LOCUS       NM_001114598            1069 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens aspartate dehydrogenase domain containing (ASPDH),
            transcript variant 1, mRNA.
ACCESSION   NM_001114598
VERSION     NM_001114598.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1069)
  AUTHORS   He,X., Kang,Y. and Chen,L.
  TITLE     Identification of ASPDH as a novel NAADP-binding protein
  JOURNAL   Biochem Biophys Res Commun 621, 168-175 (2022)
   PUBMED   35841763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008743.9, BM924033.1 and BU729215.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001114598.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM924033.1, DRR138522.357387.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159080 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389208.9/ ENSP00000373860.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC008743.9         13532-13559         c
            29-835              BM924033.1         1-807
            836-1069            BU729215.1         21-254              c
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1069
                     /gene="ASPDH"
                     /note="aspartate dehydrogenase domain containing"
                     /db_xref="GeneID:554235"
                     /db_xref="HGNC:HGNC:33856"
     exon            1..142
                     /gene="ASPDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..942
                     /gene="ASPDH"
                     /EC_number="1.4.1.21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative L-aspartate dehydrogenase; aspartate
                     dehydrogenase domain-containing protein"
                     /codon_start=1
                     /product="aspartate dehydrogenase domain-containing
                     protein isoform 1"
                     /protein_id="NP_001108070.1"
                     /db_xref="CCDS:CCDS46153.1"
                     /db_xref="GeneID:554235"
                     /db_xref="HGNC:HGNC:33856"
                     /translation="MADRGPWRVGVVGYGRLGQSLVSRLLAQGPELGLELVFVWNRDP
                     GRMAGSVPPSLQLQNLAALGERRPDLVVEVAHPKIIHESGAQILRHANLLVGSPSALS
                     DQTTERQLLEASQHWDHAVFVARGALWGAEDIRRLDAAGGLRSLRVTMATHPDGFRLE
                     GPLAAAHSPGPCTVLYEGPVRGLCPFAPRNSNTMAAAALAAPSLGFDGVIGVLVADTS
                     LTDMHVVDVELSGPRGPTGRSFAVHTRRENPAEPGAVTGSATVTAFWQSLLACCQLPS
                     RPGIHLC"
     exon            143..287
                     /gene="ASPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            288..372
                     /gene="ASPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            373..522
                     /gene="ASPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            523..743
                     /gene="ASPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            744..898
                     /gene="ASPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1069
                     /gene="ASPDH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1044..1049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASPDH"
                     /note="hexamer: AGTAAA"
     polyA_site      1069
                     /gene="ASPDH"
                     /note="major polyA site"
ORIGIN      
        1 agatgtccaa agagcagcgg ctgcccaggc cttgtgcagc gggcagcgag cagcccaggg
       61 agccaggccc cagacaccgc actcagggcc atggccgaca ggggcccgtg gagggtgggc
      121 gtggtgggct atggccgcct cggacagtcc ctcgtctccc gcctcttggc tcagggacca
      181 gaacttggcc tagaacttgt ttttgtctgg aatcgtgacc caggacgaat ggcagggagc
      241 gtgccccctt ccctgcagct ccagaacctt gctgcccttg gggaaaggcg ccctgatctg
      301 gttgtggaag tggcccatcc caaaataatc catgaatctg gggcacaaat cctgcgccat
      361 gccaatctcc tggtggggtc cccctcagct ctaagtgacc agaccacaga gcggcagctc
      421 ttggaggcct cacagcactg ggaccacgcc gtgtttgtgg cccgaggggc cctgtggggc
      481 gctgaggaca tcaggagatt ggatgcagct gggggcctcc ggagccttcg tgtcaccatg
      541 gccacacacc ccgatggctt ccggcttgag ggacccctgg ctgcagccca cagccctggg
      601 ccttgcactg tgctctacga aggccctgtc cgtgggctct gcccctttgc cccgcgaaat
      661 tccaacacca tggcggcggc tgccctggct gcccccagcc tgggcttcga tggggtgatt
      721 ggggtgctcg tggctgatac cagcctcacg gacatgcacg tggtggatgt agagctgagc
      781 ggaccccggg gccccacggg ccgaagcttt gctgtgcaca cccgcagaga gaaccctgcc
      841 gagccaggcg cggtcaccgg ctccgccacc gtcacggcct tctggcagag cctcctggcc
      901 tgctgccagc tcccctccag gccggggatc catctctgct gagaagcctc ctccctcccg
      961 agacaagatc atctgcctgg cctctcacca ccaccatccc acccctgccc tgccccactt
     1021 ccccagggtc tcccttctga ctcagtaaag atcaccgctg cctcccccc
//
