LOCUS       NM_031921               4098 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ATPase family AAA domain containing 3B (ATAD3B),
            transcript variant 1, mRNA.
ACCESSION   NM_031921
VERSION     NM_031921.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4098)
  AUTHORS   Song,B., Xu,C., Zhang,Y. and Shan,Y.
  TITLE     Circ_ATAD3B inhibits cell proliferation of breast cancer via
            mediating the miR-570-3p/MX2 axis
  JOURNAL   Prev Med 173, 107568 (2023)
   PUBMED   37286092
  REMARK    GeneRIF: Circ_ATAD3B inhibits cell proliferation of breast cancer
            via mediating the miR-570-3p/MX2 axis.
REFERENCE   2  (bases 1 to 4098)
  AUTHORS   Lu,Z., Zhang,Y., Yan,H., Su,Y., Guo,L., Liao,Y., Lu,T., Yu,H.,
            Wang,L., Li,J., Li,W., Yang,Y., Xiao,X., Lv,L., Tan,Y., Zhang,D.
            and Yue,W.
  TITLE     ATAD3B and SKIL polymorphisms associated with antipsychotic-induced
            QTc interval change in patients with schizophrenia: a genome-wide
            association study
  JOURNAL   Transl Psychiatry 12 (1), 56 (2022)
   PUBMED   35136033
  REMARK    GeneRIF: ATAD3B and SKIL polymorphisms associated with
            antipsychotic-induced QTc interval change in patients with
            schizophrenia: a genome-wide association study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4098)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 4098)
  AUTHORS   Shu,L., Hu,C., Xu,M., Yu,J., He,H., Lin,J., Sha,H., Lu,B.,
            Engelender,S., Guan,M. and Song,Z.
  TITLE     ATAD3B is a mitophagy receptor mediating clearance of oxidative
            stress-induced damaged mitochondrial DNA
  JOURNAL   EMBO J 40 (8), e106283 (2021)
   PUBMED   33665835
  REMARK    GeneRIF: ATAD3B is a mitophagy receptor mediating clearance of
            oxidative stress-induced damaged mitochondrial DNA.
REFERENCE   5  (bases 1 to 4098)
  AUTHORS   Liu,Y., Bu,L., Li,W., Wu,W., Wang,S., Diao,X., Zhou,J., Chen,G. and
            Yang,S.
  TITLE     Increased AAA-TOB3 correlates with lymph node metastasis and
            advanced stage of lung adenocarcinoma
  JOURNAL   Int J Biol Markers 32 (3), e325-e332 (2017)
   PUBMED   28623644
  REMARK    GeneRIF: AAA-TOB3 was highly expressed in lung adenocarcinoma, and
            the up-regulation of AAA-TOB3 correlated with lymph node metastasis
            and advanced stage of lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4098)
  AUTHORS   Ovaska,K., Matarese,F., Grote,K., Charapitsa,I., Cervera,A.,
            Liu,C., Reid,G., Seifert,M., Stunnenberg,H.G. and Hautaniemi,S.
  TITLE     Integrative analysis of deep sequencing data identifies estrogen
            receptor early response genes and links ATAD3B to poor survival in
            breast cancer
  JOURNAL   PLoS Comput Biol 9 (6), e1003100 (2013)
   PUBMED   23818839
  REMARK    GeneRIF: results indicated the ATAD3B gene, which does not have
            ERalpha binding site within 20 kb of its TSS, to be significantly
            associated with poor patient survival.
REFERENCE   7  (bases 1 to 4098)
  AUTHORS   Merle,N., Feraud,O., Gilquin,B., Hubstenberger,A.,
            Kieffer-Jacquinot,S., Assard,N., Bennaceur-Griscelli,A.,
            Honnorat,J. and Baudier,J.
  TITLE     ATAD3B is a human embryonic stem cell specific mitochondrial
            protein, re-expressed in cancer cells, that functions as dominant
            negative for the ubiquitous ATAD3A
  JOURNAL   Mitochondrion 12 (4), 441-448 (2012)
   PUBMED   22664726
  REMARK    GeneRIF: ATAD3B is a negative regulator of ATAD3A and may function
            as an adaptor of mitochondrial homeostasis and metabolism in human
            pluripotent embryonic stem cells and cancer cells.
REFERENCE   8  (bases 1 to 4098)
  AUTHORS   Hubstenberger,A., Labourdette,G., Baudier,J. and Rousseau,D.
  TITLE     ATAD 3A and ATAD 3B are distal 1p-located genes differentially
            expressed in human glioma cell lines and present in vitro
            anti-oncogenic and chemoresistant properties
  JOURNAL   Exp Cell Res 314 (15), 2870-2883 (2008)
   PUBMED   18639545
  REMARK    GeneRIF: These results demonstrate the potential for ATAD 3B as a
            putative marker in discriminating astrocytomas from
            oligodendrogliomas.
REFERENCE   9  (bases 1 to 4098)
  AUTHORS   He,J., Mao,C.C., Reyes,A., Sembongi,H., Di Re,M., Granycome,C.,
            Clippingdale,A.B., Fearnley,I.M., Harbour,M., Robinson,A.J.,
            Reichelt,S., Spelbrink,J.N., Walker,J.E. and Holt,I.J.
  TITLE     The AAA+ protein ATAD3 has displacement loop binding properties and
            is involved in mitochondrial nucleoid organization
  JOURNAL   J Cell Biol 176 (2), 141-146 (2007)
   PUBMED   17210950
  REMARK    GeneRIF: Results suggest that mitochondrial DNA displacement loops
            serve to recruit ATAD3 protein for the purpose of forming or
            segregating mitochondrial nucleoids.
REFERENCE   10 (bases 1 to 4098)
  AUTHORS   Schaffrik,M., Mack,B., Matthias,C., Rauch,J. and Gires,O.
  TITLE     Molecular characterization of the tumor-associated antigen AAA-TOB3
  JOURNAL   Cell Mol Life Sci 63 (18), 2162-2174 (2006)
   PUBMED   16909202
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290586.1, BC009938.2 and
            AL645728.31.
            
            On May 17, 2019 this sequence version replaced NM_031921.5.
            
            Summary: The protein encoded by this gene is localized to the
            mitochondrial inner membrane, where it can bind to a highly-related
            protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid
            complexes, and the encoded protein negatively regulates that
            interaction. This gene is expressed almost exclusively in
            pluripotent embryonic stem cells and some cancer cells. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (AAA-TOB3l).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290586.1, BC002542.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000673477.1/
                                                  ENSP00000500094.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2451              AK290586.1         3-2453
            2452-2454           BC009938.2         2579-2581
            2455-4098           AL645728.31        83323-84966         c
FEATURES             Location/Qualifiers
     source          1..4098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..4098
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /note="ATPase family AAA domain containing 3B"
                     /db_xref="GeneID:83858"
                     /db_xref="HGNC:HGNC:24007"
                     /db_xref="MIM:612317"
     exon            1..325
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2067
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /note="isoform AAA-TOB3l is encoded by transcript variant
                     1; AAA-ATPase TOB3; ATPase family AAA domain-containing
                     protein 3B"
                     /codon_start=1
                     /product="ATPase family AAA domain-containing protein 3B
                     isoform AAA-TOB3l"
                     /protein_id="NP_114127.3"
                     /db_xref="CCDS:CCDS30.1"
                     /db_xref="GeneID:83858"
                     /db_xref="HGNC:HGNC:24007"
                     /db_xref="MIM:612317"
                     /translation="MSWLFGVNKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPK
                     DKWSNFDPTGLERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQ
                     LKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQE
                     ESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEH
                     RQTVLESIRTAGTLFGEGFRAFVTDRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIE
                     ARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDVLEGVVLSPSLEARVRDIAIA
                     TRNTKKNRGLYRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAM
                     HKLFDWANTSRRGLLLFMDEADAFLRKRATEEISKDLRATLNAFLYHMGQHSNKFMLV
                     LASNLPEQFDCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQ
                     FDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASKDGVLTEAMMDACVQDAVQQYR
                     QKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLATDPSYPCLAGPCTFRICSWMGTGLC
                     PGPLSPRMSCGGGRPFCPPGHPLL"
     exon            326..402
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            403..504
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            505..564
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            565..634
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..800
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            801..870
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1026
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1083
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1209
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1334
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1386
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1457
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1625
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1734
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..4098
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2430..2435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /note="hexamer: AATAAA"
     polyA_site      2452
                     /gene="ATAD3B"
                     /gene_synonym="AAA-TOB3; TOB3"
                     /note="major polyA site"
ORIGIN      
        1 gtttcgcctg cgcagtggtc ctggccaccg gctcgcggcg cgtggaggct gctcccagcc
       61 gcgcccgagt cagactcggg tgggggtccc ggcggcggta gcggcggcgg cggtgcgagc
      121 atgtcgtggc tcttcggcgt taacaagggc cccaagggtg aaggcgcggg gccgccgccg
      181 cctttgccgc ccgcgcagcc cggggccgag ggcggcgggg accgcggttt gggagaccgg
      241 ccggcgccca aggacaaatg gagcaacttc gaccccaccg gcctggagcg cgccgccaag
      301 gcggcgcgcg agctggagca ctcgcgttac gccaaggagg ccctgaatct ggcgcagatg
      361 caggagcaga cgctgcagtt ggagcaacag tccaagctca aagagtatga ggccgccgtg
      421 gagcagctca agagcgagca gatccgggcg caggctgagg agaggaggaa gaccctgagc
      481 gaggagaccc ggcagcacca ggccagggcc cagtatcaag acaagctggc ccggcagcgc
      541 tacgaggacc aactgaagca gcagcaactt ctcaatgagg agaatttacg gaagcaggag
      601 gagtccgtgc agaagcagga agccatgcgg cgagccaccg tggagcggga gatggagctg
      661 cggcacaaga atgagatgct gcgagtggag accgaggccc gggcgcgcgc caaggccgag
      721 cgggagaatg cagacatcat ccgcgagcag atccgcctga aggcgtccga gcaccgtcag
      781 accgtcttgg agtccatcag gacggctggc accttgtttg gggaaggatt ccgtgccttt
      841 gtgacagacc gggacaaagt gacagccacg gtggctgggc tgacgctgct ggctgtcggg
      901 gtctactcag ccaagaatgc gacagccgtc actggccgct tcatcgaggc tcggctgggg
      961 aagccgtccc tagtgaggga gacgtcccgc atcacggtgc tggaggcgct gcggcacccc
     1021 atccaggtca gccggcggct cctcagtcga ccccaggacg tgctggaggg tgttgtgctt
     1081 agtcccagcc tggaagcacg ggtgcgcgac atcgccatag caaccaggaa caccaagaag
     1141 aaccggggcc tgtacaggca catcctgctg tatgggccac caggcaccgg gaagacgctg
     1201 tttgccaaga aactcgccct gcactcaggc atggactacg ccatcatgac aggcggggac
     1261 gtggccccca tggggcggga aggcgtgacc gccatgcaca agctctttga ctgggccaat
     1321 accagccggc gcggcctcct gctcttcatg gatgaagcag acgccttcct tcggaagcga
     1381 gccactgagg agataagcaa ggacctcaga gccacactga acgccttcct gtaccacatg
     1441 ggccaacaca gcaacaaatt catgctggtc ctggccagca atctgcctga gcagttcgac
     1501 tgtgccatca acagccgcat tgacgtgatg gtccacttcg acctgccgca gcaggaggag
     1561 cgggagcgcc tggtgagact gcattttgac aactgtgttc ttaagccggc cacagaagga
     1621 aaacggcgcc tgaagctggc ccagtttgac tacgggagga agtgctcgga ggtcgctcgg
     1681 ctgacggagg gcatgtcggg ccgggagatc gctcagctgg ccgtgtcctg gcaggccacg
     1741 gcatatgcct ccaaggacgg ggtcctcact gaggccatga tggacgcctg tgtgcaagat
     1801 gctgtccagc agtaccgaca gaagatgcgc tggctgaagg cggaggggcc tgggcgcggg
     1861 gtcgagcacc ccctatccgg agtccaaggc gagaccctca cctcatggag cctggccacg
     1921 gacccctcct acccctgcct tgccggcccc tgcacattta ggatatgctc ctggatgggg
     1981 actgggctgt gcccagggcc tctgtccccc aggatgtctt gtggtggcgg tcggccgttc
     2041 tgccccccag ggcaccccct gttgtaggca ctggctaggg aggggcaggc ctccttcctg
     2101 cccctcgaga cactcttggg agatgcattt tccgtctggc tcacaggggg agggtgaggc
     2161 tttgtacccc agcccctgcc caggccactg tgagggtggg tgctggctga gcccctgggg
     2221 cagaaggagt ggggcaggcg gggtctttgt tctcggctcc cacagcagag ccaggtgagg
     2281 gggggcctgc caggactaga cagaagtggg gcggcctgaa ccctgcttcc agccatggcc
     2341 aggggccacg gaacccggca ggggtgtctg aggccgccct gtcagctggc cggtccaagc
     2401 ctgtggctgg agctggtgtg tgtttatcta ataaagtccc acaggtgcct caccgccgtg
     2461 tctctctatt gactgacact gctcggggtt tcaggggcgc cctagcgtcc tcctggggtc
     2521 aaaggtgaca taagaggcag aggctggagc tttctggaga atttactgat cacagagcgg
     2581 tgtgcttcac atcagcctcg cgccacatcc gagttggggt ctgaatgctg cccgggactg
     2641 ccgcctgcgc cccaccagcc cctccctcct gaaggagggg caccccgaga agaatgaggc
     2701 tgcagagtga tgtgggggcc agcggtgact tcatgaccac actgcgccca ggtgtaagag
     2761 ggcacgcttc tgcccaggca tcgtccatgg aagacacgca gtcggccact gcagcctcgg
     2821 tcctgggtgc cctggggctg ggtcactggg ggccacaggc cacactggga gaccacagtc
     2881 ctggcatgcc atgcagctcc ctgtccccag aggtctgctc agatgcagag agctcaggaa
     2941 ccacactcgc tgcctgaatt ctgggagcag agcgtggtac ccactgcctg gctggggcct
     3001 actctgggac tgcagcccct gtccccgctg gcccaggctt ccggaggcag ctgcgtccct
     3061 gtcttggctc aaggtcaggc cggaggccag gctgtccacc tgcatctgga acctgcacag
     3121 tcactcctcc aggtcctcgc tgctggagga ctctcagaca ggaaaccttt gctttggggg
     3181 cagggtgggg tgcaggggtg gttgggggaa tcacagcaac gagacagcac agtgccatgg
     3241 cgcagagcct catattggtc gatgaaacaa tgctttctga actttgtgtc cttaggaagg
     3301 gtgtaggctg ttggttgaag taggaaacag aagaggagcc tgggcacgca acggtcccat
     3361 cggagagcag acccctcgga gctgcagtgc ttggaggggg gcggtctacc tctgctcgct
     3421 ctctccattt ctctctctac ctctgctcgc tctctccatt tctctctttt tccttttaga
     3481 gatgggttct tactctgagc ccaggctgga gtgcagtggt gtgattatag ctcactgcag
     3541 cctcgacctc ccaggctcaa gtgatcctcc tgcctcagcc tgtccagtag ccatacccta
     3601 ctaggcccta attagcccca gaggcgtgca ccaccacgcc cgctaatgct aaaaatttgt
     3661 tgtagagacc gagtcttgct ataatgccca ggctggtctc caactcttgg cctcaggaga
     3721 tcctcccgcc tctacaggat gagccaccaa gcctggcctc aattcctctt taaaggaatt
     3781 gcctaaatct taaaccagca atcaatactt tgtatttaaa attaagccag gttagactgg
     3841 gctaggtggc tcacgcctgt aatcccagca ctttgggagg ccaaggcggg tgaatcatga
     3901 ggtcaggagt ttgagaccat cctggctaac gtggcaaaac cccgtctcta ctaaaaatac
     3961 aaaaaaatta gccggcatgg tggtaggtga ctgtaatccc agctactcgg gaggctgagg
     4021 caggagactc gcttggacct gggagggaga ggttgcagtg agccgagatc acgccactgc
     4081 actccggcct gggcaaca
//
