LOCUS       NM_001288734            4791 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens arginyltransferase 1 (ATE1), transcript variant 3,
            mRNA.
ACCESSION   NM_001288734
VERSION     NM_001288734.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4791)
  AUTHORS   Shokeen,K., Baroi,M.K., Chahar,M., Das,D., Saini,H. and Kumar,S.
  TITLE     Arginyltransferase 1 (ATE1)-mediated proteasomal degradation of
            viral haemagglutinin protein: a unique host defence mechanism
  JOURNAL   J Gen Virol 105 (8) (2024)
   PUBMED   39207120
  REMARK    GeneRIF: Arginyltransferase 1 (ATE1)-mediated proteasomal
            degradation of viral haemagglutinin protein: a unique host defence
            mechanism.
REFERENCE   2  (bases 1 to 4791)
  AUTHORS   Drazic,A., Timmerman,E., Kajan,U., Marie,M., Varland,S., Impens,F.,
            Gevaert,K. and Arnesen,T.
  TITLE     The Final Maturation State of beta-actin Involves N-terminal
            Acetylation by NAA80, not N-terminal Arginylation by ATE1
  JOURNAL   J Mol Biol 434 (2), 167397 (2022)
   PUBMED   34896361
  REMARK    GeneRIF: The Final Maturation State of beta-actin Involves
            N-terminal Acetylation by NAA80, not N-terminal Arginylation by
            ATE1.
REFERENCE   3  (bases 1 to 4791)
  AUTHORS   Heo,A.J., Kim,S.B., Ji,C.H., Han,D., Lee,S.J., Lee,S.H., Lee,M.J.,
            Lee,J.S., Ciechanover,A., Kim,B.Y. and Kwon,Y.T.
  TITLE     The N-terminal cysteine is a dual sensor of oxygen and oxidative
            stress
  JOURNAL   Proc Natl Acad Sci U S A 118 (50) (2021)
   PUBMED   34893540
REFERENCE   4  (bases 1 to 4791)
  AUTHORS   Kishimoto,N., Okano,R., Akita,A., Miura,S., Irie,A., Takamune,N.
            and Misumi,S.
  TITLE     Arginyl-tRNA-protein transferase 1 contributes to governing optimal
            stability of the human immunodeficiency virus type 1 core
  JOURNAL   Retrovirology 18 (1), 30 (2021)
   PUBMED   34565409
  REMARK    GeneRIF: Arginyl-tRNA-protein transferase 1 contributes to
            governing optimal stability of the human immunodeficiency virus
            type 1 core.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4791)
  AUTHORS   Xu,C., Li,Y.M., Sun,B., Zhong,F.J. and Yang,L.Y.
  TITLE     ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated
            Suppression of Wnt/beta-Catenin Signaling
  JOURNAL   Mol Cancer Res 19 (9), 1441-1453 (2021)
   PUBMED   34158395
  REMARK    GeneRIF: ATE1 Inhibits Liver Cancer Progression through
            RGS5-Mediated Suppression of Wnt/beta-Catenin Signaling.
REFERENCE   6  (bases 1 to 4791)
  AUTHORS   Fletcher,O., Johnson,N., Orr,N., Hosking,F.J., Gibson,L.J.,
            Walker,K., Zelenika,D., Gut,I., Heath,S., Palles,C., Coupland,B.,
            Broderick,P., Schoemaker,M., Jones,M., Williamson,J.,
            Chilcott-Burns,S., Tomczyk,K., Simpson,G., Jacobs,K.B.,
            Chanock,S.J., Hunter,D.J., Tomlinson,I.P., Swerdlow,A.,
            Ashworth,A., Ross,G., dos Santos Silva,I., Lathrop,M.,
            Houlston,R.S. and Peto,J.
  TITLE     Novel breast cancer susceptibility locus at 9q31.2: results of a
            genome-wide association study
  JOURNAL   J Natl Cancer Inst 103 (5), 425-435 (2011)
   PUBMED   21263130
REFERENCE   7  (bases 1 to 4791)
  AUTHORS   Hu,R.G., Brower,C.S., Wang,H., Davydov,I.V., Sheng,J., Zhou,J.,
            Kwon,Y.T. and Varshavsky,A.
  TITLE     Arginyltransferase, its specificity, putative substrates,
            bidirectional promoter, and splicing-derived isoforms
  JOURNAL   J Biol Chem 281 (43), 32559-32573 (2006)
   PUBMED   16943202
REFERENCE   8  (bases 1 to 4791)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4791)
  AUTHORS   Rai,R. and Kashina,A.
  TITLE     Identification of mammalian arginyltransferases that modify a
            specific subset of protein substrates
  JOURNAL   Proc Natl Acad Sci U S A 102 (29), 10123-10128 (2005)
   PUBMED   16002466
REFERENCE   10 (bases 1 to 4791)
  AUTHORS   Kwon,Y.T., Kashina,A.S. and Varshavsky,A.
  TITLE     Alternative splicing results in differential expression, activity,
            and localization of the two forms of arginyl-tRNA-protein
            transferase, a component of the N-end rule pathway
  JOURNAL   Mol Cell Biol 19 (1), 182-193 (1999)
   PUBMED   9858543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731566.7, AL731542.6 and
            AC025947.9.
            
            On Aug 13, 2020 this sequence version replaced NM_001288734.1.
            
            Summary: This gene encodes an arginyltransferase, an enzyme that is
            involved in posttranslational conjugation of arginine to N-terminal
            aspartate or glutamate residues. Conjugation of arginine to the
            N-terminal aspartate or glutamate targets proteins for
            ubiquitin-dependent degradation. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (3) differs in its 5' UTR and
            initiates translation at a downstream start codon, compared to
            variant 1. The encoded isoform (3) has a shorter N-terminus,
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2946310.1,
                                           SRR18074967.234690.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AL731566.7         36801-36988         c
            189-252             AL731566.7         33223-33286         c
            253-315             AL731566.7         31306-31368         c
            316-561             AL731566.7         19863-20108         c
            562-791             AL731566.7         11348-11577         c
            792-920             AL731566.7         8823-8951           c
            921-953             AL731542.6         53945-53977         c
            954-1135            AL731542.6         25021-25202         c
            1136-1235           AL731542.6         20657-20756         c
            1236-1356           AC025947.9         131190-131310       c
            1357-4791           AC025947.9         81445-84879         c
FEATURES             Location/Qualifiers
     source          1..4791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..4791
                     /gene="ATE1"
                     /note="arginyltransferase 1"
                     /db_xref="GeneID:11101"
                     /db_xref="HGNC:HGNC:782"
                     /db_xref="MIM:607103"
     exon            1..188
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..252
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..315
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            316..561
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1535
                     /gene="ATE1"
                     /EC_number="2.3.2.8"
                     /note="isoform 3 is encoded by transcript variant 3;
                     arginyl-tRNA-protein transferase; R-transferase 1;
                     arginine-tRNA--protein transferase 1"
                     /codon_start=1
                     /product="arginyl-tRNA--protein transferase 1 isoform 3"
                     /protein_id="NP_001275663.1"
                     /db_xref="GeneID:11101"
                     /db_xref="HGNC:HGNC:782"
                     /db_xref="MIM:607103"
                     /translation="MDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSK
                     KEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKR
                     LKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVV
                     RSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGP
                     DCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFT
                     RQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSK
                     YCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQ
                     KCSERMLLFRN"
     exon            562..791
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..920
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..953
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1135
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1235
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1356
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..4791
                     /gene="ATE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4770..4775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATE1"
                     /note="hexamer: AATAAA"
     polyA_site      4791
                     /gene="ATE1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgctgc attgtggggt ggcggcggcg gccgcgctag cgacgcgggg ccgggcggct
       61 gagcgttcgc ggggccgagg ccatggcttt ctgggcgggg ggttcgccca gcgtcgtgga
      121 ctatttccct agcgaggact tctaccgctg cggctactgc aagaacgagt cgggcagccg
      181 ctccaatggc atgtgggcac attccatgac agtacaggat tatcaggatc tcatagaccg
      241 aggatggcga agaagtggaa aatatgtgta caaacctgtc atgaatcaaa catgttgtcc
      301 tcagtacaca ataagatgag cccatggatt ccacaatgga tgatgctgtt gcgggtgact
      361 ttgcattgat aaataaactg gatatacagt gtgatcttaa aacactcagt gatgacatca
      421 aagagagttt agagagtgaa ggaaaaaatt caaagaaaga agaacctcag gaattacttc
      481 agtcacaaga tttcgtagga gagaagttgg gctctggtga accgtcacat tcagttaaag
      541 ttcacacagt tcctaagcca ggcaaagggg ctgatttgag taagcctcca tgtcgaaaag
      601 caaaggaaat ccggaaagaa aggaaaaggt taaaactaat gcagcagaac ccagctggag
      661 aacttgaggg tttccaggct caaggtcacc caccatcttt gtttccacca aaggctaaat
      721 ccaaccagcc aaaatcactc gaagatttaa tttttgagtc tttaccagag aatgcatcac
      781 acaagttaga ggtgagggtg gtgagatcat ctccaccaag ttcgcagttc aaagccacac
      841 ttctggagtc ttaccaggtc tataaacgtt accagatggt tattcacaag aacccacctg
      901 atacgccaac cgaaagccag ttcacaagat tcctttgcag ttcacccttg gaggcagaga
      961 ctccccctaa tgggccagat tgtggctatg gctcctttca ccagcagtac tggcttgacg
     1021 gaaagatcat tgctgtgggg gtgattgaca tcctcccaaa ctgtgtatca tctgtgtatt
     1081 tgtactacga tcctgattat tcgtttttgt ctttgggcgt ctactctgca ctacgagaaa
     1141 ttgcttttac taggcagctt catgagaaaa cttctcaact cagctattat tatatgggtt
     1201 tctacattca ttcatgtccc aagatgaaat ataagggtca gtatagacct tctgatttgc
     1261 tgtgccctga gacatatgtt tgggtaccca ttgagcaatg cctgccttca cttgaaaact
     1321 ccaagtactg ccgtttcaac caggacccag aagcagtgga tgaggatcgc agtacggaac
     1381 ctgaccgatt gcaggtgttt cacaagagag ccatcatgcc ttacggtgtt tataagaaac
     1441 agcagaaaga cccaagtgag gaggctgctg ttctgcagta cgccagcctg gtggggcaga
     1501 agtgctccga gcggatgctg ctgttcagaa actgacctgt tcacctctgc cgggaagttc
     1561 ctgtgttgtg ctgatgattt gtgccaggat acatattcag tacctgtggg gaaataactg
     1621 tcaccaccca caaattagac attttttatt ttgactatct atggctttta aaaaatattt
     1681 tgtggcaatg tatctgtgag aatctcatag ttaatataaa gattttaaaa ctgcattatg
     1741 acctagcccc cataattggg atttatcatt ttggaggatt ctttctagag caagatacgc
     1801 tcaaattctc ctgtttgtat tttgtaaaat gaagaagtga atctaagtaa cttaatcaca
     1861 gttgtgcatt ttttttggtt ctgttagaga aattaaaaca gactgtttcc tcaggcccat
     1921 tttaaactga acttatgcta ggaaacctta agtatgggga aggtagaaag ttcatttcat
     1981 cacttagaaa atatgtcttc tcaagaacaa aactgtgctg ttacaactca gtgttcaatg
     2041 tgaaattgct gccaaatgtt atgtagttta atagagaact tgaaaaaata aaacattaaa
     2101 atggagcttg tgttagcatc aggtatccat ttgttcagga cagtcctgtt catgtctgtt
     2161 gtcttggcat agttttttcc cctagaatat agtactccct tttactctaa aaaatatccc
     2221 agtttggaca ataaaataca taattactct agttatatta tttgctttac ttctaaaaat
     2281 gtaagaaatt gaattttttt aaagaaaaat gttggttcct gccttgatct aagtctcatc
     2341 caaaggaaat aaatagtcac tagtttttta tcttacaact caggacattt gtctttggtt
     2401 attaatggaa attagtatgt gattactttc atagttatgc cacaaatcac attgaagaag
     2461 gaatcattcc gacctctgtt ccaggacaag agctagaaca atccatttct tgtcctttga
     2521 tttgagagtc acagtcaggg tggcttctgc cacccttagt aactcagagc agaggccagc
     2581 cccctccttc cctcactttc ttttgctgag tcctttgccc acctgtcaag gtggcaggca
     2641 ctgtgctggg tacaggagga cagtcagaca tgtcccttct tagctatagt cgagctgtct
     2701 gggaaacagg atgaaaaaca ggagggttat tttcttgtgc cctctttgtc agctgatccc
     2761 ctcttctgct accagctatt tggccagcaa gccgttttta gtccccactt tgcccatttt
     2821 tctgttttgg ttcatcgttt cttaaaagcc atgttataaa acatggtagt ttgaatcctg
     2881 ttgctaattt taaactttcc tctaaaatgt actgaatttt gacaaaaatt tgaaaatatc
     2941 ctcagctaac tagaataaaa aggatcataa aacaatgatt ttaaaactga aatctctaga
     3001 aactcaacat ccaagtcagc cgcatttctt cattcagagt gtgtgtgtca cacctgccaa
     3061 ggtgctgcgt actctgctaa ccgagctaga gtagtgagca aagccatttt ctctgatcac
     3121 aagattttac atttttctgg gattttgacc tgcaaagtag tctcgtaaga gcatttgaga
     3181 gacttacttg gaactgcctt cagaatctat agagcctttt ttctcttttt cctctaaaat
     3241 gaaaagagct tcattttatg attataacaa aagtgacact gtaagcagtt agaacattaa
     3301 gaagtataaa taaaaagtaa aaatcatcta caaccctacc atactcagaa ggagaaaaga
     3361 actgtcatgt atgtatacac acatacctat gtaattttaa tataaataga attatgttct
     3421 acatgctgtt ttatttcctc aacagtaaat tatggacatg tctgaaatgt gaaataaatt
     3481 tcaaaataag gcttcagaaa gtgtagtaag taatctctgc attattaaaa ataagcaggg
     3541 tagggctggt acttggctcg cttagcattt gaatgtccaa cttggtgtta tcactgtatc
     3601 ttccctccat ttgtctttgt gattagcatg taaaatggta ttcataaaga tcacaaccct
     3661 tgaatatcag atgaagagaa aacttgactc caacatctta ccacaactct ggtttcttcc
     3721 tgcagaattc attttcagag gaaaatgatg aatcatccct gtctgtgaac cactgtgctt
     3781 tccttgaggg tggcattgta ggttgacacc agcaaagact cagagtgact tgagcattgg
     3841 agatccttct acttggctgc tgtattcatg cattatgttg gtttgagaat agctagtgta
     3901 ttgatccaag tagtcaaagt gtcttaaaag gacacctatt tgtccttttg agccccagct
     3961 gagtgaatac tgatagtgga ctagaaaagc atagtcaaga aaagtgaccc accttgttac
     4021 ttgaccagca gtctagctga gagatctgat tttatgttcg taactttctg taaagaaaga
     4081 cacaaggact tttcaaagac agtttatatc tttccaaggc aggaagcttt gcatttgcaa
     4141 tcttagtgtt gtgtcccttt ctgattttca aatacatcac acctgccttc ctgttttggg
     4201 agcaaagatg taatttcaat tccccttgct accgtcctta tttaaattat ttccattcta
     4261 agagattttt gttatttttt taaatgtaat ctgagcactt ttttgtattc taaaagatag
     4321 atgatatcag ataaatatgt tgtacatttg attaaaatta tttagataaa tattactatg
     4381 ttgactttta aatagcttta tcctattttt cattcatttt gcaaatattt gttgtgtgta
     4441 gtttcttaac gtgtcagaat ctattatgta aaagaacctt tccagatttc tgaacagtat
     4501 atgctttgat tttataggct ttatattatt tcagtatgaa taaagataag gaatatgaaa
     4561 cagttaacta aaatgtatct gtcgttgcta acttgaaaaa tgaagtagaa acagttggaa
     4621 aatgtttgaa ttagaagtta ttcaagtgca cactcttttc taaaagaaag ccaatgacta
     4681 taaggcaaaa gaagtttgac tgcatgtggt attttttgct cttgtatatg ctttttgaac
     4741 aagctatttg ataaagcctg aatggaaaaa ataaagctgt ttctatctgc a
//
