LOCUS       NM_001413067            1456 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens alpha tubulin acetyltransferase 1 (ATAT1), transcript
            variant 8, mRNA.
ACCESSION   NM_001413067
VERSION     NM_001413067.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1456)
  AUTHORS   Choi,J.H., Jeong,J., Kim,J., You,E., Keum,S., Song,S., Hwang,Y.E.,
            Ji,M., Park,K.S. and Rhee,S.
  TITLE     Genetic disruption of ATAT1 causes RhoA downregulation through
            abnormal truncation of C/EBPbeta
  JOURNAL   BMB Rep 57 (6), 293-298 (2024)
   PUBMED   38835115
  REMARK    GeneRIF: Genetic disruption of ATAT1 causes RhoA downregulation
            through abnormal truncation of C/EBPbeta.
REFERENCE   2  (bases 1 to 1456)
  AUTHORS   Iuzzolino,A., Pellegrini,F.R., Rotili,D., Degrassi,F. and
            Trisciuoglio,D.
  TITLE     The alpha-tubulin acetyltransferase ATAT1: structure, cellular
            functions, and its emerging role in human diseases
  JOURNAL   Cell Mol Life Sci 81 (1), 193 (2024)
   PUBMED   38652325
  REMARK    GeneRIF: The alpha-tubulin acetyltransferase ATAT1: structure,
            cellular functions, and its emerging role in human diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1456)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 1456)
  AUTHORS   Yoshimoto,S., Morita,H., Okamura,K., Hiraki,A. and Hashimoto,S.
  TITLE     alphaTAT1-induced tubulin acetylation promotes ameloblastoma
            migration and invasion
  JOURNAL   Lab Invest 102 (1), 80-89 (2022)
   PUBMED   34508164
  REMARK    GeneRIF: alphaTAT1-induced tubulin acetylation promotes
            ameloblastoma migration and invasion.
REFERENCE   5  (bases 1 to 1456)
  AUTHORS   Ko,P., Choi,J.H., Song,S., Keum,S., Jeong,J., Hwang,Y.E., Kim,J.W.
            and Rhee,S.
  TITLE     Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell
            Invasion through the Modulation of Endoplasmic Reticulum Stress
  JOURNAL   Int J Mol Sci 22 (11), 6018 (2021)
   PUBMED   34199510
  REMARK    GeneRIF: Microtubule Acetylation Controls MDA-MB-231 Breast Cancer
            Cell Invasion through the Modulation of Endoplasmic Reticulum
            Stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1456)
  AUTHORS   Taschner,M., Vetter,M. and Lorentzen,E.
  TITLE     Atomic resolution structure of human alpha-tubulin
            acetyltransferase bound to acetyl-CoA
  JOURNAL   Proc Natl Acad Sci U S A 109 (48), 19649-19654 (2012)
   PUBMED   23071318
  REMARK    GeneRIF: analysis reveals a basic patch implicated in substrate
            binding and a conserved glutamine residue required for catalysis,
            demonstrating that the family of alpha-tubulin acetyltransferases
            uses a reaction mechanism different from other lysine
            acetyltransferases
REFERENCE   7  (bases 1 to 1456)
  AUTHORS   Friedmann,D.R., Aguilar,A., Fan,J., Nachury,M.V. and Marmorstein,R.
  TITLE     Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and
            implications for tubulin-specific acetylation
  JOURNAL   Proc Natl Acad Sci U S A 109 (48), 19655-19660 (2012)
   PUBMED   23071314
  REMARK    GeneRIF: cysteine residues play important catalytic roles through a
            ternary complex mechanism. alphaTAT1 mutations have analogous
            effects on tubulin acetylation in vitro and in cells
REFERENCE   8  (bases 1 to 1456)
  AUTHORS   Castro-Castro,A., Janke,C., Montagnac,G., Paul-Gilloteaux,P. and
            Chavrier,P.
  TITLE     ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a
            balance of acetylation of alpha-tubulin and cortactin and regulate
            MT1-MMP trafficking and breast tumor cell invasion
  JOURNAL   Eur J Cell Biol 91 (11-12), 950-960 (2012)
   PUBMED   22902175
REFERENCE   9  (bases 1 to 1456)
  AUTHORS   Shida,T., Cueva,J.G., Xu,Z., Goodman,M.B. and Nachury,M.V.
  TITLE     The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes
            rapid ciliogenesis and efficient mechanosensation
  JOURNAL   Proc Natl Acad Sci U S A 107 (50), 21517-21522 (2010)
   PUBMED   21068373
REFERENCE   10 (bases 1 to 1456)
  AUTHORS   Akella,J.S., Wloga,D., Kim,J., Starostina,N.G., Lyons-Abbott,S.,
            Morrissette,N.S., Dougan,S.T., Kipreos,E.T. and Gaertig,J.
  TITLE     MEC-17 is an alpha-tubulin acetyltransferase
  JOURNAL   Nature 467 (7312), 218-222 (2010)
   PUBMED   20829795
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662800.4.
            
            Summary: This gene encodes a protein that localizes to
            clathrin-coated pits, where it acetylates alpha tubulin on lysine
            40. This process may be important in microtubule growth, for
            instance during chemotaxis and the formation of cilium. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.376731.1,
                                           SRR18074967.3672947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376485.9/ ENSP00000365668.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AL662800.4         127049-127167
            120-180             AL662800.4         127635-127695
            181-272             AL662800.4         127811-127902
            273-333             AL662800.4         128026-128086
            334-447             AL662800.4         128207-128320
            448-549             AL662800.4         128504-128605
            550-595             AL662800.4         140552-140597
            596-664             AL662800.4         140710-140778
            665-736             AL662800.4         142351-142422
            737-980             AL662800.4         142943-143186
            981-1060            AL662800.4         146070-146149
            1061-1103           AL662800.4         146242-146284
            1104-1456           AL662800.4         146644-146996
FEATURES             Location/Qualifiers
     source          1..1456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1456
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /note="alpha tubulin acetyltransferase 1"
                     /db_xref="GeneID:79969"
                     /db_xref="HGNC:HGNC:21186"
                     /db_xref="MIM:615556"
     exon            1..119
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1278
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /EC_number="2.3.1.108"
                     /note="isoform 7 is encoded by transcript variant 8;
                     alpha-tubulin N-acetyltransferase 1; acetyltransferase
                     mec-17 homolog"
                     /codon_start=1
                     /product="alpha-tubulin N-acetyltransferase 1 isoform 7"
                     /protein_id="NP_001399996.1"
                     /db_xref="GeneID:79969"
                     /db_xref="HGNC:HGNC:21186"
                     /db_xref="MIM:615556"
                     /translation="MEFPFDVDALFPERITVLDQHLRPPARRPGTTTPARVDLQQQIM
                     TIIDELGKASAKAQNLSAPITSASRMQSNRHVVYILKDSSARPAGKGAIIGFIKVGYK
                     KLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQYMLQKERVEPHQLAIDRPS
                     QKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHRPPAPSLRATRHSRAAAVDPTPAA
                     PARKLPPKRAEGDIKPYSSSDREFLKVAVEPPWPLNRAPRRATPPAHPPPRSSSLGNS
                     PERGPLRPFVPEQELLRSLRLCPPHPTARLLLAADPGGSPAQRRRTRGTPPGLVAQSC
                     CYSRHGGVNSSSPNTGNQDSKQGEQETKNRSASEEQALSQDGSGEKPMHTAPPQAPAP
                     PAQSWTVGGDILNARFIRNLQERRSTRPW"
     exon            120..180
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            181..272
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            273..333
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            334..447
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            448..549
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            550..595
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            596..664
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            665..736
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            737..980
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1060
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1103
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1456
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1431..1436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /note="hexamer: AATAAA"
     polyA_site      1456
                     /gene="ATAT1"
                     /gene_synonym="alpha-TAT; alpha-TAT1; C6orf134; MEC17;
                     Nbla00487; TAT"
                     /note="major polyA site"
ORIGIN      
        1 gcacaatggg ccatggagtt cccgttcgat gtggacgcgc tgttcccgga gcggatcacg
       61 gtgctggacc agcacctgag gcccccagcc cgccgacccg gaaccacaac gccggcccgt
      121 gttgatctac agcagcaaat tatgaccatt atagatgaac tgggcaaggc ttctgccaag
      181 gcccagaatc tttccgctcc tatcactagt gcatcaagga tgcagagtaa ccgccatgtt
      241 gtttatattc tcaaagacag ttcagcccga ccggctggaa aaggagccat tattggtttc
      301 atcaaagttg gatacaagaa gctctttgta ctggatgatc gtgaggctca taatgaggta
      361 gaaccacttt gcatcctgga cttttacatc catgagtctg tgcaacgcca tggccatggg
      421 cgagaactct tccagtatat gttgcagaag gagcgagtgg aaccgcacca actggcaatt
      481 gaccgaccct cacagaagct gctgaaattc ctgaataagc actacaatct ggagaccaca
      541 gtcccacagg tgaacaactt tgtgatcttt gaaggcttct ttgcccatca acatcggccc
      601 cctgctccct ctctgagggc aactcgacac tctcgtgctg ctgcagtcga tcccacgccc
      661 gctgctccag caaggaagct gccacccaag agagcagagg gagacatcaa gccatactcc
      721 tctagtgacc gagaatttct gaaggtagct gtggagcctc cttggcccct aaacagggcc
      781 cctcgccgcg ccacacctcc agcccaccca cccccccgct ccagcagcct gggaaactca
      841 ccagaacgag gtcccctccg cccctttgtg ccagagcagg agctgctgcg ttccttgcgc
      901 ctctgccccc cacaccctac cgcccgcctt ctgttggctg ctgaccctgg gggcagccca
      961 gctcaacgtc gtcgcaccag ggggactccc ccaggtctgg tagcccaaag ctgctgctac
     1021 agccgccatg ggggggtgaa ttcctcatcc cccaatacag gcaaccaaga ctccaagcag
     1081 ggagaacagg aaacaaagaa taggtctgcc agtgaggagc aggccttgtc acaggatggg
     1141 tctggggaga agcccatgca cacagctcct ccacaggccc cggccccgcc agcccagtcc
     1201 tggacagtgg gtggggacat actcaacgcc aggttcattc gaaacctgca ggaacgtcgc
     1261 agcaccaggc cttggtgacc gcagccccgt caaacatctt caaagtatta tttctccctc
     1321 actacaggaa agagccaaag cccaaccctc ataatagatg gatacattca ttcattcatt
     1381 cattcagcag gcttatcaga ttcaagtcat ttgtatcttt taaccagacc aataaaagta
     1441 tttattttta tcacaa
//
