LOCUS       NM_024909               2092 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens alpha tubulin acetyltransferase 1 (ATAT1), transcript
            variant 2, mRNA.
ACCESSION   NM_024909
VERSION     NM_024909.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2092)
  AUTHORS   Choi,J.H., Jeong,J., Kim,J., You,E., Keum,S., Song,S., Hwang,Y.E.,
            Ji,M., Park,K.S. and Rhee,S.
  TITLE     Genetic disruption of ATAT1 causes RhoA downregulation through
            abnormal truncation of C/EBPbeta
  JOURNAL   BMB Rep 57 (6), 293-298 (2024)
   PUBMED   38835115
  REMARK    GeneRIF: Genetic disruption of ATAT1 causes RhoA downregulation
            through abnormal truncation of C/EBPbeta.
REFERENCE   2  (bases 1 to 2092)
  AUTHORS   Iuzzolino,A., Pellegrini,F.R., Rotili,D., Degrassi,F. and
            Trisciuoglio,D.
  TITLE     The alpha-tubulin acetyltransferase ATAT1: structure, cellular
            functions, and its emerging role in human diseases
  JOURNAL   Cell Mol Life Sci 81 (1), 193 (2024)
   PUBMED   38652325
  REMARK    GeneRIF: The alpha-tubulin acetyltransferase ATAT1: structure,
            cellular functions, and its emerging role in human diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2092)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 2092)
  AUTHORS   Yoshimoto,S., Morita,H., Okamura,K., Hiraki,A. and Hashimoto,S.
  TITLE     alphaTAT1-induced tubulin acetylation promotes ameloblastoma
            migration and invasion
  JOURNAL   Lab Invest 102 (1), 80-89 (2022)
   PUBMED   34508164
  REMARK    GeneRIF: alphaTAT1-induced tubulin acetylation promotes
            ameloblastoma migration and invasion.
REFERENCE   5  (bases 1 to 2092)
  AUTHORS   Ko,P., Choi,J.H., Song,S., Keum,S., Jeong,J., Hwang,Y.E., Kim,J.W.
            and Rhee,S.
  TITLE     Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell
            Invasion through the Modulation of Endoplasmic Reticulum Stress
  JOURNAL   Int J Mol Sci 22 (11), 6018 (2021)
   PUBMED   34199510
  REMARK    GeneRIF: Microtubule Acetylation Controls MDA-MB-231 Breast Cancer
            Cell Invasion through the Modulation of Endoplasmic Reticulum
            Stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2092)
  AUTHORS   Taschner,M., Vetter,M. and Lorentzen,E.
  TITLE     Atomic resolution structure of human alpha-tubulin
            acetyltransferase bound to acetyl-CoA
  JOURNAL   Proc Natl Acad Sci U S A 109 (48), 19649-19654 (2012)
   PUBMED   23071318
  REMARK    GeneRIF: analysis reveals a basic patch implicated in substrate
            binding and a conserved glutamine residue required for catalysis,
            demonstrating that the family of alpha-tubulin acetyltransferases
            uses a reaction mechanism different from other lysine
            acetyltransferases
REFERENCE   7  (bases 1 to 2092)
  AUTHORS   Friedmann,D.R., Aguilar,A., Fan,J., Nachury,M.V. and Marmorstein,R.
  TITLE     Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and
            implications for tubulin-specific acetylation
  JOURNAL   Proc Natl Acad Sci U S A 109 (48), 19655-19660 (2012)
   PUBMED   23071314
  REMARK    GeneRIF: cysteine residues play important catalytic roles through a
            ternary complex mechanism. alphaTAT1 mutations have analogous
            effects on tubulin acetylation in vitro and in cells
REFERENCE   8  (bases 1 to 2092)
  AUTHORS   Castro-Castro,A., Janke,C., Montagnac,G., Paul-Gilloteaux,P. and
            Chavrier,P.
  TITLE     ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a
            balance of acetylation of alpha-tubulin and cortactin and regulate
            MT1-MMP trafficking and breast tumor cell invasion
  JOURNAL   Eur J Cell Biol 91 (11-12), 950-960 (2012)
   PUBMED   22902175
REFERENCE   9  (bases 1 to 2092)
  AUTHORS   Shida,T., Cueva,J.G., Xu,Z., Goodman,M.B. and Nachury,M.V.
  TITLE     The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes
            rapid ciliogenesis and efficient mechanosensation
  JOURNAL   Proc Natl Acad Sci U S A 107 (50), 21517-21522 (2010)
   PUBMED   21068373
REFERENCE   10 (bases 1 to 2092)
  AUTHORS   Akella,J.S., Wloga,D., Kim,J., Starostina,N.G., Lyons-Abbott,S.,
            Morrissette,N.S., Dougan,S.T., Kipreos,E.T. and Gaertig,J.
  TITLE     MEC-17 is an alpha-tubulin acetyltransferase
  JOURNAL   Nature 467 (7312), 218-222 (2010)
   PUBMED   20829795
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB090032.1, AL535697.3,
            AL833858.1 and BX418559.2.
            
            On Aug 13, 2020 this sequence version replaced NM_024909.4.
            
            Summary: This gene encodes a protein that localizes to
            clathrin-coated pits, where it acetylates alpha tubulin on lysine
            40. This process may be important in microtubule growth, for
            instance during chemotaxis and the formation of cilium. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) differs in the 5' and 3' UTRs
            and coding region compared to variant 1. The encoded isoform (2)
            has distinct N- and C-termini and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833858.1, AK225107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               DB090032.1         419-537
            120-736             AL535697.3         126-742
            737-1350            AL833858.1         721-1334
            1351-2092           BX418559.2         8-749               c
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..2092
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /note="alpha tubulin acetyltransferase 1"
                     /db_xref="GeneID:79969"
                     /db_xref="HGNC:HGNC:21186"
                     /db_xref="MIM:615556"
     exon            1..119
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1014
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /EC_number="2.3.1.108"
                     /note="isoform 2 is encoded by transcript variant 2;
                     alpha-tubulin N-acetyltransferase 1; acetyltransferase
                     mec-17 homolog"
                     /codon_start=1
                     /product="alpha-tubulin N-acetyltransferase 1 isoform 2"
                     /protein_id="NP_079185.2"
                     /db_xref="CCDS:CCDS4683.2"
                     /db_xref="GeneID:79969"
                     /db_xref="HGNC:HGNC:21186"
                     /db_xref="MIM:615556"
                     /translation="MEFPFDVDALFPERITVLDQHLRPPARRPGTTTPARVDLQQQIM
                     TIIDELGKASAKAQNLSAPITSASRMQSNRHVVYILKDSSARPAGKGAIIGFIKVGYK
                     KLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQYMLQKERVEPHQLAIDRPS
                     QKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHRPPAPSLRATRHSRAAAVDPTPAA
                     PARKLPPKRAEGDIKPYSSSDREFLKVAVEPPWPLNRAPRRATPPAHPPPRSSSLGNS
                     PERGPLRPFVPEQELLRSLRLCPPHPTARLLLAADPGGSPAQRRRTSSLPRSEESRY"
     exon            120..180
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            181..272
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            273..333
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            334..447
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            448..549
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            550..595
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            596..664
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            665..736
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            737..980
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            981..2092
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /note="hexamer: AATAAA"
     polyA_site      2092
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /note="major polyA site"
ORIGIN      
        1 gcacaatggg ccatggagtt cccgttcgat gtggacgcgc tgttcccgga gcggatcacg
       61 gtgctggacc agcacctgag gcccccagcc cgccgacccg gaaccacaac gccggcccgt
      121 gttgatctac agcagcaaat tatgaccatt atagatgaac tgggcaaggc ttctgccaag
      181 gcccagaatc tttccgctcc tatcactagt gcatcaagga tgcagagtaa ccgccatgtt
      241 gtttatattc tcaaagacag ttcagcccga ccggctggaa aaggagccat tattggtttc
      301 atcaaagttg gatacaagaa gctctttgta ctggatgatc gtgaggctca taatgaggta
      361 gaaccacttt gcatcctgga cttttacatc catgagtctg tgcaacgcca tggccatggg
      421 cgagaactct tccagtatat gttgcagaag gagcgagtgg aaccgcacca actggcaatt
      481 gaccgaccct cacagaagct gctgaaattc ctgaataagc actacaatct ggagaccaca
      541 gtcccacagg tgaacaactt tgtgatcttt gaaggcttct ttgcccatca acatcggccc
      601 cctgctccct ctctgagggc aactcgacac tctcgtgctg ctgcagtcga tcccacgccc
      661 gctgctccag caaggaagct gccacccaag agagcagagg gagacatcaa gccatactcc
      721 tctagtgacc gagaatttct gaaggtagct gtggagcctc cttggcccct aaacagggcc
      781 cctcgccgcg ccacacctcc agcccaccca cccccccgct ccagcagcct gggaaactca
      841 ccagaacgag gtcccctccg cccctttgtg ccagagcagg agctgctgcg ttccttgcgc
      901 ctctgccccc cacaccctac cgcccgcctt ctgttggctg ctgaccctgg gggcagccca
      961 gctcaacgtc gtcgcaccag ctcccttccc cgctctgagg agagtcgata ctaacagcta
     1021 ccctctccct gccctgggag acctggggtg ggcagggaac ccctccctga gaacctcaga
     1081 cccactcttc cattgcatcc tgtaggaccc agtggaacct gacagagccc ataggattcc
     1141 ctcttctact ttcttagaca gcagggatgt cagggtctca aactgcctaa cactttgtag
     1201 cttttcttaa cacaaaagca ccccttctct cctaacttgg gctctgaata ctttcccaac
     1261 aggaagtctg atctgttgcc agacttcttg gttagatggc tcatacattt atctagagaa
     1321 gcacactctt gcttgctgtc aaactttaga ccaccatgga aggtctaagg gcatcctgtg
     1381 ccagggaaac tttttaagga attttatcta tgggataaac cccatattcc ctctagtgtc
     1441 tactggtggc tctaatactg ctttgtgctg cctgccacac ttgccctttg agcctgcgaa
     1501 tggccgctag tgagcaagct ctgcttcaga gcagtctagt taggtagaac agggacttac
     1561 cagcttccca aagggatcta ctcaccattg ccaaactctt catttccaca ttttgtgtag
     1621 gtgtcaggga accccaaact ggtgttgctt tggggtctct aaaggagatt ggctgacacc
     1681 accatttccc ccagatccag attctctgag ggaggttgtt tcttgagagt agatccagag
     1741 tgtcaaggat ctgttagatc ctggaatccc ttcttgcatc catccctccc tggtagctag
     1801 gtcccgatat actcctgtct tgtgagattg tcgagatgag atgggggacc actcttcctc
     1861 tgtccttcct ctctcctttc ctccatagca aggacgacct tccctgctcc atgcccagag
     1921 tatagctaga tcccttcccc tccctaccct ctgaatgtgt gctagatcag gtgccccact
     1981 gtgtttcctg aaatccttgg gagccggatc tccccatctc ccctactcac tcttcccttt
     2041 tcttctctca gtgttgtctg aataaagtgt gaaatctttt gtgttttcta aa
//
