LOCUS       NM_001413860            5244 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens aspartate beta-hydroxylase (ASPH), transcript variant
            29, mRNA.
ACCESSION   NM_001413860 XM_005251242
VERSION     NM_001413860.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5244)
  AUTHORS   Chen,Z.X., Jia,W.N., Sun,Y. and Jiang,Y.X.
  TITLE     Genotype-phenotype profile of global ASPH-associated ectopia lentis
            and clinical findings from a Chinese cohort
  JOURNAL   Gene 925, 148600 (2024)
   PUBMED   38788814
  REMARK    GeneRIF: Genotype-phenotype profile of global ASPH-associated
            ectopia lentis and clinical findings from a Chinese cohort.
REFERENCE   2  (bases 1 to 5244)
  AUTHORS   Zou,Y., Lin,J., Liu,J., Zhang,F., Yang,T., Gong,J., Jiang,T.,
            Zuo,J., Song,R., Shen,H., Shen,F. and Li,J.
  TITLE     Aspartate beta-hydroxylase (ASPH) Accelerates Intrahepatic
            Cholangiocarcinoma Metastasis via Upregulating SHH Signaling
            Pathway
  JOURNAL   Curr Protein Pept Sci 24 (5), 436-446 (2023)
   PUBMED   37132101
  REMARK    GeneRIF: Aspartate beta-hydroxylase (ASPH) Accelerates Intrahepatic
            Cholangiocarcinoma Metastasis via Upregulating SHH Signaling
            Pathway.
REFERENCE   3  (bases 1 to 5244)
  AUTHORS   Finotti,A., Treves,S., Zorzato,F., Gambari,R. and Feriotto,G.
  TITLE     Upstream stimulatory factors are involved in the P1 promoter
            directed transcription of the A beta H-J-J locus
  JOURNAL   BMC Mol Biol 9, 110 (2008)
   PUBMED   19087304
  REMARK    GeneRIF: USF1 and USF2 positively regulate the core of P1 promoter
            od AAH.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5244)
  AUTHORS   Treves,S., Franzini-Armstrong,C., Moccagatta,L., Arnoult,C.,
            Grasso,C., Schrum,A., Ducreux,S., Zhu,M.X., Mikoshiba,K.,
            Girard,T., Smida-Rezgui,S., Ronjat,M. and Zorzato,F.
  TITLE     Junctate is a key element in calcium entry induced by activation of
            InsP3 receptors and/or calcium store depletion
  JOURNAL   J Cell Biol 166 (4), 537-548 (2004)
   PUBMED   15302852
  REMARK    GeneRIF: junctate has a role in calcium homeostasis in eukaryotic
            cells
REFERENCE   5  (bases 1 to 5244)
  AUTHORS   Treves,S., Feriotto,G., Moccagatta,L., Gambari,R. and Zorzato,F.
  TITLE     Molecular cloning, expression, functional characterization,
            chromosomal localization, and gene structure of junctate, a novel
            integral calcium binding protein of sarco(endo)plasmic reticulum
            membrane
  JOURNAL   J Biol Chem 275 (50), 39555-39568 (2000)
   PUBMED   11007777
REFERENCE   6  (bases 1 to 5244)
  AUTHORS   Dinchuk,J.E., Henderson,N.L., Burn,T.C., Huber,R., Ho,S.P.,
            Link,J., O'Neil,K.T., Focht,R.J., Scully,M.S., Hollis,J.M.,
            Hollis,G.F. and Friedman,P.A.
  TITLE     Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved
            isoform of Asph missing the catalytic domain share exons with
            junctin
  JOURNAL   J Biol Chem 275 (50), 39543-39554 (2000)
   PUBMED   10956665
REFERENCE   7  (bases 1 to 5244)
  AUTHORS   Wetzel,G.T., Ding,S. and Chen,F.
  TITLE     Molecular cloning of junctin from human and developing rabbit heart
  JOURNAL   Mol Genet Metab 69 (3), 252-258 (2000)
   PUBMED   10767180
REFERENCE   8  (bases 1 to 5244)
  AUTHORS   Zhang,L., Kelley,J., Schmeisser,G., Kobayashi,Y.M. and Jones,L.R.
  TITLE     Complex formation between junctin, triadin, calsequestrin, and the
            ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic
            reticulum membrane
  JOURNAL   J Biol Chem 272 (37), 23389-23397 (1997)
   PUBMED   9287354
REFERENCE   9  (bases 1 to 5244)
  AUTHORS   Lavaissiere,L., Jia,S., Nishiyama,M., de la Monte,S., Stern,A.M.,
            Wands,J.R. and Friedman,P.A.
  TITLE     Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in
            hepatocellular carcinoma and cholangiocarcinoma
  JOURNAL   J Clin Invest 98 (6), 1313-1323 (1996)
   PUBMED   8823296
REFERENCE   10 (bases 1 to 5244)
  AUTHORS   Korioth,F., Gieffers,C. and Frey,J.
  TITLE     Cloning and characterization of the human gene encoding aspartyl
            beta-hydroxylase
  JOURNAL   Gene 150 (2), 395-399 (1994)
   PUBMED   7821814
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC067881.5 and AC090094.5.
            
            On Nov 14, 2022 this sequence version replaced XM_005251242.4.
            
            Summary: This gene is thought to play an important role in calcium
            homeostasis. The gene is expressed from two promoters and undergoes
            extensive alternative splicing. The encoded set of proteins share
            varying amounts of overlap near their N-termini but have
            substantial variations in their C-terminal domains resulting in
            distinct functional properties. The longest isoforms (a and f)
            include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain
            that hydroxylates aspartic acid or asparagine residues in the
            epidermal growth factor (EGF)-like domains of some proteins,
            including protein C, coagulation factors VII, IX, and X, and the
            complement factors C1R and C1S. Other isoforms differ primarily in
            the C-terminal sequence and lack the hydroxylase domain, and some
            have been localized to the endoplasmic and sarcoplasmic reticulum.
            Some of these isoforms are found in complexes with calsequestrin,
            triadin, and the ryanodine receptor, and have been shown to
            regulate calcium release from the sarcoplasmic reticulum. Some
            isoforms have been implicated in metastasis. [provided by RefSeq,
            Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2168631.1,
                                           SRR14038195.1832254.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC067881.5         152129-152452       c
            325-474             AC067881.5         121899-122048       c
            475-543             AC067881.5         118828-118896       c
            544-636             AC067881.5         91428-91520         c
            637-711             AC067881.5         88910-88984         c
            712-840             AC067881.5         84610-84738         c
            841-873             AC067881.5         82460-82492         c
            874-921             AC067881.5         81246-81293         c
            922-954             AC067881.5         80748-80780         c
            955-996             AC067881.5         76182-76223         c
            997-1053            AC067881.5         75807-75863         c
            1054-1098           AC067881.5         71543-71587         c
            1099-1140           AC067881.5         56838-56879         c
            1141-1226           AC090094.5         30466-30551
            1227-1313           AC090094.5         37637-37723
            1314-1464           AC090094.5         47177-47327
            1465-1601           AC090094.5         51615-51751
            1602-1700           AC090094.5         58473-58571
            1701-1790           AC090094.5         61375-61464
            1791-1928           AC090094.5         66287-66424
            1929-2064           AC090094.5         88383-88518
            2065-2156           AC090094.5         96372-96463
            2157-2290           AC090094.5         96834-96967
            2291-5244           AC090094.5         110986-113939
FEATURES             Location/Qualifiers
     source          1..5244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.3"
     gene            1..5244
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="aspartate beta-hydroxylase"
                     /db_xref="GeneID:444"
                     /db_xref="HGNC:HGNC:757"
                     /db_xref="MIM:600582"
     exon            1..324
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2441
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /EC_number="1.14.11.16"
                     /note="isoform 24 is encoded by transcript variant 29;
                     junctate; peptide-aspartate beta-dioxygenase; humbug;
                     aspartyl/asparaginyl beta-hydroxylase; cardiac junctin; A
                     beta H-J-J; ASP beta-hydroxylase"
                     /codon_start=1
                     /product="aspartyl/asparaginyl beta-hydroxylase isoform
                     24"
                     /protein_id="NP_001400789.1"
                     /db_xref="GeneID:444"
                     /db_xref="HGNC:HGNC:757"
                     /db_xref="MIM:600582"
                     /translation="MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNG
                     RKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFDVDD
                     AKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVH
                     AEHVEGEDLQQEDGPTGEPQQEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETD
                     SSEPVVEDERLHHDTDDVTYQVYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIV
                     EEVSIFPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAAEKLRK
                     RGKIEEAVNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASL
                     PDVPADLLKLSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGD
                     NDNAKKVYEEVLSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRF
                     YFHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTE
                     LVKSLERNWKLIRDEGLAVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRRNENACKG
                     APKTCTLLEKFPETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCK
                     IRCANETKTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI"
     exon            325..474
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            475..543
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            544..636
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            637..711
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            712..840
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            841..873
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            874..921
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            922..954
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            955..996
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1053
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1098
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1140
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1226
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1313
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1464
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1601
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1700
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1790
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1928
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2064
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2156
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2290
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..5244
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4549..4554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="hexamer: AATAAA"
     polyA_site      4571
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="major polyA site"
     regulatory      5221..5226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
                     /note="hexamer: AATAAA"
     polyA_site      5244
                     /gene="ASPH"
                     /gene_synonym="AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN;
                     junctin"
ORIGIN      
        1 agtcacaggt tcgtacacgc gaggccgggc gcgcgcagcc ggcaggcggg tgaagtcttc
       61 ccaggtgctg caggcggtgc tgaggcacag ggtctgctgc aggagcagcg gcccgaaccc
      121 gctccagcgg cccgccgccg ccagcggttc ccgcgtcgcg tgtgtacccc cgcgcactga
      181 aggaggtccg ccagccctca ccagcccccg cggaccgtgc aatggcccag cgtaagaatg
      241 ccaagagcag cggcaacagc agcagcagcg gctccggcag cggtagcacg agtgcgggca
      301 gcagcagccc cggggcccgg agagagacaa agcatggagg acacaagaat gggaggaaag
      361 gcggactctc aggaacttca ttcttcacgt ggtttatggt gattgcattg ctgggcgtct
      421 ggacatctgt agctgtcgtt tggtttgatc ttgttgacta tgaggaagtt ctaggaaaac
      481 taggaatcta tgatgctgat ggtgatggag attttgatgt ggatgatgcc aaagttttat
      541 taggacttaa agagagatct acttcagagc cagcagtccc gccagaagag gctgagccac
      601 acactgagcc cgaggagcag gttcctgtgg aggcagaacc ccagaatatc gaagatgaag
      661 caaaagaaca aattcagtcc cttctccatg aaatggtaca cgcagaacat gttgagggag
      721 aagacttgca acaagaagat ggacccacag gagaaccaca acaagaggat gatgagtttc
      781 ttatggcgac tgatgtagat gatagatttg agaccctgga acctgaagta tctcatgaag
      841 aaaccgagca tagttaccac gtggaagaga cagattccag tgaaccagta gtagaagatg
      901 aaagattgca ccatgataca gatgatgtaa cataccaagt ctatgaggaa caagcagtat
      961 atgaacctct agaaaatgaa gggatagaaa tcacagaagt aactgctccc cctgaggata
     1021 atcctgtaga agattcacag gtaattgtag aagaagtaag catttttcct gtggaagaac
     1081 agcaggaagt accaccagaa acaaatagaa aaacagatga tccagaacaa aaagcaaaag
     1141 ttaagaaaaa gaagcctaaa cttttaaata aatttgataa gactattaaa gctgaacttg
     1201 atgctgcaga aaaactccgt aaaaggggaa aaattgagga agcagtgaat gcatttaaag
     1261 aactagtacg caaataccct cagagtccac gagcaagata tgggaaggcg cagtgtgagg
     1321 atgatttggc tgagaagagg agaagtaatg aggtgctacg tggagccatc gagacctacc
     1381 aagaggtggc cagcctacct gatgtccctg cagacctgct gaagctgagt ttgaagcgtc
     1441 gctcagacag gcaacaattt ctaggtcata tgagaggttc cctgcttacc ctgcagagat
     1501 tagttcaact atttcccaat gatacttcct taaaaaatga ccttggcgtg ggatacctct
     1561 tgataggaga taatgacaat gcaaagaaag tttatgaaga ggtgctgagt gtgacaccta
     1621 atgatggctt tgctaaagtc cattatggct tcatcctgaa ggcacagaac aaaattgctg
     1681 agagcatccc atatttaaag gaaggaatag aatccggaga tcctggcact gatgatggga
     1741 gattttattt ccacctgggg gatgccatgc agagggttgg gaacaaagag gcatataagt
     1801 ggtatgagct tgggcacaag agaggacact ttgcatctgt ctggcaacgc tcactctaca
     1861 atgtgaatgg actgaaagca cagccttggt ggaccccaaa agaaacgggc tacacagagt
     1921 tagtaaagtc tttagaaaga aactggaagt taatccgaga tgaaggcctt gcagtgatgg
     1981 ataaagccaa aggtctcttc ctgcctgagg atgaaaacct gagggaaaaa ggggactgga
     2041 gccagttcac gctgtggcag caaggaagaa gaaatgaaaa tgcctgcaaa ggagctccta
     2101 aaacctgtac cttactagaa aagttccccg agacaacagg atgcagaaga ggacagatca
     2161 aatattccat catgcacccc gggactcacg tgtggccgca cacagggccc acaaactgca
     2221 ggctccgaat gcacctgggc ttggtgattc ccaaggaagg ctgcaagatt cgatgtgcca
     2281 acgagaccaa gacctgggag gaaggcaagg tgctcatctt tgatgactcc tttgagcacg
     2341 aggtatggca ggatgcctca tctttccggc tgatattcat cgtggatgtg tggcatccgg
     2401 aactgacacc acagcagaga cgcagccttc cagcaattta gcatgaattc atgcaagctt
     2461 gggaaactct ggagagaggc tgcctttctg gttccatctc cttgggtgtg aggatagaat
     2521 ttcgaacacc aagagtcaat tcccttgact tgcagcccga gtaattcaaa gcctcctcct
     2581 agggtcagaa gacactaaag ggaatatttg cctcgctgca attcatttag gaaacaccct
     2641 gctgtgtgtc atctcatgac agcactggtc ttctgccagt atttaaggtg aacatttgat
     2701 agcttctacc ttaccagcca aagatatttt ttccacatag aataggtcta attcaatgta
     2761 taatgagaac atatgtagaa actgtgaatg gattgcttta gtttgtaatt tttctatgca
     2821 gttatatttt tctagtgtag ctagactatt ttgtcatcat gtaccactac atttttgttt
     2881 attttaatga caagctgtat aaatgcttta cttctagcta tttaatggta gcattactgg
     2941 ggaactcaga cttccctctt ttaattcttc ttagtaaaag atactcatga aaaaagcagt
     3001 tttattttcc taacaaaaaa gaaagagctc attatgtcag tgtctatgaa ctgtacccat
     3061 cccaactctc aaatcgtttg gtttttttta tcttgattga gatcctcttc tcactatgct
     3121 agtggtggag atattgacaa aatcctattt ctttcaaaga ggaacttttc acaccgaaaa
     3181 aagagcatgg aattatttta tattgttata aaaatcccag atgcaaattt ttttaatgcc
     3241 aattattaga gcttctgggg aaaaagtata gttcacggaa ataaaactat gttctttcag
     3301 ggttgggtgg ataggtggct gctagggtgt ctggctcctg gcggctttgc catccatgag
     3361 gcaagggctg ggaacacagt gtctttgcct atggtagatc catgtgaatg tcaggaagcc
     3421 agctcttcag tcttggagat gatttctgct acaattctgt agaaagatta aggatggcag
     3481 agtaaaaggt taccaagaat gccaggatgt ttttcttggg cgtaggaggt ccagattact
     3541 ttcctttttg atgaaagagt ttggaagact gtcccatctc tctggcttga gaaatctctg
     3601 ccattttaaa catcactgtg aaatagcaat tattatcatc tgtatttagt tttaacatta
     3661 cccacaacat agaaataata ggtaaaaatc gtcttgccta ctcattccaa agatgatcaa
     3721 gtcattaatc tagcaaagta ttcatgtatc agattttgta tattttgaat caaagctaac
     3781 taggaatgtt agatataaga atgtaatgat attcatgcac tgaattctaa gccaatatga
     3841 acaaaaatgc tgcatgaatg gcacatatag gtcaccaaag ttcattcaca ggtagaaaaa
     3901 acttgtgctt tcttttccat ctaaaaacaa aaggagactt tctttatctc atttaaagaa
     3961 cagctctttg aaattgaaat tgaccctttt tgcttgacct taaggagatt agcttccagt
     4021 agatgagttt gcaaaatact tttcctgttc ttttgttttg ctggtattga aaacatccca
     4081 ctaaatcaga tgaagaggca tgggaggaaa aatatccaaa ttaattacta aaatcgagaa
     4141 gagaaggcaa actcttgaaa agtaaaaagg tgtttgtgac cttcagtatt tattgaacag
     4201 aggaaataac tgacaagggc aatacaattc aatgttcatg tagtaacatt catgtcactt
     4261 gttgaatttg gttctcatat gtatattgca tacacataaa ttcaaactat aagtcgtcat
     4321 ttttgagcca tcatcttaca ttcatgtaat gaaattatgg aagagagtaa aaactagctc
     4381 ttaacttagt aaatataata tggtatttaa aatcaggtca ctacagtaag gttctaagta
     4441 ttgccaattg aaaagctaga aatggtatta ctgttgcaaa gtgttgtcaa taattgactc
     4501 caatagcatt gtaaatactt gtatcccaca actattttaa acccaagcaa taaaatggat
     4561 tttctaattc acttcaattc tttatttctc ttacctatct atgtcttggt acataagaaa
     4621 agtgtttcca tcactgcatt ggtagaatta tttcagtgtt attatttttg tgatttcgta
     4681 tgtctacaca aaaatgaatt agtttaattt atattgtgat acagttgttt gagaaatatt
     4741 tttaattctg tttcaacttt atttctccaa gtgtataata taaaaattac ttctgttatt
     4801 gttctctacc aataggggaa aaaattaaaa cattagatcc attgagaaag agatgatgta
     4861 ataaataatt aagattagta ataatattat caggggtgat tatgaccagt tgaataatct
     4921 ctttcccttg aattatttag ctaacaaatt aactctccca aatatttaaa ataatgtaaa
     4981 atcatatttt actgcccatt attaactaaa atatttttgt ttgactttga gcaccaactg
     5041 gtaatactaa taaataccca tgtcatgcag atggctgggc gaataagaga tgtctaaaaa
     5101 tatgcactgg tcttggaaaa catggcacaa gtaaggatat catatatgat gtctgtttat
     5161 tttatgtctg atttcttttg aatgagtagt tggggactcc atttctaagg agactaggta
     5221 aataaaatga cctttgacat ttca
//
