LOCUS       NM_020437               3370 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens aspartate beta-hydroxylase domain containing 2
            (ASPHD2), mRNA.
ACCESSION   NM_020437
VERSION     NM_020437.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3370)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3370)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 3370)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3370)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   5  (bases 1 to 3370)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z99714.2 and AL161993.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020437.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.261045.1,
                                           SRR1163658.167493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215906.6/ ENSP00000215906.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               Z99714.2           14274-14500
            228-1337            Z99714.2           18406-19515
            1338-1451           Z99714.2           27473-27586
            1452-1946           Z99714.2           28111-28605
            1947-1992           AL161993.1         949-994
            1993-3367           AL161993.1         999-2373
            3368-3370           Z99714.2           30027-30029
FEATURES             Location/Qualifiers
     source          1..3370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.1"
     gene            1..3370
                     /gene="ASPHD2"
                     /note="aspartate beta-hydroxylase domain containing 2"
                     /db_xref="GeneID:57168"
                     /db_xref="HGNC:HGNC:30437"
     exon            1..227
                     /gene="ASPHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            228..1337
                     /gene="ASPHD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..1561
                     /gene="ASPHD2"
                     /codon_start=1
                     /product="aspartate beta-hydroxylase domain-containing
                     protein 2"
                     /protein_id="NP_065170.2"
                     /db_xref="CCDS:CCDS13834.2"
                     /db_xref="GeneID:57168"
                     /db_xref="HGNC:HGNC:30437"
                     /translation="MVWAPLGPPRTDCLTLLHTPSKDSPKMSLEWLVAWSWSLDGLRD
                     CIATGIQSVRDCDTTAVITVACLLVLFVWYCYHVGREQPRPYVSVNSLMQAADANGLQ
                     NGYVYCQSPECVRCTHNEGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLNSRP
                     SIQKPEVFFLPDLPTTPYFSRDAQKHDVEVLERNFQTILCEFETLYKAFSNCSLPQGW
                     KMNSTPSGEWFTFYLVNQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSP
                     GTVITEHYGPTNIRIRCHLGLKTPNGCELVVGGEPQCWAEGRCLLFDDSFLHAAFHEG
                     SAEDGPRVVFMVDLWHPNVAAAERQALDFIFAPGR"
     exon            1338..1451
                     /gene="ASPHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..3370
                     /gene="ASPHD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3345..3350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASPHD2"
                     /note="hexamer: AATAAA"
     polyA_site      3370
                     /gene="ASPHD2"
                     /note="major polyA site"
ORIGIN      
        1 agttgtggtc ttcgcggccc cgcggagcgc agcgcggcgt cggcaccggc aggggcaccg
       61 gcgcggctta ggctcgggct cgggctccgg ctcgggctcc cgcggcgtgg gctgggcagc
      121 agccaggcgg cggctccgcg gcgccgggca ggggccgtcc gcgggtccgc gccctcgggc
      181 ggcggcgtct cctgggtccc ggcagccgtc cgcgcgcccg ggcgcaggtt tggttttcct
      241 aaacaaatcc tttcacaggg accgacggca cttgataatg tgacaaaaac cagcctcttc
      301 caccccactg cagtgacttt tgccggaaag tggagcagtg ggcacggcca accttgtcgt
      361 tcatcaatgc cgcccctggc agtatctgag gatcggtggc agccatgcct ccccctgccc
      421 cagccgctcc ttccccccca cgctaatctg catggtgtgg gcgcccttgg gacccccgag
      481 gactgattgt ctgaccttgc ttcacacgcc cagtaaggac tcccccaaga tgtcgctcga
      541 gtggctggtg gcctggagct ggtcgctgga tggcctgagg gactgcatcg ccaccggcat
      601 ccagtccgtg cgggactgcg acaccaccgc tgtcatcact gtggcctgcc tcctggtcct
      661 cttcgtgtgg tactgttatc acgtgggcag ggagcagccc cggccctacg tctccgtcaa
      721 ctccctcatg caggctgccg atgccaacgg gctgcagaat ggctacgtgt actgccagtc
      781 ccctgagtgc gtgcgctgca cccacaacga gggcctcaac cagaagctgt accacaacct
      841 gcaggagtac gccaagcgct actcctggtc cggcatgggc cgcatccaca agggcatccg
      901 cgagcagggc cggtacctca acagccggcc ctccatccag aagcccgagg tcttcttcct
      961 gcccgacctg cccaccacgc cctatttctc ccgggacgca cagaaacatg atgtggaagt
     1021 gctggaacgg aacttccaga ccatcctgtg tgagtttgag accctctaca aagctttctc
     1081 aaactgcagc ctcccgcaag gatggaaaat gaacagcacc cccagcgggg agtggttcac
     1141 cttttacttg gtcaatcagg gggtttgtgt tcccaggaac tgtaggaagt gcccacggac
     1201 gtaccgcttg ctcggaagcc ttcggacctg tattgggaac aatgtttttg ggaacgcgtg
     1261 catctctgtg ctgagccctg ggactgtgat aacggagcac tatggaccca ccaacatccg
     1321 catccgatgc catttaggtc tgaaaactcc aaatggctgt gagctggtgg tggggggaga
     1381 gccccagtgc tgggcagaag ggcgctgcct tctctttgat gactctttcc tgcatgctgc
     1441 gttccatgaa ggttcagcag aggatggccc acgggtggtt ttcatggtgg atttgtggca
     1501 tccaaacgtc gcagcggccg aacggcaggc tcttgatttc atctttgctc cgggacgatg
     1561 agagtatttc ccatgctgga gtcggcgaga agggccgagg cggggcctgg gcagactgtg
     1621 gtccggtcca gtccctaccg gtgttgtttc catgctcaga aacctgcctc agcggaaagc
     1681 tcttatttgg gattttatat catgtcgggt ccctctttcc cttggttatt gtaaatggaa
     1741 acttttcggc ttgtatttcc ttagattttt tttttttcct tccaatcatt tgcttcagag
     1801 actcctttct ggcctaacag cgcattcctt tgattggtcc ttgagtgacc agagacttag
     1861 tgcccttgta agtctgtctt ctgttgctac ttgttttttt cagtgctctg aaatagagta
     1921 actaaatggt tatttgtctg aatataataa tgtaaaactt cttgtggtca tcttaaaaaa
     1981 aaaaaaaaaa aactaaaaac tgcaaaccag agagctagag aacttggcct ctgatgctgg
     2041 cacactgggg acccttcagc cacctgacgg cagggggaca gtctgcagcc cccacacctg
     2101 actggcttca gtagccaggt ggaggggctg ccagacacag tcagggtggc acacagtgtc
     2161 caggcccagg gatactgtca ccatcgctca cctcattcta aaccttgtca ggtccctgat
     2221 ggcaaaagca ttgggccagt aggactggag gctactcttt aaacatggct ttcctgcaaa
     2281 gctgaagctg gtgtccccca gcaccaagct gcggctcaca cagatcagcc acggaacgtg
     2341 tgatccgctt acctcactgc ctacagaagc cctactgcca aactgggcct ggaaaattcc
     2401 cagttttagg tgttttgagt ccacagtgat gaacgttaag gccaccaggt tggctgatag
     2461 gagctgtagg gggataggac cgcgctcacc cagcgacatt tggggaaagc ctttctctgg
     2521 caaaactgga ataatagatc tgaccaaagt ttctgttttg ctttggagtt ctgttgccta
     2581 tgtttttttt tttttcattt atttgtctgt acataaatgt tcaaacacta gacttggaga
     2641 tagtggaaga gttggccctg tgtctttgtc atggcacaaa ggtgtgcact gcgtgacaat
     2701 gacccaagcc agtgtgtgct agtgaggaga cagagaagac ctacatgccc agaggacccg
     2761 tggccgttgt gctggttttc tggtctcctg tgaagaacat gtggatctct tcccgaagga
     2821 aaaggtccca ggagaccagt ttgaggcact cactctagaa atagcctgtg ttagctgatg
     2881 tgtgaaagcg tagccggcca gccacactag agatgccttt tctgaataat gtattatgag
     2941 cagtgtcaga tttataaagc cgaggagtgg tttggaatat acagctggtc gcaggtgcag
     3001 gtccagtgtt tagatccaaa tggaaaacag cagcttctaa gaggtacaac tgttggaaga
     3061 aaacacagtt gaaatgcacc aggcaggtac tagcaagtgt gcaaagagca cgtctacatt
     3121 tgagtaaaat gtctacacag atatttgtca gtgatgagaa tgcaggaaaa ggcagacatt
     3181 tcaaacatac ctgaagtctt tttactcatt atcttgttaa agaatcactg aggtgcatga
     3241 tttctacaca tcgtgactgc tctgctctgc gtttacaaaa ccaacagccc gcgcaggtac
     3301 ctagctacct gcattcatgt gacatgtctg gggaacagaa gataaataaa ggatcttgct
     3361 gaaaaccaga
//
