LOCUS       NM_004319               7138 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens astrotactin 1 (ASTN1), transcript variant 1, mRNA.
ACCESSION   NM_004319
VERSION     NM_004319.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7138)
  AUTHORS   Chen,Q.F., Shi,F., Huang,T., Huang,C., Shen,L., Wu,P. and Li,W.
  TITLE     ASTN1 is associated with immune infiltrates in hepatocellular
            carcinoma, and inhibits the migratory and invasive capacity of
            liver cancer via the Wnt/beta-catenin signaling pathway
  JOURNAL   Oncol Rep 44 (4), 1425-1440 (2020)
   PUBMED   32945491
  REMARK    GeneRIF: ASTN1 is associated with immune infiltrates in
            hepatocellular carcinoma, and inhibits the migratory and invasive
            capacity of liver cancer via the Wnt/betacatenin signaling pathway.
REFERENCE   2  (bases 1 to 7138)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7138)
  AUTHORS   Hirose,H., Hideshima,T., Katoh,T. and Suga,H.
  TITLE     A Case Study on the Keap1 Interaction with Peptide Sequence
            Epitopes Selected by the Peptidomic mRNA Display
  JOURNAL   Chembiochem 20 (16), 2089-2100 (2019)
   PUBMED   31169361
REFERENCE   4  (bases 1 to 7138)
  AUTHORS   Hill,S.Y., Weeks,D.E., Jones,B.L., Zezza,N. and Stiffler,S.
  TITLE     ASTN1 and alcohol dependence: family-based association analysis in
            multiplex alcohol dependence families
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 159B (4), 445-455 (2012)
   PUBMED   22488871
  REMARK    GeneRIF: Family-based association analysis shows the ASTN1 gene
            significantly associated with alcohol dependence.
REFERENCE   5  (bases 1 to 7138)
  AUTHORS   Gratacos,M., Costas,J., de Cid,R., Bayes,M., Gonzalez,J.R.,
            Baca-Garcia,E., de Diego,Y., Fernandez-Aranda,F.,
            Fernandez-Piqueras,J., Guitart,M., Martin-Santos,R., Martorell,L.,
            Menchon,J.M., Roca,M., Saiz-Ruiz,J., Sanjuan,J., Torrens,M.,
            Urretavizcaya,M., Valero,J., Vilella,E., Estivill,X. and
            Carracedo,A.
  CONSRTM   Psychiatric Genetics Network Group
  TITLE     Identification of new putative susceptibility genes for several
            psychiatric disorders by association analysis of regulatory and
            non-synonymous SNPs of 306 genes involved in neurotransmission and
            neurodevelopment
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 150B (6), 808-816 (2009)
   PUBMED   19086053
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 7138)
  AUTHORS   Kahler,A.K., Djurovic,S., Kulle,B., Jonsson,E.G., Agartz,I.,
            Hall,H., Opjordsmoen,S., Jakobsen,K.D., Hansen,T., Melle,I.,
            Werge,T., Steen,V.M. and Andreassen,O.A.
  TITLE     Association analysis of schizophrenia on 18 genes involved in
            neuronal migration: MDGA1 as a new susceptibility gene
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (7), 1089-1100 (2008)
   PUBMED   18384059
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7138)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   8  (bases 1 to 7138)
  AUTHORS   Ohara,O., Nagase,T., Ishikawa,K., Nakajima,D., Ohira,M., Seki,N.
            and Nomura,N.
  TITLE     Construction and characterization of human brain cDNA libraries
            suitable for analysis of cDNA clones encoding relatively large
            proteins
  JOURNAL   DNA Res 4 (1), 53-59 (1997)
   PUBMED   9179496
REFERENCE   9  (bases 1 to 7138)
  AUTHORS   Fink,J.M., Hirsch,B.A., Zheng,C., Dietz,G., Hatten,M.E. and
            Ross,M.E.
  TITLE     Astrotactin (ASTN), a gene for glial-guided neuronal migration,
            maps to human chromosome 1q25.2
  JOURNAL   Genomics 40 (1), 202-205 (1997)
   PUBMED   9070947
REFERENCE   10 (bases 1 to 7138)
  AUTHORS   Edmondson,J.C., Liem,R.K., Kuster,J.E. and Hatten,M.E.
  TITLE     Astrotactin: a novel neuronal cell surface antigen that mediates
            neuron-astroglial interactions in cerebellar microcultures
  JOURNAL   J Cell Biol 106 (2), 505-517 (1988)
   PUBMED   3276720
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL021398.1, BC146795.1, AL031290.1 and BF507471.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004319.2.
            
            Summary: Astrotactin is a neuronal adhesion molecule required for
            glial-guided migration of young postmitotic neuroblasts in cortical
            regions of developing brain, including cerebrum, hippocampus,
            cerebellum, and olfactory bulb (Fink et al., 1995).[supplied by
            OMIM, Jun 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146795.1, SRR1803617.73824.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361833.7/ ENSP00000354536.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL021398.1         58307-58328
            23-2750             BC146795.1         13-2740
            2751-2838           AL031290.1         115099-115186       c
            2839-4727           BC146795.1         2829-4717
            4728-7115           AL031290.1         81489-83876         c
            7116-7138           BF507471.1         21-43               c
FEATURES             Location/Qualifiers
     source          1..7138
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..7138
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /note="astrotactin 1"
                     /db_xref="GeneID:460"
                     /db_xref="HGNC:HGNC:773"
                     /db_xref="MIM:600904"
     exon            1..319
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..3921
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="astrotactin-1 isoform 1 precursor"
                     /protein_id="NP_004310.1"
                     /db_xref="CCDS:CCDS1319.1"
                     /db_xref="GeneID:460"
                     /db_xref="HGNC:HGNC:773"
                     /db_xref="MIM:600904"
                     /translation="MALAGLCALLACCWGPAAVLATAAGDVDPSKELECKLKSITVSA
                     LPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELPYFVLEISGNTED
                     IPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGM
                     IALLLSILCLVMILYTRRRWCKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLR
                     NARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTRTLDSLQ
                     GCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINN
                     KARAGSAFLNPEGDSGTEAENDPQLTFYTDPSRSRRRSRVGSPRSPVNKTTLTLISIT
                     SCVIGLVCSSHVNCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFS
                     QQNSSGPWAMDLCARRLLDPCEHQCDPETGECLCYEGYMKDPVHKHLCIRNEWGTNQG
                     PWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCK
                     TDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLD
                     STGCVCPSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPDDPTLYNILM
                     FCGCIEDYKLGVDGRSCQLITETCPEGSDCGESRELPMNQTLFGEMFFGYNNHSKEVA
                     AGQVLKGTFRQNNFARGLDQQLPDGLVVATVPLENQCLEEISEPTPDPDFLTGMVNFS
                     EVSGYPVLQHWKVRSVMYHIKLNQVAISQALSNALHSLDGATSRADFVALLDQFGNHY
                     IQEAIYGFEESCSIWYPNKQVQRRLWLEYEDISKGNSPSDESEERERDPKVLTFPEYI
                     TSLSDSGTKHMAAGVRMECHSKGRCPSSCPLCHVTSSPDTPAEPVLLEVTKAAPIYEL
                     VTNNQTQRLLQEATMSSLWCSGTGDVIEDWCRCDSTAFGADGLPTCAPLPQPVLRLST
                     VHEPSSTLVVLEWEHSEPPIGVQIVDYLLRQEKVTDRMDHSKVETETVLSFVDDIISG
                     AKSPCAMPSQVPDKQLTTISLIIRCLEPDTIYMFTLWGVDNTGRRSRPSDVIVKTPCP
                     VVDDVKAQEIADKIYNLFNGYTSGKEQQTAYNTLLDLGSPTLHRVLYHYNQHYESFGE
                     FTWRCEDELGPRKAGLILSQLGDLSSWCNGLLQEPKISLRRSSLKYLGCRYSEIKPYG
                     LDWAELSRDLRKTCEEQTLSIPYNDYGDSKEI"
     exon            320..507
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            508..901
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1048
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1156
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1306
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1474
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1559
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1634
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1772
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1923
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2090
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2285
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2413
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2518
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2707
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2976
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3110
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3262
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3398
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3499
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3683
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..7138
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7119..7124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /note="hexamer: AACAAA"
     polyA_site      7138
                     /gene="ASTN1"
                     /gene_synonym="ASTN"
                     /note="major polyA site"
ORIGIN      
        1 atcgcagcgc taggaggaag gcggccgggg ctcaagatgg ctttagccgg gctctgcgcc
       61 ctgctcgcct gctgctgggg gccggcggcg gtgctggcca cggccgccgg cgacgtggat
      121 ccatccaagg agctggagtg caagctcaaa agcatcacgg tgtcggcact gcccttcctg
      181 cgcgagaacg acctgagcat catgcacagc ccctcggcct cggagcccaa gctcctcttc
      241 tcggtgcgca acgacttccc gggagaaatg gtcgtggtgg acgacctgga gaacacggag
      301 ctgccctact tcgtgctgga gatctcaggg aacacagagg atatcccttt ggtgcgctgg
      361 aggcagcagt ggctggagaa tggcactttg ctttttcaca ttcatcacca agatggtgcc
      421 ccaagccttc ctggacaaga ccccactgaa gaaccccaac atgagtcggc agaagaggag
      481 ctgaggatcc tccacatctc agtcatgggt ggcatgatcg ctctgctgct gtccatcttg
      541 tgcctggtga tgatcctgta tactcgccgg cgctggtgca aacgccgccg ggtcccgcag
      601 ccccagaaga gtgccagtgc tgaggcagcc aatgagattc actacattcc ttctgtgctg
      661 atcggcgggc acggacggga gagcctgcgc aatgcccgcg tgcagggcca caactccagt
      721 ggcaccctga gcatccggga gacacctatc ctggacggct atgagtatga catcactgat
      781 ctgcgccacc atctgcagag ggagtgcatg aacggagggg aggactttgc cagccaggtc
      841 acgcgcaccc tcgactccct gcagggctgc aatgaaaagt cggggatgga cctcacacca
      901 ggaagtgaca atgccaagct gtcactgatg aacaagtata aagataatat tatagccact
      961 agccctgtgg actccaacca ccagcaagcc acccttctct ctcacacctc cagcagccag
     1021 agaaagcgga tcaacaacaa agcaagagct ggttccgcct tcttgaaccc tgaaggggat
     1081 tctggcacag aggcagaaaa cgacccccag ctgacctttt acacggatcc ttcaaggagc
     1141 aggaggcgta gtagagtggg ttctccccga agtcctgtga ataagaccac cttgaccctg
     1201 atcagcatca ccagctgtgt gattggcctc gtgtgctcct ctcacgtcaa ctgccctctc
     1261 gttgtcaaga tcaccctgca tgtccctgag cacctgattg ctgatgggag ccgcttcatc
     1321 ttgctggagg ggagccagct ggatgccagt gactggctga accctgccca agtggttctc
     1381 ttctctcagc agaactccag cggaccctgg gccatggacc tctgtgcccg gcggctcctg
     1441 gacccctgtg aacaccaatg tgaccccgaa actggggaat gcctctgcta tgaaggctac
     1501 atgaaggatc cagtacataa gcacctttgc attcggaacg aatgggggac aaaccagggg
     1561 ccatggcctt acacaatatt tcagcgaggc tttgacctgg ttttgggaga gcagccctct
     1621 gataaaatat ttagattcac ctacactctt ggggagggca tgtggttgcc cctcagcaag
     1681 agctttgtga ttccaccagc cgaactggcc atcaatccat cagcaaagtg caagacggac
     1741 atgactgtga tggaggatgc tgtggaggtc agagaggagc tgatgacttc atcctccttc
     1801 gacagcctgg aggttctctt agattccttt gggccggtgc gcgactgcag caaagataac
     1861 gggggctgca gtaagaattt ccgctgtatt tcagatcgca agctggactc cactggttgc
     1921 gtgtgcccat ctggactcag tcccatgaag gacagctctg gctgctatga ccgccacatc
     1981 ggggtggact gttccgacgg cttcaacggc ggctgtgagc agctgtgcct ccagcagatg
     2041 gcgcccttcc cggacgaccc caccttgtat aacatcctca tgttctgtgg gtgcatcgag
     2101 gactacaagc ttggtgtgga tggacgctct tgccaactca tcacggagac ctgtccagag
     2161 ggaagtgact gtggggaaag cagggagctt cccatgaacc agaccctctt tggggagatg
     2221 ttctttggtt acaacaacca ttccaaggaa gtggctgccg gacaggtgct gaaaggaaca
     2281 ttcaggcaaa acaactttgc tcgtggttta gaccagcaac tgccagatgg tcttgtggtg
     2341 gccactgtgc ccctggagaa tcaatgccta gaggagatct cggagcccac ccctgaccct
     2401 gacttcctga ctgggatggt gaacttcagt gaagtgtctg ggtaccctgt gctgcagcac
     2461 tggaaggtcc ggtctgtgat gtaccacatc aaactcaacc aagtggccat ctctcaggcc
     2521 ctcagcaatg ctctccactc gctggatggg gctacatctc gtgcagattt tgtggcgctg
     2581 ttggaccagt tcggcaacca ttacatccag gaagctatct acggctttga ggagtcctgt
     2641 tctatctggt acccaaacaa gcaggtccag cggcgactct ggctggagta tgaagacatc
     2701 agtaaaggca actccccatc agatgagtct gaggagcggg aaagagaccc caaggtgctg
     2761 acattcccag aatacatcac cagcttgtca gactccggca ccaagcacat ggcggctgga
     2821 gtccgcatgg agtgccacag caagggacga tgcccctcgt cctgccccct gtgtcatgtg
     2881 acatccagcc ctgacacccc tgctgagccg gttctgctgg aggtgaccaa agcagccccc
     2941 atctatgaac tagtgaccaa caaccagacc cagaggctct tgcaggaggc taccatgagc
     3001 tctctctggt gctcagggac tggagatgtc atcgaggact ggtgtcgatg tgactccact
     3061 gcttttggag ctgatggact ccccacctgt gcgcctctcc cacagcctgt gctgagactc
     3121 tccacggttc acgagcccag cagcactctt gtggtcctgg agtgggaaca ctcagagcca
     3181 ccaatcgggg tgcagattgt agattacctc ctccgtcaag agaaagtcac tgacaggatg
     3241 gaccactcca aagtggagac agaaacagtg ctgagctttg tggacgacat catctctgga
     3301 gcaaagtctc cttgtgcaat gccatctcag gtgccggaca agcagctcac caccatctct
     3361 ctgatcatac gatgcctgga acctgacacc atttacatgt tcacgctgtg gggagtggac
     3421 aacacaggac ggcgctccag gccaagcgac gtgatcgtga agaccccatg ccccgtggtg
     3481 gatgatgtca aggctcaaga aatagcagac aagatctaca atctcttcaa tggctacact
     3541 agtgggaagg agcagcagac cgcctacaac accctcctgg atctgggttc ccccacctta
     3601 caccgggtcc tctaccacta taaccagcac tatgagagtt ttggggaatt cacctggcga
     3661 tgtgaggatg agttaggtcc caggaaagct ggtctcatcc tttcccagct tggggacctc
     3721 agcagttggt gcaatggact ccttcaggaa cccaagataa gcttgcggcg cagctcactc
     3781 aagtacctgg ggtgccgcta cagcgagatc aaaccctacg gacttgactg ggcggagctc
     3841 agccgggacc tcaggaagac gtgtgaggag cagaccctga gtatccccta caacgactat
     3901 ggggacagca aagagatcta gcaccataag gccagggagc tgctgccaga atgaagtagg
     3961 aaagaggagg gatccatctg ggttggtctg tggattttta atatttttta atggaacatg
     4021 aaaacctcca cagcaacatc gaaaccaggg agaaagtgat ccttgctccc tgcagaactt
     4081 cttcagtatg atgttctcca tctgcatgat tgggaaatct gccagccagt ggcttcatgc
     4141 agtgccatat ttctttagag gattactttg gggtttgctt tgccattaat ttgttccatt
     4201 catttttttt tccctgagaa gtttaccaaa atgctcaaga gctctgccgt gctccccatg
     4261 aaaagtctat taagtaggca ccctgtgctc actcagttcc taaatccatt gcaactggga
     4321 gcagaggtga ggccagaaag ttgttaggcc tgccgcaggc cccaccctca agcattcctc
     4381 aggaagcgtc tcactctggg agccttggcc ctgctcacag agagagacaa tagaaaattg
     4441 aggaaggtgg cccttgtctg tgtctcctgg ttttcttcct aggccttgct atcactattt
     4501 ccatacccga aaggtgaaac cagctttcat tataggcccc agtgggccac ttgggttttg
     4561 agatccttcc ttattttaag ccaggactgg gattaaatct ccctctgtca gatctctgtc
     4621 ccttcctctg aacaacatga tctttgagag ggaacaagat gccatctgtc aactgcacct
     4681 tcagaaaagt ctacctggga gactagttag cagtccacat tcaagaggag acttggagtt
     4741 tattgttttt taaaaaaacc atgcttcctt tggatagact tctccagcct accaatatat
     4801 atccatgtgc ctggattatc tttaaccccc acacctctta ccttggacag gtaaggcttg
     4861 gccgatgtct gattgggacc aggaggggtc aacactttca tatcagtgtt acagtgaact
     4921 aaagctatta ttgatcacaa aaaacttctg ttcatcccca ccttgctaaa tttgcttgtg
     4981 ttgctagttt tgcaaatcgt ttctctgatg accataagca ggaggattcc accatggtca
     5041 ctgcccatcc agtcacaggg attctgtgta gggaagcacc actgattgca gttaacatct
     5101 agagtgttgt ttccatccca ctgcccaagc attggcatgg tcatgaatgg tggcccagcc
     5161 aacaggaagc ccagcctttc agaaagagcc tggcaaggcc ctgttgacta gcaatggcct
     5221 tagctgtccc acacaactca gtggcctgaa cacacacctt cagccaccat gcctttgacc
     5281 agggctcctc atctggaaac atatgagaaa ggtcagcaaa cagatgcaag acctataagg
     5341 ctagtcattg agctatattg gttttttttc taaatagtag tagtgacaga taacatttat
     5401 tgagtgcttg ctgtatgcca ggcgctgatg taagcacttt aggtatcatt gaattctcac
     5461 agcaactcct gaggaaagtg ctattcttgt ctccatttta gtgttgagga aaacgaggca
     5521 aagagaggtt atacaacttg cctcaaatcc cttgtgcact gtaactcaca ctgagtttca
     5581 gtgtgatttc aggctgttgg tctccagggc acaggatctt agctactctg ggatacccag
     5641 ttctgttttc agtatcatct ggcacacaac tgtccaagct ctcagcccca cagggaacct
     5701 gcccagagag ctttaccttt cccaagcatc tgtggcatgg acatgtcctc tgtgcagtgg
     5761 aaggaggagg ggcgaaagta cgcccttagc ctttggagct agagcaccct tgggacccct
     5821 agttccactg cacatggccc tcctccccac cctcatgact gggaaggaag cctgtgatga
     5881 ggctgagata aagcacaggg tggtttcact ctcctctctc cttctttcca aacactgaag
     5941 gatttatttc aaactctcta atgcacctgc ctcagagatt cccctacttt caaagcaaag
     6001 atcagcagaa aaattggctg tcccacctgt ggcaaatgct ggagcctcag ttaaagtgcc
     6061 tcaaggggca aatatttcac cattgccaga gaagatgtga caggccaatc agacagggcc
     6121 cagagcatct ctttgctgct actgttttgc catccttcta ttcatatctg tgcagaacac
     6181 ggtgttttaa gcttgagtga aaggagggtg aggctgccga tgccttcctg cccagaagtg
     6241 gatgatgtgg gagttgacag gccagggaga gggtgaagca ggtatcagag tcactcctct
     6301 gtaccctctc cttctgtttt tattttaggc acactatctt cctctctcct atctttccct
     6361 cagtctccca agttcctcta ccttctttat ctttgtcttt tacttcttct ttctgtgacc
     6421 ctcctttttt ggcctcctct ttccccaaga ctttcttcct cctgtttctc gttgagttct
     6481 ccccactgaa tgtgtgtatg tatgtacaca cacacacacg tgtgcacaca caatgcacac
     6541 aactcctatg actggctcct acttacattc aagttaaaaa ggctgatatg aacagggcag
     6601 gggaaaatct taggatggtt gtacaattga ctggaggatt ttttcccctt ggaagacact
     6661 attgatctca acctgctgac ttttcctaat gcttacctga aggaacccat cctggctaga
     6721 aagggtgatg gtactggacc ggtattcaac cttgagtttt caagctgcca aacaggtctt
     6781 aagggaggtg cttatatccc accaacactc tcccagctcc catgtcccca agacctctgg
     6841 agtttcctct tgaatgtaca tgaaccactg taatagcatt agacttttaa ttgagtgtgc
     6901 aatcgttttc catggagttt ggtccgttca ttatttttta gttaactaca cttcttgata
     6961 ttcaaatgtt ctattaaaaa aactgagtat gaagaaaaac actttactac tgcagaagga
     7021 agaaagaata taatatgacc atcttcaggt ataacagtgt tgtttaaaag agaattattg
     7081 tatgattata aaagatgaaa taattaactg aataataaaa caaagctatt agtaagca
//
