LOCUS       NM_017419               1696 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens acid sensing ion channel subunit family member 5
            (ASIC5), mRNA.
ACCESSION   NM_017419
VERSION     NM_017419.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Lefevre,C.M., Diakov,A., Haerteis,S., Korbmacher,C., Grunder,S. and
            Wiemuth,D.
  TITLE     Pharmacological and electrophysiological characterization of the
            human bile acid-sensitive ion channel (hBASIC)
  JOURNAL   Pflugers Arch 466 (2), 253-263 (2014)
   PUBMED   23842738
  REMARK    GeneRIF: hBASIC shares further key features with its rat ortholog:
            it is blocked by extracellular divalent cations, is inhibited by
            micromolar concentrations of the diarylamidine diminazene, and
            activated by millimolar concentrations of flufenamic acid.
REFERENCE   2  (bases 1 to 1696)
  AUTHORS   Wiemuth,D., Sahin,H., Falkenburger,B.H., Lefevre,C.M., Wasmuth,H.E.
            and Grunder,S.
  TITLE     BASIC--a bile acid-sensitive ion channel highly expressed in bile
            ducts
  JOURNAL   FASEB J 26 (10), 4122-4130 (2012)
   PUBMED   22735174
REFERENCE   3  (bases 1 to 1696)
  AUTHORS   Schaefer,L., Sakai,H., Mattei,M., Lazdunski,M. and Lingueglia,E.
  TITLE     Molecular cloning, functional expression and chromosomal
            localization of an amiloride-sensitive Na(+) channel from human
            small intestine
  JOURNAL   FEBS Lett 471 (2-3), 205-210 (2000)
   PUBMED   10767424
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093830.3 and AJ252011.1.
            
            On May 17, 2019 this sequence version replaced NM_017419.2.
            
            Summary: This gene belongs to the amiloride-sensitive Na+ channel
            and degenerin (NaC/DEG) family, members of which have been
            identified in many animal species ranging from the nematode to
            human. The amiloride-sensitive Na(+) channel encoded by this gene
            is primarily expressed in the small intestine, however, its exact
            function is not known. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ252011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267769 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000537611.3/ ENSP00000442477.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC093830.3         30897-30900         c
            5-91                AJ252011.1         1-87
            92-398              AC093830.3         28071-28377         c
            399-1696            AJ252011.1         395-1692
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..1696
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /note="acid sensing ion channel subunit family member 5"
                     /db_xref="GeneID:51802"
                     /db_xref="HGNC:HGNC:17537"
                     /db_xref="MIM:616693"
     exon            1..91
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1569
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /note="amiloride-sensitive sodium channel; human intestine
                     Na(+) channel; amiloride-sensitive cation channel 5,
                     intestinal; acid sensing (proton gated) ion channel family
                     member 5; acid sensing ion channel family member 5"
                     /codon_start=1
                     /product="acid-sensing ion channel 5"
                     /protein_id="NP_059115.1"
                     /db_xref="CCDS:CCDS3793.1"
                     /db_xref="GeneID:51802"
                     /db_xref="HGNC:HGNC:17537"
                     /db_xref="MIM:616693"
                     /translation="MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAIS
                     TSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVE
                     KMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAAS
                     HQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQA
                     KRKVSVSGRGLSLLFNVNQEAFTDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVG
                     MHARVTIRQVKTVHQEYPWGECNPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFL
                     LPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFP
                     SQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLG
                     LFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC"
     exon            92..398
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /inference="alignment:Splign:2.1.0"
     exon            399..636
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /inference="alignment:Splign:2.1.0"
     exon            637..762
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /inference="alignment:Splign:2.1.0"
     exon            763..912
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1060
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1117
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1286
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1378
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1696
                     /gene="ASIC5"
                     /gene_synonym="ACCN5; HINAC; INAC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgatgaaa attgggttac cctgaggact cttgcttaac tgaaatcaca aatggagcag
       61 acagaaaaat caaaagtata tgctgagaac ggactcttag aaaagataaa gctttgcctt
      121 tcaaagaaac cactgccatc tcccactgag cgaaagaagt ttgaccatga ctttgccatc
      181 tccacttcct ttcatgggat acacaatatt gttcagaacc ggagcaaaat tcgcagggtg
      241 ctctggttgg tggtggttct gggctcagtc tcacttgtga catggcagat ctacattcgc
      301 ttgctcaact acttcacatg gccaaccaca acgtccattg aggttcaata tgtggaaaag
      361 atggagttcc cagctgtgac attttgtaat ttgaacaggt tccaaacaga tgctgtagcc
      421 aaatttggtg ttattttttt cttatggcac attgtatcca aagtcctcca tcttcaagaa
      481 attactgcca attccactgg ctctagagag gctactgatt ttgctgcaag tcaccaaaac
      541 ttcagcattg tggaatttat caggaacaaa ggtttttatc tcaacaatag cactttgttg
      601 gactgtgagt tttttggaaa gccatgtagc ccaaaggatt ttgcacatgt cttcactgaa
      661 tatggaaatt gttttacttt taatcatggt gaaactctcc aagcaaagag aaaagtgagt
      721 gtctctggaa gaggtttgag cttactcttc aatgtgaatc aggaggcatt cactgataac
      781 ccagcccttg gtttcgttga tgctgggatc atctttgtta tccattcacc aaagaaggtg
      841 ccacagtttg atgggttagg cttgttgtca cctgtgggaa tgcacgcaag ggtaaccatc
      901 cgccaagtga agacagttca tcaagaatac ccttggggag aatgcaatcc taacatcaag
      961 ctgcagaatt ttagcagcta cagcacttct ggttgcttga aggaatgcaa agcccagcac
     1021 ataaaaaagc aatgtggatg tgtgcctttt cttcttcctg gatatgggat agaatgtgac
     1081 ctacaaaagt acttcagctg tgtttctcct gtacttgacc acattgaatt taaggattta
     1141 tgtacagtag gaacacataa ctctagctgc cccgtttctt gtgaagaaat agaatacccg
     1201 gccactattt cttattcctc ttttccaagt caaaaagctt tgaaatatct ttccaagaag
     1261 ttgaatcaaa gccggaaata catcagggag aatcttgtaa aaattgaaat taactatagt
     1321 gacctaaact ataagataac ccagcagcaa aaggcggtga gtgtgtctga gttacttgca
     1381 gatcttggtg gtcagctggg tctattttgt ggggccagtc tgatcacgat catagaaatt
     1441 attgaatatc tattcaccaa tttctactgg atatgcattt tctttttgct gaagatatct
     1501 gaaatgaccc agtggactcc tccacctcag aatcatctgg gaaataaaaa taggatagag
     1561 gagtgttaat ggtcacttag aataaaatag tttccttttc atgatacctt cagatttatc
     1621 ttgactaatt cattgttacg tcacttttct atagttttga gagttcgata aaagccatta
     1681 aagatatgta tctctt
//
