LOCUS       NM_001674               1940 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens activating transcription factor 3 (ATF3), transcript
            variant 1, mRNA.
ACCESSION   NM_001674
VERSION     NM_001674.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Hu,H., Liu,Y., Qiu,C., Zhang,L., Cui,H. and Gu,J.
  TITLE     LINC00894 inhibited neuron cellular apoptosis and regulated
            activating transcription factor 3 expression
  JOURNAL   Gene 927, 148670 (2024)
   PUBMED   38857714
  REMARK    GeneRIF: LINC00894 inhibited neuron cellular apoptosis and
            regulated activating transcription factor 3 expression.
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Wen,Y., Liu,Y., Li,Q., Tan,J., Fu,X., Liang,Y., Tuo,Y., Liu,L.,
            Zhou,X., LiuFu,D., Fan,X., Chen,C., Chen,Z., Wang,Z., Fan,S.,
            Liu,R., Pan,L., Zhang,Y. and Tang,W.H.
  TITLE     Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal
            Aortic Aneurysm
  JOURNAL   Circ Res 134 (11), 1495-1511 (2024)
   PUBMED   38686580
  REMARK    GeneRIF: Spatiotemporal ATF3 Expression Determines VSMC Fate in
            Abdominal Aortic Aneurysm.
REFERENCE   3  (bases 1 to 1940)
  AUTHORS   Miyazaki,K., Inoue,S., Yamada,K., Watanabe,M., Liu,Q., Watanabe,T.,
            Adachi,M.T., Tanaka,Y. and Kitajima,S.
  TITLE     Differential usage of alternate promoters of the human stress
            response gene ATF3 in stress response and cancer cells
  JOURNAL   Nucleic Acids Res 37 (5), 1438-1451 (2009)
   PUBMED   19136462
  REMARK    GeneRIF: In human prostate and Hodgkin Reed-Sternberg cancer cells
            with elevated expression of ATF3, the P1 promoter was
            constitutively activated and its chromatin structure was modified
            into active configuration.
REFERENCE   4  (bases 1 to 1940)
  AUTHORS   Hua,B., Tamamori-Adachi,M., Luo,Y., Tamura,K., Morioka,M.,
            Fukuda,M., Tanaka,Y. and Kitajima,S.
  TITLE     A splice variant of stress response gene ATF3 counteracts
            NF-kappaB-dependent anti-apoptosis through inhibiting recruitment
            of CREB-binding protein/p300 coactivator
  JOURNAL   J Biol Chem 281 (3), 1620-1629 (2006)
   PUBMED   16291753
REFERENCE   5  (bases 1 to 1940)
  AUTHORS   Pan,Y., Chen,H., Siu,F. and Kilberg,M.S.
  TITLE     Amino acid deprivation and endoplasmic reticulum stress induce
            expression of multiple activating transcription factor-3 mRNA
            species that, when overexpressed in HepG2 cells, modulate
            transcription by the human asparagine synthetase promoter
  JOURNAL   J Biol Chem 278 (40), 38402-38412 (2003)
   PUBMED   12881527
  REMARK    GeneRIF: ATF3 isoforms have a role in the transcriptional
            regulation of the ASNS gene in response to nutrient deprivation
REFERENCE   6  (bases 1 to 1940)
  AUTHORS   Hashimoto,Y., Zhang,C., Kawauchi,J., Imoto,I., Adachi,M.T.,
            Inazawa,J., Amagasa,T., Hai,T. and Kitajima,S.
  TITLE     An alternatively spliced isoform of transcriptional repressor ATF3
            and its induction by stress stimuli
  JOURNAL   Nucleic Acids Res 30 (11), 2398-2406 (2002)
   PUBMED   12034827
  REMARK    GeneRIF: An alternatively spliced isoform of transcriptional
            repressor ATF3 and its induction by stress stimuli.
REFERENCE   7  (bases 1 to 1940)
  AUTHORS   Liang,G., Wolfgang,C.D., Chen,B.P., Chen,T.H. and Hai,T.
  TITLE     ATF3 gene. Genomic organization, promoter, and regulation
  JOURNAL   J Biol Chem 271 (3), 1695-1701 (1996)
   PUBMED   8576171
REFERENCE   8  (bases 1 to 1940)
  AUTHORS   Chen,B.P., Liang,G., Whelan,J. and Hai,T.
  TITLE     ATF3 and ATF3 delta Zip. Transcriptional repression versus
            activation by alternatively spliced isoforms
  JOURNAL   J Biol Chem 269 (22), 15819-15826 (1994)
   PUBMED   7515060
REFERENCE   9  (bases 1 to 1940)
  AUTHORS   Hsu,J.C., Bravo,R. and Taub,R.
  TITLE     Interactions among LRF-1, JunB, c-Jun, and c-Fos define a
            regulatory program in the G1 phase of liver regeneration
  JOURNAL   Mol Cell Biol 12 (10), 4654-4665 (1992)
   PUBMED   1406655
REFERENCE   10 (bases 1 to 1940)
  AUTHORS   Hai,T.W., Liu,F., Coukos,W.J. and Green,M.R.
  TITLE     Transcription factor ATF cDNA clones: an extensive family of
            leucine zipper proteins able to selectively form DNA-binding
            heterodimers
  JOURNAL   Genes Dev 3 (12B), 2083-2090 (1989)
   PUBMED   2516827
  REMARK    Erratum:[Genes Dev 1990 Apr;4(4):682]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL560585.3, BC006322.2,
            AI949953.1 and CD742713.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001674.3.
            
            Summary: This gene encodes a member of the mammalian activation
            transcription factor/cAMP responsive element-binding (CREB) protein
            family of transcription factors. This gene is induced by a variety
            of signals, including many of those encountered by cancer cells,
            and is involved in the complex process of cellular stress response.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. It is possible that alternative splicing of
            this gene may be physiologically important in the regulation of
            target genes. [provided by RefSeq, Apr 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1), which represses rather than activates transcription from
            promoters with ATF-binding elements. Both variants 1 and 3 encode
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006322.2, L19871.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341491.9/ ENSP00000344352.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL560585.3         134-142
            10-1435             BC006322.2         1-1426
            1436-1572           AI949953.1         376-512             c
            1573-1940           CD742713.1         16-383              c
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..1940
                     /gene="ATF3"
                     /note="activating transcription factor 3"
                     /db_xref="GeneID:467"
                     /db_xref="HGNC:HGNC:785"
                     /db_xref="MIM:603148"
     exon            1..170
                     /gene="ATF3"
                     /inference="alignment:Splign:2.1.0"
     exon            171..414
                     /gene="ATF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..720
                     /gene="ATF3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclic AMP-dependent transcription factor ATF-3;
                     cAMP-dependent transcription factor ATF-3"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-3
                     isoform 1"
                     /protein_id="NP_001665.1"
                     /db_xref="CCDS:CCDS1506.1"
                     /db_xref="GeneID:467"
                     /db_xref="HGNC:HGNC:785"
                     /db_xref="MIM:603148"
                     /translation="MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEE
                     LRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAK
                     CRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNG
                     RTPEDERNLFIQQIKEGTLQS"
     exon            415..522
                     /gene="ATF3"
                     /inference="alignment:Splign:2.1.0"
     exon            523..1940
                     /gene="ATF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1912..1917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF3"
                     /note="hexamer: AATAAA"
     polyA_site      1940
                     /gene="ATF3"
                     /note="major polyA site"
ORIGIN      
        1 acagtcgcac gcagccaggc gcgcactgca cagctctctt ctctcgccgc cgcccgagcg
       61 cacccttcag cccgcgcgcc ggccgtgagt cctcggtgct cgcccgccgg ccagacaaac
      121 agcccgcccg accccgtccc gaccctggcc gccccgagcg gagcctggag caaaatgatg
      181 cttcaacacc caggccaggt ctctgcctcg gaagtgagtg cttctgccat cgtcccctgc
      241 ctgtcccctc ctgggtcact ggtgtttgag gattttgcta acctgacgcc ctttgtcaag
      301 gaagagctga ggtttgccat ccagaacaag cacctctgcc accggatgtc ctctgcgctg
      361 gaatcagtca ctgtcagcga cagacccctc ggggtgtcca tcacaaaagc cgaggtagcc
      421 cctgaagaag atgaaaggaa aaagaggcga cgagaaagaa ataagattgc agctgcaaag
      481 tgccgaaaca agaagaagga gaagacggag tgcctgcaga aagagtcgga gaagctggaa
      541 agtgtgaatg ctgaactgaa ggctcagatt gaggagctca agaacgagaa gcagcatttg
      601 atatacatgc tcaaccttca tcggcccacg tgtattgtcc gggctcagaa tgggaggact
      661 ccagaagatg agagaaacct ctttatccaa cagataaaag aaggaacatt gcagagctaa
      721 gcagtcgtgg tatgggggcg actggggagt cctcattgaa tcctcatttt atacccaaaa
      781 ccctgaagcc attggagagc tgtcttcctg tgtacctcta gaatcccagc agcagagaac
      841 catcaaggcg ggagggcctg cagtgattca gcaggccctt cccattctgc cccagagtgg
      901 gtcttggacc agggcaagtg catctttgcc tcaactccag gatttaggcc ttaacacact
      961 ggccattctt atgttccaga tggcccccag ctggtgtcct gcccgccttt catctggatt
     1021 ctacaaaaaa ccaggatgcc caccgttagg attcaggcag cagtgtctgt acctcgggtg
     1081 ggagggatgg ggccatctcc ttcaccgtgg ctaccattgt cactcgtagg ggatgtggag
     1141 tgagaacagc atttagtgaa gttgtgcaac ggccagggtt gtgctttcta gcaaatatgc
     1201 tgttatgtcc agaaattgtg tgtgcaagaa aactaggcaa tgtactcttc cgatgtttgt
     1261 gtcacacaac actgatgtga cttttatatg ctttttctca gatctggttt ctaagagttt
     1321 tggggggcgg ggctgtcacc acgtgcagta tctcaagata ttcaggtggc cagaagagct
     1381 tgtcagcaag aggaggacag aattctccca gcgttaacac aaaatccatg ggcagtatga
     1441 tggcaggtcc tctgttgcaa actcagttcc aaagtcacag gaagaaagca gaaagttcaa
     1501 cttccaaagg gttaggactc tccactcaat gtcttaggtc aggagttgtg tctaggctgg
     1561 aagagccaaa gaatattcca ttttcctttc cttgtggttg aaaaccacag tcagtggaga
     1621 gatgtttgga aaccacagtc agtggagcct gggtggtacc caggctttag cattattgga
     1681 tgtcaatagc attgtttttg tcatgtagct gttttaagaa atctggccca gggtgtttgc
     1741 agctgtgaga agtcactcac actggccaca aggacgctgg ctactgtcta ttaaaattct
     1801 gatgtttctg tgaaattctc agagtgttta attgtactca atggtatcat tacaattttc
     1861 tgtaagagaa aatattactt atttatccta gtattcctaa cctgtcagaa taataaatat
     1921 tggaaccaag acatggtaaa
//
