LOCUS       NM_004192               2065 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens acetylserotonin O-methyltransferase like (ASMTL),
            transcript variant 1, mRNA.
ACCESSION   NM_004192 XM_942506
VERSION     NM_004192.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2065)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2065)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2065)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2065)
  AUTHORS   Ried,K., Rao,E., Schiebel,K. and Rappold,G.A.
  TITLE     Gene duplications as a recurrent theme in the evolution of the
            human pseudoautosomal region 1: isolation of the gene ASMTL
  JOURNAL   Hum Mol Genet 7 (11), 1771-1778 (1998)
   PUBMED   9736779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA005122.1, AK001090.1,
            AK301844.1, BM129217.1, AK225770.1 and BU688748.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004192.3.
            
            Summary: The protein encoded by this gene has an N-terminus that is
            similar to the multicopy associated filamentation (maf) protein of
            Bacillus subtilis and to orfE of Escherichia coli, while the
            C-terminus is similar to N-acetylserotonin O-methyltransferase.
            This gene is located in the pseudoautosomal region 1 (PAR1) of X
            and Y chromosomes. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.28568.1,
                                           SRR11853561.29198.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381317.9/ ENSP00000370718.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DA005122.1         69-104
            37-505              AK001090.1         1-469
            506-750             AK301844.1         483-727
            751-1035            BM129217.1         268-552
            1036-1454           AK225770.1         1026-1444
            1455-2063           AK301844.1         1432-2040
            2064-2065           BU688748.1         19-20               c
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="X"
                     /map="Y"
     gene            1..2065
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /note="acetylserotonin O-methyltransferase like"
                     /db_xref="GeneID:8623"
                     /db_xref="HGNC:HGNC:751"
                     /db_xref="MIM:300162"
                     /db_xref="MIM:400011"
     exon            1..162
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1935
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /EC_number="3.6.1.9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acetylserotonin N-methyltransferase-like; probable
                     bifunctional dTTP/UTP pyrophosphatase/methyltransferase
                     protein; N-acetylserotonin O-methyltransferase-like
                     protein"
                     /codon_start=1
                     /product="probable bifunctional dTTP/UTP
                     pyrophosphatase/methyltransferase protein isoform 1"
                     /protein_id="NP_004183.2"
                     /db_xref="CCDS:CCDS43917.1"
                     /db_xref="GeneID:8623"
                     /db_xref="HGNC:HGNC:751"
                     /db_xref="MIM:300162"
                     /db_xref="MIM:400011"
                     /translation="MVLCPVIGKLLHKRVVLASASPRRQEILSNAGLRFEVVPSKFKE
                     KLDKASFATPYGYAMETAKQKALEVANRLYQKDLRAPDVVIGADTIVTVGGLILEKPV
                     DKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLDTRVSEFYEETKVKFSELSEELL
                     WEYVHSGEPMDKAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKLYYPPRPE
                     DLRRSVKHDSIPAADTFEDLSDVEGGGSEPTQRDAGSRDEKAEAGEAGQATAEAECHR
                     TRETLPPFPTRLLELIEGFMLSKGLLTACKLKVFDLLKDEAPQKAADIASKVDASACG
                     MERLLDICAAMGLLEKTEQGYSNTETANVYLASDGEYSLHGFIMHNNDLTWNLFTYLE
                     FAIREGTNQHHRALGKKAEDLFQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLS
                     RFSSACDVGGCTGALARELAREYPRMQVTVFDLPDIIELAAHFQPPGPQAVQIHFAAG
                     DFFRDPLPSAELYVLCRILHDWPDDKVHKLLSRVAESCKPGAGLLLVETLLDEEKRVA
                     QRALMQSLNMLVQTEGKERSLGEYQCLLELHGFHQVQVVHLGGVLDAILATKVAP"
     exon            163..294
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     exon            295..342
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     exon            343..407
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     exon            408..469
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     exon            470..578
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     exon            579..966
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1129
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1314
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1447
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1591
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1714
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..2065
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2045..2050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /note="hexamer: AATAAA"
     polyA_site      2065
                     /gene="ASMTL"
                     /gene_synonym="ASMTLX; ASMTLY; ASTML"
                     /note="major polyA site"
ORIGIN      
        1 cagccgcgct gcgcgcaccg cgggctccgg gctcagaagt gcggacgccc ggctcccggc
       61 gtggacgcca tggtgctgtg cccggtgatt gggaagctgc tgcacaagcg cgtggtgctg
      121 gccagcgcct ccccacgccg tcaggagatc ctcagcaacg cgggtctcag gtttgaggtg
      181 gtcccctcca agtttaaaga gaagctggac aaagcctcct tcgctactcc gtatgggtac
      241 gccatggaga ccgccaagca gaaggccctg gaggtggcca accggctgta ccagaaagac
      301 ctgcgggccc ccgacgtggt cattggagcg gacacgatcg tgacagtcgg ggggctgatt
      361 ctggagaagc cggtggacaa gcaggacgcc tacaggatgc tgtcccggtt gagtgggaga
      421 gaacacagcg tgttcacagg tgtcgcgatc gtccactgct ccagcaaaga ccatcagctg
      481 gacaccaggg tctcggaatt ctacgaggaa acgaaggtga agttctcgga gctgtccgag
      541 gagctgctct gggaatacgt ccacagcggg gagcccatgg acaaagctgg cggctacggg
      601 atccaggccc tgggcggcat gctggtggag tccgtacacg gggactttct gaacgtggtg
      661 ggattcccgc tgaaccactt ctgcaagcag ctggtgaagc tctactaccc gccccgtccg
      721 gaggacctgc ggcggagtgt caagcacgac tccatcccgg ccgcggacac cttcgaagac
      781 ctcagtgacg tggagggggg cggctcggag cccactcaga gggacgcggg cagccgcgat
      841 gagaaggccg aggcgggaga ggcgggacag gccacggcag aggctgagtg tcacaggact
      901 cgggagaccc tgcctccgtt cccgacacgc ctcctggagc tgattgaggg ctttatgcta
      961 tccaagggcc tgctcaccgc ttgcaaactg aaggtgttcg atttgttaaa agatgaagca
     1021 ccccagaagg ctgcggatat tgccagcaaa gtggacgcct ctgcgtgtgg aatggagagg
     1081 cttctggaca tctgtgctgc catggggctc ctggagaaga cagagcaagg ttacagtaac
     1141 acagagacag cgaacgtcta cctggcatcg gatggcgaat actctctgca cggcttcatc
     1201 atgcacaata atgacctcac atggaacctc tttacatacc tggagtttgc catccgagag
     1261 ggaacaaacc agcaccacag ggcgttgggg aagaaggcgg aagatctgtt ccaggatgcg
     1321 tactaccaga gcccggagac gcggctgagg ttcatgcggg ccatgcacgg catgacgaag
     1381 ctgactgcgt gccaggtggc cacggccttc aatctgtccc gcttctcctc cgcctgcgac
     1441 gtgggaggct gcacgggtgc actggcccga gagctggccc gtgagtaccc tcgtatgcag
     1501 gtgactgtgt ttgacctccc agacattatc gagctggccg cccacttcca accccccgga
     1561 ccgcaggcag tgcagatcca cttcgcagca ggtgactttt tcagggaccc cctccccagc
     1621 gctgagctgt acgtcctgtg ccggatcctg catgactggc cagacgacaa agtccacaag
     1681 ttactcagca gggtcgccga gagctgcaag ccaggggccg gcctgctgct ggtggagacg
     1741 ctcctggatg aggagaagag ggtggcgcag cgcgccctga tgcagtcact gaacatgctg
     1801 gtgcagactg aaggcaagga gcggagcctg ggcgagtatc agtgcttgct ggagctgcac
     1861 ggcttccacc aggtgcaggt ggtgcacttg gggggtgtcc tggatgccat cttggccacc
     1921 aaagtggccc cctgaagccc aggcagcatg ttcattatag ggatgtcctc ccccaggctg
     1981 caggtggacc gcccggtccc caagtaccat aggacagtca cataggagcg tgtagtcgtg
     2041 actgaataaa gaaagcaaaa gcctg
//
