LOCUS       NM_007041               4895 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens arginyltransferase 1 (ATE1), transcript variant 2,
            mRNA.
ACCESSION   NM_007041
VERSION     NM_007041.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4895)
  AUTHORS   Shokeen,K., Baroi,M.K., Chahar,M., Das,D., Saini,H. and Kumar,S.
  TITLE     Arginyltransferase 1 (ATE1)-mediated proteasomal degradation of
            viral haemagglutinin protein: a unique host defence mechanism
  JOURNAL   J Gen Virol 105 (8) (2024)
   PUBMED   39207120
  REMARK    GeneRIF: Arginyltransferase 1 (ATE1)-mediated proteasomal
            degradation of viral haemagglutinin protein: a unique host defence
            mechanism.
REFERENCE   2  (bases 1 to 4895)
  AUTHORS   Drazic,A., Timmerman,E., Kajan,U., Marie,M., Varland,S., Impens,F.,
            Gevaert,K. and Arnesen,T.
  TITLE     The Final Maturation State of beta-actin Involves N-terminal
            Acetylation by NAA80, not N-terminal Arginylation by ATE1
  JOURNAL   J Mol Biol 434 (2), 167397 (2022)
   PUBMED   34896361
  REMARK    GeneRIF: The Final Maturation State of beta-actin Involves
            N-terminal Acetylation by NAA80, not N-terminal Arginylation by
            ATE1.
REFERENCE   3  (bases 1 to 4895)
  AUTHORS   Heo,A.J., Kim,S.B., Ji,C.H., Han,D., Lee,S.J., Lee,S.H., Lee,M.J.,
            Lee,J.S., Ciechanover,A., Kim,B.Y. and Kwon,Y.T.
  TITLE     The N-terminal cysteine is a dual sensor of oxygen and oxidative
            stress
  JOURNAL   Proc Natl Acad Sci U S A 118 (50) (2021)
   PUBMED   34893540
REFERENCE   4  (bases 1 to 4895)
  AUTHORS   Kishimoto,N., Okano,R., Akita,A., Miura,S., Irie,A., Takamune,N.
            and Misumi,S.
  TITLE     Arginyl-tRNA-protein transferase 1 contributes to governing optimal
            stability of the human immunodeficiency virus type 1 core
  JOURNAL   Retrovirology 18 (1), 30 (2021)
   PUBMED   34565409
  REMARK    GeneRIF: Arginyl-tRNA-protein transferase 1 contributes to
            governing optimal stability of the human immunodeficiency virus
            type 1 core.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4895)
  AUTHORS   Xu,C., Li,Y.M., Sun,B., Zhong,F.J. and Yang,L.Y.
  TITLE     ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated
            Suppression of Wnt/beta-Catenin Signaling
  JOURNAL   Mol Cancer Res 19 (9), 1441-1453 (2021)
   PUBMED   34158395
  REMARK    GeneRIF: ATE1 Inhibits Liver Cancer Progression through
            RGS5-Mediated Suppression of Wnt/beta-Catenin Signaling.
REFERENCE   6  (bases 1 to 4895)
  AUTHORS   Fletcher,O., Johnson,N., Orr,N., Hosking,F.J., Gibson,L.J.,
            Walker,K., Zelenika,D., Gut,I., Heath,S., Palles,C., Coupland,B.,
            Broderick,P., Schoemaker,M., Jones,M., Williamson,J.,
            Chilcott-Burns,S., Tomczyk,K., Simpson,G., Jacobs,K.B.,
            Chanock,S.J., Hunter,D.J., Tomlinson,I.P., Swerdlow,A.,
            Ashworth,A., Ross,G., dos Santos Silva,I., Lathrop,M.,
            Houlston,R.S. and Peto,J.
  TITLE     Novel breast cancer susceptibility locus at 9q31.2: results of a
            genome-wide association study
  JOURNAL   J Natl Cancer Inst 103 (5), 425-435 (2011)
   PUBMED   21263130
REFERENCE   7  (bases 1 to 4895)
  AUTHORS   Hu,R.G., Brower,C.S., Wang,H., Davydov,I.V., Sheng,J., Zhou,J.,
            Kwon,Y.T. and Varshavsky,A.
  TITLE     Arginyltransferase, its specificity, putative substrates,
            bidirectional promoter, and splicing-derived isoforms
  JOURNAL   J Biol Chem 281 (43), 32559-32573 (2006)
   PUBMED   16943202
REFERENCE   8  (bases 1 to 4895)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4895)
  AUTHORS   Rai,R. and Kashina,A.
  TITLE     Identification of mammalian arginyltransferases that modify a
            specific subset of protein substrates
  JOURNAL   Proc Natl Acad Sci U S A 102 (29), 10123-10128 (2005)
   PUBMED   16002466
REFERENCE   10 (bases 1 to 4895)
  AUTHORS   Kwon,Y.T., Kashina,A.S. and Varshavsky,A.
  TITLE     Alternative splicing results in differential expression, activity,
            and localization of the two forms of arginyl-tRNA-protein
            transferase, a component of the N-end rule pathway
  JOURNAL   Mol Cell Biol 19 (1), 182-193 (1999)
   PUBMED   9858543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731566.7, AL731542.6 and
            AC025947.9.
            
            On Jun 2, 2019 this sequence version replaced NM_007041.3.
            
            Summary: This gene encodes an arginyltransferase, an enzyme that is
            involved in posttranslational conjugation of arginine to N-terminal
            aspartate or glutamate residues. Conjugation of arginine to the
            N-terminal aspartate or glutamate targets proteins for
            ubiquitin-dependent degradation. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            exon in the central coding region, compared to variant 1. The
            encoded isoform (2) is the same length as isoform 1 but has a
            unique internal segment.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022026.1, SRR11853560.4315.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AL731566.7         36801-36988         c
            189-252             AL731566.7         33223-33286         c
            253-315             AL731566.7         31306-31368         c
            316-419             AL731566.7         22747-22850         c
            420-665             AL731566.7         19863-20108         c
            666-895             AL731566.7         11348-11577         c
            896-1024            AL731566.7         7798-7926           c
            1025-1057           AL731542.6         53945-53977         c
            1058-1239           AL731542.6         25021-25202         c
            1240-1339           AL731542.6         20657-20756         c
            1340-1460           AC025947.9         131190-131310       c
            1461-4895           AC025947.9         81445-84879         c
FEATURES             Location/Qualifiers
     source          1..4895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..4895
                     /gene="ATE1"
                     /note="arginyltransferase 1"
                     /db_xref="GeneID:11101"
                     /db_xref="HGNC:HGNC:782"
                     /db_xref="MIM:607103"
     exon            1..188
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1639
                     /gene="ATE1"
                     /EC_number="2.3.2.8"
                     /note="isoform 2 is encoded by transcript variant 2;
                     arginyl-tRNA-protein transferase; R-transferase 1;
                     arginine-tRNA--protein transferase 1"
                     /codon_start=1
                     /product="arginyl-tRNA--protein transferase 1 isoform 2"
                     /protein_id="NP_008972.2"
                     /db_xref="CCDS:CCDS31299.1"
                     /db_xref="GeneID:11101"
                     /db_xref="HGNC:HGNC:782"
                     /db_xref="MIM:607103"
                     /translation="MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTV
                     QDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLA
                     KGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKK
                     EEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRL
                     KLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVP
                     VSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPD
                     CGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTR
                     QLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKY
                     CRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQK
                     CSERMLLFRN"
     exon            189..252
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..315
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            316..419
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..665
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..895
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1024
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1057
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1239
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1339
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1460
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..4895
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4874..4879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATE1"
                     /note="hexamer: AATAAA"
     polyA_site      4895
                     /gene="ATE1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgctgc attgtggggt ggcggcggcg gccgcgctag cgacgcgggg ccgggcggct
       61 gagcgttcgc ggggccgagg ccatggcttt ctgggcgggg ggttcgccca gcgtcgtgga
      121 ctatttccct agcgaggact tctaccgctg cggctactgc aagaacgagt cgggcagccg
      181 ctccaatggc atgtgggcac attccatgac agtacaggat tatcaggatc tcatagaccg
      241 aggatggcga agaagtggaa aatatgtgta caaacctgtc atgaatcaaa catgttgtcc
      301 tcagtacaca ataaggtgcc gacctttaca atttcagcct tcaaaatctc acaagaaggt
      361 tttgaaaaaa atgttgaaat ttctagctaa aggggaggtt cccaaaggaa gttgtgagga
      421 tgagcccatg gattccacaa tggatgatgc tgttgcgggt gactttgcat tgataaataa
      481 actggatata cagtgtgatc ttaaaacact cagtgatgac atcaaagaga gtttagagag
      541 tgaaggaaaa aattcaaaga aagaagaacc tcaggaatta cttcagtcac aagatttcgt
      601 aggagagaag ttgggctctg gtgaaccgtc acattcagtt aaagttcaca cagttcctaa
      661 gccaggcaaa ggggctgatt tgagtaagcc tccatgtcga aaagcaaagg aaatccggaa
      721 agaaaggaaa aggttaaaac taatgcagca gaacccagct ggagaacttg agggtttcca
      781 ggctcaaggt cacccaccat ctttgtttcc accaaaggct aaatccaacc agccaaaatc
      841 actcgaagat ttaatttttg agtctttacc agagaatgca tcacacaagt tagaggtgag
      901 gttagtacct gtctcctttg aggacccaga gttcaagtcg tctttcagcc agtccttttc
      961 tttgtatgtc aagtatcaag tggccataca ccaggatcca cccgatgaat gtgggaagac
     1021 tgagttcaca agattccttt gcagttcacc cttggaggca gagactcccc ctaatgggcc
     1081 agattgtggc tatggctcct ttcaccagca gtactggctt gacggaaaga tcattgctgt
     1141 gggggtgatt gacatcctcc caaactgtgt atcatctgtg tatttgtact acgatcctga
     1201 ttattcgttt ttgtctttgg gcgtctactc tgcactacga gaaattgctt ttactaggca
     1261 gcttcatgag aaaacttctc aactcagcta ttattatatg ggtttctaca ttcattcatg
     1321 tcccaagatg aaatataagg gtcagtatag accttctgat ttgctgtgcc ctgagacata
     1381 tgtttgggta cccattgagc aatgcctgcc ttcacttgaa aactccaagt actgccgttt
     1441 caaccaggac ccagaagcag tggatgagga tcgcagtacg gaacctgacc gattgcaggt
     1501 gtttcacaag agagccatca tgccttacgg tgtttataag aaacagcaga aagacccaag
     1561 tgaggaggct gctgttctgc agtacgccag cctggtgggg cagaagtgct ccgagcggat
     1621 gctgctgttc agaaactgac ctgttcacct ctgccgggaa gttcctgtgt tgtgctgatg
     1681 atttgtgcca ggatacatat tcagtacctg tggggaaata actgtcacca cccacaaatt
     1741 agacattttt tattttgact atctatggct tttaaaaaat attttgtggc aatgtatctg
     1801 tgagaatctc atagttaata taaagatttt aaaactgcat tatgacctag cccccataat
     1861 tgggatttat cattttggag gattctttct agagcaagat acgctcaaat tctcctgttt
     1921 gtattttgta aaatgaagaa gtgaatctaa gtaacttaat cacagttgtg catttttttt
     1981 ggttctgtta gagaaattaa aacagactgt ttcctcaggc ccattttaaa ctgaacttat
     2041 gctaggaaac cttaagtatg gggaaggtag aaagttcatt tcatcactta gaaaatatgt
     2101 cttctcaaga acaaaactgt gctgttacaa ctcagtgttc aatgtgaaat tgctgccaaa
     2161 tgttatgtag tttaatagag aacttgaaaa aataaaacat taaaatggag cttgtgttag
     2221 catcaggtat ccatttgttc aggacagtcc tgttcatgtc tgttgtcttg gcatagtttt
     2281 ttcccctaga atatagtact cccttttact ctaaaaaata tcccagtttg gacaataaaa
     2341 tacataatta ctctagttat attatttgct ttacttctaa aaatgtaaga aattgaattt
     2401 ttttaaagaa aaatgttggt tcctgccttg atctaagtct catccaaagg aaataaatag
     2461 tcactagttt tttatcttac aactcaggac atttgtcttt ggttattaat ggaaattagt
     2521 atgtgattac tttcatagtt atgccacaaa tcacattgaa gaaggaatca ttccgacctc
     2581 tgttccagga caagagctag aacaatccat ttcttgtcct ttgatttgag agtcacagtc
     2641 agggtggctt ctgccaccct tagtaactca gagcagaggc cagccccctc cttccctcac
     2701 tttcttttgc tgagtccttt gcccacctgt caaggtggca ggcactgtgc tgggtacagg
     2761 aggacagtca gacatgtccc ttcttagcta tagtcgagct gtctgggaaa caggatgaaa
     2821 aacaggaggg ttattttctt gtgccctctt tgtcagctga tcccctcttc tgctaccagc
     2881 tatttggcca gcaagccgtt tttagtcccc actttgccca tttttctgtt ttggttcatc
     2941 gtttcttaaa agccatgtta taaaacatgg tagtttgaat cctgttgcta attttaaact
     3001 ttcctctaaa atgtactgaa ttttgacaaa aatttgaaaa tatcctcagc taactagaat
     3061 aaaaaggatc ataaaacaat gattttaaaa ctgaaatctc tagaaactca acatccaagt
     3121 cagccgcatt tcttcattca gagtgtgtgt gtcacacctg ccaaggtgct gcgtactctg
     3181 ctaaccgagc tagagtagtg agcaaagcca ttttctctga tcacaagatt ttacattttt
     3241 ctgggatttt gacctgcaaa gtagtctcgt aagagcattt gagagactta cttggaactg
     3301 ccttcagaat ctatagagcc ttttttctct ttttcctcta aaatgaaaag agcttcattt
     3361 tatgattata acaaaagtga cactgtaagc agttagaaca ttaagaagta taaataaaaa
     3421 gtaaaaatca tctacaaccc taccatactc agaaggagaa aagaactgtc atgtatgtat
     3481 acacacatac ctatgtaatt ttaatataaa tagaattatg ttctacatgc tgttttattt
     3541 cctcaacagt aaattatgga catgtctgaa atgtgaaata aatttcaaaa taaggcttca
     3601 gaaagtgtag taagtaatct ctgcattatt aaaaataagc agggtagggc tggtacttgg
     3661 ctcgcttagc atttgaatgt ccaacttggt gttatcactg tatcttccct ccatttgtct
     3721 ttgtgattag catgtaaaat ggtattcata aagatcacaa cccttgaata tcagatgaag
     3781 agaaaacttg actccaacat cttaccacaa ctctggtttc ttcctgcaga attcattttc
     3841 agaggaaaat gatgaatcat ccctgtctgt gaaccactgt gctttccttg agggtggcat
     3901 tgtaggttga caccagcaaa gactcagagt gacttgagca ttggagatcc ttctacttgg
     3961 ctgctgtatt catgcattat gttggtttga gaatagctag tgtattgatc caagtagtca
     4021 aagtgtctta aaaggacacc tatttgtcct tttgagcccc agctgagtga atactgatag
     4081 tggactagaa aagcatagtc aagaaaagtg acccaccttg ttacttgacc agcagtctag
     4141 ctgagagatc tgattttatg ttcgtaactt tctgtaaaga aagacacaag gacttttcaa
     4201 agacagttta tatctttcca aggcaggaag ctttgcattt gcaatcttag tgttgtgtcc
     4261 ctttctgatt ttcaaataca tcacacctgc cttcctgttt tgggagcaaa gatgtaattt
     4321 caattcccct tgctaccgtc cttatttaaa ttatttccat tctaagagat ttttgttatt
     4381 tttttaaatg taatctgagc acttttttgt attctaaaag atagatgata tcagataaat
     4441 atgttgtaca tttgattaaa attatttaga taaatattac tatgttgact tttaaatagc
     4501 tttatcctat ttttcattca ttttgcaaat atttgttgtg tgtagtttct taacgtgtca
     4561 gaatctatta tgtaaaagaa cctttccaga tttctgaaca gtatatgctt tgattttata
     4621 ggctttatat tatttcagta tgaataaaga taaggaatat gaaacagtta actaaaatgt
     4681 atctgtcgtt gctaacttga aaaatgaagt agaaacagtt ggaaaatgtt tgaattagaa
     4741 gttattcaag tgcacactct tttctaaaag aaagccaatg actataaggc aaaagaagtt
     4801 tgactgcatg tggtattttt tgctcttgta tatgcttttt gaacaagcta tttgataaag
     4861 cctgaatgga aaaaataaag ctgtttctat ctgca
//
