LOCUS       NM_015338               7052 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens ASXL transcriptional regulator 1 (ASXL1), transcript
            variant 1, mRNA.
ACCESSION   NM_015338
VERSION     NM_015338.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7052)
  AUTHORS   Wang,M., Zhao,H.Y., Li,D.Q. and Chen,P.
  TITLE     [Relationship between DTA Mutations and Thromboembolism in Patients
            with Myeloproliferative Neoplasms]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 32 (3), 819-824 (2024)
   PUBMED   38926973
  REMARK    GeneRIF: [Relationship between DTA Mutations and Thromboembolism in
            Patients with Myeloproliferative Neoplasms].
REFERENCE   2  (bases 1 to 7052)
  AUTHORS   Kohnke,T., Nuno,K.A., Alder,C.C., Gars,E.J., Phan,P., Fan,A.C. and
            Majeti,R.
  TITLE     Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein
            Associated with Aberrant Deubiquitination of H2AK119
  JOURNAL   Blood Cancer Discov 5 (3), 202-223 (2024)
   PUBMED   38359087
  REMARK    GeneRIF: Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated
            Protein Associated with Aberrant Deubiquitination of H2AK119.
REFERENCE   3  (bases 1 to 7052)
  AUTHORS   Collins,T.B., Laranjeira,A.B.A., Kong,T., Fulbright,M.C.,
            Fisher,D.A.C., Sturgeon,C.M., Batista,L.F.Z. and Oh,S.T.
  TITLE     Altered erythropoiesis via JAK2 and ASXL1 mutations in
            myeloproliferative neoplasms
  JOURNAL   Exp Hematol 132, 104178 (2024)
   PUBMED   38340948
  REMARK    GeneRIF: Altered erythropoiesis via JAK2 and ASXL1 mutations in
            myeloproliferative neoplasms.
REFERENCE   4  (bases 1 to 7052)
  AUTHORS   Ahn,H.J., An,H.Y., Ryu,G., Lim,J., Sun,C., Song,H., Choi,S.Y.,
            Lee,H., Maurer,T., Nachun,D., Kwon,S., Lee,S.R., Lip,G.Y.H., Oh,S.,
            Jaiswal,S., Koh,Y. and Choi,E.K.
  TITLE     Clonal haematopoiesis of indeterminate potential and atrial
            fibrillation: an east Asian cohort study
  JOURNAL   Eur Heart J 45 (10), 778-790 (2024)
   PUBMED   38231881
  REMARK    GeneRIF: Clonal haematopoiesis of indeterminate potential and
            atrial fibrillation: an east Asian cohort study.
REFERENCE   5  (bases 1 to 7052)
  AUTHORS   Johnson,S.M., Haberberger,J., Galeotti,J., Ramkissoon,L.,
            Coombs,C.C., Richardson,D.R., Foster,M.C., Duncan,D.,
            Montgomery,N.D., Ferguson,N.L. and Zeidner,J.F.
  TITLE     Comprehensive genomic profiling reveals molecular subsets of
            ASXL1-mutated myeloid neoplasms
  JOURNAL   Leuk Lymphoma 65 (2), 209-218 (2024)
   PUBMED   37921062
  REMARK    GeneRIF: Comprehensive genomic profiling reveals molecular subsets
            of ASXL1-mutated myeloid neoplasms.
            Review article
REFERENCE   6  (bases 1 to 7052)
  AUTHORS   Wang,J., Yuan,Y., Zhou,Y., Guo,L., Zhang,L., Kuai,X., Deng,B.,
            Pan,Z., Li,D. and He,F.
  TITLE     Protein interaction data set highlighted with human Ras-MAPK/PI3K
            signaling pathways
  JOURNAL   J Proteome Res 7 (9), 3879-3889 (2008)
   PUBMED   18624398
REFERENCE   7  (bases 1 to 7052)
  AUTHORS   Scotto,L., Narayan,G., Nandula,S.V., Arias-Pulido,H.,
            Subramaniyam,S., Schneider,A., Kaufmann,A.M., Wright,J.D.,
            Pothuri,B., Mansukhani,M. and Murty,V.V.
  TITLE     Identification of copy number gain and overexpressed genes on
            chromosome arm 20q by an integrative genomic approach in cervical
            cancer: potential role in progression
  JOURNAL   Genes Chromosomes Cancer 47 (9), 755-765 (2008)
   PUBMED   18506748
REFERENCE   8  (bases 1 to 7052)
  AUTHORS   Cho,Y.S., Kim,E.J., Park,U.H., Sin,H.S. and Um,S.J.
  TITLE     Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts
            as a ligand-dependent coactivator for retinoic acid receptor
  JOURNAL   J Biol Chem 281 (26), 17588-17598 (2006)
   PUBMED   16606617
REFERENCE   9  (bases 1 to 7052)
  AUTHORS   Fisher,C.L., Berger,J., Randazzo,F. and Brock,H.W.
  TITLE     A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE
            1, maps to chromosome 20q11
  JOURNAL   Gene 306, 115-126 (2003)
   PUBMED   12657473
REFERENCE   10 (bases 1 to 7052)
  AUTHORS   Russell,B., Tan,W.H. and Graham,J.M. Jr.
  TITLE     Bohring-Opitz Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29446906
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121583.25, BC137280.1,
            AL034550.31 and BU686340.1.
            
            On Aug 31, 2019 this sequence version replaced NM_015338.5.
            
            Summary: This gene is similar to the Drosophila additional sex
            combs gene, which encodes a chromatin-binding protein required for
            normal determination of segment identity in the developing embryo.
            The protein is a member of the Polycomb group of proteins, which
            are necessary for the maintenance of stable repression of homeotic
            and other loci. The protein is thought to disrupt chromatin in
            localized areas, enhancing transcription of certain genes while
            repressing the transcription of other genes. The protein encoded by
            this gene functions as a ligand-dependent co-activator for retinoic
            acid receptor in cooperation with nuclear receptor coactivator 1.
            Mutations in this gene are associated with myelodysplastic
            syndromes and chronic myelomonocytic leukemia. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ438952.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375687.10/ ENSP00000364839.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               AL121583.25        7715-8141
            428-5624            BC137280.1         178-5374
            5625-7019           AL034550.31        2666-4060
            7020-7052           BU686340.1         18-50               c
FEATURES             Location/Qualifiers
     source          1..7052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..7052
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /note="ASXL transcriptional regulator 1"
                     /db_xref="GeneID:171023"
                     /db_xref="HGNC:HGNC:18318"
                     /db_xref="MIM:612990"
     exon            1..502
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..5071
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative Polycomb group protein ASXL1; additional sex
                     combs like transcriptional regulator 1; additional sex
                     combs like 1, transcriptional regulator"
                     /codon_start=1
                     /product="polycomb group protein ASXL1 isoform 1"
                     /protein_id="NP_056153.2"
                     /db_xref="CCDS:CCDS13201.1"
                     /db_xref="GeneID:171023"
                     /db_xref="HGNC:HGNC:18318"
                     /db_xref="MIM:612990"
                     /translation="MKDKQKKKKERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLK
                     EMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKKDALQWSRHPATVEGEEP
                     EDTADVESCGSNEASTVSGENDVSLDETSSNASCSTESQSRPLSNPRDSYRASSQANK
                     QKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIR
                     GQAEVTQDPAPLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHAL
                     PSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFFTHAAQSWRERLADGEFTHEMQ
                     VRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGES
                     VRIQRGPATRQRDGHFKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYK
                     DGEAKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAEPDNLARASASPDRIP
                     SLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEE
                     PKVPPIRIQLSRIKPPWVVKGQPTYQICPRIIPTTESSCRGWTGARTLADIKARALQV
                     RGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACGHPEPRGGPS
                     TPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLT
                     DGLGDASQLPVAPTGDQPCQALPLLSSQTSVAERLVEQPQLHPDVRTECESGTTSWES
                     DDEEQGPTVPADNGPIPSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSPTDC
                     LQNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPE
                     SREHIPSVEPQVGEEWEKAAPTPPALPGDLTAEEGLDPLDSLTSLWTVPSRGGSDSNG
                     SYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVD
                     KDEKPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQ
                     PRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLPPAHDDSMSESPQVPLTKDQSHGS
                     LRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNC
                     KAVPSFDSLHPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKS
                     PGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKKLFGSGNVAATLQRPRPA
                     DPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPL
                     KANAENRKATGHSPLELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSI
                     KQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGASHSASLSLQMFT
                     DSSTVESISLQCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLVVR"
     exon            503..585
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            586..588
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            589..697
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            698..818
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            819..916
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1010
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1163
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1327
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1424
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1530
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..2164
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..7052
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5070..5075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /note="hexamer: AATAAA"
     polyA_site      5091
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /note="major polyA site"
     regulatory      6123..6128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /note="hexamer: ATTAAA"
     polyA_site      6149
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
     regulatory      7032..7037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /note="hexamer: AATAAA"
     polyA_site      7052
                     /gene="ASXL1"
                     /gene_synonym="BOPS; MDS"
                     /note="major polyA site"
ORIGIN      
        1 acacacactc acacacaccc acggcagaca cgcacgcacc cgggcgccga agggaaagcc
       61 gcgtctcgcc ctcccgcccc gccgtcggtc ctgtctcagt ccctcagcag agcgggaaag
      121 cggaggccgg agccgtgacc tctgaccccg tggttatgcg gagccgccgc attccttagc
      181 gatcgcgggg cagccgccgc tgccgccgtg ggcgactgac gcagcgcggg cgcgtggagc
      241 cgccgccgcc cctcccccac cgccgctctc gcgccagccg gtccccgcgt gcccgcccct
      301 tctccccggc cgcacccgag acctcgcgcg ccgccgctgc cacgcgcccc ccccaccgcc
      361 gccgccgccc cagccccgcg ccaccgcccc agcccgccca gcccggaggt cccgcgtgga
      421 gctgccgccg ccgccgggga gaaggatgaa ggacaaacag aagaagaaga aggagcgcac
      481 gtgggccgag gccgcgcgcc tggtattaga aaactactcg gatgctccaa tgacaccaaa
      541 acagattctg caggtcatag aggcagaagg actaaaggaa atgagaagtg ggacttcccc
      601 tctcgcatgc ctcaatgcta tgctacattc caattcaaga ggaggagagg ggttgtttta
      661 taaactgcct ggccgaatca gccttttcac gctcaagaag gatgccctgc agtggtctcg
      721 ccatccagct acagtggagg gagaggagcc agaggacacg gctgatgtgg agagctgtgg
      781 gtctaatgaa gccagcactg tgagtggtga aaacgatgta tctcttgatg aaacatcttc
      841 gaacgcatcc tgttctacag aatctcagag tcgacctctt tccaatccca gggacagcta
      901 cagagcttcc tcacaggcga acaaacaaaa gaaaaagact ggggtgatgc tgcctcgagt
      961 tgtcctgact cctctgaagg taaacggggc ccacgtggaa tctgcatcag ggttctcggg
     1021 ctgccacgcc gatggcgaga gcggcagccc gtccagcagc agcagcggct ctctggccct
     1081 gggcagcgct gctattcgtg gccaggccga ggtcacccag gaccctgccc cgctcctgag
     1141 aggcttccgg aagccagcca caggtcaaat gaagcgcaac agaggggaag aaatagattt
     1201 tgagacacct gggtccattc ttgtcaacac caacctccgt gccctgatca actctcggac
     1261 cttccatgcc ttaccatcac acttccagca gcagctcctc ttcctcctgc ctgaagtaga
     1321 cagacaggtg gggacggatg gcctgttgcg tctcagcagc agtgcactaa ataacgagtt
     1381 ttttacccat gcggctcaga gctggcggga gcgcctggct gatggtgaat ttactcatga
     1441 gatgcaagtc aggatacgac aggaaatgga gaaggaaaag aaggtggaac aatggaaaga
     1501 aaagttcttt gaagactact atggacagaa gctgggtttg accaaagaag agtcattgca
     1561 gcagaacgtg ggccaggagg aggctgaaat caaaagtggc ttgtgtgtcc caggagaatc
     1621 agtgcgtata cagcgtggtc cagccacccg acagcgagat gggcatttta agaaacgctc
     1681 tcggccagat ctccgaacca gagccagaag gaatctgtac aaaaaacagg agtcagaaca
     1741 agcaggggtt gctaaggatg caaaatctgt ggcctcagat gttcccctct acaaggatgg
     1801 ggaggctaag actgacccag cagggctgag cagtccccat ctgccaggca catcctctgc
     1861 agcacccgac ctggagggtc ccgaattccc agttgagtct gtggcttctc ggatccaggc
     1921 tgagccagac aacttggcac gtgcctctgc atctccagac agaattccta gcctgcctca
     1981 ggaaactgtg gatcaggaac ccaaggatca gaagaggaaa tcctttgagc aggcggcctc
     2041 tgcatccttt cccgaaaaga agccccggct tgaagatcgt cagtcctttc gtaacacaat
     2101 tgaaagtgtt cacaccgaaa agccacagcc cactaaagag gagcccaaag tcccgcccat
     2161 ccggattcaa ctttcacgta tcaaaccacc ctgggtggtt aaaggtcagc ccacttacca
     2221 gatatgcccc cggatcatcc ccaccacgga gtcctcctgc cggggttgga ctggcgccag
     2281 gaccctcgca gacattaaag cccgtgctct gcaggtccga ggggcgagag gtcaccactg
     2341 ccatagagag gcggccacca ctgccatcgg aggggggggt ggcccgggtg gaggtggcgg
     2401 cggggccacc gatgagggag gtggcagagg cagcagcagt ggtgatggtg gtgaggcctg
     2461 tggccaccct gagcccaggg gaggcccgag cacccctgga aagtgtacgt cagatctaca
     2521 gcgaacacaa ctactgccgc cttatcctct aaatggggag catacccagg ccggaactgc
     2581 catgtccaga gctaggagag aggacctgcc ttctctgaga aaggaggaaa gctgcctact
     2641 acagagggct acagttggac tcacagatgg gctaggagat gcctcccaac tccccgttgc
     2701 tcccactggg gaccagccat gccaggcctt gcccctactg tcctcccaaa cctcagtagc
     2761 tgagagatta gtggagcagc ctcagttgca tccggatgtt agaactgaat gtgagtctgg
     2821 caccacttcc tgggaaagtg atgatgagga gcaaggaccc accgttcctg cagacaatgg
     2881 tcccattccg tctctagtgg gagatgatac attagagaaa ggaactggcc aagctcttga
     2941 cagtcatccc actatgaagg atcctgtaaa tgtgaccccc agttccacac ctgaatcctc
     3001 accgactgat tgcctgcaga acagagcatt tgatgacgaa ttagggcttg gtggctcatg
     3061 ccctcctatg agggaaagtg atactagaca agaaaacttg aaaaccaagg ctctcgtttc
     3121 taacagttct ttgcattgga tacccatccc atcgaatgat gaggtagtga aacagcccaa
     3181 accagaatcc agagaacaca taccatctgt tgagccccag gttggagagg agtgggagaa
     3241 agctgctccc acccctcctg cattgcctgg ggatttgaca gctgaggagg gtctagatcc
     3301 tcttgacagc cttacttcac tctggactgt gccatctcga ggaggcagtg acagcaatgg
     3361 cagttactgt caacaggtgg acattgaaaa gctgaaaatc aacggagact ctgaagcact
     3421 gagtcctcac ggtgagtcca cggatacagc ctctgacttt gaaggtcacc tcacggagga
     3481 cagcagtgag gctgacacta gagaagctgc agtgacaaag ggatcttcgg tggacaagga
     3541 tgagaaaccc aattggaacc aatctgcccc actgtccaag gtgaatggtg acatgcgtct
     3601 ggttacaagg acagatggga tggttgctcc tcagagctgg gtgtctcgag tatgtgcggt
     3661 ccgccaaaag atcccagatt ccctactgct ggccagtact gagtaccagc caagagccgt
     3721 gtgcctgtcc atgcctgggt cctcagtgga ggccactaac ccacttgtga tgcagttgct
     3781 gcagggtagc ttgcccctag agaaggttct tccaccagcc cacgatgaca gcatgtcaga
     3841 atccccacaa gtaccactta caaaagacca gagccatggc tcgctacgca tgggatcttt
     3901 acatggtctt ggaaaaaaca gtggcatggt tgatggaagc agccccagtt ctttaagggc
     3961 tttgaaggag cctcttctgc cagatagctg tgaaacaggc actggtcttg ccaggattga
     4021 ggccacccag gctcctggag caccccaaaa gaattgcaag gcagtcccaa gttttgactc
     4081 cctccatcca gtgacaaatc ccattacatc ctctaggaaa ctggaagaaa tggattccaa
     4141 agagcagttc tcttccttta gttgtgaaga tcagaaggaa gtccgtgcta tgtcacagga
     4201 cagtaattca aatgctgctc caggaaagag cccaggagat cttactacct cgagaacacc
     4261 tcgtttctca tctccaaatg tgatctcctt tggtccagag cagacaggtc gggccctggg
     4321 tgatcagagc aatgttacag gccaagggaa gaagcttttt ggctctggga atgtggctgc
     4381 aacccttcag cgccccaggc ctgcggaccc gatgcctctt cctgctgaga tccctccagt
     4441 ttttcccagt gggaagttgg gaccaagcac aaactccatg tctggtgggg tacagactcc
     4501 aagggaagac tgggctccaa agccacatgc ctttgttggc agcgtcaaga atgagaagac
     4561 ttttgtgggg ggtcctctta aggcaaatgc cgagaacagg aaagctactg ggcatagtcc
     4621 cctggaactg gtgggtcact tggaagggat gccctttgtc atggacttgc ccttctggaa
     4681 attaccccga gagccaggga aggggctcag tgagcctctg gagccttctt ctctcccctc
     4741 ccaactcagc atcaagcagg cattttatgg gaagctttct aaactccaac tgagttccac
     4801 cagctttaat tattcctcta gctctcccac ctttcccaaa ggccttgctg gaagtgtggt
     4861 gcagctgagc cacaaagcaa actttggtgc gagccacagt gcatcacttt ccttgcaaat
     4921 gttcactgac agcagcacgg tggaaagcat ctcgctccag tgtgcgtgca gcctgaaagc
     4981 catgatcatg tgccaaggct gcggtgcgtt ctgtcacgat gactgtattg gaccctcaaa
     5041 gctctgtgta ttgtgccttg tggtgagata ataaattatg gccatgggaa acattgtata
     5101 tttagtgtgt gtattttgat aatgattgat cttaaatctg tatacagaat atcattgata
     5161 taatactctt taggcaggag cactcttgcc ttcccccaaa atttacactg ctaaagccct
     5221 ctgtcacttg gcgacccttc tggtcttgct ggaggggttt cctgggtata acccattggg
     5281 ctgcccaagg ccagccagcc tgagctctcc tgcaagacag agcctgatgt ggcacggagt
     5341 ggggttgcgg ggggtggggg gactgcctga ctcccagagg gacttgaaac tgaagcaaga
     5401 aggttgcatt ctccaccaag ggagttaacc tacctgaact aagtagaaat gccagtcttc
     5461 cactaccccc tccctgccat cttttcttct gctactttgg ggagttgatg gccaggaaag
     5521 aagccagcac agggttaaag taactcctgg cattgcccac cagggggctg gtgcacctgc
     5581 tgacctcagg gtcacagttg agtcatttgc cagttgacgg agcaagtttg accttggttc
     5641 tgttgctgaa gcaaatttgg aacttttctg tctcagtgtg atccactaac ccacaggatc
     5701 atttggaacc ttgaatagct ctgcttggac aatggggttg gggaataggg ttgtctttcc
     5761 tatgaaaatg ccatctgtag accttgtgag tcagccgtcc agatgtttgc aggtgaattc
     5821 ctctgcttga catcctccct gtcactttgg accctatggg agtgggcatc tccacgcacc
     5881 tgtgtatgtg aaagtcattt tacatttcaa agcagtgtgt gtttcttatt tttatatttt
     5941 taactcttta ttcttggatg tataaagtga actttttggc ttctgtaagt atgctctatg
     6001 cacctctaat gttttatcat gtatttatat gttgtacaca gtactggctg attctgtaaa
     6061 tggatgtatt gtacagagaa catgaacgtc tcttcctaat tttacatctt cagcatcatt
     6121 gcattaaagt ggtgtaatct ccttctctac atctgttgtc agagccactg agtgctgtgc
     6181 tgctcgacgt gagggtgaaa tgattgactt gtgacctgcc aggttgcccg atgccctgtt
     6241 gggtcaccgg ctggacctgc tgcagcctgc agagccacag tcagcctgcc cacatgccac
     6301 cgagcaaacg catcttgctt ttcacatctc tcctcctaca gccttaatgg ctgcttgctg
     6361 ccatatgtga caaatcacca ccaccagtgt taagtgcttc tggattcatg ggtgagttcc
     6421 ctgggcagcc cccaggaagg ccttccagat ctggctccag ggtcaccacc tgtcacagca
     6481 atacctggga ccatgctctc ctgggactgt gaggctcctt ttgacgtact tttgacatca
     6541 ggcaggtttg ggaagaaaca aagccatgcc tgctcctgcc tctctcccaa catgtttcca
     6601 gcaagtagat gcccctgtgt gtgttttccc ttgccttgtt tcctgcctta tatcttgtat
     6661 ttcgacttat tacagagttg agggttcttg cttaatttag atcaagtata aaatttgtat
     6721 gacttcaagt ctcattttat ctgaaaggtt tttttctcat ttaatctgat gtggcatttt
     6781 cgtcatctga agcatgagtg acaagttggg aatgatgtgg tgatttagaa tgcagtattg
     6841 gccaagtcca agttgtcaac ttaagcgtct gtttaccaaa gaccgggaac aggggcccaa
     6901 acatgtccag tcctcttctt ccctctgctg gaacctttgg ggacactcaa gggtacagtt
     6961 tgacactgat ctggtccatg aggctgccca gagaaagcac tgcttctgta tgtctcttgt
     7021 ggtattggaa caataaaccc gtacaacctg ca
//
