LOCUS       NP_570124                475 aa            linear   PRI 27-APR-2025
DEFINITION  ankyrin repeat, SAM and basic leucine zipper domain-containing
            protein 1 isoform 1 [Homo sapiens].
ACCESSION   NP_570124
VERSION     NP_570124.1
DBSOURCE    REFSEQ: accession NM_130768.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 475)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (residues 1 to 475)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 475)
  AUTHORS   Wang,Q., Liu,X., Tang,N., Archambeault,D.R., Li,J., Song,H.,
            Tang,C., He,B., Matzuk,M.M. and Wang,Y.
  TITLE     GASZ promotes germ cell derivation from embryonic stem cells
  JOURNAL   Stem Cell Res 11 (2), 845-860 (2013)
   PUBMED   23816659
  REMARK    GeneRIF: Data reveal a potential role of GASZ during embryonic germ
            cell development and provide a powerful in vitro system for
            dissecting the molecular pathways in early germ cell formation
            during embryogenesis.
REFERENCE   4  (residues 1 to 475)
  AUTHORS   Liu,C.T., Monda,K.L., Taylor,K.C., Lange,L., Demerath,E.W.,
            Palmas,W., Wojczynski,M.K., Ellis,J.C., Vitolins,M.Z., Liu,S.,
            Papanicolaou,G.J., Irvin,M.R., Xue,L., Griffin,P.J., Nalls,M.A.,
            Adeyemo,A., Liu,J., Li,G., Ruiz-Narvaez,E.A., Chen,W.M., Chen,F.,
            Henderson,B.E., Millikan,R.C., Ambrosone,C.B., Strom,S.S., Guo,X.,
            Andrews,J.S., Sun,Y.V., Mosley,T.H., Yanek,L.R., Shriner,D.,
            Haritunians,T., Rotter,J.I., Speliotes,E.K., Smith,M.,
            Rosenberg,L., Mychaleckyj,J., Nayak,U., Spruill,I., Garvey,W.T.,
            Pettaway,C., Nyante,S., Bandera,E.V., Britton,A.F., Zonderman,A.B.,
            Rasmussen-Torvik,L.J., Chen,Y.D., Ding,J., Lohman,K.,
            Kritchevsky,S.B., Zhao,W., Peyser,P.A., Kardia,S.L., Kabagambe,E.,
            Broeckel,U., Chen,G., Zhou,J., Wassertheil-Smoller,S.,
            Neuhouser,M.L., Rampersaud,E., Psaty,B., Kooperberg,C.,
            Manson,J.E., Kuller,L.H., Ochs-Balcom,H.M., Johnson,K.C.,
            Sucheston,L., Ordovas,J.M., Palmer,J.R., Haiman,C.A., McKnight,B.,
            Howard,B.V., Becker,D.M., Bielak,L.F., Liu,Y., Allison,M.A.,
            Grant,S.F., Burke,G.L., Patel,S.R., Schreiner,P.J., Borecki,I.B.,
            Evans,M.K., Taylor,H., Sale,M.M., Howard,V., Carlson,C.S.,
            Rotimi,C.N., Cushman,M., Harris,T.B., Reiner,A.P., Cupples,L.A.,
            North,K.E. and Fox,C.S.
  TITLE     Genome-wide association of body fat distribution in African
            ancestry populations suggests new loci
  JOURNAL   PLoS Genet 9 (8), e1003681 (2013)
   PUBMED   23966867
REFERENCE   5  (residues 1 to 475)
  AUTHORS   Schunkert,H., Konig,I.R., Kathiresan,S., Reilly,M.P., Assimes,T.L.,
            Holm,H., Preuss,M., Stewart,A.F., Barbalic,M., Gieger,C.,
            Absher,D., Aherrahrou,Z., Allayee,H., Altshuler,D., Anand,S.S.,
            Andersen,K., Anderson,J.L., Ardissino,D., Ball,S.G.,
            Balmforth,A.J., Barnes,T.A., Becker,D.M., Becker,L.C., Berger,K.,
            Bis,J.C., Boekholdt,S.M., Boerwinkle,E., Braund,P.S., Brown,M.J.,
            Burnett,M.S., Buysschaert,I., Carlquist,J.F., Chen,L., Cichon,S.,
            Codd,V., Davies,R.W., Dedoussis,G., Dehghan,A., Demissie,S.,
            Devaney,J.M., Diemert,P., Do,R., Doering,A., Eifert,S.,
            Mokhtari,N.E., Ellis,S.G., Elosua,R., Engert,J.C., Epstein,S.E., de
            Faire,U., Fischer,M., Folsom,A.R., Freyer,J., Gigante,B.,
            Girelli,D., Gretarsdottir,S., Gudnason,V., Gulcher,J.R.,
            Halperin,E., Hammond,N., Hazen,S.L., Hofman,A., Horne,B.D.,
            Illig,T., Iribarren,C., Jones,G.T., Jukema,J.W., Kaiser,M.A.,
            Kaplan,L.M., Kastelein,J.J., Khaw,K.T., Knowles,J.W., Kolovou,G.,
            Kong,A., Laaksonen,R., Lambrechts,D., Leander,K., Lettre,G., Li,M.,
            Lieb,W., Loley,C., Lotery,A.J., Mannucci,P.M., Maouche,S.,
            Martinelli,N., McKeown,P.P., Meisinger,C., Meitinger,T.,
            Melander,O., Merlini,P.A., Mooser,V., Morgan,T., Muhleisen,T.W.,
            Muhlestein,J.B., Munzel,T., Musunuru,K., Nahrstaedt,J.,
            Nelson,C.P., Nothen,M.M., Olivieri,O., Patel,R.S., Patterson,C.C.,
            Peters,A., Peyvandi,F., Qu,L., Quyyumi,A.A., Rader,D.J.,
            Rallidis,L.S., Rice,C., Rosendaal,F.R., Rubin,D., Salomaa,V.,
            Sampietro,M.L., Sandhu,M.S., Schadt,E., Schafer,A., Schillert,A.,
            Schreiber,S., Schrezenmeir,J., Schwartz,S.M., Siscovick,D.S.,
            Sivananthan,M., Sivapalaratnam,S., Smith,A., Smith,T.B.,
            Snoep,J.D., Soranzo,N., Spertus,J.A., Stark,K., Stirrups,K.,
            Stoll,M., Tang,W.H., Tennstedt,S., Thorgeirsson,G.,
            Thorleifsson,G., Tomaszewski,M., Uitterlinden,A.G., van Rij,A.M.,
            Voight,B.F., Wareham,N.J., Wells,G.A., Wichmann,H.E., Wild,P.S.,
            Willenborg,C., Witteman,J.C., Wright,B.J., Ye,S., Zeller,T.,
            Ziegler,A., Cambien,F., Goodall,A.H., Cupples,L.A., Quertermous,T.,
            Marz,W., Hengstenberg,C., Blankenberg,S., Ouwehand,W.H., Hall,A.S.,
            Deloukas,P., Thompson,J.R., Stefansson,K., Roberts,R.,
            Thorsteinsdottir,U., O'Donnell,C.J., McPherson,R., Erdmann,J. and
            Samani,N.J.
  CONSRTM   Cardiogenics; CARDIoGRAM Consortium
  TITLE     Large-scale association analysis identifies 13 new susceptibility
            loci for coronary artery disease
  JOURNAL   Nat Genet 43 (4), 333-338 (2011)
   PUBMED   21378990
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 475)
  AUTHORS   Zink,D., Amaral,M.D., Englmann,A., Lang,S., Clarke,L.A.,
            Rudolph,C., Alt,F., Luther,K., Braz,C., Sadoni,N., Rosenecker,J.
            and Schindelhauer,D.
  TITLE     Transcription-dependent spatial arrangements of CFTR and adjacent
            genes in human cell nuclei
  JOURNAL   J Cell Biol 166 (6), 815-825 (2004)
   PUBMED   15364959
REFERENCE   7  (residues 1 to 475)
  AUTHORS   Yan,W., Rajkovic,A., Viveiros,M.M., Burns,K.H., Eppig,J.J. and
            Matzuk,M.M.
  TITLE     Identification of Gasz, an evolutionarily conserved gene expressed
            exclusively in germ cells and encoding a protein with four ankyrin
            repeats, a sterile-alpha motif, and a basic leucine zipper
  JOURNAL   Mol Endocrinol 16 (6), 1168-1184 (2002)
   PUBMED   12040005
REFERENCE   8  (residues 1 to 475)
  AUTHORS   Zenklusen,J.C., Conti,C.J. and Green,E.D.
  TITLE     Mutational and functional analyses reveal that ST7 is a highly
            conserved tumor-suppressor gene on human chromosome 7q31
  JOURNAL   Nat Genet 27 (4), 392-398 (2001)
   PUBMED   11279520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB457846.1 and AF461259.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461259.1, AK093445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284629.7/ ENSP00000284629.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.2"
     Protein         1..475
                     /product="ankyrin repeat, SAM and basic leucine zipper
                     domain-containing protein 1 isoform 1"
                     /note="ankyrin-like 1; ankyrin repeat, SAM and basic
                     leucine zipper domain-containing protein 1; ankyrin-like
                     protein 1; germ cell-specific ankyrin, SAM and basic
                     leucine zipper domain-containing protein"
                     /calculated_mol_wt=53327
     Region          1..25
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWH4.1)"
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8VD46; propagated from
                     UniProtKB/Swiss-Prot (Q8WWH4.1)"
     Site            18
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8VD46; propagated from
                     UniProtKB/Swiss-Prot (Q8WWH4.1)"
     Site            20
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8VD46; propagated from
                     UniProtKB/Swiss-Prot (Q8WWH4.1)"
     Region          45..74
                     /region_name="ANK 1. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWH4.1)"
     Region          <53..234
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          78..109
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          78..107
                     /region_name="ANK 2. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWH4.1)"
     Site            order(110,112,116..117,121..123,125..126,134,137,146,148,
                     150,154..155,158..160,162..163,167,170,179,181,183,
                     187..188,191..193,195..196,200,203)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          110..146
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          110..144
                     /region_name="ANK 3. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWH4.1)"
     Region          148..179
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          148..177
                     /region_name="ANK 4. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWH4.1)"
     Region          181..210
                     /region_name="ANK 5. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWH4.1)"
     Region          181..206
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          214..243
                     /region_name="ANK 6. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWH4.1)"
     Region          272..334
                     /region_name="SAM_ASZ1"
                     /note="SAM domain of ASZ1 subfamily; cd09521"
                     /db_xref="CDD:188920"
     CDS             1..475
                     /gene="ASZ1"
                     /gene_synonym="ALP1; ANKL1; C7orf7; CT1.19; GASZ; Orf3"
                     /coded_by="NM_130768.3:34..1461"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS5772.1"
                     /db_xref="GeneID:136991"
                     /db_xref="HGNC:HGNC:1350"
                     /db_xref="MIM:605797"
ORIGIN      
        1 maasalrglp vagggesses eddgweigyl drtsqklkrl lpieekkekf kkamtigdvs
       61 lvqelldsgi svdsnfqygw tplmyaasva naelvrvlld rganasfekd kqsilitacs
      121 ahgseeqilk cvelllsrna dpnvacrrlm tpimyaardg htqvvallva hgaevntqde
      181 ngytaltwaa rqghknivlk llelgankml qtkdgkmpse iakrnkhhei fnllsftlnp
      241 legklqqltk edtickiltt dsdrekdhif ssytafgdle vflhglgleh mtdllkerdi
      301 tlrhlltmre deftkngits kdqqkilaal kelqveeiqf gelseetkle isgdeflnfl
      361 lklnkqcghl itavqnvite lpvnsqkitl ewaspqnfts vceelvnnve dlsekvcklk
      421 dliqklqner endpthiqlr eevstwnsri lkrtaiticg fgfllfickl tfqrk
//
