LOCUS       NM_005171               2412 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens activating transcription factor 1 (ATF1), transcript
            variant 3, mRNA.
ACCESSION   NM_005171
VERSION     NM_005171.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2412)
  AUTHORS   Guo,W., Yan,S. and Zhao,G.
  TITLE     Upregulated ATF1 Promotes Lipopolysaccharide Induced Inflammatory
            Response and Inhibits Osteogenic Differentiation of Human
            Periodontal Ligament Cells by Regulating NF-kappaB Pathway
  JOURNAL   Discov Med 36 (182), 518-526 (2024)
   PUBMED   38531792
  REMARK    GeneRIF: Upregulated ATF1 Promotes Lipopolysaccharide Induced
            Inflammatory Response and Inhibits Osteogenic Differentiation of
            Human Periodontal Ligament Cells by Regulating NF-kappaB Pathway.
REFERENCE   2  (bases 1 to 2412)
  AUTHORS   Mei,J., Liu,Y., Sheng,Y., Liu,Y., Chen,L., Wang,H., Cheng,M.,
            Zhai,Z. and Xu,L.
  TITLE     ATF1 promotes the malignancy of lung adenocarcinoma cells by
            transcriptionally regulating ZNF143 expression
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (5), 769-782 (2023)
   PUBMED   37158648
  REMARK    GeneRIF: ATF1 promotes the malignancy of lung adenocarcinoma cells
            by transcriptionally regulating ZNF143 expression.
REFERENCE   3  (bases 1 to 2412)
  AUTHORS   Aktar,S., Arii,J., Nguyen,T.T.H., Huang,J.R., Nishimura,M. and
            Mori,Y.
  TITLE     ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon
            Induction
  JOURNAL   J Virol 96 (19), e0126422 (2022)
   PUBMED   36154610
  REMARK    GeneRIF: ATF1 Restricts Human Herpesvirus 6A Replication via Beta
            Interferon Induction.
REFERENCE   4  (bases 1 to 2412)
  AUTHORS   Li,B.X., David,L.L., Davis,L.E. and Xiao,X.
  TITLE     Protein arginine methyltransferase 5 is essential for oncogene
            product EWSR1-ATF1-mediated gene transcription in clear cell
            sarcoma
  JOURNAL   J Biol Chem 298 (10), 102434 (2022)
   PUBMED   36041632
  REMARK    GeneRIF: Protein arginine methyltransferase 5 is essential for
            oncogene product EWSR1-ATF1-mediated gene transcription in clear
            cell sarcoma.
REFERENCE   5  (bases 1 to 2412)
  AUTHORS   Endo,S., Yoshino,Y., Shirota,M., Watanabe,G. and Chiba,N.
  TITLE     BRCA1/ATF1-Mediated Transactivation is Involved in Resistance to
            PARP Inhibitors and Cisplatin
  JOURNAL   Cancer Res Commun 1 (2), 90-105 (2021)
   PUBMED   36860287
  REMARK    GeneRIF: BRCA1/ATF1-Mediated Transactivation is Involved in
            Resistance to PARP Inhibitors and Cisplatin.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2412)
  AUTHORS   Pongubala,J.M. and Atchison,M.L.
  TITLE     Activating transcription factor 1 and cyclic AMP response element
            modulator can modulate the activity of the immunoglobulin kappa 3'
            enhancer
  JOURNAL   J Biol Chem 270 (17), 10304-10313 (1995)
   PUBMED   7730336
REFERENCE   7  (bases 1 to 2412)
  AUTHORS   Liu,F., Thompson,M.A., Wagner,S., Greenberg,M.E. and Green,M.R.
  TITLE     Activating transcription factor-1 can mediate Ca(2+)- and
            cAMP-inducible transcriptional activation
  JOURNAL   J Biol Chem 268 (9), 6714-6720 (1993)
   PUBMED   8384217
REFERENCE   8  (bases 1 to 2412)
  AUTHORS   Rehfuss,R.P., Walton,K.M., Loriaux,M.M. and Goodman,R.H.
  TITLE     The cAMP-regulated enhancer-binding protein ATF-1 activates
            transcription in response to cAMP-dependent protein kinase A
  JOURNAL   J Biol Chem 266 (28), 18431-18434 (1991)
   PUBMED   1655749
REFERENCE   9  (bases 1 to 2412)
  AUTHORS   Yoshimura,T., Fujisawa,J. and Yoshida,M.
  TITLE     Multiple cDNA clones encoding nuclear proteins that bind to the
            tax-dependent enhancer of HTLV-1: all contain a leucine zipper
            structure and basic amino acid domain
  JOURNAL   EMBO J 9 (8), 2537-2542 (1990)
   PUBMED   2196176
REFERENCE   10 (bases 1 to 2412)
  AUTHORS   Hai,T.W., Liu,F., Coukos,W.J. and Green,M.R.
  TITLE     Transcription factor ATF cDNA clones: an extensive family of
            leucine zipper proteins able to selectively form DNA-binding
            heterodimers
  JOURNAL   Genes Dev 3 (12B), 2083-2090 (1989)
   PUBMED   2516827
  REMARK    Erratum:[Genes Dev 1990 Apr;4(4):682]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA468394.1 and AC013244.39.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005171.4.
            
            Summary: This gene encodes an activating transcription factor,
            which belongs to the ATF subfamily and bZIP (basic-region leucine
            zipper) family. It influences cellular physiologic processes by
            regulating the expression of downstream target genes, which are
            related to growth, survival, and other cellular activities. This
            protein is phosphorylated at serine 63 in its kinase-inducible
            domain by serine/threonine kinases, cAMP-dependent protein kinase
            A, calmodulin-dependent protein kinase I/II, mitogen- and
            stress-activated protein kinase and cyclin-dependent kinase 3
            (cdk-3). Its phosphorylation enhances its transactivation and
            transcriptional activities, and enhances cell transformation.
            Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome
            22 induced by translocation generates chimeric proteins in
            angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene
            has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313406.1, SRR3476690.783463.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262053.8/ ENSP00000262053.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               DA468394.1         96-556
            462-541             AC013244.39        61157-61236         c
            542-724             AC013244.39        56554-56736         c
            725-884             AC013244.39        56307-56466         c
            885-2412            AC013244.39        49584-51111         c
FEATURES             Location/Qualifiers
     source          1..2412
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..2412
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="activating transcription factor 1"
                     /db_xref="GeneID:466"
                     /db_xref="HGNC:HGNC:783"
                     /db_xref="MIM:123803"
     exon            1..207
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     exon            208..306
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1029
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="isoform c is encoded by transcript variant 3;
                     cyclic AMP-dependent transcription factor ATF-1;
                     cAMP-dependent transcription factor ATF-1"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-1
                     isoform c"
                     /protein_id="NP_005162.1"
                     /db_xref="CCDS:CCDS8803.1"
                     /db_xref="GeneID:466"
                     /db_xref="HGNC:HGNC:783"
                     /db_xref="MIM:123803"
                     /translation="MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDS
                     SDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIY
                     QTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQI
                     LVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREI
                     RLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV"
     exon            307..407
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     exon            408..541
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     exon            542..724
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     exon            725..884
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     exon            885..2412
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1015..1020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="hexamer: AATAAA"
     polyA_site      1036
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="major polyA site"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="hexamer: ATTAAA"
     regulatory      2385..2390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="hexamer: AATATA"
     polyA_site      2386
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="major polyA site"
     polyA_site      2412
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
ORIGIN      
        1 agtagcggcc ctgactgccg aggaaacggt agcttaggac agttggctgt taagtgacac
       61 tgattctccc cgccccgcct gacccccgag aaggaggctt gtcccccgct gcgtgagggg
      121 gtggggaagt gggtagtgaa ttcggatcta cctgggaggg gggagtggaa gttcccgccc
      181 cggagagcgg cgaggcggca gccacagttg attatggaag attcccacaa gagtaccacg
      241 tcagagacag cacctcaacc tggttcagca gttcagggag ctcacatttc tcatattgct
      301 caacaggtat catctttatc agaaagtgag gagtcccagg actcatccga cagcataggc
      361 tcctcacaga aagcccacgg gatcctagca cggcgcccat cttacagaaa aattttgaaa
      421 gacttatctt ctgaagatac acggggcaga aaaggagacg gagaaaattc tggagtttct
      481 gctgctgtca cttctatgtc tgttccaact cccatctatc agactagcag cggacagtac
      541 attgccattg ccccaaatgg agccttacag ttggcaagtc caggcacaga tggagtacag
      601 ggacttcaga cattaaccat gacaaattca ggcagtactc agcaaggtac aactattctt
      661 cagtatgcac agacctctga tggacagcag atacttgtgc ccagcaatca ggtggtcgta
      721 caaactgcat caggagatat gcaaacatat cagatccgaa ctacaccttc agctacttct
      781 ctgccacaaa ctgtggtgat gacatctcct gtgactctca cctctcagac aactaagaca
      841 gatgaccccc aattgaaaag agaaataagg ttaatgaaaa acagagaagc tgctcgagaa
      901 tgtcgcagaa agaagaaaga atatgtgaaa tgcctggaaa accgagttgc agtcctggaa
      961 aatcaaaata aaactctaat agaagagtta aaaactttga aggatcttta ttccaataaa
     1021 agtgtttgat tcctaagaaa gaaaatattt ttgtggacat gcataaaaat taaatggatt
     1081 tcctagtgga gttttataaa ttaaaaggtc aaaactgaag ctttttattt aggcttttcc
     1141 aaatcaagga taaatatctt acgcacgata tctagtgaca gaggagaaag tggaaaatga
     1201 cctcaaggaa gctacgggca caactggaag ctttgtagaa attaaacata ttcaaggagc
     1261 aagaaatgaa ctttcagcag tctaaatttt ctaaataacc aatagttgcc aatctaaaat
     1321 ggcagagaag atgaaatttg ataaactgaa ttttttttaa aaatccattt accctacagg
     1381 tttgcatttg tttgctgaaa tttacctttt tttagttata tatatgtgtg tgtgtgtgtg
     1441 taatttctgc caataaattc taaattacaa aggtaagaga aaacctagta cattactaaa
     1501 tatataaagt atatgttctg attatgtata cttgttctag tgtcaagtct ttttaagtgg
     1561 gtttttaaaa gtttgttatt ggacttgaat ggatttttga gactaggtta attatttttg
     1621 aggtcttatc ctaaaaggca tctaaggtac atgaatggag tatggtgatt ttataacatt
     1681 ttttatcaga atggaaaaag aactgtttaa aagtttgata cttttaaata gttggttttt
     1741 ttgcttactc tggtaatgat tttctacaaa tacataataa attgtttttt tgagtctata
     1801 ttctgtatgc agttgaatat ccattactta ttctgctgtg ctttaataga atggaatgtt
     1861 tacaggccct taaaatatta tttttaaaaa accttctgaa gatacatacc aaagtttttc
     1921 caagaagatt ttataatcaa tttaataatg taaggtttat cagattctat aatagtatag
     1981 ttattaaggc aattttatgt tagagactat tttgtaatgt agtgagtggt acctttataa
     2041 gaaaagtgac tgccaatata tttttatagc tgatctttat aaattctaat gttgagtttt
     2101 taatgattat tttaaatgtt tatatagttt agtaaaattt gcatctcaaa gtatcatttt
     2161 tatattatgg gacgttttca gattggctaa tatttgcatt gtaaattttg tatgcagttt
     2221 atctaaaatt caaaaatact gtcagtacac cagcgtttaa catctatatt ccaatttgta
     2281 tacagtttaa aattgtactg caaaactatt gtgtgctctt acacagtatg catcatattg
     2341 ttgtctgtga aattaaagga catttgatag tctactgaat gtaaaatata atgcttggta
     2401 tatgaatgat aa
//
