccctttcc ttatatggtg aaaactctaa tagtctctct tcagcggagc
      481 cactgaagga agataagcct gtcactggtc ctaggaacaa gactgaaaat ggactgactc
      541 caaagaaaaa aattcaggtg aattcaaaac cttcaattca gcccaagcct ttattgcttc
      601 cagcagcacc caagactcaa acaaactcca gtgttccagc aaaaaccatc attattcaga
      661 cagtaccaac gcttatgcca ttggcaaagc agcaaccaat tatcagttta caacctgcac
      721 ccactaaagg ccagacggtt ttgctgtctc agcctactgt ggtacaactt caagcacctg
      781 gagttctgcc ctctgctcag ccagtccttg ctgttgctgg gggagtcaca cagctcccta
      841 atcacgtggt gaatgtggta ccagcccctt cagcgaatag cccagtgaat ggaaaacttt
      901 ccgtgactaa acctgtccta caaagtacca tgagaaatgt cggttcagat attgctgtgc
      961 taaggagaca gcaacgtatg ataaaaaatc gagaatccgc ttgtcagtct cgcaagaaga
     1021 agaaagaata tatgctaggg ttagaggcga gattaaaggc tgccctctca gaaaacgagc
     1081 aactgaagaa agaaaatgga acactgaagc ggcagctgga tgaagttgtg tcagagaacc
     1141 agaggcttaa agtccctagt ccaaagcgaa gagttgtctg tgtgatgata gtattggcat
     1201 ttataatact gaactatgga cctatgagca tgttggaaca ggattccagg agaatgaacc
     1261 ctagtgtgag ccctgcaaat caaaggaggc accttctagg attttctgct aaagaggcac
     1321 aggacacatc agatggtatt atccagaaaa acagctacag atatgatcat tctgtttcaa
     1381 atgacaaagc cctgatggtg ctaactgaag aaccattgct ttacattcct ccacctcctt
     1441 gtcagcccct aattaacaca acagagtctc tcaggttaaa tcatgaactt cgaggatggg
     1501 ttcatagaca tgaagtagaa aggaccaagt caagaagaat gacaaataat caacagaaaa
     1561 cccgtattct tcagggtgct ctggaacagg gctcaaattc tcagctgatg gctgttcaat
     1621 acacagaaac cactagtagt atcagcagga actcagggag tgagctacaa gtgtattatg
     1681 cttcacccag aagttatcaa gacttttttg aagccatccg cagaagggga gacacatttt
     1741 atgttgtgtc atttcgaagg gatcacctgc tgttaccagc taccacccat aacaagacca
     1801 caagaccaaa aatgtcaatt gtgttaccag caataaacat aaatgagaat gtgatcaatg
     1861 ggcaggacta cgaagtgatg atgcagattg actgtcaggt gatggacacc aggatcctcc
     1921 atatcaaaag ttcgtcagtt cctccttacc tccgagatca gcagaggaat caaaccaaca
     1981 ccttctttgg ctcccctccc gcagccacag aggcaaccca cgttgtcagc accatccctg
     2041 agtcattaca atagcaccct gcagctatgc tggaaaactg agcgtgggac cctgccagac
     2101 tgaagagcag gtgagcaaaa tgctgctttc tgccttggtg gcaggcagag aactgtctcg
     2161 tactagaatt caaggaggaa agaagaagaa ataaaagaag ctgctccatt tttcatcatc
     2221 tacccatcta tttggaaagc actggaattc agatgcaaga gaacaatgtt tcttcagtgg
     2281 caaatgtagc cctgcatcct ccagtgttac ctggtgtaga tttttttttc tgtacctttc
     2341 taaacctctc ttccctctgt gatggttttg tgtttaaaca gtcatcttct tttaaataat
     2401 atccacctct cctttttgcc atttcactta ttgattcata aagtgaattt tatttaaagc
     2461 tatgccacac atgcatgttc aaatggtttc cactgattcg atttttcatt catttaatgc
     2521 aaacccattc tggatattgt gcttatttga gaaaacacat ttcaaaacca gaaaagccaa
     2581 aaacactcca aaaacaagca aaacaatttg gagctttaga taaaaggaaa aactcccagt
     2641 tggtaaagtt tatctttact taggatttgt ggctcacacc taaacaaagg gggtcaggga
     2701 gtgggtacaa atttgagaaa atagaagggt aagggaaggg ccagtggtgg ggtttggaga
     2761 gaggagatag ctccattaat acacatgttt aaaagatgga aagttcacgc ctgtaatccc
     2821 agcactttgg gaggccgagg cgggtggatc acgaggtcag gagatcaaga ccatcccggc
     2881 taaaacggtg aaaccccgtc tctactaaaa atacaaaaaa ttagccgggc gtagtgacgg
     2941 gcgcctgtag tcccagctac ttgggaggct gaggcaggag aatggcgtga acccgggagg
     3001 cggagcttgc agtgagccga gatcccgcca ctgcactcca gcctgggcga cagagcgaga
     3061 ctccgtctca aaaaaaaaaa aaaaaaaaaa aaaagatgga aagttcgatg tgactgcagt
     3121 atgagattaa agccacaact attgtttatt ttggggactc taggccacca agtattagca
     3181 cacatactta tgttttctct actaatctgg tccaggtcct catggaccac aggacaaagc
     3241 tttcattttc attcattctt ctattgaaat tataccaaat tcagctgagg aatatggaag
     3301 taactttaga cttaaacaag acaaaagttt tttcactgaa gaattgacaa gtatttgctc
     3361 cttaaaacaa cgcagattag tgaacgtgga ttcctgctga gggagtgcat cccataatat
     3421 ggcaataatt ttcagtttct ccaacgaaaa gatagtgaag gaattaaatc ttttgtcctc
     3481 ccatggttaa aaaaaaaaaa aaagctgtgt tcatttttac tgtactatgc ctcttttttc
     3541 accatagtag acaattatgt ttcatttgat gaattcatag aactggatct catacagcga
     3601 tgtcctctct aatgttctac ctttcagttt ctaaagtgag tcttcctccc tctcctacaa
     3661 aacttttcaa ttttttgatg taactcatct acaaatactg tttcttaccc cagttgactt
     3721 gcctttgtca gatttcttct tgttccacac tatagcaatc aatttctctt cttccttaca
     3781 agaaagggaa cgagaaattg tagcaacctc tcaaggatta tatgcagcta gttagttttc
     3841 tgcctgtgaa attaggtctg gctcctaaat aattttaaag aaccatcagc acttctaact
     3901 ctctggacag gtgcctcttt gtccaagcta gttaaatgct ttccaaggaa atcagttcaa
     3961 cttttgtgag cggggaaaag cagggcttta ttgttgtgtt acctgggagt ctggagtttg
     4021 aaaagtgcta attaaccttc ctctttttcc acattacaaa cctttttaag cagcgcagca
     4081 ctccccttag atttggctat cctgggtgat tttcagacaa gaaccatttt ctctggggac
     4141 cattcttctg ctgggtgcca aggaatataa ggcaaatgcc cagaagacct tcaggtgact
     4201 gggcagtctt atcatgggat atttcttctg gccctgcccc ttcccattct gtaatgtgaa
     4261 ttagccacac cagaggctgt gaccatggct agtagacagt ggcaacatag tcatccccaa
     4321 gatgctaatc ttctgctgga actgtcatac gttatcatgg tcaatgtaaa cctggtttgt
     4381 gtggggtgat tataaataga gtttccctcc tctctgtgac agaatcacag gagaaggacc
     4441 catctcgtgg ccttcttgtt cttagcgctt cacttttact tcatccctcg attcccagct
     4501 ttttctatca tcattttgcc aactcctcag atgcaagact ttggttatgt catactcacc
     4561 aacgttagtc cctctcttcc aggtgaaaag gtgggtagcg gttgggaggg agtctccact
     4621 gaagagcagg aaggtggtag cagggccggc agctctgcca cagagctagg ggtgcctgta
     4681 aggtgccgcc tagagcagcc tgggagcttt gccttctttt gtctctcact agcccttcta
     4741 ctctttgtca ttgcctgttc ttgagtggat ctttgaaatg aggggacagg attctcctaa
     4801 gggtagagtt tcaggaaatg agtgaaaggc aattgacaaa tgcaaagaag tagtcacttt
     4861 ttaaattgct ggcaaagcta taattaatcc ctaggcacaa ttgtagtttt tattttaatg
     4921 tttgtatgca caaggccctt taggaaatga gaagttgcca tgccagatta attttttttt
     4981 ttttttttgg tgggattgcc ttttgggggt tgcagccaga aattgtgggt aatgtgtgta
     5041 tttttttatt tattaaattt taaacaggat tgtgcaagct tatgagacaa ttagataaac
     5101 tcatggagga ggcaggtcct cctgttatta gatgattttg tgctcttggg gctgacaata
     5161 atacactctt gggaagtgat ggtagagact gatgggaata gtctttctgc ctggttgcaa
     5221 gtcccaaatt tttaagggtt aatggaagta agtggatgtt tcctcatgtt aactactgaa
     5281 tcagatgtta ggagcttgtc cctttggggt tgacttatgc ccagcagtac agggacacag
     5341 cttcattaga gtgttagtgt aaactaactc caaagttagg agttaatgtg aaaggatcat
     5401 ccttgaaaca aatctgctgt ttgccatgct tgtagtacag aaacttcaca tggagttttg
     5461 ggtgggattt gtgttttcac aagtaaaaaa tccctcacga ttataaaact cagagcatca
     5521 tctaattttt ttttttaatg actacaagtt ccagcacaaa actggcattt ctttgccatt
     5581 tcttgccagt aagaagttga cacggaggta tttgaaagca atgttatgtg agtcattctt
     5641 aagtgttcca agtaagttta gaaacagaaa aggaacttgg gattcaaatt gatttttcaa
     5701 atcattttta aagagacatc atcctgacta aatcttagcc tgaaccttcc tcccctgtgt
     5761 gtattccccg gtagtcaccg cagcgagatg ctggtgagac tgccgtggtg gcatttagca
     5821 tcgttaaaac tggaaaactc tcaagctctt tgccactttc ctactatttt ttgattcttg
     5881 ccattttacc aagcttaggt tgtgaaactt gacagaaatg tattacagga aaaacttata
     5941 attgtatttg actttctaac acattgcaaa gtttcaaagt gactttcact ttcaacaaca
     6001 tattagaagt aaccactttt gctttcacag cctgaagagt tagagcctga tctgatgccc
     6061 cctttcactc tgaagtcatg ggaaattttc cagccatgaa agccctcttt ccactgcata
     6121 ctgatgggct gactcagctt ccttcagccg actgagatct tttcatacta ttggctattt
     6181 cataccaatt aacctcttaa ataagattgt gaattgccaa aattgataga cacttattac
     6241 cacctgtgga ctccatattc cttaccacaa atgttatttt catcagtcct gagtcatttt
     6301 aacttacaga aattaggatt gttgctgcta atatgaatac caattataac ttttagaaac
     6361 aagaataaag cctaaaagag aatgaaatat aagaaatgtt cgttcccacc cctaataaca
     6421 tttggaagtg aatattccca ttttcttcca cccacaggga ttgggattga tttttaattt
     6481 cctaggaaac aatactagac tacccaaaaa gatgttgcca gaatccaaaa ggaactatgc
     6541 tcgtaaaaga aatgcagttt tctcctacct aaaaaaaaga aagtaaagtg tgttctgttc
     6601 ttatcttttt aatgactaag ctttaaacag tttattttgg gtaagactag aactttcggc
     6661 catttgttct aatatgtgtg ttattagatg caatagaatt tatgaaaaga agaatgacaa
     6721 aggtatctga ttagaaaatt tgatcttacg catgaatcca tgtcatggcc agccactgtc
     6781 acatagtggg tgccattctc aacatattgg tttgctaact ttaagcatta gggatttagc
     6841 acactaaaat acttttaatt atattaggtt tggtaactaa ggagtaaata aatcataatt
     6901 tatcatttgc caaggccaac aaacaacact attgtgctgt ttgctctcaa tgaagttgaa
     6961 taaaccagga ggcttggcat atccccttta tgttaatccc agctagagat tagtaggttg
     7021 actttcacag caattgtata ttgatccatt ttaactcatc cttgccataa tttccaggcc
     7081 agtcaccagg acagaggaga tgatggggaa acagagcttt agatgaaaac tactatgcac
     7141 tactagcctt agaggcactg gtttcctgtt accactttgg caagtatgga tggtctaagt
     7201 ccagtagggc ttcatccatg gagccattag aactgagggg ggagtgttag agatgccatt
     7261 tcaccaggat ctttttgctc aggttgtacc catgccaatt gaagaacgtg ttaaagatga
     7321 ggaggagaga tgtaccattc tctcccttaa taatgatgtt ggtttgcaaa acctaaagaa
     7381 ataataacaa cagactattt catactttca agcaagtctt tatactacct gttatttctc
     7441 taaaattcaa ataaagaatt tttaaactta
//
