LOCUS       NM_001412975            2266 bp    mRNA    linear   PRI 11-APR-2024
DEFINITION  Homo sapiens activating transcription factor 1 (ATF1), transcript
            variant 17, mRNA.
ACCESSION   NM_001412975
VERSION     NM_001412975.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2266)
  AUTHORS   Guo,W., Yan,S. and Zhao,G.
  TITLE     Upregulated ATF1 Promotes Lipopolysaccharide Induced Inflammatory
            Response and Inhibits Osteogenic Differentiation of Human
            Periodontal Ligament Cells by Regulating NF-kappaB Pathway
  JOURNAL   Discov Med 36 (182), 518-526 (2024)
   PUBMED   38531792
  REMARK    GeneRIF: Upregulated ATF1 Promotes Lipopolysaccharide Induced
            Inflammatory Response and Inhibits Osteogenic Differentiation of
            Human Periodontal Ligament Cells by Regulating NF-kappaB Pathway.
REFERENCE   2  (bases 1 to 2266)
  AUTHORS   Mei,J., Liu,Y., Sheng,Y., Liu,Y., Chen,L., Wang,H., Cheng,M.,
            Zhai,Z. and Xu,L.
  TITLE     ATF1 promotes the malignancy of lung adenocarcinoma cells by
            transcriptionally regulating ZNF143 expression
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (5), 769-782 (2023)
   PUBMED   37158648
  REMARK    GeneRIF: ATF1 promotes the malignancy of lung adenocarcinoma cells
            by transcriptionally regulating ZNF143 expression.
REFERENCE   3  (bases 1 to 2266)
  AUTHORS   Aktar,S., Arii,J., Nguyen,T.T.H., Huang,J.R., Nishimura,M. and
            Mori,Y.
  TITLE     ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon
            Induction
  JOURNAL   J Virol 96 (19), e0126422 (2022)
   PUBMED   36154610
  REMARK    GeneRIF: ATF1 Restricts Human Herpesvirus 6A Replication via Beta
            Interferon Induction.
REFERENCE   4  (bases 1 to 2266)
  AUTHORS   Li,B.X., David,L.L., Davis,L.E. and Xiao,X.
  TITLE     Protein arginine methyltransferase 5 is essential for oncogene
            product EWSR1-ATF1-mediated gene transcription in clear cell
            sarcoma
  JOURNAL   J Biol Chem 298 (10), 102434 (2022)
   PUBMED   36041632
  REMARK    GeneRIF: Protein arginine methyltransferase 5 is essential for
            oncogene product EWSR1-ATF1-mediated gene transcription in clear
            cell sarcoma.
REFERENCE   5  (bases 1 to 2266)
  AUTHORS   Endo,S., Yoshino,Y., Shirota,M., Watanabe,G. and Chiba,N.
  TITLE     BRCA1/ATF1-Mediated Transactivation is Involved in Resistance to
            PARP Inhibitors and Cisplatin
  JOURNAL   Cancer Res Commun 1 (2), 90-105 (2021)
   PUBMED   36860287
  REMARK    GeneRIF: BRCA1/ATF1-Mediated Transactivation is Involved in
            Resistance to PARP Inhibitors and Cisplatin.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2266)
  AUTHORS   Pongubala,J.M. and Atchison,M.L.
  TITLE     Activating transcription factor 1 and cyclic AMP response element
            modulator can modulate the activity of the immunoglobulin kappa 3'
            enhancer
  JOURNAL   J Biol Chem 270 (17), 10304-10313 (1995)
   PUBMED   7730336
REFERENCE   7  (bases 1 to 2266)
  AUTHORS   Liu,F., Thompson,M.A., Wagner,S., Greenberg,M.E. and Green,M.R.
  TITLE     Activating transcription factor-1 can mediate Ca(2+)- and
            cAMP-inducible transcriptional activation
  JOURNAL   J Biol Chem 268 (9), 6714-6720 (1993)
   PUBMED   8384217
REFERENCE   8  (bases 1 to 2266)
  AUTHORS   Rehfuss,R.P., Walton,K.M., Loriaux,M.M. and Goodman,R.H.
  TITLE     The cAMP-regulated enhancer-binding protein ATF-1 activates
            transcription in response to cAMP-dependent protein kinase A
  JOURNAL   J Biol Chem 266 (28), 18431-18434 (1991)
   PUBMED   1655749
REFERENCE   9  (bases 1 to 2266)
  AUTHORS   Yoshimura,T., Fujisawa,J. and Yoshida,M.
  TITLE     Multiple cDNA clones encoding nuclear proteins that bind to the
            tax-dependent enhancer of HTLV-1: all contain a leucine zipper
            structure and basic amino acid domain
  JOURNAL   EMBO J 9 (8), 2537-2542 (1990)
   PUBMED   2196176
REFERENCE   10 (bases 1 to 2266)
  AUTHORS   Hai,T.W., Liu,F., Coukos,W.J. and Green,M.R.
  TITLE     Transcription factor ATF cDNA clones: an extensive family of
            leucine zipper proteins able to selectively form DNA-binding
            heterodimers
  JOURNAL   Genes Dev 3 (12B), 2083-2090 (1989)
   PUBMED   2516827
  REMARK    Erratum:[Genes Dev 1990 Apr;4(4):682]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013244.39.
            
            Summary: This gene encodes an activating transcription factor,
            which belongs to the ATF subfamily and bZIP (basic-region leucine
            zipper) family. It influences cellular physiologic processes by
            regulating the expression of downstream target genes, which are
            related to growth, survival, and other cellular activities. This
            protein is phosphorylated at serine 63 in its kinase-inducible
            domain by serine/threonine kinases, cAMP-dependent protein kinase
            A, calmodulin-dependent protein kinase I/II, mitogen- and
            stress-activated protein kinase and cyclin-dependent kinase 3
            (cdk-3). Its phosphorylation enhances its transactivation and
            transcriptional activities, and enhances cell transformation.
            Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome
            22 induced by translocation generates chimeric proteins in
            angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene
            has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1803617.165417.1, DRR138524.443567.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968540, SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC013244.39        106227-106276       c
            51-149              AC013244.39        90508-90606         c
            150-261             AC013244.39        74737-74848         c
            262-395             AC013244.39        61157-61290         c
            396-578             AC013244.39        56554-56736         c
            579-738             AC013244.39        56307-56466         c
            739-2266            AC013244.39        49584-51111         c
FEATURES             Location/Qualifiers
     source          1..2266
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..2266
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="activating transcription factor 1"
                     /db_xref="GeneID:466"
                     /db_xref="HGNC:HGNC:783"
                     /db_xref="MIM:123803"
     exon            1..50
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     exon            51..149
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     exon            150..261
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     exon            262..395
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..883
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="isoform e is encoded by transcript variant 17;
                     cyclic AMP-dependent transcription factor ATF-1;
                     cAMP-dependent transcription factor ATF-1"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-1
                     isoform e"
                     /protein_id="NP_001399904.1"
                     /db_xref="GeneID:466"
                     /db_xref="HGNC:HGNC:783"
                     /db_xref="MIM:123803"
                     /translation="MSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTN
                     SGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVM
                     TSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKT
                     LIEELKTLKDLYSNKSV"
     exon            396..578
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     exon            579..738
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     exon            739..2266
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      869..874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="hexamer: AATAAA"
     polyA_site      890
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="major polyA site"
     regulatory      2206..2211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="hexamer: ATTAAA"
     regulatory      2239..2244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="hexamer: AATATA"
     polyA_site      2240
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
                     /note="major polyA site"
     polyA_site      2266
                     /gene="ATF1"
                     /gene_synonym="EWS-ATF1; FUS/ATF-1; TREB36"
ORIGIN      
        1 gcttccggcc tccgcgcctc ggtgcagagc tgcgctgcgc ccttccagtc ttgattatgg
       61 aagattccca caagagtacc acgtcagaga cagcacctca acctggttca gcagttcagg
      121 gagctcacat ttctcatatt gctcaacagt tcttttttag gtatcatctt tatcagaaag
      181 tgaggagtcc caggactcat ccgacagcat aggctcctca cagaaagccc acgggatcct
      241 agcacggcgc ccatcttaca gaaaaatttt gaaagactta tcttctgaag atacacgggg
      301 cagaaaagga gacggagaaa attctggagt ttctgctgct gtcacttcta tgtctgttcc
      361 aactcccatc tatcagacta gcagcggaca gtacattgcc attgccccaa atggagcctt
      421 acagttggca agtccaggca cagatggagt acagggactt cagacattaa ccatgacaaa
      481 ttcaggcagt actcagcaag gtacaactat tcttcagtat gcacagacct ctgatggaca
      541 gcagatactt gtgcccagca atcaggtggt cgtacaaact gcatcaggag atatgcaaac
      601 atatcagatc cgaactacac cttcagctac ttctctgcca caaactgtgg tgatgacatc
      661 tcctgtgact ctcacctctc agacaactaa gacagatgac ccccaattga aaagagaaat
      721 aaggttaatg aaaaacagag aagctgctcg agaatgtcgc agaaagaaga aagaatatgt
      781 gaaatgcctg gaaaaccgag ttgcagtcct ggaaaatcaa aataaaactc taatagaaga
      841 gttaaaaact ttgaaggatc tttattccaa taaaagtgtt tgattcctaa gaaagaaaat
      901 atttttgtgg acatgcataa aaattaaatg gatttcctag tggagtttta taaattaaaa
      961 ggtcaaaact gaagcttttt atttaggctt ttccaaatca aggataaata tcttacgcac
     1021 gatatctagt gacagaggag aaagtggaaa atgacctcaa ggaagctacg ggcacaactg
     1081 gaagctttgt agaaattaaa catattcaag gagcaagaaa tgaactttca gcagtctaaa
     1141 ttttctaaat aaccaatagt tgccaatcta aaatggcaga gaagatgaaa tttgataaac
     1201 tgaatttttt ttaaaaatcc atttacccta caggtttgca tttgtttgct gaaatttacc
     1261 tttttttagt tatatatatg tgtgtgtgtg tgtgtaattt ctgccaataa attctaaatt
     1321 acaaaggtaa gagaaaacct agtacattac taaatatata aagtatatgt tctgattatg
     1381 tatacttgtt ctagtgtcaa gtctttttaa gtgggttttt aaaagtttgt tattggactt
     1441 gaatggattt ttgagactag gttaattatt tttgaggtct tatcctaaaa ggcatctaag
     1501 gtacatgaat ggagtatggt gattttataa cattttttat cagaatggaa aaagaactgt
     1561 ttaaaagttt gatactttta aatagttggt ttttttgctt actctggtaa tgattttcta
     1621 caaatacata ataaattgtt tttttgagtc tatattctgt atgcagttga atatccatta
     1681 cttattctgc tgtgctttaa tagaatggaa tgtttacagg cccttaaaat attattttta
     1741 aaaaaccttc tgaagataca taccaaagtt tttccaagaa gattttataa tcaatttaat
     1801 aatgtaaggt ttatcagatt ctataatagt atagttatta aggcaatttt atgttagaga
     1861 ctattttgta atgtagtgag tggtaccttt ataagaaaag tgactgccaa tatattttta
     1921 tagctgatct ttataaattc taatgttgag tttttaatga ttattttaaa tgtttatata
     1981 gtttagtaaa atttgcatct caaagtatca tttttatatt atgggacgtt ttcagattgg
     2041 ctaatatttg cattgtaaat tttgtatgca gtttatctaa aattcaaaaa tactgtcagt
     2101 acaccagcgt ttaacatcta tattccaatt tgtatacagt ttaaaattgt actgcaaaac
     2161 tattgtgtgc tcttacacag tatgcatcat attgttgtct gtgaaattaa aggacatttg
     2221 atagtctact gaatgtaaaa tataatgctt ggtatatgaa tgataa
//
