LOCUS       NM_130768               1835 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ankyrin repeat, SAM and basic leucine zipper domain
            containing 1 (ASZ1), transcript variant 1, mRNA.
ACCESSION   NM_130768
VERSION     NM_130768.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1835)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 1835)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1835)
  AUTHORS   Wang,Q., Liu,X., Tang,N., Archambeault,D.R., Li,J., Song,H.,
            Tang,C., He,B., Matzuk,M.M. and Wang,Y.
  TITLE     GASZ promotes germ cell derivation from embryonic stem cells
  JOURNAL   Stem Cell Res 11 (2), 845-860 (2013)
   PUBMED   23816659
  REMARK    GeneRIF: Data reveal a potential role of GASZ during embryonic germ
            cell development and provide a powerful in vitro system for
            dissecting the molecular pathways in early germ cell formation
            during embryogenesis.
REFERENCE   4  (bases 1 to 1835)
  AUTHORS   Liu,C.T., Monda,K.L., Taylor,K.C., Lange,L., Demerath,E.W.,
            Palmas,W., Wojczynski,M.K., Ellis,J.C., Vitolins,M.Z., Liu,S.,
            Papanicolaou,G.J., Irvin,M.R., Xue,L., Griffin,P.J., Nalls,M.A.,
            Adeyemo,A., Liu,J., Li,G., Ruiz-Narvaez,E.A., Chen,W.M., Chen,F.,
            Henderson,B.E., Millikan,R.C., Ambrosone,C.B., Strom,S.S., Guo,X.,
            Andrews,J.S., Sun,Y.V., Mosley,T.H., Yanek,L.R., Shriner,D.,
            Haritunians,T., Rotter,J.I., Speliotes,E.K., Smith,M.,
            Rosenberg,L., Mychaleckyj,J., Nayak,U., Spruill,I., Garvey,W.T.,
            Pettaway,C., Nyante,S., Bandera,E.V., Britton,A.F., Zonderman,A.B.,
            Rasmussen-Torvik,L.J., Chen,Y.D., Ding,J., Lohman,K.,
            Kritchevsky,S.B., Zhao,W., Peyser,P.A., Kardia,S.L., Kabagambe,E.,
            Broeckel,U., Chen,G., Zhou,J., Wassertheil-Smoller,S.,
            Neuhouser,M.L., Rampersaud,E., Psaty,B., Kooperberg,C.,
            Manson,J.E., Kuller,L.H., Ochs-Balcom,H.M., Johnson,K.C.,
            Sucheston,L., Ordovas,J.M., Palmer,J.R., Haiman,C.A., McKnight,B.,
            Howard,B.V., Becker,D.M., Bielak,L.F., Liu,Y., Allison,M.A.,
            Grant,S.F., Burke,G.L., Patel,S.R., Schreiner,P.J., Borecki,I.B.,
            Evans,M.K., Taylor,H., Sale,M.M., Howard,V., Carlson,C.S.,
            Rotimi,C.N., Cushman,M., Harris,T.B., Reiner,A.P., Cupples,L.A.,
            North,K.E. and Fox,C.S.
  TITLE     Genome-wide association of body fat distribution in African
            ancestry populations suggests new loci
  JOURNAL   PLoS Genet 9 (8), e1003681 (2013)
   PUBMED   23966867
REFERENCE   5  (bases 1 to 1835)
  AUTHORS   Schunkert,H., Konig,I.R., Kathiresan,S., Reilly,M.P., Assimes,T.L.,
            Holm,H., Preuss,M., Stewart,A.F., Barbalic,M., Gieger,C.,
            Absher,D., Aherrahrou,Z., Allayee,H., Altshuler,D., Anand,S.S.,
            Andersen,K., Anderson,J.L., Ardissino,D., Ball,S.G.,
            Balmforth,A.J., Barnes,T.A., Becker,D.M., Becker,L.C., Berger,K.,
            Bis,J.C., Boekholdt,S.M., Boerwinkle,E., Braund,P.S., Brown,M.J.,
            Burnett,M.S., Buysschaert,I., Carlquist,J.F., Chen,L., Cichon,S.,
            Codd,V., Davies,R.W., Dedoussis,G., Dehghan,A., Demissie,S.,
            Devaney,J.M., Diemert,P., Do,R., Doering,A., Eifert,S.,
            Mokhtari,N.E., Ellis,S.G., Elosua,R., Engert,J.C., Epstein,S.E., de
            Faire,U., Fischer,M., Folsom,A.R., Freyer,J., Gigante,B.,
            Girelli,D., Gretarsdottir,S., Gudnason,V., Gulcher,J.R.,
            Halperin,E., Hammond,N., Hazen,S.L., Hofman,A., Horne,B.D.,
            Illig,T., Iribarren,C., Jones,G.T., Jukema,J.W., Kaiser,M.A.,
            Kaplan,L.M., Kastelein,J.J., Khaw,K.T., Knowles,J.W., Kolovou,G.,
            Kong,A., Laaksonen,R., Lambrechts,D., Leander,K., Lettre,G., Li,M.,
            Lieb,W., Loley,C., Lotery,A.J., Mannucci,P.M., Maouche,S.,
            Martinelli,N., McKeown,P.P., Meisinger,C., Meitinger,T.,
            Melander,O., Merlini,P.A., Mooser,V., Morgan,T., Muhleisen,T.W.,
            Muhlestein,J.B., Munzel,T., Musunuru,K., Nahrstaedt,J.,
            Nelson,C.P., Nothen,M.M., Olivieri,O., Patel,R.S., Patterson,C.C.,
            Peters,A., Peyvandi,F., Qu,L., Quyyumi,A.A., Rader,D.J.,
            Rallidis,L.S., Rice,C., Rosendaal,F.R., Rubin,D., Salomaa,V.,
            Sampietro,M.L., Sandhu,M.S., Schadt,E., Schafer,A., Schillert,A.,
            Schreiber,S., Schrezenmeir,J., Schwartz,S.M., Siscovick,D.S.,
            Sivananthan,M., Sivapalaratnam,S., Smith,A., Smith,T.B.,
            Snoep,J.D., Soranzo,N., Spertus,J.A., Stark,K., Stirrups,K.,
            Stoll,M., Tang,W.H., Tennstedt,S., Thorgeirsson,G.,
            Thorleifsson,G., Tomaszewski,M., Uitterlinden,A.G., van Rij,A.M.,
            Voight,B.F., Wareham,N.J., Wells,G.A., Wichmann,H.E., Wild,P.S.,
            Willenborg,C., Witteman,J.C., Wright,B.J., Ye,S., Zeller,T.,
            Ziegler,A., Cambien,F., Goodall,A.H., Cupples,L.A., Quertermous,T.,
            Marz,W., Hengstenberg,C., Blankenberg,S., Ouwehand,W.H., Hall,A.S.,
            Deloukas,P., Thompson,J.R., Stefansson,K., Roberts,R.,
            Thorsteinsdottir,U., O'Donnell,C.J., McPherson,R., Erdmann,J. and
            Samani,N.J.
  CONSRTM   Cardiogenics; CARDIoGRAM Consortium
  TITLE     Large-scale association analysis identifies 13 new susceptibility
            loci for coronary artery disease
  JOURNAL   Nat Genet 43 (4), 333-338 (2011)
   PUBMED   21378990
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1835)
  AUTHORS   Zink,D., Amaral,M.D., Englmann,A., Lang,S., Clarke,L.A.,
            Rudolph,C., Alt,F., Luther,K., Braz,C., Sadoni,N., Rosenecker,J.
            and Schindelhauer,D.
  TITLE     Transcription-dependent spatial arrangements of CFTR and adjacent
            genes in human cell nuclei
  JOURNAL   J Cell Biol 166 (6), 815-825 (2004)
   PUBMED   15364959
REFERENCE   7  (bases 1 to 1835)
  AUTHORS   Yan,W., Rajkovic,A., Viveiros,M.M., Burns,K.H., Eppig,J.J. and
            Matzuk,M.M.
  TITLE     Identification of Gasz, an evolutionarily conserved gene expressed
            exclusively in germ cells and encoding a protein with four ankyrin
            repeats, a sterile-alpha motif, and a basic leucine zipper
  JOURNAL   Mol Endocrinol 16 (6), 1168-1184 (2002)
   PUBMED   12040005
REFERENCE   8  (bases 1 to 1835)
  AUTHORS   Zenklusen,J.C., Conti,C.J. and Green,E.D.
  TITLE     Mutational and functional analyses reveal that ST7 is a highly
            conserved tumor-suppressor gene on human chromosome 7q31
  JOURNAL   Nat Genet 27 (4), 392-398 (2001)
   PUBMED   11279520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB457846.1 and AF461259.1.
            
            On May 17, 2019 this sequence version replaced NM_130768.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461259.1, AK093445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284629.7/ ENSP00000284629.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DB457846.1         31-34
            5-1835              AF461259.1         1-1831
FEATURES             Location/Qualifiers
     source          1..1835
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.2"
     gene            1..1835
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /note="ankyrin repeat, SAM and basic leucine zipper domain
                     containing 1"
                     /db_xref="GeneID:136991"
                     /db_xref="HGNC:HGNC:1350"
                     /db_xref="MIM:605797"
     exon            1..138
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1461
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin-like 1; ankyrin repeat, SAM and basic leucine
                     zipper domain-containing protein 1; ankyrin-like protein
                     1; germ cell-specific ankyrin, SAM and basic leucine
                     zipper domain-containing protein"
                     /codon_start=1
                     /product="ankyrin repeat, SAM and basic leucine zipper
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_570124.1"
                     /db_xref="CCDS:CCDS5772.1"
                     /db_xref="GeneID:136991"
                     /db_xref="HGNC:HGNC:1350"
                     /db_xref="MIM:605797"
                     /translation="MAASALRGLPVAGGGESSESEDDGWEIGYLDRTSQKLKRLLPIE
                     EKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRG
                     ANASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDG
                     HTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMP
                     SEIAKRNKHHEIFNLLSFTLNPLEGKLQQLTKEDTICKILTTDSDREKDHIFSSYTAF
                     GDLEVFLHGLGLEHMTDLLKERDITLRHLLTMREDEFTKNGITSKDQQKILAALKELQ
                     VEEIQFGELSEETKLEISGDEFLNFLLKLNKQCGHLITAVQNVITELPVNSQKITLEW
                     ASPQNFTSVCEELVNNVEDLSEKVCKLKDLIQKLQNERENDPTHIQLREEVSTWNSRI
                     LKRTAITICGFGFLLFICKLTFQRK"
     exon            139..238
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            239..361
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            362..473
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            474..585
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            586..720
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            721..845
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            846..921
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            922..978
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1088
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1194
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1308
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1835
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1724..1729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /note="hexamer: ATTAAA"
     polyA_site      1749
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggtgcc gacagggagc ttccttggct ggcatggcgg cgagcgcgct gcgaggcctg
       61 ccagtggctg gcggaggcga gagtagcgag agcgaggatg atggctggga gattgggtat
      121 ctcgaccgga cgtctcagaa attgaaaagg ctattaccca ttgaagaaaa gaaagaaaaa
      181 tttaagaaag caatgaccat cggagatgtt tcattggtcc aggagctcct agattctggc
      241 attagtgtag attccaactt tcagtatgga tggactcccc ttatgtatgc tgctagtgtt
      301 gccaatgcag agctggttcg ggtccttttg gacagaggtg ctaatgcaag ctttgagaag
      361 gataagcaaa gtattttgat aactgcatgt tctgctcatg gctcagagga acagatcttg
      421 aagtgtgtag aactactact ttcaagaaat gctgatccaa atgttgcttg taggagactt
      481 atgaccccaa tcatgtatgc tgctcgagat ggtcacaccc aggttgttgc tctccttgtt
      541 gctcatggag cagaagttaa tacccaggat gagaatggtt acactgcttt aacgtgggca
      601 gcacgtcagg gtcataaaaa tatagttttg aagttgcttg aacttggagc taataaaatg
      661 ctacaaacca aagatggaaa gatgccaagt gagattgcaa aaagaaacaa acatcatgag
      721 atcttcaact tactttcttt tactttaaat ccattggaag gaaaacttca acagctaact
      781 aaagaagaca ctatttgtaa aatattgaca acagattctg atagagaaaa agatcacatt
      841 tttagttcat atacagcatt tggagatctg gaagtatttt tacatggtct tggacttgaa
      901 catatgacag atttactaaa ggaaagggat ataacgttaa gacatctttt gaccatgagg
      961 gaagatgaat ttacaaagaa tggaattacc agtaaagacc agcagaaaat tctggctgct
     1021 cttaaagaac tacaggtaga agagatacaa tttggagagc tatctgaaga gacaaagttg
     1081 gaaatcagtg gtgatgagtt cctcaacttt cttctcaaat taaataaaca gtgtggccat
     1141 ttaataacag ctgtacagaa tgttattact gagttacctg taaattctca aaagataaca
     1201 ctggaatggg cttctcccca gaattttact tcagtttgtg aagaattggt taataatgtt
     1261 gaagatttga gtgaaaaggt ctgcaaacta aaagacctaa ttcaaaagtt gcaaaatgaa
     1321 cgggaaaatg atccaactca tatacaatta agggaagaag tatctacatg gaatagtaga
     1381 attttgaaga ggacagctat taccatatgc ggattcggtt ttcttctttt catttgcaag
     1441 ctaactttcc agaggaaata atccaaatat ttgttttaag ttatatatac acatcttatt
     1501 gaaccatcca aaaatcattg cttttaactg tttgcagcac aatataactt tacattcttt
     1561 gccaatattc cataggaaaa attttgacaa tgtggagttt ttttttaaaa agtggtttgt
     1621 tactttgact tataaataca atttgttatg tttatgttaa ttgtgattag gtagtaaagt
     1681 ataagtaatt ttttggtttg atcgtatcta aatcacattc aaaattaaag ttatatctaa
     1741 tatctttgac attttttaaa gtgtgttcat ttgtcagtga atcgtacagg atttgtaaag
     1801 tgttcataaa ttgagctttc ttttgtttct ttttt
//
