LOCUS       NM_001413861            5241 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens aspartate beta-hydroxylase (ASPH), transcript variant
            30, mRNA.
ACCESSION   NM_001413861 XM_047421789
VERSION     NM_001413861.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5241)
  AUTHORS   Chen,Z.X., Jia,W.N., Sun,Y. and Jiang,Y.X.
  TITLE     Genotype-phenotype profile of global ASPH-associated ectopia lentis
            and clinical findings from a Chinese cohort
  JOURNAL   Gene 925, 148600 (2024)
   PUBMED   38788814
  REMARK    GeneRIF: Genotype-phenotype profile of global ASPH-associated
            ectopia lentis and clinical findings from a Chinese cohort.
REFERENCE   2  (bases 1 to 5241)
  AUTHORS   Zou,Y., Lin,J., Liu,J., Zhang,F., Yang,T., Gong,J., Jiang,T.,
            Zuo,J., Song,R., Shen,H., Shen,F. and Li,J.
  TITLE     Aspartate beta-hydroxylase (ASPH) Accelerates Intrahepatic
            Cholangiocarcinoma Metastasis via Upregulating SHH Signaling
            Pathway
  JOURNAL   Curr Protein Pept Sci 24 (5), 436-446 (2023)
   PUBMED   37132101
  REMARK    GeneRIF: Aspartate beta-hydroxylase (ASPH) Accelerates Intrahepatic
            Cholangiocarcinoma Metastasis via Upregulating SHH Signaling
            Pathway.
REFERENCE   3  (bases 1 to 5241)
  AUTHORS   Finotti,A., Treves,S., Zorzato,F., Gambari,R. and Feriotto,G.
  TITLE     Upstream stimulatory factors are involved in the P1 promoter
            directed transcription of the A beta H-J-J locus
  JOURNAL   BMC Mol Biol 9, 110 (2008)
   PUBMED   19087304
  REMARK    GeneRIF: USF1 and USF2 positively regulate the core of P1 promoter
            od AAH.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5241)
  AUTHORS   Treves,S., Franzini-Armstrong,C., Moccagatta,L., Arnoult,C.,
            Grasso,C., Schrum,A., Ducreux,S., Zhu,M.X., Mikoshiba,K.,
            Girard,T., Smida-Rezgui,S., Ronjat,M. and Zorzato,F.
  TITLE     Junctate is a key element in calcium entry induced by activation of
            InsP3 receptors and/or calcium store depletion
  JOURNAL   J Cell Biol 166 (4), 537-548 (2004)
   PUBMED   15302852
  REMARK    GeneRIF: junctate has a role in calcium homeostasis in eukaryotic
            cells
REFERENCE   5  (bases 1 to 5241)
  AUTHORS   Treves,S., Feriotto,G., Moccagatta,L., Gambari,R. and Zorzato,F.
  TITLE     Molecular cloning, expression, functional characterization,
            chromosomal localization, and gene structure of junctate, a novel
            integral calcium binding protein of sarco(endo)plasmic reticulum
            membrane
  JOURNAL   J Biol Chem 275 (50), 39555-39568 (2000)
   PUBMED   11007777
REFERENCE   6  (bases 1 to 5241)
  AUTHORS   Dinchuk,J.E., Henderson,N.L., Burn,T.C., Huber,R., Ho,S.P.,
            Link,J., O'Neil,K.T., Focht,R.J., Scully,M.S., Hollis,J.M.,
            Hollis,G.F. and Friedman,P.A.
  TITLE     Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved
            isoform of Asph missing the catalytic domain share exons with
            junctin
  JOURNAL   J Biol Chem 275 (50), 39543-39554 (2000)
   PUBMED   10956665
REFERENCE   7  (bases 1 to 5241)
  AUTHORS   Wetzel,G.T., Ding,S. and Chen,F.
  TITLE     Molecular cloning of junctin from human and developing rabbit heart
  JOURNAL   Mol Genet Metab 69 (3), 252-258 (2000)
   PUBMED   10767180
REFERENCE   8  (bases 1 to 5241)
  AUTHORS   Zhang,L., Kelley,J., Schmeisser,G., Kobayashi,Y.M. and Jones,L.R.
  TITLE     Complex formation between junctin, triadin, calsequestrin, and the
            ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic
            reticulum membrane
  JOURNAL   J Biol Chem 272 (37), 23389-23397 (1997)
   PUBMED   9287354
REFERENCE   9  (bases 1 to 5241)
  AUTHORS   Lavaissiere,L., Jia,S., Nishiyama,M., de la Monte,S., Stern,A.M.,
            Wands,J.R. and Friedman,P.A.
  TITLE     Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in
            hepatocellular carcinoma and cholangiocarcinoma
  JOURNAL   J Clin Invest 98 (6), 1313-1323 (1996)
   PUBMED   8823296
REFERENCE   10 (bases 1 to 5241)
  AUTHORS   Korioth,F., Gieffers,C. and Frey,J.
  TITLE     Cloning and characterization of the human gene encoding aspartyl
            beta-hydroxylase
  JOURNAL   Gene 150 (2), 395-399 (1994)
   PUBMED   7821814
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC067881.5 and AC090094.5.
            
            On Nov 14, 2022 this sequence version replaced XM_047421789.1.
            
            Summary: This gene is thought to play an important role in calcium
            homeostasis. The gene is expressed from two promoters and undergoes
            extensive alternative splicing. The encoded set of proteins share
            varying amounts of overlap near their N-termini but have
            substantial variations in their C-terminal domains resulting in
            distinct functional properties. The longest isoforms (a and f)
            include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain
            that hydroxylates aspartic acid or asparagine residues in the
            epidermal growth factor (EGF)-like domains of some proteins,
            including protein C, coagulation factors VII, IX, and X, and the
            complement factors C1R and C1S. Other isoforms differ primarily in
            the C-terminal sequence and lack the hydroxylase domain, and some
            have been localized to the endoplasmic and sarcoplasmic reticulum.
            Some of these isoforms are found in complexes with calsequestrin,
            triadin, and the ryanodine receptor, and have been shown to
            regulate calcium release from the sarcoplasmic reticulum. Some
            isoforms have been implicated in metastasis. [provided by RefSeq,
            Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3198749.1,
                                           SRR14038196.3200928.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC067881.5         152129-152452       c
            325-474             AC067881.5         121899-122048       c
            475-543             AC067881.5         118828-118896       c
            544-636             AC067881.5         91428-91520         c
            637-711             AC067881.5         88910-88984         c
            712-840             AC067881.5         84610-84738         c
            841-873             AC067881.5         82460-82492         c
            874-921             AC067881.5         81246-81293         c
            922-954             AC067881.5         80748-80780         c
            955-993             AC067881.5         76182-76220         c
            994-1050            AC067881.5         75807-75863         c
            1051-1095           AC067881.5         71543-71587         c
            1096-1137           AC067881.5         56838-56879         c
            1138-1223           AC090094.5         30466-30551
            1224-1310           AC090094.5         37637-37723
            1311-1461           AC090094.5         47177-47327
            1462-1598           AC090094.5         51615-51751
            1599-1697           AC090094.5         58473-58571
            1698-1787           AC090094.5         61375-61464
            1788-1925           AC090094.5         66287-66424
            1926-2061           AC090094.5         88383-88518
            2062-2153           AC090094.5         96372-96463
            2154-2287           AC090094.5         96834-96967
            2288-5241           AC090094.5         110986-113939
FEATURES             Location/Qualifiers
     source          1..5241
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.3"
     gene            1..5241
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="aspartate beta-hydroxylase"
                     /db_xref="GeneID:444"
                     /db_xref="HGNC:HGNC:757"
                     /db_xref="MIM:600582"
     exon            1..324
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2438
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /EC_number="1.14.11.16"
                     /note="isoform 25 is encoded by transcript variant 30;
                     junctate; peptide-aspartate beta-dioxygenase; humbug;
                     aspartyl/asparaginyl beta-hydroxylase; cardiac junctin; A
                     beta H-J-J; ASP beta-hydroxylase"
                     /codon_start=1
                     /product="aspartyl/asparaginyl beta-hydroxylase isoform
                     25"
                     /protein_id="NP_001400790.1"
                     /db_xref="GeneID:444"
                     /db_xref="HGNC:HGNC:757"
                     /db_xref="MIM:600582"
                     /translation="MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNG
                     RKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFDVDD
                     AKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVH
                     AEHVEGEDLQQEDGPTGEPQQEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETD
                     SSEPVVEDERLHHDTDDVTYQVYEEQVYEPLENEGIEITEVTAPPEDNPVEDSQVIVE
                     EVSIFPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAAEKLRKR
                     GKIEEAVNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLP
                     DVPADLLKLSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDN
                     DNAKKVYEEVLSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFY
                     FHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTEL
                     VKSLERNWKLIRDEGLAVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRRNENACKGA
                     PKTCTLLEKFPETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKI
                     RCANETKTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI"
     exon            325..474
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            475..543
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            544..636
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            637..711
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            712..840
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            841..873
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            874..921
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            922..954
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            955..993
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1050
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1095
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1137
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1223
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1310
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1461
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1598
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1697
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1787
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1925
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2061
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2153
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2287
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..5241
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4546..4551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="hexamer: AATAAA"
     polyA_site      4568
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="major polyA site"
     regulatory      5218..5223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="hexamer: AATAAA"
     polyA_site      5241
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
ORIGIN      
        1 agtcacaggt tcgtacacgc gaggccgggc gcgcgcagcc ggcaggcggg tgaagtcttc
       61 ccaggtgctg caggcggtgc tgaggcacag ggtctgctgc aggagcagcg gcccgaaccc
      121 gctccagcgg cccgccgccg ccagcggttc ccgcgtcgcg tgtgtacccc cgcgcactga
      181 aggaggtccg ccagccctca ccagcccccg cggaccgtgc aatggcccag cgtaagaatg
      241 ccaagagcag cggcaacagc agcagcagcg gctccggcag cggtagcacg agtgcgggca
      301 gcagcagccc cggggcccgg agagagacaa agcatggagg acacaagaat gggaggaaag
      361 gcggactctc aggaacttca ttcttcacgt ggtttatggt gattgcattg ctgggcgtct
      421 ggacatctgt agctgtcgtt tggtttgatc ttgttgacta tgaggaagtt ctaggaaaac
      481 taggaatcta tgatgctgat ggtgatggag attttgatgt ggatgatgcc aaagttttat
      541 taggacttaa agagagatct acttcagagc cagcagtccc gccagaagag gctgagccac
      601 acactgagcc cgaggagcag gttcctgtgg aggcagaacc ccagaatatc gaagatgaag
      661 caaaagaaca aattcagtcc cttctccatg aaatggtaca cgcagaacat gttgagggag
      721 aagacttgca acaagaagat ggacccacag gagaaccaca acaagaggat gatgagtttc
      781 ttatggcgac tgatgtagat gatagatttg agaccctgga acctgaagta tctcatgaag
      841 aaaccgagca tagttaccac gtggaagaga cagattccag tgaaccagta gtagaagatg
      901 aaagattgca ccatgataca gatgatgtaa cataccaagt ctatgaggaa caagtatatg
      961 aacctctaga aaatgaaggg atagaaatca cagaagtaac tgctccccct gaggataatc
     1021 ctgtagaaga ttcacaggta attgtagaag aagtaagcat ttttcctgtg gaagaacagc
     1081 aggaagtacc accagaaaca aatagaaaaa cagatgatcc agaacaaaaa gcaaaagtta
     1141 agaaaaagaa gcctaaactt ttaaataaat ttgataagac tattaaagct gaacttgatg
     1201 ctgcagaaaa actccgtaaa aggggaaaaa ttgaggaagc agtgaatgca tttaaagaac
     1261 tagtacgcaa ataccctcag agtccacgag caagatatgg gaaggcgcag tgtgaggatg
     1321 atttggctga gaagaggaga agtaatgagg tgctacgtgg agccatcgag acctaccaag
     1381 aggtggccag cctacctgat gtccctgcag acctgctgaa gctgagtttg aagcgtcgct
     1441 cagacaggca acaatttcta ggtcatatga gaggttccct gcttaccctg cagagattag
     1501 ttcaactatt tcccaatgat acttccttaa aaaatgacct tggcgtggga tacctcttga
     1561 taggagataa tgacaatgca aagaaagttt atgaagaggt gctgagtgtg acacctaatg
     1621 atggctttgc taaagtccat tatggcttca tcctgaaggc acagaacaaa attgctgaga
     1681 gcatcccata tttaaaggaa ggaatagaat ccggagatcc tggcactgat gatgggagat
     1741 tttatttcca cctgggggat gccatgcaga gggttgggaa caaagaggca tataagtggt
     1801 atgagcttgg gcacaagaga ggacactttg catctgtctg gcaacgctca ctctacaatg
     1861 tgaatggact gaaagcacag ccttggtgga ccccaaaaga aacgggctac acagagttag
     1921 taaagtcttt agaaagaaac tggaagttaa tccgagatga aggccttgca gtgatggata
     1981 aagccaaagg tctcttcctg cctgaggatg aaaacctgag ggaaaaaggg gactggagcc
     2041 agttcacgct gtggcagcaa ggaagaagaa atgaaaatgc ctgcaaagga gctcctaaaa
     2101 cctgtacctt actagaaaag ttccccgaga caacaggatg cagaagagga cagatcaaat
     2161 attccatcat gcaccccggg actcacgtgt ggccgcacac agggcccaca aactgcaggc
     2221 tccgaatgca cctgggcttg gtgattccca aggaaggctg caagattcga tgtgccaacg
     2281 agaccaagac ctgggaggaa ggcaaggtgc tcatctttga tgactccttt gagcacgagg
     2341 tatggcagga tgcctcatct ttccggctga tattcatcgt ggatgtgtgg catccggaac
     2401 tgacaccaca gcagagacgc agccttccag caatttagca tgaattcatg caagcttggg
     2461 aaactctgga gagaggctgc ctttctggtt ccatctcctt gggtgtgagg atagaatttc
     2521 gaacaccaag agtcaattcc cttgacttgc agcccgagta attcaaagcc tcctcctagg
     2581 gtcagaagac actaaaggga atatttgcct cgctgcaatt catttaggaa acaccctgct
     2641 gtgtgtcatc tcatgacagc actggtcttc tgccagtatt taaggtgaac atttgatagc
     2701 ttctacctta ccagccaaag atattttttc cacatagaat aggtctaatt caatgtataa
     2761 tgagaacata tgtagaaact gtgaatggat tgctttagtt tgtaattttt ctatgcagtt
     2821 atatttttct agtgtagcta gactattttg tcatcatgta ccactacatt tttgtttatt
     2881 ttaatgacaa gctgtataaa tgctttactt ctagctattt aatggtagca ttactgggga
     2941 actcagactt ccctctttta attcttctta gtaaaagata ctcatgaaaa aagcagtttt
     3001 attttcctaa caaaaaagaa agagctcatt atgtcagtgt ctatgaactg tacccatccc
     3061 aactctcaaa tcgtttggtt ttttttatct tgattgagat cctcttctca ctatgctagt
     3121 ggtggagata ttgacaaaat cctatttctt tcaaagagga acttttcaca ccgaaaaaag
     3181 agcatggaat tattttatat tgttataaaa atcccagatg caaatttttt taatgccaat
     3241 tattagagct tctggggaaa aagtatagtt cacggaaata aaactatgtt ctttcagggt
     3301 tgggtggata ggtggctgct agggtgtctg gctcctggcg gctttgccat ccatgaggca
     3361 agggctggga acacagtgtc tttgcctatg gtagatccat gtgaatgtca ggaagccagc
     3421 tcttcagtct tggagatgat ttctgctaca attctgtaga aagattaagg atggcagagt
     3481 aaaaggttac caagaatgcc aggatgtttt tcttgggcgt aggaggtcca gattactttc
     3541 ctttttgatg aaagagtttg gaagactgtc ccatctctct ggcttgagaa atctctgcca
     3601 ttttaaacat cactgtgaaa tagcaattat tatcatctgt atttagtttt aacattaccc
     3661 acaacataga aataataggt aaaaatcgtc ttgcctactc attccaaaga tgatcaagtc
     3721 attaatctag caaagtattc atgtatcaga ttttgtatat tttgaatcaa agctaactag
     3781 gaatgttaga tataagaatg taatgatatt catgcactga attctaagcc aatatgaaca
     3841 aaaatgctgc atgaatggca catataggtc accaaagttc attcacaggt agaaaaaact
     3901 tgtgctttct tttccatcta aaaacaaaag gagactttct ttatctcatt taaagaacag
     3961 ctctttgaaa ttgaaattga ccctttttgc ttgaccttaa ggagattagc ttccagtaga
     4021 tgagtttgca aaatactttt cctgttcttt tgttttgctg gtattgaaaa catcccacta
     4081 aatcagatga agaggcatgg gaggaaaaat atccaaatta attactaaaa tcgagaagag
     4141 aaggcaaact cttgaaaagt aaaaaggtgt ttgtgacctt cagtatttat tgaacagagg
     4201 aaataactga caagggcaat acaattcaat gttcatgtag taacattcat gtcacttgtt
     4261 gaatttggtt ctcatatgta tattgcatac acataaattc aaactataag tcgtcatttt
     4321 tgagccatca tcttacattc atgtaatgaa attatggaag agagtaaaaa ctagctctta
     4381 acttagtaaa tataatatgg tatttaaaat caggtcacta cagtaaggtt ctaagtattg
     4441 ccaattgaaa agctagaaat ggtattactg ttgcaaagtg ttgtcaataa ttgactccaa
     4501 tagcattgta aatacttgta tcccacaact attttaaacc caagcaataa aatggatttt
     4561 ctaattcact tcaattcttt atttctctta cctatctatg tcttggtaca taagaaaagt
     4621 gtttccatca ctgcattggt agaattattt cagtgttatt atttttgtga tttcgtatgt
     4681 ctacacaaaa atgaattagt ttaatttata ttgtgataca gttgtttgag aaatattttt
     4741 aattctgttt caactttatt tctccaagtg tataatataa aaattacttc tgttattgtt
     4801 ctctaccaat aggggaaaaa attaaaacat tagatccatt gagaaagaga tgatgtaata
     4861 aataattaag attagtaata atattatcag gggtgattat gaccagttga ataatctctt
     4921 tcccttgaat tatttagcta acaaattaac tctcccaaat atttaaaata atgtaaaatc
     4981 atattttact gcccattatt aactaaaata tttttgtttg actttgagca ccaactggta
     5041 atactaataa atacccatgt catgcagatg gctgggcgaa taagagatgt ctaaaaatat
     5101 gcactggtct tggaaaacat ggcacaagta aggatatcat atatgatgtc tgtttatttt
     5161 atgtctgatt tcttttgaat gagtagttgg ggactccatt tctaaggaga ctaggtaaat
     5221 aaaatgacct ttgacatttc a
//
