LOCUS       NM_014109               5547 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens ATPase family AAA domain containing 2 (ATAD2), mRNA.
ACCESSION   NM_014109 NM_032365
VERSION     NM_014109.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5547)
  AUTHORS   Zhang,Z., Huo,W. and Li,J.
  TITLE     circATAD2 mitigates CD8+ T cells antitumor immune surveillance in
            breast cancer via IGF2BP3/m6A/PD-L1 manner
  JOURNAL   Cancer Immunol Immunother 73 (7), 130 (2024)
   PUBMED   38748254
  REMARK    GeneRIF: circATAD2 mitigates CD8[+] T cells antitumor immune
            surveillance in breast cancer via IGF2BP3/m[6]A/PD-L1 manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5547)
  AUTHORS   Cho,C., Ganser,C., Uchihashi,T., Kato,K. and Song,J.J.
  TITLE     Structure of the human ATAD2 AAA+ histone chaperone reveals
            mechanism of regulation and inter-subunit communication
  JOURNAL   Commun Biol 6 (1), 993 (2023)
   PUBMED   37770645
  REMARK    GeneRIF: Structure of the human ATAD2 AAA+ histone chaperone
            reveals mechanism of regulation and inter-subunit communication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5547)
  AUTHORS   Sun,T. and Liu,Z.
  TITLE     MicroRNA-139-5p suppresses non-small cell lung cancer progression
            by targeting ATAD2
  JOURNAL   Pathol Res Pract 249, 154719 (2023)
   PUBMED   37595446
  REMARK    GeneRIF: MicroRNA-139-5p suppresses non-small cell lung cancer
            progression by targeting ATAD2.
REFERENCE   4  (bases 1 to 5547)
  AUTHORS   Wang,C., Yin,Y., Sun,Z., Wang,Y., Li,F., Wang,Y., Zhang,Z. and
            Chen,X.
  TITLE     ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in
            Endometrial Cancer and Is Associated with Its Immune Infiltration
  JOURNAL   Dis Markers 2022, 2334338 (2022)
   PUBMED   36479043
  REMARK    GeneRIF: ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis
            in Endometrial Cancer and Is Associated with Its Immune
            Infiltration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5547)
  AUTHORS   Liu,H., Wen,Q., Yan,S., Zeng,W., Zou,Y., Liu,Q., Zhang,G., Zou,J.
            and Zou,X.
  TITLE     Tumor-Promoting ATAD2 and Its Preclinical Challenges
  JOURNAL   Biomolecules 12 (8), 1040 (2022)
   PUBMED   36008934
  REMARK    GeneRIF: Tumor-Promoting ATAD2 and Its Preclinical Challenges.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5547)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 5547)
  AUTHORS   Zou,J.X., Revenko,A.S., Li,L.B., Gemo,A.T. and Chen,H.W.
  TITLE     ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha,
            is required for coregulator occupancy and chromatin modification
  JOURNAL   Proc Natl Acad Sci U S A 104 (46), 18067-18072 (2007)
   PUBMED   17998543
  REMARK    GeneRIF: ANCCA associates directly with ERalpha and ACTR. It is
            selectively recruited to a subset of ERalpha target genes (cyclin
            D1, c-myc, and E2F1) and is required for their estrogen-induced
            expression and breast cancer cell proliferation.
REFERENCE   8  (bases 1 to 5547)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 5547)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
REFERENCE   10 (bases 1 to 5547)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP314109.1, BC113656.1,
            CB159561.1 and CA441499.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014109.3.
            
            Summary: A large family of ATPases has been described, whose key
            feature is that they share a conserved region of about 220 amino
            acids that contains an ATP-binding site. The proteins that belong
            to this family either contain one or two AAA (ATPases Associated
            with diverse cellular Activities) domains. AAA family proteins
            often perform chaperone-like functions that assist in the assembly,
            operation, or disassembly of protein complexes. The protein encoded
            by this gene contains two AAA domains, as well as a bromodomain.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC112942.1, SRR1803612.226958.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287394.10/ ENSP00000287394.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                BP314109.1         19-86
            69-4719             BC113656.1         1-4651
            4720-5104           CB159561.1         117-501
            5105-5547           CA441499.1         16-458              c
FEATURES             Location/Qualifiers
     source          1..5547
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..5547
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /note="ATPase family AAA domain containing 2"
                     /db_xref="GeneID:29028"
                     /db_xref="HGNC:HGNC:30123"
                     /db_xref="MIM:611941"
     exon            1..261
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..4263
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /EC_number="3.6.1.3"
                     /note="AAA nuclear coregulator cancer-associated protein"
                     /codon_start=1
                     /product="ATPase family AAA domain-containing protein 2"
                     /protein_id="NP_054828.2"
                     /db_xref="CCDS:CCDS6343.1"
                     /db_xref="GeneID:29028"
                     /db_xref="HGNC:HGNC:30123"
                     /db_xref="MIM:611941"
                     /translation="MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGA
                     AQKKPAATTAKAGDGSSVKEVETYHRTRALRSLRKDAQNSSDSSFEKNVEITEQLANG
                     RHFTRQLARQQADKKKEEHREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRI
                     RSRYSGVNQSMLFDKLITNTAEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNM
                     YTRGKQKDIQRTDEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDD
                     DEDDEDEEDGEEENQKRYYLRQRKATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYR
                     LSSAGPRSPYCKRMNRRRHAIHSSDSTSSSSSEDEQHFERRRKRSRNRAINRCLPLNF
                     RKDELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPE
                     VFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGE
                     SERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRG
                     EIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFL
                     EELAENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVA
                     MQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEALQRVFPHAEFRTNKTLDSDIS
                     CPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHLNRNACYQPMSFRPRILIV
                     GEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAPSI
                     VYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPHSALPEEVQELFIRD
                     YGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEPRSLTA
                     EEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMD
                     LSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAI
                     IKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEK
                     LKTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIESDTEE
                     TQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTACT
                     ELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILS
                     QPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQCIYRHRKDHDKTSLIQK
                     MEQEVENFSCSR"
     exon            262..410
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            411..460
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            461..626
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            627..729
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            730..817
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1021
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1139
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1247
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1356
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1472
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1647
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1736
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1896
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1987
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2302
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2435
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2622
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2808
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2944
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3141
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3301
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3424
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3568
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3958
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..4092
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            4093..4221
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     exon            4222..5547
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4877..4882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /note="hexamer: AATAAA"
     polyA_site      4895
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /note="major polyA site"
     regulatory      5517..5522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /note="hexamer: AATAAA"
     polyA_site      5547
                     /gene="ATAD2"
                     /gene_synonym="ANCCA; CT137; PRO2000"
                     /note="major polyA site"
ORIGIN      
        1 agaattcgga gcgcggaaga gccagagctg cgagcgcctg gagctggatc tctctccggt
       61 cgcgcacgcc gaggccagta gggagagaag atggtggttc tccgcagcag cttggagctg
      121 cacaaccact ccgcggcctc ggccacgggc tccttggacc tgtccagtga cttcctcagt
      181 ctggagcaca tcggccggag gcggctccgc tcggccggcg cggcgcagaa gaaacccgcg
      241 gcgaccacag ccaaagcggg cgatgggtca tcagttaagg aagttgaaac ctaccaccgg
      301 acacgtgctt taagatcttt gagaaaagat gcacagaatt cttcagattc tagttttgag
      361 aagaatgtgg aaataacgga gcaacttgct aatggcaggc attttacaag gcagttggcc
      421 agacagcagg ctgataaaaa aaaagaagag cacagagaag acaaagtgat tccagttact
      481 cggtcattga gggctagaaa catcgttcaa agtacagaac acttacatga agataatggt
      541 gatgttgaag tgcgtcgaag ttgtaggatt agaagtcgtt atagtggtgt aaaccagtcc
      601 atgctgtttg acaaacttat aactaacact gctgaagctg tacttcaaaa aatggatgac
      661 atgaagaaga tgcgtagaca gcgaatgaga gaacttgaag acttgggagt gtttaatgaa
      721 acagaagaaa gcaatcttaa tatgtacaca agaggaaaac agaaagatat tcaaagaact
      781 gatgaagaaa caactgataa tcaagaaggc agtgtggagt catctgaaga gggtgaagac
      841 caagaacatg aagatgatgg tgaagatgaa gatgatgaag atgatgatga tgatgacgat
      901 gatgatgatg atgatgatga tgaagatgat gaagatgaag aagatggaga agaagagaat
      961 cagaagcgat attatcttag acagagaaaa gctactgttt actatcaggc tccattggaa
     1021 aaacctcgtc accagagaaa gcccaacata ttttatagtg gcccagcttc tcctgcaaga
     1081 ccaagatacc gattatcttc cgcaggacca agaagtcctt actgtaaacg aatgaacagg
     1141 cgaaggcatg caatccacag tagtgactcg acttcatctt cctcctctga agatgaacag
     1201 cactttgaga ggcggaggaa aaggagtcgt aatagggcta tcaataggtg cctcccacta
     1261 aattttcgga aagatgaatt aaaaggcatt tataaagatc gaatgaaaat tggagcaagc
     1321 cttgccgatg ttgatccaat gcaactagat tcttcagtac gatttgatag tgttggtggc
     1381 ctgtctaatc atatagcagc tctaaaagag atggtggtgt ttccattact ttatccagaa
     1441 gtctttgaaa aatttaaaat tcaaccccca agaggttgtt tgttttatgg gccacctgga
     1501 actggaaaga ctctggttgc cagagcactt gccaatgagt gcagtcaagg ggataaaaga
     1561 gtagcatttt tcatgaggaa aggtgctgat tgtctaagta aatgggtagg agaatctgaa
     1621 agacagctac gattgctgtt tgatcaggcc tatcagatgc gcccatcaat tatttttttt
     1681 gacgaaattg atggtctggc tccagtacgg tcaagcaggc aagatcagat tcacagttct
     1741 attgtttcca ccctgctagc tcttatggat ggattggaca gcagagggga aattgtggtc
     1801 attggtgcta cgaacaggct agattctata gatcctgctt tacgaaggcc tggtcgcttt
     1861 gatagagaat tcctctttag cctgcctgat aaagaggctc gaaaagagat tctaaagatt
     1921 cacaccaggg attggaatcc caaaccactg gacacatttt tagaagagct agcagaaaac
     1981 tgtgttggat actgtggagc agatattaaa tcaatatgtg ctgaagctgc tttatgtgct
     2041 ttacgacgac gctacccaca gatctatacc actagtgaga aactgcagtt ggatctctct
     2101 tcaattaata tctcagctaa ggatttcgag gtagctatgc aaaagatgat accagcctcc
     2161 caaagagctg tgacatcacc tgggcaggca ctgtccaccg ttgtgaaacc actcctgcaa
     2221 aacactgttg acaagatttt agaagccctg cagagagtat ttccacatgc agaattcaga
     2281 acaaataaaa cattagactc agatatttct tgtcctctgc tagaaagtga cttggcttac
     2341 agtgatgatg atgttccatc agtttatgaa aatggacttt ctcagaaatc ttctcataag
     2401 gcaaaagaca attttaattt tcttcatttg aatagaaatg cttgttacca acctatgtct
     2461 tttcgaccaa gaatattgat agtaggagaa ccaggatttg ggcaaggttc tcacttggca
     2521 ccagctgtca ttcatgcttt ggaaaagttt actgtatata cattagacat tcctgttctt
     2581 tttggagtta gtactacatc ccctgaagaa acatgtgccc aggtgattcg tgaagctaag
     2641 agaacagcac caagtatagt gtatgttcct catatccacg tgtggtggga aatagttgga
     2701 ccgacactta aagccacatt taccacatta ttacagaata ttccttcatt tgctccagtt
     2761 ttactacttg caacttctga caaaccccat tccgctttgc cagaagaggt gcaagaattg
     2821 tttatccgtg attatggaga gatttttaat gtccagttac cggataaaga agaacggaca
     2881 aaattttttg aagatttaat tctaaaacaa gctgctaagc ctcctatatc aaaaaagaaa
     2941 gcagttttgc aggctttgga ggtactccca gtagcaccac cacctgagcc aagatcactg
     3001 acagcagaag aagtgaaacg actagaagaa caagaagaag atacatttag agaactgagg
     3061 attttcttaa gaaatgttac acataggctt gctattgaca agcgattccg agtgtttact
     3121 aagcctgttg accctgatga ggttcctgat tatgtcactg taataaagca accaatggac
     3181 ctttcatctg taatcagtaa aattgatcta cacaagtatc tgactgtgaa agactatttg
     3241 agagatattg atctaatctg tagtaatgcc ttagaataca atccagatag agatcctgga
     3301 gatcgtctta ttaggcatag agcctgtgct ttaagagata ctgcctatgc cataattaaa
     3361 gaagaacttg atgaagactt tgagcagctc tgtgaagaaa ttcaggaatc tagaaagaaa
     3421 agaggttgta gctcctccaa atatgccccg tcttactacc atgtgatgcc aaagcaaaat
     3481 tccactcttg ttggtgataa aagatcagac ccagagcaga atgaaaagct aaagacaccg
     3541 agtactcctg tggcttgcag cactcctgct cagttgaaga ggaaaattcg caaaaagtca
     3601 aactggtact taggcaccat aaaaaagcga aggaagattt cacaggcaaa ggatgatagc
     3661 cagaatgcca tagatcacaa aattgagagt gatacagagg aaactcaaga cacaagtgta
     3721 gatcataatg agaccggaaa cacaggagag tcttcggtgg aagaaaatga aaaacagcaa
     3781 aatgcctctg aaagcaaact ggaattgaga aataattcaa atacttgtaa tatagagaat
     3841 gagcttgaag actctaggaa gactacagca tgtacagaat tgagagacaa gattgcttgt
     3901 aatggagatg cttctagctc tcagataata catatttctg atgaaaatga aggaaaagaa
     3961 atgtgtgttc tgcgaatgac tcgagctaga cgttcccagg tagaacagca gcagctcatc
     4021 actgttgaaa aggctttggc aattctttct cagcctacac cctcacttgt tgtggatcat
     4081 gagcgattaa aaaatctttt gaagactgtt gttaaaaaaa gtcaaaacta caacatattt
     4141 cagttggaaa atttgtatgc agtaatcagc caatgtattt atcggcatcg caaggaccat
     4201 gataaaacat cacttattca gaaaatggag caagaggtag aaaacttcag ttgttccaga
     4261 tgatgatgtc atggtatcga gtattcttta tattcagttc ctatttaagt catttttgtc
     4321 atgtccgcct aattgatgta gtatgaaacc ctgcatcttt aaggaaaaga ttaaaatagt
     4381 aaaataaaag tatttaaact ttcctgatat ttatgtacat attaagataa atgtcatgtg
     4441 taagataact gataaatatt ggaactttgc tagaacaaga ccctgtagta atagtaataa
     4501 tagttgaagt ttggccaact cttaataaag ttattttggt aactaatgtt ttatggcact
     4561 taagaataat tagcagcgtt aaattttgtt tgtattaagc acttttaatt ttatccttcc
     4621 taaaaatagt ttattgtatc tgacaagaaa cttacttaac cattgtgtcc ttcccatctt
     4681 ttttgtcatc tttgttttct tcaaatgccc tcctcccatc tgccttgaga ttccctcgtc
     4741 ttcacttaaa agccagagtg caagtcatga tttgcgggag ggctcttgaa ccacttctgg
     4801 ctgcaccaca attctgtact tgagtatcac agtcattgtt tttgagacaa acatttttat
     4861 aattctaatt tgggttaata aagattttaa atatttcttg gtttactttt gtaattatat
     4921 acacaacaaa tgtattaata actaccttgt taaacacctt ttaatagcac aaggttttta
     4981 tatttgcaag ctgttgatat ctttctaaaa ctgtttaggt tatagtctat tgatactttt
     5041 tatatacaat tttataaata taaatattat aattttatat taatggtacc aaaaatacat
     5101 ttcttaaggt taaaagcatg cacttccatg catacttgct tttggggaga gtggggagaa
     5161 gacattctaa taatcagttt gtgaaatagc ttctgttgga aaccttttga ggggaataag
     5221 gaatggtcat ctaaaatgag agattctgga ttttaatgca gttcaaagtt gagctgtatt
     5281 tttgttgttg atttatctgg atttttttta aagccttcta aaacccagtg aattcaatac
     5341 cttaattagt acatactatc ttatgtaatg cataaagcaa tgccagtcac tgagaacatt
     5401 taaatatatt tatattcctg gagatacaca ttctcatttt tgttggttta ttataaatta
     5461 ttcttctaga tgcatctttt ataactagga tttcattttg tgtgtatagc ttatgtaata
     5521 aattttaaag gtgaaaactc tcttaaa
//
