LOCUS       NM_001413895            4995 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens aspartate beta-hydroxylase (ASPH), transcript variant
            63, mRNA.
ACCESSION   NM_001413895
VERSION     NM_001413895.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4995)
  AUTHORS   Chen,Z.X., Jia,W.N., Sun,Y. and Jiang,Y.X.
  TITLE     Genotype-phenotype profile of global ASPH-associated ectopia lentis
            and clinical findings from a Chinese cohort
  JOURNAL   Gene 925, 148600 (2024)
   PUBMED   38788814
  REMARK    GeneRIF: Genotype-phenotype profile of global ASPH-associated
            ectopia lentis and clinical findings from a Chinese cohort.
REFERENCE   2  (bases 1 to 4995)
  AUTHORS   Zou,Y., Lin,J., Liu,J., Zhang,F., Yang,T., Gong,J., Jiang,T.,
            Zuo,J., Song,R., Shen,H., Shen,F. and Li,J.
  TITLE     Aspartate beta-hydroxylase (ASPH) Accelerates Intrahepatic
            Cholangiocarcinoma Metastasis via Upregulating SHH Signaling
            Pathway
  JOURNAL   Curr Protein Pept Sci 24 (5), 436-446 (2023)
   PUBMED   37132101
  REMARK    GeneRIF: Aspartate beta-hydroxylase (ASPH) Accelerates Intrahepatic
            Cholangiocarcinoma Metastasis via Upregulating SHH Signaling
            Pathway.
REFERENCE   3  (bases 1 to 4995)
  AUTHORS   Finotti,A., Treves,S., Zorzato,F., Gambari,R. and Feriotto,G.
  TITLE     Upstream stimulatory factors are involved in the P1 promoter
            directed transcription of the A beta H-J-J locus
  JOURNAL   BMC Mol Biol 9, 110 (2008)
   PUBMED   19087304
  REMARK    GeneRIF: USF1 and USF2 positively regulate the core of P1 promoter
            od AAH.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4995)
  AUTHORS   Treves,S., Franzini-Armstrong,C., Moccagatta,L., Arnoult,C.,
            Grasso,C., Schrum,A., Ducreux,S., Zhu,M.X., Mikoshiba,K.,
            Girard,T., Smida-Rezgui,S., Ronjat,M. and Zorzato,F.
  TITLE     Junctate is a key element in calcium entry induced by activation of
            InsP3 receptors and/or calcium store depletion
  JOURNAL   J Cell Biol 166 (4), 537-548 (2004)
   PUBMED   15302852
  REMARK    GeneRIF: junctate has a role in calcium homeostasis in eukaryotic
            cells
REFERENCE   5  (bases 1 to 4995)
  AUTHORS   Treves,S., Feriotto,G., Moccagatta,L., Gambari,R. and Zorzato,F.
  TITLE     Molecular cloning, expression, functional characterization,
            chromosomal localization, and gene structure of junctate, a novel
            integral calcium binding protein of sarco(endo)plasmic reticulum
            membrane
  JOURNAL   J Biol Chem 275 (50), 39555-39568 (2000)
   PUBMED   11007777
REFERENCE   6  (bases 1 to 4995)
  AUTHORS   Dinchuk,J.E., Henderson,N.L., Burn,T.C., Huber,R., Ho,S.P.,
            Link,J., O'Neil,K.T., Focht,R.J., Scully,M.S., Hollis,J.M.,
            Hollis,G.F. and Friedman,P.A.
  TITLE     Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved
            isoform of Asph missing the catalytic domain share exons with
            junctin
  JOURNAL   J Biol Chem 275 (50), 39543-39554 (2000)
   PUBMED   10956665
REFERENCE   7  (bases 1 to 4995)
  AUTHORS   Wetzel,G.T., Ding,S. and Chen,F.
  TITLE     Molecular cloning of junctin from human and developing rabbit heart
  JOURNAL   Mol Genet Metab 69 (3), 252-258 (2000)
   PUBMED   10767180
REFERENCE   8  (bases 1 to 4995)
  AUTHORS   Zhang,L., Kelley,J., Schmeisser,G., Kobayashi,Y.M. and Jones,L.R.
  TITLE     Complex formation between junctin, triadin, calsequestrin, and the
            ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic
            reticulum membrane
  JOURNAL   J Biol Chem 272 (37), 23389-23397 (1997)
   PUBMED   9287354
REFERENCE   9  (bases 1 to 4995)
  AUTHORS   Lavaissiere,L., Jia,S., Nishiyama,M., de la Monte,S., Stern,A.M.,
            Wands,J.R. and Friedman,P.A.
  TITLE     Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in
            hepatocellular carcinoma and cholangiocarcinoma
  JOURNAL   J Clin Invest 98 (6), 1313-1323 (1996)
   PUBMED   8823296
REFERENCE   10 (bases 1 to 4995)
  AUTHORS   Korioth,F., Gieffers,C. and Frey,J.
  TITLE     Cloning and characterization of the human gene encoding aspartyl
            beta-hydroxylase
  JOURNAL   Gene 150 (2), 395-399 (1994)
   PUBMED   7821814
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC067881.5 and AC090094.5.
            
            Summary: This gene is thought to play an important role in calcium
            homeostasis. The gene is expressed from two promoters and undergoes
            extensive alternative splicing. The encoded set of proteins share
            varying amounts of overlap near their N-termini but have
            substantial variations in their C-terminal domains resulting in
            distinct functional properties. The longest isoforms (a and f)
            include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain
            that hydroxylates aspartic acid or asparagine residues in the
            epidermal growth factor (EGF)-like domains of some proteins,
            including protein C, coagulation factors VII, IX, and X, and the
            complement factors C1R and C1S. Other isoforms differ primarily in
            the C-terminal sequence and lack the hydroxylase domain, and some
            have been localized to the endoplasmic and sarcoplasmic reticulum.
            Some of these isoforms are found in complexes with calsequestrin,
            triadin, and the ryanodine receptor, and have been shown to
            regulate calcium release from the sarcoplasmic reticulum. Some
            isoforms have been implicated in metastasis. [provided by RefSeq,
            Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.785331.1,
                                           SRR14038196.3105643.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC067881.5         152129-152452       c
            325-474             AC067881.5         121899-122048       c
            475-543             AC067881.5         118828-118896       c
            544-636             AC067881.5         91428-91520         c
            637-669             AC067881.5         82460-82492         c
            670-717             AC067881.5         81246-81293         c
            718-750             AC067881.5         80748-80780         c
            751-792             AC067881.5         76182-76223         c
            793-849             AC067881.5         75807-75863         c
            850-891             AC067881.5         56838-56879         c
            892-977             AC090094.5         30466-30551
            978-1064            AC090094.5         37637-37723
            1065-1215           AC090094.5         47177-47327
            1216-1352           AC090094.5         51615-51751
            1353-1451           AC090094.5         58473-58571
            1452-1541           AC090094.5         61375-61464
            1542-1679           AC090094.5         66287-66424
            1680-1815           AC090094.5         88383-88518
            1816-1907           AC090094.5         96372-96463
            1908-2041           AC090094.5         96834-96967
            2042-4995           AC090094.5         110986-113939
FEATURES             Location/Qualifiers
     source          1..4995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.3"
     gene            1..4995
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="aspartate beta-hydroxylase"
                     /db_xref="GeneID:444"
                     /db_xref="HGNC:HGNC:757"
                     /db_xref="MIM:600582"
     exon            1..324
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2192
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /EC_number="1.14.11.16"
                     /note="isoform 51 is encoded by transcript variant 63;
                     junctate; peptide-aspartate beta-dioxygenase; humbug;
                     aspartyl/asparaginyl beta-hydroxylase; cardiac junctin; A
                     beta H-J-J; ASP beta-hydroxylase"
                     /codon_start=1
                     /product="aspartyl/asparaginyl beta-hydroxylase isoform
                     51"
                     /protein_id="NP_001400824.1"
                     /db_xref="GeneID:444"
                     /db_xref="HGNC:HGNC:757"
                     /db_xref="MIM:600582"
                     /translation="MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNG
                     RKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFDVDD
                     AKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAETEHSYHVEETDSSEPVVEDER
                     LHHDTDDVTYQVYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEETNRKTDDP
                     EQKAKVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVNAFKELVRKYPQSPRAR
                     YGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLKLSLKRRSDRQQFLGHM
                     RGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEVLSVTPNDGFAKVHY
                     GFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAYKWYELGHK
                     RGHFASVWQRSLYNVNGLKAQPWWTPKETGYTELVKSLERNWKLIRDEGLAVMDKAKG
                     LFLPEDENLREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGCRRGQIKYS
                     IMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFDDSFEHE
                     VWQDASSFRLIFIVDVWHPELTPQQRRSLPAI"
     exon            325..474
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            475..543
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            544..636
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            637..669
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            670..717
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            718..750
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            751..792
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            793..849
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            850..891
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            892..977
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1064
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1215
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1352
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1451
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1541
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1679
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1815
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1907
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2041
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..4995
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4300..4305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="hexamer: AATAAA"
     polyA_site      4322
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="major polyA site"
     regulatory      4972..4977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="hexamer: AATAAA"
     polyA_site      4995
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
ORIGIN      
        1 agtcacaggt tcgtacacgc gaggccgggc gcgcgcagcc ggcaggcggg tgaagtcttc
       61 ccaggtgctg caggcggtgc tgaggcacag ggtctgctgc aggagcagcg gcccgaaccc
      121 gctccagcgg cccgccgccg ccagcggttc ccgcgtcgcg tgtgtacccc cgcgcactga
      181 aggaggtccg ccagccctca ccagcccccg cggaccgtgc aatggcccag cgtaagaatg
      241 ccaagagcag cggcaacagc agcagcagcg gctccggcag cggtagcacg agtgcgggca
      301 gcagcagccc cggggcccgg agagagacaa agcatggagg acacaagaat gggaggaaag
      361 gcggactctc aggaacttca ttcttcacgt ggtttatggt gattgcattg ctgggcgtct
      421 ggacatctgt agctgtcgtt tggtttgatc ttgttgacta tgaggaagtt ctaggaaaac
      481 taggaatcta tgatgctgat ggtgatggag attttgatgt ggatgatgcc aaagttttat
      541 taggacttaa agagagatct acttcagagc cagcagtccc gccagaagag gctgagccac
      601 acactgagcc cgaggagcag gttcctgtgg aggcagaaac cgagcatagt taccacgtgg
      661 aagagacaga ttccagtgaa ccagtagtag aagatgaaag attgcaccat gatacagatg
      721 atgtaacata ccaagtctat gaggaacaag cagtatatga acctctagaa aatgaaggga
      781 tagaaatcac agaagtaact gctccccctg aggataatcc tgtagaagat tcacaggtaa
      841 ttgtagaaga aacaaataga aaaacagatg atccagaaca aaaagcaaaa gttaagaaaa
      901 agaagcctaa acttttaaat aaatttgata agactattaa agctgaactt gatgctgcag
      961 aaaaactccg taaaagggga aaaattgagg aagcagtgaa tgcatttaaa gaactagtac
     1021 gcaaataccc tcagagtcca cgagcaagat atgggaaggc gcagtgtgag gatgatttgg
     1081 ctgagaagag gagaagtaat gaggtgctac gtggagccat cgagacctac caagaggtgg
     1141 ccagcctacc tgatgtccct gcagacctgc tgaagctgag tttgaagcgt cgctcagaca
     1201 ggcaacaatt tctaggtcat atgagaggtt ccctgcttac cctgcagaga ttagttcaac
     1261 tatttcccaa tgatacttcc ttaaaaaatg accttggcgt gggatacctc ttgataggag
     1321 ataatgacaa tgcaaagaaa gtttatgaag aggtgctgag tgtgacacct aatgatggct
     1381 ttgctaaagt ccattatggc ttcatcctga aggcacagaa caaaattgct gagagcatcc
     1441 catatttaaa ggaaggaata gaatccggag atcctggcac tgatgatggg agattttatt
     1501 tccacctggg ggatgccatg cagagggttg ggaacaaaga ggcatataag tggtatgagc
     1561 ttgggcacaa gagaggacac tttgcatctg tctggcaacg ctcactctac aatgtgaatg
     1621 gactgaaagc acagccttgg tggaccccaa aagaaacggg ctacacagag ttagtaaagt
     1681 ctttagaaag aaactggaag ttaatccgag atgaaggcct tgcagtgatg gataaagcca
     1741 aaggtctctt cctgcctgag gatgaaaacc tgagggaaaa aggggactgg agccagttca
     1801 cgctgtggca gcaaggaaga agaaatgaaa atgcctgcaa aggagctcct aaaacctgta
     1861 ccttactaga aaagttcccc gagacaacag gatgcagaag aggacagatc aaatattcca
     1921 tcatgcaccc cgggactcac gtgtggccgc acacagggcc cacaaactgc aggctccgaa
     1981 tgcacctggg cttggtgatt cccaaggaag gctgcaagat tcgatgtgcc aacgagacca
     2041 agacctggga ggaaggcaag gtgctcatct ttgatgactc ctttgagcac gaggtatggc
     2101 aggatgcctc atctttccgg ctgatattca tcgtggatgt gtggcatccg gaactgacac
     2161 cacagcagag acgcagcctt ccagcaattt agcatgaatt catgcaagct tgggaaactc
     2221 tggagagagg ctgcctttct ggttccatct ccttgggtgt gaggatagaa tttcgaacac
     2281 caagagtcaa ttcccttgac ttgcagcccg agtaattcaa agcctcctcc tagggtcaga
     2341 agacactaaa gggaatattt gcctcgctgc aattcattta ggaaacaccc tgctgtgtgt
     2401 catctcatga cagcactggt cttctgccag tatttaaggt gaacatttga tagcttctac
     2461 cttaccagcc aaagatattt tttccacata gaataggtct aattcaatgt ataatgagaa
     2521 catatgtaga aactgtgaat ggattgcttt agtttgtaat ttttctatgc agttatattt
     2581 ttctagtgta gctagactat tttgtcatca tgtaccacta catttttgtt tattttaatg
     2641 acaagctgta taaatgcttt acttctagct atttaatggt agcattactg gggaactcag
     2701 acttccctct tttaattctt cttagtaaaa gatactcatg aaaaaagcag ttttattttc
     2761 ctaacaaaaa agaaagagct cattatgtca gtgtctatga actgtaccca tcccaactct
     2821 caaatcgttt ggtttttttt atcttgattg agatcctctt ctcactatgc tagtggtgga
     2881 gatattgaca aaatcctatt tctttcaaag aggaactttt cacaccgaaa aaagagcatg
     2941 gaattatttt atattgttat aaaaatccca gatgcaaatt tttttaatgc caattattag
     3001 agcttctggg gaaaaagtat agttcacgga aataaaacta tgttctttca gggttgggtg
     3061 gataggtggc tgctagggtg tctggctcct ggcggctttg ccatccatga ggcaagggct
     3121 gggaacacag tgtctttgcc tatggtagat ccatgtgaat gtcaggaagc cagctcttca
     3181 gtcttggaga tgatttctgc tacaattctg tagaaagatt aaggatggca gagtaaaagg
     3241 ttaccaagaa tgccaggatg tttttcttgg gcgtaggagg tccagattac tttccttttt
     3301 gatgaaagag tttggaagac tgtcccatct ctctggcttg agaaatctct gccattttaa
     3361 acatcactgt gaaatagcaa ttattatcat ctgtatttag ttttaacatt acccacaaca
     3421 tagaaataat aggtaaaaat cgtcttgcct actcattcca aagatgatca agtcattaat
     3481 ctagcaaagt attcatgtat cagattttgt atattttgaa tcaaagctaa ctaggaatgt
     3541 tagatataag aatgtaatga tattcatgca ctgaattcta agccaatatg aacaaaaatg
     3601 ctgcatgaat ggcacatata ggtcaccaaa gttcattcac aggtagaaaa aacttgtgct
     3661 ttcttttcca tctaaaaaca aaaggagact ttctttatct catttaaaga acagctcttt
     3721 gaaattgaaa ttgacccttt ttgcttgacc ttaaggagat tagcttccag tagatgagtt
     3781 tgcaaaatac ttttcctgtt cttttgtttt gctggtattg aaaacatccc actaaatcag
     3841 atgaagaggc atgggaggaa aaatatccaa attaattact aaaatcgaga agagaaggca
     3901 aactcttgaa aagtaaaaag gtgtttgtga ccttcagtat ttattgaaca gaggaaataa
     3961 ctgacaaggg caatacaatt caatgttcat gtagtaacat tcatgtcact tgttgaattt
     4021 ggttctcata tgtatattgc atacacataa attcaaacta taagtcgtca tttttgagcc
     4081 atcatcttac attcatgtaa tgaaattatg gaagagagta aaaactagct cttaacttag
     4141 taaatataat atggtattta aaatcaggtc actacagtaa ggttctaagt attgccaatt
     4201 gaaaagctag aaatggtatt actgttgcaa agtgttgtca ataattgact ccaatagcat
     4261 tgtaaatact tgtatcccac aactatttta aacccaagca ataaaatgga ttttctaatt
     4321 cacttcaatt ctttatttct cttacctatc tatgtcttgg tacataagaa aagtgtttcc
     4381 atcactgcat tggtagaatt atttcagtgt tattattttt gtgatttcgt atgtctacac
     4441 aaaaatgaat tagtttaatt tatattgtga tacagttgtt tgagaaatat ttttaattct
     4501 gtttcaactt tatttctcca agtgtataat ataaaaatta cttctgttat tgttctctac
     4561 caatagggga aaaaattaaa acattagatc cattgagaaa gagatgatgt aataaataat
     4621 taagattagt aataatatta tcaggggtga ttatgaccag ttgaataatc tctttccctt
     4681 gaattattta gctaacaaat taactctccc aaatatttaa aataatgtaa aatcatattt
     4741 tactgcccat tattaactaa aatatttttg tttgactttg agcaccaact ggtaatacta
     4801 ataaataccc atgtcatgca gatggctggg cgaataagag atgtctaaaa atatgcactg
     4861 gtcttggaaa acatggcaca agtaaggata tcatatatga tgtctgttta ttttatgtct
     4921 gatttctttt gaatgagtag ttggggactc catttctaag gagactaggt aaataaaatg
     4981 acctttgaca tttca
//
