LOCUS       NM_024857               6873 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ATPase family AAA domain containing 5 (ATAD5), mRNA.
ACCESSION   NM_024857 XM_942426 XM_945964
VERSION     NM_024857.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6873)
  AUTHORS   Park,S.H., Kim,N., Kang,N., Ryu,E., Lee,E.A., Ra,J.S., Gartner,A.,
            Kang,S., Myung,K. and Lee,K.Y.
  TITLE     Short-range end resection requires ATAD5-mediated PCNA unloading
            for faithful homologous recombination
  JOURNAL   Nucleic Acids Res 51 (19), 10519-10535 (2023)
   PUBMED   37739427
  REMARK    GeneRIF: Short-range end resection requires ATAD5-mediated PCNA
            unloading for faithful homologous recombination.
REFERENCE   2  (bases 1 to 6873)
  AUTHORS   Itzkovich,Z., Choudhary,K., Arbel,M. and Kupiec,M.
  TITLE     Effects of Defective Unloading and Recycling of PCNA Revealed by
            the Analysis of ELG1 Mutants
  JOURNAL   Int J Mol Sci 24 (2), 1568 (2023)
   PUBMED   36675081
  REMARK    GeneRIF: Effects of Defective Unloading and Recycling of PCNA
            Revealed by the Analysis of ELG1 Mutants.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6873)
  AUTHORS   Park,S.H., Kim,Y., Ra,J.S., Wie,M.W., Kang,M.S., Kang,S., Myung,K.
            and Lee,K.Y.
  TITLE     Timely termination of repair DNA synthesis by ATAD5 is important in
            oxidative DNA damage-induced single-strand break repair
  JOURNAL   Nucleic Acids Res 49 (20), 11746-11764 (2021)
   PUBMED   34718749
  REMARK    GeneRIF: Timely termination of repair DNA synthesis by ATAD5 is
            important in oxidative DNA damage-induced single-strand break
            repair.
REFERENCE   4  (bases 1 to 6873)
  AUTHORS   Kim,S.J., Wie,M., Park,S.H., Kim,T.M., Park,J.H., Kim,S., Myung,K.
            and Lee,K.Y.
  TITLE     ATAD5 suppresses centrosome over-duplication by regulating UAF1 and
            ID1
  JOURNAL   Cell Cycle 19 (15), 1952-1968 (2020)
   PUBMED   32594826
  REMARK    GeneRIF: ATAD5 suppresses centrosome over-duplication by regulating
            UAF1 and ID1.
REFERENCE   5  (bases 1 to 6873)
  AUTHORS   Kim,S., Kang,N., Park,S.H., Wells,J., Hwang,T., Ryu,E., Kim,B.G.,
            Hwang,S., Kim,S.J., Kang,S., Lee,S., Stirling,P., Myung,K. and
            Lee,K.Y.
  TITLE     ATAD5 restricts R-loop formation through PCNA unloading and RNA
            helicase maintenance at the replication fork
  JOURNAL   Nucleic Acids Res 48 (13), 7218-7238 (2020)
   PUBMED   32542338
  REMARK    GeneRIF: ATAD5 restricts R-loop formation through PCNA unloading
            and RNA helicase maintenance at the replication fork.
REFERENCE   6  (bases 1 to 6873)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   7  (bases 1 to 6873)
  AUTHORS   Douglas,J., Cilliers,D., Coleman,K., Tatton-Brown,K., Barker,K.,
            Bernhard,B., Burn,J., Huson,S., Josifova,D., Lacombe,D., Malik,M.,
            Mansour,S., Reid,E., Cormier-Daire,V., Cole,T. and Rahman,N.
  CONSRTM   Childhood Overgrowth Collaboration
  TITLE     Mutations in RNF135, a gene within the NF1 microdeletion region,
            cause phenotypic abnormalities including overgrowth
  JOURNAL   Nat Genet 39 (8), 963-965 (2007)
   PUBMED   17632510
REFERENCE   8  (bases 1 to 6873)
  AUTHORS   Ishii,H., Inageta,T., Mimori,K., Saito,T., Sasaki,H., Isobe,M.,
            Mori,M., Croce,C.M., Huebner,K., Ozawa,K. and Furukawa,Y.
  TITLE     Frag1, a homolog of alternative replication factor C subunits,
            links replication stress surveillance with apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 102 (27), 9655-9660 (2005)
   PUBMED   15983387
  REMARK    GeneRIF: The Frag1 signal pathway, by linking replication stress
            surveillance with apoptosis induction, plays a central role in
            determining whether DNA damage is compatible with cell survival or
            whether it requires cell elimination by apoptosis.
REFERENCE   9  (bases 1 to 6873)
  AUTHORS   Jenne,D.E., Tinschert,S., Reimann,H., Lasinger,W., Thiel,G.,
            Hameister,H. and Kehrer-Sawatzki,H.
  TITLE     Molecular characterization and gene content of breakpoint
            boundaries in patients with neurofibromatosis type 1 with 17q11.2
            microdeletions
  JOURNAL   Am J Hum Genet 69 (3), 516-527 (2001)
   PUBMED   11468690
REFERENCE   10 (bases 1 to 6873)
  AUTHORS   Jenne,D.E., Tinschert,S., Stegmann,E., Reimann,H., Nurnberg,P.,
            Horn,D., Naumann,I., Buske,A. and Thiel,G.
  TITLE     A common set of at least 11 functional genes is lost in the
            majority of NF1 patients with gross deletions
  JOURNAL   Genomics 66 (1), 93-97 (2000)
   PUBMED   10843809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127024.4, AL832103.1, AJ314648.2, DR159473.1 and DB527289.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024857.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ314648.2, AY557611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321990.5/ ENSP00000313171.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC127024.4         115213-115216
            5-39                AL832103.1         2-36
            40-6281             AJ314648.2         4-6245
            6282-6425           DR159473.1         224-367
            6426-6548           DB527289.1         6-128
            6549-6819           DR159473.1         490-760
            6820-6873           DB527289.1         400-453
FEATURES             Location/Qualifiers
     source          1..6873
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..6873
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /note="ATPase family AAA domain containing 5"
                     /db_xref="GeneID:79915"
                     /db_xref="HGNC:HGNC:25752"
                     /db_xref="MIM:609534"
     exon            1..448
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..5917
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /note="enhanced level of genomic instability 1 homolog;
                     chromosome fragility-associated gene 1 protein; chromosome
                     fragility associated gene 1"
                     /codon_start=1
                     /product="ATPase family AAA domain-containing protein 5"
                     /protein_id="NP_079133.3"
                     /db_xref="CCDS:CCDS11260.1"
                     /db_xref="GeneID:79915"
                     /db_xref="HGNC:HGNC:25752"
                     /db_xref="MIM:609534"
                     /translation="MVGVLAMAAAAAPPPVKDCEIEPCKKRKKDDDTSTCKTITKYLS
                     PLGKTRDRVFAPPKPSNILDYFRKTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPL
                     EMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLR
                     YKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSE
                     SLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKE
                     NKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPK
                     KTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVK
                     PKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENS
                     GIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFF
                     LKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTS
                     IPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLK
                     ASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEAT
                     DGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPER
                     KKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLF
                     LVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAA
                     LDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALG
                     EFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQI
                     EHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEEL
                     SKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRRAE
                     LEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTGVGKTAAVYACA
                     QELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKK
                     ISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENNKG
                     IKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLNA
                     IKTFMATTKRPVILTTSDPTFSLMFDGCFEEIKFSTPSLLNVASYLQMICLTENFRTD
                     VKDFVTLLTANTCDIRKSILYLQFWIRSGGGVLEERPLTLYRGNSRNVQLVCSEHGLD
                     NKIYPKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQ
                     LLTEFQMRNVDFLYSNLEFILPLPVDTIPETKNFCGPSVTVDASAATKSMNCLARKHS
                     EREQPLKKSQKKKQKKTLVILDDSDLFDTDLDFPDQSISLSSVSSSSNAEESKTGDEE
                     SKARDKGNNPETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVRE
                     QNKYGRNDFSWTNGKVTSGLCDEFSLESNDGWTSQSSGELKAAAEALSFTKCSSAISK
                     ALETLNSCKKLGRDPTNDLTFYVSQKRNNVYFSQSAANLDNAWKRISVIKSVFSSRSL
                     LYVGNRQASIIEYLPTLRNICKTEKLKEQGKSKRRFLHYFEGIHLDIPKETVNTLAAD
                     FP"
     exon            449..2349
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2458
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2623
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2750
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2832
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..3017
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3175
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3338
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3518
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3615
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3616..3695
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3838
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..3989
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3990..4166
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4300
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4301..4394
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4395..4459
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4460..4640
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4641..4822
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4823..5679
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            5680..5838
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            5839..6873
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6030
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
     regulatory      6832..6837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /note="hexamer: ATTAAA"
     polyA_site      6873
                     /gene="ATAD5"
                     /gene_synonym="C17orf41; ELG1; FRAG1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcagga cggcgcgaaa acccaattga caagaattcc ctccgaagct ctgtggtccg
       61 atctgcggtc cgcttgcttt ccctgcccgg tcccgagcgc tcagcctgaa gcgccgcttt
      121 cgagggcacc ctgcatacac tggccgcgcc tcagggatct cattgcccgc gctttctcat
      181 tgcctctttc cgtgttcgat tcggctgatc tgggcccagc ctccgctccc gctctctgtc
      241 ggtgggcgcg ggggaatccg aaacggctca gcagaatccc agcagcttgc tgctactgga
      301 gcgggccgcc tccatggcct ccaggcaggc cgggctggac cgcgtgaggt cctaggagac
      361 gggattccgg gaagcgggga gtatggtggg ggtcctggcc atggcggctg cagctgctcc
      421 gcctcccgtg aaggactgcg agattgagcc atgcaaaaag cgaaagaaag atgatgacac
      481 atctacctgc aaaacaatta caaaatattt atcaccacta gggaagacta gagacagggt
      541 ttttgctcca ccaaaaccta gtaatattct ggattatttt agaaagactt cacccacaaa
      601 tgagaagaca caattaggga aagagtgcaa gataaagtca cctgaatcag tacctgttga
      661 cagcaacaaa gactgtacga cacctttgga aatgttctca aatgtagagt ttaagaagaa
      721 aagaaagagg gttaatttat ctcatcaact aaataatatt aaaactgaaa atgaagctcc
      781 aattgaaatt agtagcgacg atagcaaaga agactatagt ttaaataatg attttgtgga
      841 aagtagtact tctgttttac gttacaagaa acaagtagag gtacttgcag aaaacattca
      901 agatacaaaa agtcaaccaa atactatgac ctccctgcaa aattctaaaa aagtaaatcc
      961 taaacaaggg accacaaaaa atgacttcaa aaagttgaga aaaaggaaat gcagagatgt
     1021 agtagatcta tctgaaagct tacccttggc agaggaacta aatttgctta aaaaagatgg
     1081 taaagatact aaacagatgg agaatactac aagccatgca aactctagag ataacgtaac
     1141 tgaagcagcc cagttaaatg atagtataat aactgtctca tatgaggaat ttttaaaaag
     1201 tcacaaggaa aataaagtgg aagagatacc agactctaca atgtcaattt gtgttccttc
     1261 tgaaactgtc gacgaaatag tcaaaagtgg ttatataagt gaatcagaaa actccgaaat
     1321 ttcccagcag gtacgcttta agacagttac tgttcttgca caggttcacc ctattccgcc
     1381 caaaaagaca gggaaaatac cccgaatttt cttgaaacaa aagcaatttg aaatggaaaa
     1441 tagtttatct gatcctgaga atgaacagac agttcagaaa agaaaatcta atgttgttat
     1501 acaggaggaa gaattagaat tggctgtttt ggaagctgga agttctgaag ctgtgaaacc
     1561 aaaatgcact ctagaagaaa gacagcaatt tatgaaagca tttaggcagc cagcatcaga
     1621 tgcacttaaa aatggagtta aaaagtcttc tgataagcag aaagacctta atgaaaaatg
     1681 tctatatgaa gtaggaagag atgataattc taaaaaaatc atggaaaatt ctggtatcca
     1741 aatggtttca aaaaatggca atttacagtt acacactgat aaaggaagtt ttctgaagga
     1801 gaaaaataaa aagctaaaga agaagaataa gaaaacatta gatactgggg ctattccagg
     1861 caaaaacaga gagggaaaca ctcaaaagaa agaaacaacc tttttcttaa aagagaaaca
     1921 atatcaaaat agaatgagtt taagacaaag gaaaacagag tttttcaaaa gcagcacttt
     1981 atttaacaat gaaagtcttg tttatgaaga tatagcaaat gatgaccttc taaaggtttc
     2041 ctctctgtgt aacaataata aattgtcaag aaaaaccagc ataccagtta aagatattaa
     2101 gcttacacag tctaaagctg aatctgaagc cagcttgcta aatgtttcca cgcccaagtc
     2161 aactagaaga tctggaagaa ttagcagcac acctactaca gaaaccatta gaggtattga
     2221 ttctgacgat gtacaagata atagtcaact aaaggcttcc actcaaaaag cagccaactt
     2281 atcggaaaag cacagcttat atacagcaga attaataaca gtaccctttg attcagagag
     2341 ccctattaga atgaaattca ccagaattag tactcccaaa aaatctaaga aaaaatctaa
     2401 caaaagatct gagaaatctg aagcaactga tggaggtttt acttctcaga ttagaaaggc
     2461 aagcaatact tcaaaaaaca tatcaaaagc aaaacaattg attgaaaaag caaaagcttt
     2521 acacatcagt aggtcaaagg tgactgaaga aatagcgata cccttaaggc gctcctctag
     2581 acatcagaca cttcctgaaa ggaagaaatt gtcagaaaca gaagattctg ttataataat
     2641 agattcaagt cctactgctt taaagcatcc agagaaaaat cagaagaaac ttcagtgttt
     2701 gaatgatgtg ctaggaaaaa aacttaacac atccactaaa aatgtacctg gaaaaatgaa
     2761 agtcgctcct ttatttcttg tcagaaaagc acaaaaagca gctgatcctg tccctagttt
     2821 tgatgaaagc agtcaagata catctgaaaa atctcaggat tgtgatgttc aatgtaaagc
     2881 aaagcgtgac ttcctaatga gtggtttgcc agatttgttg aaacggcaaa ttgcaaagaa
     2941 agctgctgcg ctggatgtgt acaatgcagt gagtaccagt ttccagagag tcgtacatgt
     3001 gcaacaaaag gatgatgggt gttgtttgtg gcatttgaaa ccaccctctt gtcctctctt
     3061 aactaaattt aaagaactga acactaaagt aatagatctc tcaaaatgtg gtattgctct
     3121 tggtgaattt tcaacattga attcaaagtt gaaaagcggt aactctgctg ctgtgttcat
     3181 gaggacaagg aaggaattta ctgaagaagt aagaaatctt ttgcttgagg aaattaggtg
     3241 gtcaaatcct gaattttcat tgaaaaaata ttttccctta ctcctaaaaa aacaaattga
     3301 gcaccaagta ctttcttccg agtgtcatag taaacaagaa ctggaggctg atgtcagcca
     3361 taaagaaacc aaaaggaaac tcgtagaagc agaaaattct aagtcaaaaa gaaagaaacc
     3421 aaatgagtat tcaaaaaatc tggagaagac caataggaag tcagaagaac ttagcaaaag
     3481 aaacaactct tctgggataa agctagattc ttccaaagat tctggaactg aagacatgct
     3541 ttggacagaa aagtatcaac ctcagactgc cagtgaactt ataggaaatg agttagctat
     3601 aaaaaagtta catagttggt tgaaagactg gaaaagaaga gctgaattgg aagaaaggca
     3661 gaatctgaag ggaaaaagag atgagaaaca tgaagatttc tcgggtggca tagactttaa
     3721 aggcagttca gatgatgaag aagagagtcg tctttgcaat actgtcctta taacagggcc
     3781 aacaggagtg ggaaaaactg ctgcagtgta tgcttgtgcc caggagcttg gatttaagat
     3841 atttgaagtg aatgcctctt cccagcgcag tggtagacaa attctatctc agttgaagga
     3901 agctactcag tcccatcaag tagacaaaca aggtgtaaac tcacaaaaac cctgtttttt
     3961 taatagctac tacataggca agtcaccaaa aaaaataagc tcccctaaga aagttgttac
     4021 atcaccaaga aaagttcctc caccatcacc aaaaagtagt ggaccaaagc gagcacttcc
     4081 tcccaaaacc ttggcaaatt attttaaagt atctcccaaa cctaaaaata atgaagaaat
     4141 aggaatgctt ctggaaaata ataaaggaat aaaaaattct tttgaacaga aacaaattac
     4201 tcagactaaa tctacaaatg caactaattc aaatgtcaaa gacgttggag ctgaagaacc
     4261 cagcagaaaa aatgcaacat ctcttattct ttttgaggag gttgatgtaa tttttgatga
     4321 agatgctggg tttttgaatg caatcaaaac attcatggca acaactaaac gacctgtaat
     4381 ccttactaca agtgacccaa catttagttt aatgtttgat ggctgctttg aagaaatcaa
     4441 gttcagtact ccttccctgc taaatgttgc cagctaccta caaatgattt gcttaactga
     4501 gaattttaga actgatgtaa aagactttgt aaccttgtta actgcaaata cttgtgatat
     4561 cagaaaaagt atcctttact tacaattctg gattagaagt ggaggtggag ttttagaaga
     4621 acgaccatta accctttatc gtggaaatag cagaaatgta caactagttt gctctgaaca
     4681 tggccttgat aacaaaattt accctaaaaa tactaaaaag aaacgtgtag accttccaaa
     4741 atgtgacagt ggctgtgctg agaccttgtt tggccttaag aacatttttt ccccatctga
     4801 agacttattt tcatttttaa agcacaaaat cacaatgaag gaagaatggc ataaattcat
     4861 ccagcttctt acagaattcc aaatgcggaa tgtagatttt ttatatagta atcttgagtt
     4921 tattctacca ttaccagttg ataccattcc agaaactaaa aacttttgtg gcccatcagt
     4981 aactgtggat gccagtgcag caacaaaaag tatgaattgt cttgctagga aacactctga
     5041 aagagaacag ccattgaaaa agtcccagaa aaagaaacaa aagaaaacat tggtaatatt
     5101 agatgatagt gatctatttg acactgactt ggactttcct gatcaatcta ttagcctgtc
     5161 ctctgtatca tcttcctcaa atgcagaaga aagcaaaacc ggagacgaag aaagcaaagc
     5221 cagagacaaa ggaaacaatc cagagacaaa gaaatctatt ccttgtcctc ctaaaacaac
     5281 tgcaggaaaa aaatgttctg cccttgtttc tcattgttta aattctctct ctgagttcat
     5341 ggataacatg tccttcttag atgcactttt aactgatgta agggaacaaa acaaatacgg
     5401 tagaaatgac tttagttgga caaatggaaa ggttacaagt ggactttgtg atgagtttag
     5461 tcttgagagt aatgatggat ggacttctca aagctctgga gaattaaagg cagctgcaga
     5521 agctctcagc tttactaaat gttcttctgc tatttcaaaa gcattggaaa ccttgaattc
     5581 ttgcaagaaa ttaggaagag atccaaccaa cgatcttact ttttatgttt cacaaaagcg
     5641 caataatgta tactttagtc agtcagcagc taatttagac aatgcttgga agaggatatc
     5701 agtcattaaa agtgtatttt cgagtcgatc tcttctctat gtgggtaata gacaagctag
     5761 tataattgaa tacctgccaa cccttcgaaa catctgtaag actgagaagc taaaagaaca
     5821 aggaaaaagt aaaagaagat tcctgcacta ttttgaagga attcatcttg acattccaaa
     5881 agagactgtg aatactttgg cagctgactt cccttaatgt tccatactaa caatgctttg
     5941 tatagattat catgtggtcc ttaagataca tttttatatt atgtggatct tcatggaaaa
     6001 gtatatttct cgatgtacat tttaaacaaa caatttgtat atttttttat tggcgggtaa
     6061 atatttaaaa tatttgagtt acaaatttta tatatgattg taattttttt tctgaatttt
     6121 ttgtattatc tgatttagct ttgttggagt attttttgta tgtgagtgaa ctgtttctgg
     6181 aaggtagagt tcattaagat gaactcccta tttcaagtgt ttatattata tattagctta
     6241 atattcagat acattatctt ggctgctaac attagtgtca ctaaagttgg tatacaatct
     6301 cccactgcta aatttgactg gctttacaaa aacaaaaaca ttatctggtg aattatattt
     6361 ttaacctaaa agttaaggat cctcatattg tacagttttt tttgtgtgct tttttttttt
     6421 ttttttgaga cggaatcttg ctctgtcacc caggctggag tgcagtggcc tggtatcggc
     6481 tcagtgcaac ttttgcctcc cgggttcaag cgattatcct gcctcagcct cctgaatagc
     6541 tgggattaca ggcatgtgcc accttgccca gctaattttt gtatttttag aagagacagg
     6601 gttttaccat gttggttagg ctggtctctt aactcctgac ctcaagtgat ccatctgcct
     6661 cggcctccca aagtgctggg atcacaggcg tgagccacct cacctggcct atattgtaca
     6721 gttttgaaca gtatagatgc atacctgttt acaaatgtgt atgaagatag atatttttac
     6781 ctcttatttg ttcaatttac tttttcttgt attaattagt atattgatct aattaaaggt
     6841 taaagctaaa ggctttatga aatgtttaaa aaa
//
