LOCUS       NM_001193646            2007 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens activating transcription factor 5 (ATF5), transcript
            variant 2, also known as alpha, mRNA.
ACCESSION   NM_001193646
VERSION     NM_001193646.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2007)
  AUTHORS   Xu,W.N., Zheng,H.L., Yang,R.Z., Sun,Y.F., Peng,B.R., Liu,C.,
            Song,J., Jiang,S.D. and Zhu,L.X.
  TITLE     The mitochondrial UPR induced by ATF5 attenuates intervertebral
            disc degeneration via cooperating with mitophagy
  JOURNAL   Cell Biol Toxicol 40 (1), 16 (2024)
   PUBMED   38472656
  REMARK    GeneRIF: The mitochondrial UPR induced by ATF5 attenuates
            intervertebral disc degeneration via cooperating with mitophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2007)
  AUTHORS   Cao,M., Lai,P., Liu,X., Liu,F., Qin,Y., Tu,P. and Wang,Y.
  TITLE     ATF5 promotes malignant T cell survival through the PI3K/AKT/mTOR
            pathway in cutaneous T cell lymphoma
  JOURNAL   Front Immunol 14, 1282996 (2023)
   PUBMED   38223508
  REMARK    GeneRIF: ATF5 promotes malignant T cell survival through the
            PI3K/AKT/mTOR pathway in cutaneous T cell lymphoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2007)
  AUTHORS   Banerjee,D., Boboila,S., Okochi,S., Angelastro,J.M.,
            Kadenhe-Chiweshe,A.V., Lopez,G., Califano,A., Connolly,E.P.,
            Greene,L.A. and Yamashiro,D.J.
  TITLE     Activating Transcription Factor 5 Promotes Neuroblastoma Metastasis
            by Inducing Anoikis Resistance
  JOURNAL   Cancer Res Commun 3 (12), 2518-2530 (2023)
   PUBMED   38014922
  REMARK    GeneRIF: Activating Transcription Factor 5 Promotes Neuroblastoma
            Metastasis by Inducing Anoikis Resistance.
REFERENCE   4  (bases 1 to 2007)
  AUTHORS   Wang,X., Yu,X., Li,Y., Liu,F., Du,L., Xie,N. and Wang,C.
  TITLE     ATF5 Attenuates Apoptosis in Hippocampal Neurons with Seizures
            Evoked by Mg2+-Free Medium via Regulating Mitochondrial Unfolded
            Protein Response
  JOURNAL   Neurochem Res 48 (1), 62-71 (2023)
   PUBMED   35939173
  REMARK    GeneRIF: ATF5 Attenuates Apoptosis in Hippocampal Neurons with
            Seizures Evoked by Mg[2+]-Free Medium via Regulating Mitochondrial
            Unfolded Protein Response.
REFERENCE   5  (bases 1 to 2007)
  AUTHORS   Andreev,D.E., O'Connor,P.B., Fahey,C., Kenny,E.M., Terenin,I.M.,
            Dmitriev,S.E., Cormican,P., Morris,D.W., Shatsky,I.N. and
            Baranov,P.V.
  TITLE     Translation of 5' leaders is pervasive in genes resistant to eIF2
            repression
  JOURNAL   Elife 4, e03971 (2015)
   PUBMED   25621764
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2007)
  AUTHORS   Zhou,D., Palam,L.R., Jiang,L., Narasimhan,J., Staschke,K.A. and
            Wek,R.C.
  TITLE     Phosphorylation of eIF2 directs ATF5 translational control in
            response to diverse stress conditions
  JOURNAL   J Biol Chem 283 (11), 7064-7073 (2008)
   PUBMED   18195013
  REMARK    GeneRIF: ATF4 contributes to basal ATF5 transcription, and eIF2
            kinases direct the translational expression of multiple
            transcription regulators by a mechanism involving delayed
            translation reinitiation
REFERENCE   7  (bases 1 to 2007)
  AUTHORS   Watatani,Y., Ichikawa,K., Nakanishi,N., Fujimoto,M., Takeda,H.,
            Kimura,N., Hirose,H., Takahashi,S. and Takahashi,Y.
  TITLE     Stress-induced translation of ATF5 mRNA is regulated by the
            5'-untranslated region
  JOURNAL   J Biol Chem 283 (5), 2543-2553 (2008)
   PUBMED   18055463
  REMARK    GeneRIF: translation of ATF5 is regulated by the alternative 5'-UTR
            region of its mRNA, and ATF5 may play a role in protecting cells
            from amino acid limitation or arsenite-induced oxidative stress
REFERENCE   8  (bases 1 to 2007)
  AUTHORS   White,J.H., McIllhinney,R.A., Wise,A., Ciruela,F., Chan,W.Y.,
            Emson,P.C., Billinton,A. and Marshall,F.H.
  TITLE     The GABAB receptor interacts directly with the related
            transcription factors CREB2 and ATFx
  JOURNAL   Proc Natl Acad Sci U S A 97 (25), 13967-13972 (2000)
   PUBMED   11087824
REFERENCE   9  (bases 1 to 2007)
  AUTHORS   Pati,D., Meistrich,M.L. and Plon,S.E.
  TITLE     Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target
            repressors of cyclic AMP-induced transcription for proteolysis
  JOURNAL   Mol Cell Biol 19 (7), 5001-5013 (1999)
   PUBMED   10373550
REFERENCE   10 (bases 1 to 2007)
  AUTHORS   Nishizawa,M. and Nagata,S.
  TITLE     cDNA clones encoding leucine-zipper proteins which interact with
            G-CSF gene promoter element 1-binding protein
  JOURNAL   FEBS Lett 299 (1), 36-38 (1992)
   PUBMED   1371974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011452.6.
            
            On Oct 26, 2020 this sequence version replaced NM_001193646.1.
            
            Transcript Variant: This variant (2, also known as alpha) differs
            in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073613.1, AB021663.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000423777.7/ ENSP00000396954.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 18055463
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC011452.6         35709-35904
            197-493             AC011452.6         37236-37532
            494-2007            AC011452.6         38926-40439
FEATURES             Location/Qualifiers
     source          1..2007
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2007
                     /gene="ATF5"
                     /gene_synonym="ATFX; HMFN0395"
                     /note="activating transcription factor 5"
                     /db_xref="GeneID:22809"
                     /db_xref="HGNC:HGNC:790"
                     /db_xref="MIM:606398"
     exon            1..196
                     /gene="ATF5"
                     /gene_synonym="ATFX; HMFN0395"
                     /inference="alignment:Splign:2.1.0"
     regulatory      70..81
                     /regulatory_class="uORF"
                     /gene="ATF5"
                     /gene_synonym="ATFX; HMFN0395"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:18055463]"
                     /note="this uORF is predicted to encode a 3 aa peptide
                     (PMID:18055463)"
     regulatory      192..371
                     /regulatory_class="uORF"
                     /gene="ATF5"
                     /gene_synonym="ATFX; HMFN0395"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:18055463]"
                     /note="this uORF is predicted to encode a 59 aa peptide
                     (PMID:18055463)"
     exon            197..493
                     /gene="ATF5"
                     /gene_synonym="ATFX; HMFN0395"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..1164
                     /gene="ATF5"
                     /gene_synonym="ATFX; HMFN0395"
                     /note="transcription factor ATFx; cAMP-dependent
                     transcription factor ATF-5"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-5"
                     /protein_id="NP_001180575.1"
                     /db_xref="CCDS:CCDS12789.1"
                     /db_xref="GeneID:22809"
                     /db_xref="HGNC:HGNC:790"
                     /db_xref="MIM:606398"
                     /translation="MSLLATLGLELDRALLPASGLGWLVDYGKLPPAPAPLAPYEVLG
                     GALEGGLPVGGEPLAGDGFSDWMTERVDFTALLPLEPPLPPGTLPQPSPTPPDLEAMA
                     SLLKKELEQMEDFFLDAPPLPPPSPPPLPPPPLPPAPSLPLSLPSFDLPQPPVLDTLD
                     LLAIYCRNEAGQEEVGMPPLPPPQQPPPPSPPQPSRLAPYPHPATTRGDRKQKKRDQN
                     KSAALRYRQRKRAEGEALEGECQGLEARNRELKERAESVEREIQYVKDLLIEVYKARS
                     QRTRSC"
     exon            494..2007
                     /gene="ATF5"
                     /gene_synonym="ATFX; HMFN0395"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1984..1989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF5"
                     /gene_synonym="ATFX; HMFN0395"
                     /note="hexamer: AATAAA"
     polyA_site      2007
                     /gene="ATF5"
                     /gene_synonym="ATFX; HMFN0395"
                     /note="major polyA site"
ORIGIN      
        1 attccctgtc ctcggatcac agtctcttct cactacagtg tcgccgcctc tgcctgcgta
       61 gccccggcca tggctctgta gcctcgaccc ctttgtgccc ccggcccgtc tccgcgctca
      121 ccacgcctgc gctctccgct cccaccttct ttcttcagcc gaggccgccg ccgcctctcc
      181 ttgctgcagc catggagtct tccactttcg ccttggtgcc tgtcttcgcc cacctgagca
      241 tcctccagag cctcgtgcca gctgctggtg cagcctctcc tgttgccatc agtgcccagc
      301 acctgtgcta cagccatgtc actcctggcg accctggggc tggagctgga cagggccctg
      361 ctcccagcta gtgggctggg atggctcgta gactatggga aactcccccc ggcccctgcc
      421 cccctggctc cctatgaggt ccttggggga gccctggagg gcgggcttcc agtgggggga
      481 gagcccctgg caggtgatgg cttctctgac tggatgactg agcgagttga tttcacagct
      541 ctcctccctc tggagcctcc cttacccccc ggcaccctcc cccaaccttc cccaacccca
      601 cctgacctgg aagctatggc ctccctcctc aagaaggagc tggaacagat ggaagacttc
      661 ttcctagatg ccccgcccct cccaccaccc tccccgccgc cactaccacc accaccacta
      721 ccaccagccc cctccctccc cctgtccctc ccctcctttg acctccccca gccccctgtc
      781 ttggatactc tggacttgct ggccatctac tgccgcaacg aggccgggca ggaggaagtg
      841 gggatgccgc ctctgccccc gccacagcag ccccctcctc cttctccacc tcaaccttct
      901 cgcctggccc cctacccaca tcctgccacc acccgagggg accgcaagca aaagaagaga
      961 gaccagaaca agtcggcggc tctgaggtac cgccagcgga agcgggcaga gggtgaggcc
     1021 ctggagggcg agtgccaggg gctggaggca cggaatcgcg agctgaagga acgggcagag
     1081 tccgtggagc gcgagatcca gtacgtcaag gacctgctca tcgaggttta caaggcccgg
     1141 agccagagga cccgtagctg ctagaagggc aggggtgtgg cttctggggg ctggtcttca
     1201 gctctggcgc cttcatcccc ctgcctctac cttcattcca aacccctctc ggccgggtgc
     1261 agtggcttat gcttgtaatc ccagcacttt gggaggccaa ggcaggagga tcgtttgagg
     1321 ccaggaggtc aataccagcc tgggcaacat agtaagaccc tgtctctatt aaaaaaaaaa
     1381 aatcaaccct tcttccccac caaaccaccc aactcctctc tactcttatc cttttatcct
     1441 ctgtctctgc ttatcacctc tcttgcgtat ttctggatct ccttccctcc tttctcgtcc
     1501 aaatcatgaa atgtttggcc ttagtcaatg tctatgcccg tcacataaca gccgaggcac
     1561 cgaggcccac agggaagcag ctgggagctt ggaaacctgg tctcttgaat ttcaaacctg
     1621 gtttcttaca ggtggttgtc tggggtgggt ggagtggcga caggatagag ctgaaggact
     1681 atgcaaatga ggaagtaagt cagggcgggc tttgagaagg ggacccatat cctacaggca
     1741 aaaagcaggc taggtgacct tgggacacta cgctaaggga gggaggctaa aggcggccag
     1801 gtttgcagtg cgggaagatg agcaggccag tgggaggagg ggcagggcag ggctgtagtt
     1861 ggtgactggg tgttcatttt agctctaaga aaaaaaatca gtgtttcgtg aaggtgttgg
     1921 agaggggctg tgtctgggtg agggatggcg gggtactgat ttttttggga ggttatgagc
     1981 aaaaataaaa cgaaacattt cctctgg
//
