LOCUS       NM_020039               4024 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens acid sensing ion channel subunit 1 (ASIC1), transcript
            variant 1, mRNA.
ACCESSION   NM_020039
VERSION     NM_020039.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4024)
  AUTHORS   Wang,Y.M., Tang,H., Tang,Y.J., Liu,J., Yin,Y.F., Tang,Y.L.,
            Feng,Y.G. and Gu,H.F.
  TITLE     ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy
  JOURNAL   J Adv Res 63, 195-206 (2024)
   PUBMED   37931656
  REMARK    GeneRIF: ASIC1/RIP1 accelerates atherosclerosis via disrupting
            lipophagy.
REFERENCE   2  (bases 1 to 4024)
  AUTHORS   Lai,K., Pritisanac,I., Liu,Z.Q., Liu,H.W., Gong,L.N., Li,M.X.,
            Lu,J.F., Qi,X., Xu,T.L., Forman-Kay,J., Shi,H.B., Wang,L.Y. and
            Yin,S.K.
  TITLE     Glutamate acts on acid-sensing ion channels to worsen ischaemic
            brain injury
  JOURNAL   Nature 631 (8022), 826-834 (2024)
   PUBMED   38987597
  REMARK    GeneRIF: Glutamate acts on acid-sensing ion channels to worsen
            ischaemic brain injury.
REFERENCE   3  (bases 1 to 4024)
  AUTHORS   Liu,Y., Wang,B., Cheng,Y., Fang,Y., Hou,Y., Mao,Y., Wu,X.,
            Jiang,D., He,Y. and Jin,C.
  TITLE     ASIC1 promotes migration and invasion of hepatocellular carcinoma
            via the PRKACA/AP-1 signaling pathway
  JOURNAL   Carcinogenesis 45 (6), 399-408 (2024)
   PUBMED   38306794
  REMARK    GeneRIF: ASIC1 promotes migration and invasion of hepatocellular
            carcinoma via the PRKACA/AP-1 signaling pathway.
REFERENCE   4  (bases 1 to 4024)
  AUTHORS   Pissas,K.P., Grunder,S. and Tian,Y.
  TITLE     Functional expression of the proton sensors ASIC1a, TMEM206, and
            OGR1 together with BKCa channels is associated with cell volume
            changes and cell death under strongly acidic conditions in DAOY
            medulloblastoma cells
  JOURNAL   Pflugers Arch 476 (6), 923-937 (2024)
   PUBMED   38627262
  REMARK    GeneRIF: Functional expression of the proton sensors ASIC1a,
            TMEM206, and OGR1 together with BKCa channels is associated with
            cell volume changes and cell death under strongly acidic conditions
            in DAOY medulloblastoma cells.
REFERENCE   5  (bases 1 to 4024)
  AUTHORS   Wang,T., Wang,Q., Pan,G., Jia,G., Li,X., Wang,C., Zhang,L. and
            Zuo,C.
  TITLE     ASIC1a involves the acid-mediated activation of pancreatic stellate
            cells associated with autophagy induction
  JOURNAL   Physiol Res 72 (1), 49-57 (2023)
   PUBMED   36545882
  REMARK    GeneRIF: ASIC1a involves the acid-mediated activation of pancreatic
            stellate cells associated with autophagy induction.
REFERENCE   6  (bases 1 to 4024)
  AUTHORS   Bubien,J.K., Keeton,D.A., Fuller,C.M., Gillespie,G.Y., Reddy,A.T.,
            Mapstone,T.B. and Benos,D.J.
  TITLE     Malignant human gliomas express an amiloride-sensitive Na+
            conductance
  JOURNAL   Am J Physiol 276 (6), C1405-C1410 (1999)
   PUBMED   10362604
REFERENCE   7  (bases 1 to 4024)
  AUTHORS   Bassilana,F., Champigny,G., Waldmann,R., de Weille,J.R.,
            Heurteaux,C. and Lazdunski,M.
  TITLE     The acid-sensitive ionic channel subunit ASIC and the mammalian
            degenerin MDEG form a heteromultimeric H+-gated Na+ channel with
            novel properties
  JOURNAL   J Biol Chem 272 (46), 28819-28822 (1997)
   PUBMED   9360943
REFERENCE   8  (bases 1 to 4024)
  AUTHORS   Waldmann,R., Champigny,G., Bassilana,F., Heurteaux,C. and
            Lazdunski,M.
  TITLE     A proton-gated cation channel involved in acid-sensing
  JOURNAL   Nature 386 (6621), 173-177 (1997)
   PUBMED   9062189
REFERENCE   9  (bases 1 to 4024)
  AUTHORS   Garcia-Anoveros,J., Derfler,B., Neville-Golden,J., Hyman,B.T. and
            Corey,D.P.
  TITLE     BNaC1 and BNaC2 constitute a new family of human neuronal sodium
            channels related to degenerins and epithelial sodium channels
  JOURNAL   Proc Natl Acad Sci U S A 94 (4), 1459-1464 (1997)
   PUBMED   9037075
REFERENCE   10 (bases 1 to 4024)
  AUTHORS   Corey,D.P. and Garcia-Anoveros,J.
  TITLE     Mechanosensation and the DEG/ENaC ion channels
  JOURNAL   Science 273 (5273), 323-324 (1996)
   PUBMED   8685718
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025154.31.
            
            On Jun 2, 2019 this sequence version replaced NM_020039.3.
            
            Summary: This gene encodes a member of the acid-sensing ion channel
            (ASIC) family of proteins, which are part of the
            degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members
            of the ASIC family are sensitive to amiloride and function in
            neurotransmission. The encoded proteins function in learning, pain
            transduction, touch sensation, and development of memory and fear.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U78180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AC025154.31        109986-110306
            322-699             AC025154.31        111141-111518
            700-895             AC025154.31        112149-112344
            896-1046            AC025154.31        129603-129753
            1047-1174           AC025154.31        130390-130517
            1175-1331           AC025154.31        130811-130967
            1332-1388           AC025154.31        131314-131370
            1389-1542           AC025154.31        132292-132445
            1543-1772           AC025154.31        132888-133117
            1773-1852           AC025154.31        133492-133571
            1853-1957           AC025154.31        133650-133754
            1958-4024           AC025154.31        133935-136001
FEATURES             Location/Qualifiers
     source          1..4024
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..4024
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /note="acid sensing ion channel subunit 1"
                     /db_xref="GeneID:41"
                     /db_xref="HGNC:HGNC:100"
                     /db_xref="MIM:602866"
     exon            1..321
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..699
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..2062
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /note="isoform a is encoded by transcript variant 1;
                     Cation channel, amiloride-sensitive, neuronal, 2;
                     acid-sensing ion channel 1a protein; brain sodium channel
                     2; amiloride-sensitive cation channel 2, neuronal; acid
                     sensing (proton gated) ion channel 1"
                     /codon_start=1
                     /product="acid-sensing ion channel 1 isoform a"
                     /protein_id="NP_064423.2"
                     /db_xref="CCDS:CCDS8796.1"
                     /db_xref="GeneID:41"
                     /db_xref="HGNC:HGNC:100"
                     /db_xref="MIM:602866"
                     /translation="MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRA
                     LWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQ
                     VSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDR
                     AGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGL
                     EIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ
                     EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDA
                     PYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAK
                     KFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVA
                     PYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGASILTVLELFDYAYEVIK
                     HKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPAR
                     GTFEDFTC"
     exon            700..895
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1046
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1174
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1331
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1388
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1542
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1772
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1852
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1957
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..4024
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3122..3127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /note="hexamer: TATAAA"
     polyA_site      3140
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
     regulatory      4005..4010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /note="hexamer: AATAAA"
     polyA_site      4024
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /note="major polyA site"
ORIGIN      
        1 ccccctcccc tcccgccgcc tcccggccgg acgatggatc cctgcagatc ccagggctga
       61 gagcaccgcg caccgcgccg agcccgggca gaccgagccg aggcgagcga gccagcgagc
      121 cagcgcgcgc gggcgggcgg acagatcgga gccgagcggg gccgggcggg gcgctccctg
      181 cagggctctg cgcggcgtgc cgcggcggcc gcgggctccg gccccgggcc atgagcccct
      241 ccgcgactcg gcgctgagcc cgccaccggt ccagcgcccc aggacccgcc gccggctgcc
      301 ggcttgccga agccccctca ggatcccctc aacaaggatg gaactgaagg ccgaggagga
      361 ggaggtgggt ggcgtccagc cggtgagcat ccaggccttc gccagcagct ccacactgca
      421 cggcctggcc cacatcttct cctacgagcg gctgtctctg aagcgggcac tgtgggccct
      481 gtgcttcctg ggctccctgg ctgtgctgct gtgtgtgtgc acggagcgtg tgcagtacta
      541 cttccactac caccatgtca ccaagctcga cgaggtggct gcctctcagc ttaccttccc
      601 tgctgtcacg ctgtgcaacc tcaacgagtt ccgctttagc caagtctcca agaatgacct
      661 gtatcatgct ggggagctgc tggccctgct caacaacagg tatgagatac cagacacaca
      721 gatggcagat gaaaagcagc tggagatact gcaggacaaa gccaacttcc gcagcttcaa
      781 acccaaaccc ttcaacatgc gtgagttcta cgaccgagct gggcacgaca ttcgagacat
      841 gctgctctcc tgccacttcc ggggggaggt ctgcagcgct gaagacttca aggtggtctt
      901 cacacgctat ggaaagtgct acacgttcaa ctcgggccga gatgggcggc cgcggctgaa
      961 gaccatgaag ggtgggacgg gcaatgggct ggaaatcatg ctggacatcc agcaggacga
     1021 gtacctgcct gtgtgggggg agactgacga gacgtccttc gaagcaggca tcaaagtgca
     1081 gatccatagt caggatgaac ctcctttcat cgaccagctg ggctttggcg tggccccagg
     1141 cttccagacc tttgtggcct gccaggagca gcggctcatc tacctgcccc caccctgggg
     1201 cacctgcaaa gctgttacca tggactcgga tttggatttc ttcgactcct acagcatcac
     1261 tgcctgccgc atcgactgtg agacgcgcta cctggtggag aactgcaact gccgcatggt
     1321 gcacatgcca ggggatgccc catactgtac tccagagcag tacaaggagt gtgcagatcc
     1381 tgctctggac ttcctggtgg agaaggacca ggagtactgc gtgtgtgaaa tgccttgcaa
     1441 cctgacccgc tatggcaaag agctgtccat ggtcaagatc cccagcaaag cctcagccaa
     1501 gtacctggcc aagaagttca acaaatctga gcaatacata ggggagaaca tcctggtgct
     1561 ggacattttc tttgaagtcc tcaactatga gaccattgaa cagaagaagg cctatgagat
     1621 tgcagggctc ctgggtgagc tgctgatgac acctgtcccc ttctcatgcc atgggcatgg
     1681 cgtggctccc tatcatccaa aagcagggtg ctcacttctg tcccatgagg gtcctccacc
     1741 ccagaggccc ttccccaaac cctgttgtct tggtgacatc gggggccaga tggggctgtt
     1801 catcggggcc agcatcctca cggtgctgga gctctttgac tacgcctacg aggtcattaa
     1861 gcacaagctg tgccgacgag gaaaatgcca gaaggaggcc aaaaggagca gtgcggacaa
     1921 gggcgtggcc ctcagcctgg acgacgtcaa aagacacaac ccgtgcgaga gccttcgggg
     1981 ccaccctgcc gggatgacat acgctgccaa catcctacct caccatccgg cccgaggcac
     2041 gttcgaggac tttacctgct gagccccgca ggccgctgaa ccaaaggcct agatggggag
     2101 gactaggaga gcgagggggc ccccagctgc ctcctcacat ctgccctggg gactccccac
     2161 actccggggc agatctttcc tcttgtctgt ggtaaggaag gagtcttgac catagagtcc
     2221 tctctctgcc tctatcccat tctttttaca tttaacaaaa ctaatctaaa aaagaactaa
     2281 aaagggagaa cggggcaagg gacctcaggc tgcccctctc tcctccatgc tgcctcccct
     2341 agctcccagc ctgaattctg tctatctagc tgtctgccat ctgagtgtcc atctacattc
     2401 tgctgccacc agtcaccaaa ggcccttccc agtgaggggt ggaagggatc tctggggtct
     2461 ggaatttggc cccaaaccag agaatgtacc ttaaggggga gggctagtgt gggggaggga
     2521 ggcttcccca gccttaagag accctctcag cccagtgact gtccccaaac ccaagtctcc
     2581 tggcaggaac taaaacctca gccccactct ctcacaccat gtggaatctc gtgggggtcg
     2641 gggatcccct taagaagtgg taatggggac aagatgcggc cctggtgctg taggctacat
     2701 cctgatacct ataagttcac ccccacccca cagctgctgg agagaaatcc caagaggcag
     2761 cccttcctca ccatcccatt aaagaccggg ctggttagcg tccagctcag ggagaagggc
     2821 gctagtgcct aacctcactg gtccctctcc cggaggccct tgtagagggc cacgtccata
     2881 aattttctta tggaactctc ccacatcctc ttccccaact tcatttgctt ctctcaacaa
     2941 cctcatctgc attttctatt tctatatgat acagactcta tattgctata tctctgtata
     3001 tactttccca gccctgtctg tctccacccc atcccctctt gtctctgaga accattctcc
     3061 caccccaagt tccaccttct atgtttctac tccctccctg gtctctgaat gccttcgcct
     3121 gtataaagag ttggactctc tcccctggtg tctgtactgt gtacacacat ccctctgaga
     3181 agcacaagga gacgacacgc gcattgtaac ctttgcactg tctcagtggc gacaaaggaa
     3241 gctgtgaatc acaagctctg cctctttctg gcctcaccct ctcccccaac ccgggcaccc
     3301 tcggccctcc ctgcagcctt aacattctct tcccctgctc ctcctatccc attgccctct
     3361 gcccagctga cagtggcatc cccagggaag gggttgctgt agagatagcc cccacccagg
     3421 ggatggaggt ctaccctgga cactaagcca agtgtgtcag agacagaagg gagctgggga
     3481 ttggcgactc ctgaagttgg ggcagtggga tgctgacagg cagaagctga ggtcctcagt
     3541 cagtggcctt tcctccttct gggtgcccag ccccctttcc tcacctgata cccaagccca
     3601 ccacttttat tttctggtga ggtgggtttg ggaggaaaga gaggcctaga ggaggagttg
     3661 aaagctctgc tgttgtctca ccctatctta atgagagaca agtgaggtgg agggcctgcc
     3721 ccccctccct ccaccagaca ctccttccag gcctgagccc caacccctct tcaggccttc
     3781 cttccctagc tgtgtcttgg tcttcaatcc cagaacagga cctgtgagca gctgcattgg
     3841 cctggagctg gagagtaagg ctgtaggatc tttggaatct cttggttcct aagagtttcc
     3901 tcagagatca tacctcccca gagggaagca ggaatgaggc caaaaagtgt gcattggata
     3961 ggggaacagc aggcagggct ctgggtgacg catgcctctg gtctaataaa ctgggtttca
     4021 acca
//
